Gene: MIF

4282
GIF|GLIF|MMIF
macrophage migration inhibitory factor
protein-coding
22q11.23
Ensembl:ENSG00000240972 MIM:153620 Vega:OTTHUMG00000150773 UniprotKB:P14174
NG_012099.1
PubMed
0   ANCO-SNPs
OD|ND|AD
24   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.778e-1 (AD)  2.641e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UBALD10.822
TMEM2400.82
LRFN10.815
MESP10.815
ZNF6530.814
ARMC50.807
PICK10.804
SAC3D10.802
CALY0.802
TMEM1210.788

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EBF1-0.462
REST-0.456
KCNJ15-0.435
RAET1E-0.432
FZD10-0.422
PABPC4L-0.421
P2RY14-0.418
TBX15-0.417
DISC1-0.417
PDE3A-0.415

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB018803,4-Dihydroxycinnamic AcidSmall Molecule331-39-5Experimental|InvestigationalTarget
DB027287-Hydroxy-2-Oxo-Chromene-3-Carboxylic Acid Ethyl EsterSmall MoleculeExperimentalTarget
DB04272Citric AcidSmall Molecule77-92-9Approved|NutraceuticalTarget
DB077183-(4-HYDROXY-PHENYL)PYRUVIC ACIDSmall MoleculeExperimentalTarget
DB078883-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTERSmall MoleculeExperimentalTarget
DB083334-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIMESmall MoleculeExperimentalTarget
DB083343-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIMESmall MoleculeExperimentalTarget
DB083354-HYDROXYBENZALDEHYDE O-(3,3-DIMETHYLBUTANOYL)OXIMESmall MoleculeExperimentalTarget
DB087656-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDESmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0252051,10-phenanthroline"1,10-phenanthroline results in increased expression of MIF mRNA"19502547
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of MIF mRNA"19162173
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MIF mRNA"12376462
C4624993-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazoleacetic acid methyl ester"3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazoleacetic acid methyl ester results in decreased activity of MIF protein"20127836
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Cadmium results in increased expression of MIF mRNA]23085580
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of MIF mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of MIF protein"25670856
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to MIF protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to MIF protein]26598702
C0105904-hydroxyphenylpyruvic acid[CP protein co-treated with 4-hydroxyphenylpyruvic acid] results in decreased activity of MIF protein26091949
D000082AcetaminophenAcetaminophen affects the expression of MIF mRNA25064622
C056165acetovanilloneacetovanillone inhibits the reaction [TNF protein results in increased expression of MIF mRNA]22414048
D020106AcrylamideAcrylamide affects the expression of MIF mRNA28959563
C412373AG 1879AG 1879 inhibits the reaction [MIF protein results in increased expression of MMP2 protein]16872482
C412373AG 1879AG 1879 inhibits the reaction [MIF protein results in increased phosphorylation of JUN protein]16872482
C412373AG 1879AG 1879 inhibits the reaction [MIF protein results in increased phosphorylation of MAPK8 protein]16872482
C412373AG 1879AG 1879 inhibits the reaction [MIF protein results in increased phosphorylation of PRKCD protein]16872482
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of MIF protein16751997
D000638AmiodaroneAmiodarone affects the expression of MIF mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MIF mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of MIF mRNA24449571
D001151ArsenicArsenic affects the expression of MIF protein24675094
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to MIF protein]26598702
C006632arsenic trioxidearsenic trioxide results in decreased expression of MIF protein19364129|2541905
C047721artemisic acidartemisic acid results in decreased expression of MIF mRNA23063590
D001194AsbestosAsbestos results in increased expression of MIF protein25162674
D017636Asbestos, Amphibole"Asbestos, Amphibole results in decreased expression of MIF protein"20855422
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MIF mRNA27195522
D004958EstradiolEstradiol results in decreased expression of MIF mRNA24349563
D004958EstradiolEstradiol results in increased expression of MIF mRNA11861973
