Gene: CXCL9

4283
CMK|Humig|MIG|SCYB9|crg-10
C-X-C motif chemokine ligand 9
protein-coding
4q21.1
Ensembl:ENSG00000138755 MIM:601704 Vega:OTTHUMG00000160889 UniprotKB:Q07325
NC_000004.12
PubMed
0   ANCO-SNPs
ND
14   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.650e-1 (AD)  4.546e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CXCL110.803
ETV70.767
GBP50.733
IDO10.732
CCL80.726
BATF20.723
ZBP10.722
IL270.72
CCL70.715
IFIH10.715

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NME5-0.318
GABRA5-0.316
HCN2-0.297
RAB26-0.283
SCRT1-0.281
KCNN1-0.28
HRH3-0.28
IFITM10-0.277
ADAMTSL2-0.274
CBLN1-0.274

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0208881,2-dielaidoylphosphatidylethanolamine"1,2-dielaidoylphosphatidylethanolamine results in decreased expression of CXCL9 mRNA"14668052
C0700461,2-dioleoyloxy-3-(trimethylammonium)propane"[Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of CXCL9 mRNA"22129739
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of CXCL9 mRNA"23146750
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of CXCL9 mRNA21983209
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CXCL9 mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CXCL9 mRNA"25380136
C496492abrineabrine results in increased expression of CXCL9 mRNA22595364
D000082AcetaminophenAcetaminophen affects the expression of CXCL9 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of CXCL9 mRNA12153990|1557851
D000082AcetaminophenIFNG protein promotes the reaction [Acetaminophen results in increased expression of CXCL9 mRNA]12153990
D000082AcetaminophenKLRB1C protein promotes the reaction [Acetaminophen results in increased expression of CXCL9 mRNA]15578514
C006418adrenocorticotropin zincadrenocorticotropin zinc results in decreased expression of CXCL9 mRNA19920212
D000393Air PollutantsAir Pollutants results in increased expression of CXCL9 mRNA26618301
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of CXCL9 mRNA28522335
C064176alpha-viniferinalpha-viniferin inhibits the reaction [IFNG protein results in increased expression of CXCL9 mRNA]20424383
C064176alpha-viniferinalpha-viniferin inhibits the reaction [IFNG protein results in increased expression of CXCL9 protein]20424383
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CXCL9 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CXCL9 mRNA24449571
C004984apocarotenalapocarotenal results in increased expression of CXCL9 mRNA17034753
C000228aristolochic acid I[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of CXCL9 mRNA23912714
C042310aristolochic acid II[aristolochic acid I co-treated with aristolochic acid II] results in increased expression of CXCL9 mRNA23912714
D001151ArsenicArsenic affects the expression of CXCL9 protein24675094
C006632arsenic trioxidearsenic trioxide results in decreased expression of CXCL9 mRNA18414637
D001205Ascorbic Acid[Tretinoin co-treated with Ascorbic Acid] results in increased expression of CXCL9 mRNA16443354
D016589AstemizoleAstemizole results in decreased expression of CXCL9 mRNA20221588
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of CXCL9 mRNA26377693
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of CXCL9 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CXCL9 mRNA23735875
D019207beta Carotenebeta Carotene results in increased expression of CXCL9 mRNA17034753
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of CXCL9 mRNA18692832
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid results in decreased expression of CXCL9 mRNA18192240
D001688Biological ProductsBiological Products results in increased expression of CXCL9 mRNA24471457
D001688Biological ProductsBiological Products results in increased expression of CXCL9 protein24471457
D001688Biological ProductsProtein Kinase Inhibitors inhibits the reaction [Biological Products results in increased expression of CXCL9 mRNA]24471457
D001688Biological ProductsProtein Kinase Inhibitors inhibits the reaction [Biological Products results in increased expression of CXCL9 protein]24471457
D001688Biological ProductsVPC32183 inhibits the reaction [Biological Products results in increased expression of CXCL9 mRNA]24471457