D004958EstradiolTetrachlorodibenzodioxin promotes the reaction [Estradiol results in increased expression of MIF mRNA]11861973
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of MIF mRNA26496021
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in increased expression of MIF mRNA15912405
C006780bisphenol Abisphenol A results in increased secretion of MIF protein26021997
C006780bisphenol Abisphenol A affects the expression of MIF mRNA21786754
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of MIF mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of MIF mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MIF gene28505145
D001761BleomycinBleomycin results in decreased expression of MIF protein25933445
C006794brevianamide Abrevianamide A results in increased expression of MIF mRNA19818335
C032036bromobenzenebromobenzene metabolite binds to MIF protein17305373
D002065BuspironeBuspirone results in decreased expression of MIF mRNA24136188
C026105butylidenephthalidebutylidenephthalide results in increased expression of MIF protein23770345
D002104Cadmium3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Cadmium results in increased expression of MIF mRNA]23085580
D002104CadmiumCadmium binds to MIF protein23085580
D002104CadmiumCadmium results in increased expression of MIF mRNA23085580
D002104CadmiumMIF protein results in decreased susceptibility to Cadmium23085580
C028031cadmium acetatecadmium acetate results in increased expression of MIF mRNA12965115
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of MIF mRNA25993096
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of MIF promoter22457795
D002211CapsaicinCapsaicin results in increased expression of MIF protein22150557
D002211Capsaicin[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MIF protein]22150557
D002211CapsaicinNaproxen inhibits the reaction [Capsaicin results in increased expression of MIF protein]22150557
D002211CapsaicinSumatriptan inhibits the reaction [Capsaicin results in increased expression of MIF protein]22150557
D002220CarbamazepineCarbamazepine affects the expression of MIF mRNA25979313
D002392CatechinCatechin results in decreased expression of MIF mRNA15465739
C026690cerous chloridecerous chloride results in increased expression of MIF23712967
C100187chloropicrinchloropicrin results in decreased expression of MIF mRNA28476498
D002746ChlorpromazineChlorpromazine affects the expression of MIF mRNA25064622
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of MIF mRNA28472532
C012843cinnamic aldehydecinnamic aldehyde results in increased expression of MIF mRNA11244134
C000488cladosporincladosporin results in increased expression of MIF mRNA19818335
D007464ClioquinolClioquinol results in increased expression of MIF mRNA19502547
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of MIF mRNA17602206
D003035Cobalt[tungsten carbide co-treated with Cobalt] results in increased expression of MIF mRNA18078969
C018021cobaltous chloridecobaltous chloride results in increased expression of MIF mRNA19502547
C060728cobalt oxidecobalt oxide analog results in increased expression of MIF mRNA24821434
C026305cobalt sulfatecobalt sulfate results in increased expression of MIF mRNA19502547
D019327Copper SulfateCopper Sulfate results in decreased expression of MIF mRNA19549813
C015763cumene[cumene co-treated with KRAS gene mutant form] results in increased expression of MIF mRNA18648096
D003474CurcuminCurcumin results in decreased expression of MIF18462866
D003520CyclophosphamideCyclophosphamide affects the localization of and affects the expression of MIF protein19066630
D003520CyclophosphamideCyclophosphamide promotes the reaction [MIF protein binds to CXCR4 protein]19066630
D016572CyclosporineCyclosporine affects the expression of MIF mRNA25064622
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of MIF mRNA]27941970
D003907DexamethasoneDexamethasone results in decreased expression of MIF mRNA21041162
D016264Dextran SulfateDextran Sulfate results in increased expression of MIF mRNA12105854
D016264Dextran SulfateMIF protein affects the reaction [Dextran Sulfate results in decreased expression of IL4 mRNA]12105854
D016264Dextran SulfateMIF protein affects the reaction [Dextran Sulfate results in increased expression of IFNG mRNA]12105854
D016264Dextran SulfateMIF protein affects the reaction [Dextran Sulfate results in increased expression of MMP13 mRNA]12105854
D016264Dextran SulfateMIF protein affects the reaction [Dextran Sulfate results in increased expression of TNF mRNA]12105854
D003976DiazinonDiazinon results in increased methylation of MIF gene22964155
D003976DiazinonDiazinon results in increased expression of MIF protein19647006
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MIF mRNA21266533
D004041Dietary FatsDietary Fats results in increased expression of MIF mRNA18457598
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of MIF mRNA17602206
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MIF mRNA18544905
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid] results in increased expression of MIF mRNA18544905
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of MIF mRNA27638505
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of MIF mRNA"12376462
D004139DinitrofluorobenzeneDinitrofluorobenzene results in increased expression of MIF mRNA11244134
D004281Docosahexaenoic AcidsDocosahexaenoic Acids results in decreased expression of MIF mRNA16623957
D004317DoxorubicinDoxorubicin affects the expression of MIF protein29385562
D004317DoxorubicinDoxorubicin results in decreased expression of MIF mRNA27181935
C509867E804 bisindoleE804 bisindole inhibits the reaction [Lipopolysaccharides results in increased expression of MIF mRNA]23107598
C509867E804 bisindoleE804 bisindole results in increased expression of MIF mRNA23107598
C509867E804 bisindoleLipopolysaccharides inhibits the reaction [E804 bisindole results in increased expression of MIF mRNA]23107598
C031818enterotoxin B, staphylococcal"MIF protein affects the susceptibility to enterotoxin B, staphylococcal"9892616
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of MIF protein23301498
D000431EthanolEthanol results in increased expression of MIF mRNA15353170
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MIF mRNA25064622
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MIF mRNA17555576
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MIF mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MIF mRNA15576828|1617478
D018120FinasterideFinasteride results in increased expression of MIF mRNA24136188
D005419FlavonoidsFlavonoids results in increased expression of MIF mRNA15465739
D005473FluoxetineMIF affects the susceptibility to Fluoxetine20177408
D005485FlutamideFlutamide results in increased expression of MIF mRNA24136188
D005492Folic AcidFolic Acid affects the expression of MIF mRNA17320366
D037741FullerenesFullerenes analog results in increased expression of MIF mRNA22342292
C043055gallium arsenidegallium arsenide results in increased expression of MIF mRNA14560044
D005839GentamicinsGentamicins results in decreased expression of MIF mRNA22061828
D005839GentamicinsGentamicins results in increased expression of MIF mRNA22061828
D019812Heparan Sulfate ProteoglycansMIF protein binds to Heparan Sulfate Proteoglycans26852939
D019812Heparan Sulfate Proteoglycans"N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [MIF protein binds to Heparan Sulfate Proteoglycans]]"26852939
D019812Heparan Sulfate ProteoglycansSDC1 protein inhibits the reaction [MIF protein binds to Heparan Sulfate Proteoglycans]26852939
D019812Heparan Sulfate ProteoglycansTetradecanoylphorbol Acetate inhibits the reaction [MIF protein binds to Heparan Sulfate Proteoglycans]26852939
D006493HeparinMIF protein binds to Heparin26852939
D017313FenretinideFenretinide results in increased expression of MIF mRNA28973697
D006851Hydrochloric AcidHydrochloric Acid results in increased expression of MIF mRNA12853844
D006851Hydrochloric AcidHydrochloric Acid results in increased expression of MIF protein12853844
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MIF mRNA25613284
D007501Iron[Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of MIF mRNA22198552
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of MIF protein17337753
C410337K 7174K 7174 results in decreased expression of MIF mRNA24086573
D007657Ketone BodiesKetone Bodies results in decreased expression of MIF mRNA15469884
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of MIF mRNA18544905