D001688Biological ProductsVPC32183 inhibits the reaction [Biological Products results in increased expression of CXCL9 protein]24471457
C006780bisphenol Abisphenol A affects the expression of CXCL9 mRNA25181051
D001761BleomycinBleomycin results in increased expression of CXCL9 protein29175452
D019256Cadmium ChlorideCadmium Chloride affects the expression of CXCL9 mRNA25993096
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of CXCL9 promoter22457795
D002118Calcium[CTSS protein results in increased cleavage of and results in decreased activity of CXCL9 protein] which results in decreased uptake of Calcium25833952
D002118Calcium[CXCL9 protein binds to and results in increased activity of CXCR3 protein] which results in increased abundance of Calcium12517959
D002118Calcium[[CXCL9 protein binds to and results in increased activity of CXCR3 protein] which results in increased abundance of Calcium] which results in increased expression of EGR1 mRNA12517959
D002118Calcium[CXCL9 protein binds to and results in increased activity of CXCR3 protein] which results in increased uptake of Calcium25833952
D002118CalciumCXCL9 protein results in increased abundance of Calcium12517959
D000074262Canola OilCanola Oil metabolite results in decreased expression of CXCL9 mRNA27363782
D002784Cholesterol"[Cholesterol co-treated with 1,2-dioleoyloxy-3-(trimethylammonium)propane] results in increased expression of CXCL9 mRNA"22129739
D002809Chondroitin SulfatesChondroitin Sulfates inhibits the reaction [CTSB protein results in increased degradation of CXCL9 protein]25833952
C034456CMF regimenCXCL9 mRNA results in increased susceptibility to CMF regimen18925433
C000593591coagulin-Lcoagulin-L inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL9 protein]27568862
C000593591coagulin-Lcoagulin-L inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL9 protein]27568862
D003035CobaltTNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL9 mRNA]23503329
D003035Cobalt[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL9 mRNA23503329
C018021cobaltous chloridecobaltous chloride results in decreased expression of CXCL9 mRNA24386269
D003042CocaineCocaine results in decreased expression of CXCL9 mRNA17898221
D003436Croton OilCroton Oil results in decreased expression of CXCL9 mRNA19647056
C038459curdlancurdlan affects the expression of CXCL9 mRNA19904525
D003520CyclophosphamideCyclophosphamide affects the expression of CXCL9 mRNA18957084
D003520CyclophosphamideCyclophosphamide results in increased expression of CXCL9 mRNA15331540|2104116
D003520CyclophosphamideCyclophosphamide results in increased expression of CXCL9 protein18957084
D016572CyclosporineCyclosporine results in decreased expression of CXCL9 mRNA27989131
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of CXCL9 mRNA23914054
C014347decitabinedecitabine affects the methylation of CXCL9 promoter17488656
D003703DemecolcineDemecolcine results in increased expression of CXCL9 mRNA23649840
C007262deoxynivalenoldeoxynivalenol results in increased expression of CXCL9 mRNA22968694
D003907DexamethasoneDexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL9 protein]27568862
D003907DexamethasoneDexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL9 protein]27568862
D003907DexamethasoneDexamethasone results in increased expression of CXCL9 mRNA21041162
D003907DexamethasoneTNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL9 mRNA]23503329
D003907Dexamethasone[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL9 mRNA23503329
D016264Dextran SulfateDextran Sulfate results in increased expression of CXCL9 mRNA23894361
D004041Dietary FatsDietary Fats results in decreased expression of CXCL9 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of CXCL9 mRNA18457598|2501614
C014476diethyl maleatediethyl maleate results in decreased expression of CXCL9 mRNA21161181
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CXCL9 mRNA21041162
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of CXCL9 mRNA"27840820
D004128DimethylnitrosamineDimethylnitrosamine affects the expression of CXCL9 mRNA11356909
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of CXCL9 mRNA25380136
D004237DiuronDiuron results in decreased expression of CXCL9 mRNA25152437