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid] results in increased expression of MIF mRNA18544905
D001556LindaneLindane results in increased expression of MIF mRNA24349563
D008070LipopolysaccharidesINS protein inhibits the reaction [Lipopolysaccharides results in increased expression of MIF protein]20699433
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of MIF mRNA9122163
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of MIF protein20699433
D008070LipopolysaccharidesE804 bisindole inhibits the reaction [Lipopolysaccharides results in increased expression of MIF mRNA]23107598
D008070LipopolysaccharidesLipopolysaccharides inhibits the reaction [E804 bisindole results in increased expression of MIF mRNA]23107598
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of MIF mRNA23107598
D008070Lipopolysaccharidesmethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of MIF mRNA]15933225
D008070LipopolysaccharidesMIF protein affects the susceptibility to Lipopolysaccharides9892616
D008694MethamphetamineMethamphetamine results in decreased expression of MIF mRNA19149911
D008715MethionineMethionine deficiency results in increased expression of MIF mRNA15924568
C008435methyldithiocarbamatemethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased expression of MIF mRNA]15933225
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MIF mRNA23458150
D008777MethyltestosteroneMethyltestosterone results in increased expression of MIF mRNA29191790
D015735MifepristoneMifepristone results in increased expression of MIF mRNA19439560
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of MIF protein27384973
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of MIF protein20045430
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of MIF mRNA27321306
C568376MT19c compoundMT19c compound results in decreased expression of MIF mRNA21781307
D009151Mustard GasMustard Gas results in decreased expression of MIF mRNA12884408
D009151Mustard GasMustard Gas results in increased expression of MIF mRNA18955075
D009173Mycophenolic AcidMycophenolic Acid results in increased expression of MIF mRNA19818335
D009183MycotoxinsMycotoxins results in increased expression of MIF mRNA19818335
C092152N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide"N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [MIF protein binds to Heparan Sulfate Proteoglycans]]"26852939
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased secretion of MIF protein"20800606
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MIF mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MIF mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MIF mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MIF mRNA"25554681
D009281NaphthalenesNaphthalenes results in decreased expression of MIF protein17337753
D009288Naproxen[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MIF protein]22150557
D009288NaproxenNaproxen inhibits the reaction [Capsaicin results in increased expression of MIF protein]22150557
C051752nefazodonenefazodone results in increased expression of MIF mRNA24136188
D009532Nickel[Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of MIF mRNA22198552
C029938nickel sulfatenickel sulfate results in increased expression of MIF mRNA11751209
C025589ochratoxin Aochratoxin A results in decreased expression of MIF mRNA23358140
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of MIF mRNA17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of MIF mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of MIF mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of MIF mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of MIF mRNA]17655762
D010100OxygenOxygen deficiency results in increased expression of MIF mRNA19502547|2651600
D010100OxygenHIF1A protein promotes the reaction [Oxygen deficiency results in increased expression of MIF mRNA]20880076
D010100OxygenOxygen deficiency results in increased expression of MIF mRNA20880076
D010100OxygenOxygen results in increased expression of MIF mRNA10781441|2363781
D010100OxygenOxygen results in increased expression of MIF protein23637810
D010269ParaquatParaquat affects the expression of MIF mRNA25064622
D010269ParaquatParaquat results in decreased expression of MIF mRNA21371552