D004298DopamineDopamine results in increased expression of CXCL9 mRNA25818600
C044101endotoxin, Escherichia coli"endotoxin, Escherichia coli results in decreased expression of CXCL9 mRNA"15919760
C007630estradiol 17 beta-cypionateestradiol 17 beta-cypionate results in increased expression of CXCL9 mRNA22497863
D004997Ethinyl EstradiolEthinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of CXCL9 mRNA]12072388
C024565ethylene dichlorideethylene dichloride results in decreased expression of CXCL9 mRNA28189721
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of CXCL9 mRNA23649840
D015025ZearalenoneZearalenone results in increased expression of CXCL9 mRNA27757495
D005485FlutamideFlutamide results in increased expression of CXCL9 mRNA24793618
D005557FormaldehydeFormaldehyde results in increased expression of CXCL9 mRNA23649840
C064925gadodiamidegadodiamide results in increased expression of CXCL9 mRNA20959327
C007834genipingenipin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL9 mRNA]22687549
D005897GlafenineGlafenine results in decreased expression of CXCL9 mRNA24136188
D017313FenretinideFenretinide results in decreased expression of CXCL9 mRNA28973697
D000068877Imatinib MesylateImatinib Mesylate inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased secretion of CXCL9 protein]21935477
C016517indole-3-carbinolindole-3-carbinol affects the expression of CXCL9 mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CXCL9 mRNA25613284
D0150561-Methyl-3-isobutylxanthineTNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL9 mRNA]23503329
D0150561-Methyl-3-isobutylxanthine[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL9 mRNA23503329
D007545IsoproterenolIsoproterenol results in decreased expression of CXCL9 mRNA20003209
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL9 mRNA]26582142
D007840LatexLatex analog results in increased expression of CXCL9 mRNA24768652
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL9 mRNA"23090859
C433788lipopolysaccharide, E. coli O26-B6"nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL9 mRNA]"23090859
D008070Lipopolysaccharidescoagulin-L inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL9 protein]27568862
D008070LipopolysaccharidesDexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL9 protein]27568862
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CXCL9 protein27568862
D008070LipopolysaccharidesLipopolysaccharides results in increased secretion of CXCL9 protein22127699
D008070Lipopolysaccharidescoagulin-L inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL9 protein]27568862
D008070LipopolysaccharidesDexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL9 protein]27568862
D008070Lipopolysaccharidesgenipin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL9 mRNA]22687549
D008070Lipopolysaccharides(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL9 mRNA]26582142
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CXCL9 mRNA15154616
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CXCL9 mRNA15919760
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CXCL9 mRNA19136613|1942667
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of CXCL9 protein27568862
D008070LipopolysaccharidesLipopolysaccharides results in increased secretion of CXCL9 protein16321413
D008070LipopolysaccharidesLuteolin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL9 mRNA]19426678
D008070Lipopolysaccharidesmethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL9 protein]16321413
D008070LipopolysaccharidesNFKB1 protein promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CXCL9 mRNA]15154616
D008070LipopolysaccharidesRELA protein affects the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of CXCL9 mRNA]15154616
D047311LuteolinLuteolin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL9 mRNA]19426678
D047311LuteolinLuteolin inhibits the reaction [Poly I-C results in increased expression of CXCL9 mRNA]19426678
C008435methyldithiocarbamatemethyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL9 protein]16321413
C008435methyldithiocarbamatemethyldithiocarbamate inhibits the reaction [Poly I-C results in increased secretion of CXCL9 protein]24056979