D052638Particulate Matteroxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of MIF mRNA]17655762
D052638Particulate MatterParticulate Matter affects the expression of MIF mRNA17655762
D052638Particulate MatterParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of MIF mRNA]17655762
D052638Particulate MatterParticulate Matter results in decreased expression of MIF mRNA24769257
D052638Particulate MatterParticulate Matter results in increased expression of MIF protein27295300
D010634PhenobarbitalPhenobarbital results in increased expression of MIF mRNA19162173
C006253pirinixic acidpirinixic acid results in increased expression of MIF mRNA23811191
D010936Plant ExtractsPlant Extracts results in increased expression of MIF mRNA15465739
D059808PolyphenolsPolyphenols results in increased expression of MIF mRNA15465739
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of MIF mRNA19162173
D011374ProgesteroneProgesterone results in decreased expression of MIF mRNA23018184
D011374ProgesteroneProgesterone results in decreased expression of MIF mRNA19690047
C010313pseudocumenepseudocumene results in decreased expression of MIF protein17337753
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [MIF protein results in increased phosphorylation of JUN protein]16872482
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [MIF protein results in increased phosphorylation of PRKCD protein]16872482
D011748PyrogallolPyrogallol results in decreased expression of MIF mRNA20362636
D011794QuercetinQuercetin results in increased expression of MIF mRNA19729006
C071924Ro 31-8425Ro 31-8425 inhibits the reaction [MIF protein results in increased expression of MMP2 protein]16872482
C085746rottlerinrottlerin inhibits the reaction [MIF protein results in increased expression of MMP2 protein]16872482
D012524SarinSarin results in increased expression of MIF protein28973502
D012822Silicon DioxideSilicon Dioxide analog affects the secretion of MIF protein25895662
D012834SilverSilver results in increased expression of MIF mRNA22342292
D013241SterigmatocystinSterigmatocystin results in increased expression of MIF mRNA19818335
D018170Sumatriptan[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MIF protein]22150557
D018170SumatriptanSumatriptan inhibits the reaction [Capsaicin results in increased expression of MIF protein]22150557
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MIF mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MIF mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [Estradiol results in increased expression of MIF mRNA]11861973
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of MIF mRNA28973375
D013752TetracyclineTetracycline affects the expression of MIF mRNA25064622
D013755Tetradecanoylphorbol Acetate[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of MIF mRNA9122163
D013755Tetradecanoylphorbol Acetate"N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [MIF protein binds to Heparan Sulfate Proteoglycans]]"26852939
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate inhibits the reaction [MIF protein binds to Heparan Sulfate Proteoglycans]26852939
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MIF mRNA25613284
D013853ThioacetamideThioacetamide affects the expression of MIF mRNA25064622
C402696TMC 120ATMC 120A results in increased expression of MIF mRNA19818335
D014212TretinoinTretinoin results in increased expression of MIF mRNA17218384
C012589trichostatin Atrichostatin A results in increased expression of MIF mRNA15901671
C012589trichostatin Atrichostatin A results in increased expression of MIF mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of MIF mRNA19042947
D014303TrinitrotolueneTrinitrotoluene affects the expression of MIF mRNA21346803
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate results in decreased expression of MIF protein24685621
D014414Tungsten[Nickel co-treated with Iron co-treated with Tungsten] results in increased expression of MIF mRNA22198552
C002802tungsten carbide[tungsten carbide co-treated with Cobalt] results in increased expression of MIF mRNA18078969
D014635Valproic AcidValproic Acid affects the expression of MIF mRNA25064622
D014635Valproic AcidValproic Acid results in increased expression of MIF mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of MIF mRNA25979313