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CXCL9 mRNA"26251327
D009183MycotoxinsMycotoxins results in increased expression of CXCL9 mRNA19818335
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of CXCL9 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CXCL9 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CXCL9 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CXCL9 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CXCL9 mRNA"25554681|2604865
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CXCL9 protein"26048651
C015380neoechinulinneoechinulin results in decreased expression of CXCL9 mRNA19818335
D009532NickelNickel results in increased expression of CXCL9 mRNA24768652|2558310
D009532NickelTNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL9 mRNA]23503329
D009532Nickel[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL9 mRNA23503329
C022838nickel chloride"nickel chloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL9 mRNA]"23090859
C022838nickel chloridenickel chloride affects the expression of CXCL9 mRNA22110744
C028007nickel monoxidenickel monoxide results in decreased expression of CXCL9 mRNA19167457
C012655nimesulide[nimesulide results in decreased activity of PTGS2 protein] which results in increased expression of CXCL9 mRNA22561872
D0151124-Nitroquinoline-1-oxide4-Nitroquinoline-1-oxide results in increased expression of CXCL9 mRNA22561872
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of CXCL9 mRNA25729387
D010081OxazoloneOxazolone results in decreased expression of CXCL9 mRNA11379042
D010081OxazoloneOxazolone results in increased expression of CXCL9 mRNA19647056|2882677
D010081OxazoloneOxazolone results in increased expression of CXCL9 mRNA21893156
D010126Ozone[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of CXCL9 protein27472835
D000073878Palm OilPalm Oil results in decreased expression of CXCL9 mRNA18042831
D052638Particulate MatterParticulate Matter results in increased expression of CXCL9 mRNA26618301
C011272perfosfamideperfosfamide results in decreased expression of CXCL9 mRNA19429390
D010476PerfumePerfume results in increased expression of CXCL9 mRNA24768652
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [sodium arsenite results in decreased expression of CXCL9 mRNA]19349368
C539933pevonedistatpevonedistat affects the expression of CXCL9 mRNA24634471
D010634PhenobarbitalPhenobarbital results in increased expression of CXCL9 mRNA23091169
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of CXCL9 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of CXCL9 mRNA18445702|2081375
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of CXCL9 protein29175452
D011070Poly I-CLuteolin inhibits the reaction [Poly I-C results in increased expression of CXCL9 mRNA]19426678
D011070Poly I-Cmethyldithiocarbamate inhibits the reaction [Poly I-C results in increased secretion of CXCL9 protein]24056979
D011070Poly I-CPoly I-C results in increased expression of CXCL9 mRNA19426678
D011070Poly I-CPoly I-C results in increased secretion of CXCL9 protein24056979
D011192Potassium DichromatePotassium Dichromate results in increased expression of CXCL9 mRNA23608068
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of CXCL9 mRNA18692832
D011374ProgesteroneProgesterone results in increased expression of CXCL9 mRNA18692832
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [Biological Products results in increased expression of CXCL9 mRNA]24471457
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [Biological Products results in increased expression of CXCL9 protein]24471457
D017382Reactive Oxygen SpeciesCXCL9 protein results in increased activity of Reactive Oxygen Species12517959
D017382Reactive Oxygen Species[CXCL9 protein results in increased activity of Reactive Oxygen Species] which results in decreased transport of Sodium12517959
C059514resveratrolresveratrol results in decreased expression of CXCL9 mRNA21189227
C059514resveratrolresveratrol inhibits the reaction [IFNG protein results in increased expression of CXCL9 mRNA]21189227
C089730rosiglitazonerosiglitazone results in increased expression of CXCL9 mRNA21172411