D001335Vehicle Emissionsoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of MIF mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the expression of MIF mRNA17655762
D001335Vehicle EmissionsVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of MIF mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions results in increased expression of MIF protein27295300
C025643vinclozolinvinclozolin results in increased expression of MIF mRNA18629315
C016837zinc chloridezinc chloride results in decreased expression of MIF mRNA18947441
D015034Zinc OxideZinc Oxide affects the expression of MIF mRNA28648595
D015054ZymosanMIF gene mutant form inhibits the reaction [Zymosan results in increased expression of MMP2 protein]16872482

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0002020protease binding-IEA-  
GO:0004167dopachrome isomerase activity-IDA17526494  
GO:0005102signaling receptor binding-IPI12782713  
GO:0005125cytokine activity-IDA12782713  
GO:0005126cytokine receptor binding-IDA21817065  
GO:0005126cytokine receptor binding-IPI17045821  
GO:0005515protein binding-IPI12681488  15757663  17526494  18677096  26280537  27107014  
GO:0042056chemoattractant activity-IDA19602265  
GO:0042802identical protein binding-IPI20534506  
GO:0050178phenylpyruvate tautomerase activity-IDA16285950  21817065  
GO ID GO Term Qualifier Evidence PubMed
GO:0001516prostaglandin biosynthetic process-IDA12782713  
GO:0002906negative regulation of mature B cell apoptotic process-IEA-  
GO:0006954inflammatory response-IEA-  
GO:0007166cell surface receptor signaling pathway-IDA12782713  
GO:0007569cell aging-IEA-  
GO:0008283cell proliferation-IDA12782713  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010629negative regulation of gene expression-IDA10562313  
GO:0010739positive regulation of protein kinase A signaling-IDA17045821  
GO:0010760negative regulation of macrophage chemotaxis-IDA21817065  
GO:0019752carboxylic acid metabolic process-IDA12782713  
GO:0030330DNA damage response, signal transduction by p53 class mediator-IEA-  
GO:0030890positive regulation of B cell proliferation-IDA12782713  
GO:0031666positive regulation of lipopolysaccharide-mediated signaling pathway-IEA-  
GO:0032269negative regulation of cellular protein metabolic process-IEA-  
GO:0032760positive regulation of tumor necrosis factor production-IDA21817065  
GO:0033033negative regulation of myeloid cell apoptotic process-IEA-  
GO:0033138positive regulation of peptidyl-serine phosphorylation-IDA17045821  
GO:0035722interleukin-12-mediated signaling pathway-TAS-  
GO:0042327positive regulation of phosphorylation-IDA12782713  
GO:0043030regulation of macrophage activation-NAS12782713  
GO:0043066negative regulation of apoptotic process-IDA12782713  
GO:0043312neutrophil degranulation-TAS-  
GO:0043406positive regulation of MAP kinase activity-IEA-  
GO:0043518negative regulation of DNA damage response, signal transduction by p53 class mediator-IDA17045821  
GO:0045087innate immune response-IEA-  
GO:0048146positive regulation of fibroblast proliferation-IDA12782713  
GO:0050715positive regulation of cytokine secretion-IDA19602265  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IDA17045821  
GO:0050900leukocyte migration-TAS-  
GO:0050918positive chemotaxis-IEA-  
GO:0061078positive regulation of prostaglandin secretion involved in immune response-IEA-  
GO:0061081positive regulation of myeloid leukocyte cytokine production involved in immune response-IEA-  
GO:0070207protein homotrimerization-IPI17526494  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA12782713  17045821  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IGI21817065  
GO:0071157negative regulation of cell cycle arrest-IDA10562313  
GO:0090238positive regulation of arachidonic acid secretion-IEA-  
GO:0090344negative regulation of cell aging-IDA10562313  
GO:1902166negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator-IDA17045821  
GO:2000343positive regulation of chemokine (C-X-C motif) ligand 2 production-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-HDA27068509  
GO:0005576extracellular region-IDA12782713  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA21817065  
GO:0005654nucleoplasm-IDA-  
GO:0005829cytosol-IDA-  
GO:0009986cell surface-IDA12782713  