D012406RoxarsoneRoxarsone results in decreased expression of CXCL9 mRNA18414637
D012643SeleniumSelenium results in decreased expression of CXCL9 mRNA18997278
C009250sevofluranesevoflurane results in increased expression of CXCL9 protein26206149
D012822Silicon DioxideSilicon Dioxide results in increased expression of CXCL9 mRNA21540303
D012822Silicon DioxideSilicon Dioxide results in increased expression of CXCL9 mRNA23221170
D012822Silicon DioxideSilicon Dioxide results in increased expression of CXCL9 mRNA22431001
D012906SmokeSmoke affects the expression of CXCL9 mRNA23693141
D012964Sodium[CXCL9 protein results in increased activity of Reactive Oxygen Species] which results in decreased transport of Sodium12517959
C017947sodium arsenitePertussis Toxin inhibits the reaction [sodium arsenite results in decreased expression of CXCL9 mRNA]19349368
C017947sodium arsenitesodium arsenite results in decreased expression of CXCL9 mRNA19349368
C017947sodium arsenitesodium arsenite results in increased expression of CXCL9 mRNA21911445
D053260SootSoot results in decreased expression of CXCL9 mRNA22461453
D053260SootSoot results in increased expression of CXCL9 mRNA22461453|2655175
C075117squalestatin 1squalestatin 1 results in increased expression of CXCL9 mRNA27225895
C075117squalestatin 1squalestatin 1 results in increased expression of CXCL9 mRNA27225895
D013241SterigmatocystinSterigmatocystin results in increased expression of CXCL9 mRNA19818335
D013467SulindacSulindac inhibits the reaction [IFNG protein results in increased expression of CXCL9 mRNA]17010317
C061133tamibarotenetamibarotene results in decreased expression of CXCL9 mRNA20861477
D013739TestosteroneTestosterone results in increased expression of CXCL9 mRNA15788153
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CXCL9 mRNA21041162
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CXCL9 mRNA15644576|2121527
D013755Tetradecanoylphorbol AcetateIL17RA gene mutant form inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CXCL9 mRNA]22359662
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased expression of CXCL9 mRNA22359662
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CXCL9 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of CXCL9 mRNA21259345|2340900
C009495titanium dioxidetitanium dioxide results in increased expression of CXCL9 protein23557971
C402696TMC 120ATMC 120A results in decreased expression of CXCL9 mRNA19818335
D014028Tobacco Smoke PollutionNFE2L2 protein affects the reaction [Tobacco Smoke Pollution affects the expression of CXCL9 mRNA]20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CXCL9 mRNA20133372
C479163tofacitinibtofacitinib results in decreased expression of CXCL9 mRNA22941906
C479163tofacitinibtofacitinib inhibits the reaction [IFNG protein results in increased expression of CXCL9 mRNA]24213371
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in decreased expression of CXCL9 mRNA"11379042
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of CXCL9 mRNA"19647056|2882677
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of CXCL9 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of CXCL9 mRNA"19682533
D014212Tretinoin[Tretinoin co-treated with Ascorbic Acid] results in increased expression of CXCL9 mRNA16443354
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CXCL9 mRNA21893156
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of CXCL9 mRNA17982090
D014303TrinitrotolueneTrinitrotoluene affects the expression of CXCL9 mRNA21346803
D014635Valproic AcidValproic Acid results in decreased expression of CXCL9 mRNA29154799
C066075vanadium pentoxidevanadium pentoxide results in increased expression of CXCL9 mRNA17459161
D014750VincristineVincristine results in increased expression of CXCL9 mRNA23649840
C529824VPC32183VPC32183 inhibits the reaction [Biological Products results in increased expression of CXCL9 mRNA]24471457
C529824VPC32183VPC32183 inhibits the reaction [Biological Products results in increased expression of CXCL9 protein]24471457
D015032ZincTNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL9 mRNA]23503329
D015032Zinc[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CXCL9 mRNA23503329