GO:0031982vesicle-HDA19190083  
GO:0034774secretory granule lumen-TAS-  
GO:0043209myelin sheath-IEA-  
GO:0070062extracellular exosome-HDA19056867  20458337  23533145  
GO:1904813ficolin-1-rich granule lumen-TAS-  
KEGG ID KEGG Term
hsa00350Tyrosine metabolism
hsa00360Phenylalanine metabolism
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS
R-HSA-447115Interleukin-12 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-6798695Neutrophil degranulationTAS
R-HSA-8950505Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulationTAS
R-HSA-9020591Interleukin-12 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23460910Anti-TNF therapy reduces serum levels of chemerin in rheumatoid arthritis: a new mechanism by which anti-TNF might reduce inflammation. (2013)Herenius MMPLoS One
21674000Immunological and cardiometabolic risk factors in the prediction of type 2 diabetes and coronary events: MONICA/KORA Augsburg case-cohort study. (2011)Herder CPLoS One
23794947Increased levels of macrophage migration inhibitory factor in patients with familial mediterranean Fever. (2013)Savran YInt J Med Sci
10719790Linear CT-scan measurements in alcohol-dependent patients with and without delirium tremens. (2000 Feb)Maes MAlcohol
4579901In vitro migration of human alveolar macrophages: effects of cigarette smoking. (1973 Aug)Warr GAInfect Immun
21750916Macrophage migration inhibitory factor gene -173G>C polymorphism and risk of bladder cancer in southeast China: a case-control analysis. (2012 Mar)Yuan QMol Biol Rep
12473586Quantification of macrophage migration inhibitory factor mRNA expression in non-small cell lung cancer tissues and its clinical significance. (2002 Dec)Tomiyasu MClin Cancer Res
27990285Non-small cell lung cancer is characterised by a distinct inflammatory signature in serum compared with chronic obstructive pulmonary disease. (2016 Nov)Eide HAClin Transl Immunology
12618703Macrophage migration inhibitory factor is associated with aneurysmal expansion. (2003 Mar)Pan JHJ Vasc Surg
26911630Lipoprotein(a) level and MIF gene variant predict incident metabolic syndrome and mortality. (2016 Feb)Onat AJ Investig Med
27190066Macrophage migration inhibitory factor, a role in COPD. (2016 Jul 1)Husebo GRAm J Physiol Lung Cell Mol Physiol
16308104Localized fibrous tumors (LFTs) of the pleura: clinical data, asbestos burden, and syntactic structure analysis applied to newly defined angiogenic/growth-regulatory effectors. (2005)Kayser KPathol Res Pract
14621194Chromosomal aberrations, profiles of expression of growth-related markers including galectins and environmental hazards in relation to the incidence of chondroid pulmonary hamartomas. (2003)Kayser KPathol Res Pract
17182930Activators of plasminogen and the progression of small abdominal aortic aneurysms. (2006 Nov)Lindholt JSAnn N Y Acad Sci
26895959Association Between MIF-AS rs755622 and Nephrolithiasis Risk in a Chinese Population. (2016 Feb 20)Ma GMed Sci Monit
7384651Reference values for flow-volume curves during forced vital capacity breathing in male children and young adults. (1980)Todisco TRespiration
10428298Chlamydia pneumoniae antibodies and angiographically demonstrated coronary artery disease in a sample population from Italy. (1999 Jul)Cellesi CAtherosclerosis
9244752[Anti-Chlamydia pneumoniae antibodies and production of interleukin 6 in acute myocardial infarct]. (1997 May)Vergassola RG Ital Cardiol
8617406Opioid and anti-opioid peptides. (1995)Cesselin FFundam Clin Pharmacol
23291023[The expression of macrophage migration inhibition factor in pulmonary tissues of smokers with or without chronic obstructive pulmonary disease]. (2012 Nov)She WBZhonghua Nei Ke Za Zhi
18466513Evaluating gene x gene and gene x smoking interaction in rheumatoid arthritis using candidate genes in GAW15. (2007)Mei LBMC Proc
18640786Hostility is related to clusters of T-cell cytokines and chemokines in healthy men. (2008 Sep)Mommersteeg PMPsychoneuroendocrinology
9747745Humoral immune response to Chlamydia pneumoniae in twin discordant for smoking. (1998 Sep)von Hertzen LJ Intern Med
12787697Relationships between activators and inhibitors of plasminogen, and the progression of small abdominal aortic aneurysms. (2003 Jun)Lindholt JSEur J Vasc Endovasc Surg