D015034Zinc OxideZinc Oxide results in increased expression of CXCL919897006
D015054Zymosan[Zymosan co-treated with IFNG protein] results in increased expression of CXCL9 mRNA15154616

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005125cytokine activity-TAS2115167  
GO:0005515protein binding-IPI18275857  21314817  25416956  
GO:0008009chemokine activity-IBA21873635  
GO:0008009chemokine activity-IDA12782716  
GO:0045236CXCR chemokine receptor binding-IBA21873635  
GO:0048248CXCR3 chemokine receptor binding-IDA12782716  
GO ID GO Term Qualifier Evidence PubMed
GO:0006935chemotaxis-IDA12782716  
GO:0006952defense response-TAS2115167  
GO:0006954inflammatory response-IBA21873635  
GO:0006955immune response-IBA21873635  
GO:0006968cellular defense response-TAS10570316  
GO:0007165signal transduction-TAS10201891  10201901  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007267cell-cell signaling-TAS8476424  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0030593neutrophil chemotaxis-IBA21873635  
GO:0030595leukocyte chemotaxis-IBA21873635  
GO:0042127regulation of cell proliferation-IDA12782716  
GO:0043950positive regulation of cAMP-mediated signaling-IDA12782716  
GO:0045663positive regulation of myoblast differentiation-IEA-  
GO:0051281positive regulation of release of sequestered calcium ion into cytosol-IDA12782716  
GO:0051607defense response to virus-IEA-  
GO:0061844antimicrobial humoral immune response mediated by antimicrobial peptide-IBA21873635  
GO:0070098chemokine-mediated signaling pathway-IBA21873635  
GO:0071222cellular response to lipopolysaccharide-IBA21873635  
GO:1901741positive regulation of myoblast fusion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0009897external side of plasma membrane-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04062Chemokine signaling pathway
hsa04620Toll-like receptor signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-380108Chemokine receptors bind chemokinesTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24997814Differential expression of the inflammation-associated chemokines/cytokines in mouse lung after exposure to cigarette smoke and smoking cessation. (2014 Jun)Li JRZhongguo Yi Xue Ke Xue Yuan Xue Bao
24249745Circulating inflammation markers and prospective risk for lung cancer. (2013 Dec 18)Shiels MSJ Natl Cancer Inst
19635926Smoking-dependent reprogramming of alveolar macrophage polarization: implication for pathogenesis of chronic obstructive pulmonary disease. (2009 Aug 15)Shaykhiev RJ Immunol
25496999Genes expressed in coronary thrombi are associated with ischemic time in patients with acute myocardial infarction. (2015 Feb)Helseth RThromb Res
26220734Circulating Inflammation Markers, Risk of Lung Cancer, and Utility for Risk Stratification. (2015 Oct)Shiels MSJ Natl Cancer Inst
28340238Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice. (2017 Sep 1)Gotts JENicotine Tob Res
29716923Interferon Gamma Messenger RNA Signature in Tumor Biopsies Predicts Outcomes in Patients with Non-Small-Cell Lung Carcinoma or Urothelial Cancer Treated with Durvalumab. (2018 May 1)Higgs BWClin Cancer Res
22178353Genetic contribution to C-reactive protein levels in severe obesity. (2012 Mar)Faucher GMol Genet Metab
28915241The relative contribution of DNA methylation and genetic variants on protein biomarkers for human diseases. (2017 Sep)Ahsan MPLoS Genet
25228925A systems biology approach reveals a link between systemic cytokines and skeletal muscle energy metabolism in a rodent smoking model and human COPD. (2014)Davidsen PKGenome Med
17868461Inverse association of plasma IL-13 and inflammatory chemokines with lung function impairment in stable COPD: a cross-sectional cohort study. (2007 Sep 14)Lee JSRespir Res
20022114Differential gene expression analysis in human monocyte-derived macrophages: impact of cigarette smoke on host defence. (2010 Feb)Doyle IMol Immunol
23748423Nicotine potentiates proatherogenic effects of oxLDL by stimulating and upregulating macrophage CD36 signaling. (2013 Aug 15)Zhou MSAm J Physiol Heart Circ Physiol
19629358[Inflammatory cells and their mediators in COPD pathogenesis]. (2009 May-Jun)Costa CHRev Assoc Med Bras (1992)