Gene: MITF

4286
CMM8|COMMAD|MI|WS2|WS2A|bHLHe32
melanogenesis associated transcription factor
protein-coding
3p13
Ensembl:ENSG00000187098 MIM:156845 Vega:OTTHUMG00000149921 UniprotKB:O75030
NG_011631.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.555e-1 (AD)  4.936e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDK60.845
TBC1D120.835
TMCC30.826
SOS20.821
SLC44A10.815
FRMD4B0.814
VEZF10.811
PRR5L0.809
FAM107B0.805
RASGRP30.798

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDH22-0.443
PRTN3-0.438
TCERG1L-0.429
CUX2-0.426
PCDH8-0.426
YBX2-0.42
ASB2-0.419
GSG1-0.41
LTK-0.408
POU3F1-0.405

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cannabidiol results in increased expression of MITF mRNA]28601556
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [chaetocin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of MITF protein]]26748310
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal results in decreased expression of MITF protein]"21816215
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal results in decreased expression of MITF protein]"21816215
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sweroside results in increased expression of MITF protein]26051519
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of MITF protein26051519
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MITF mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MITF mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MITF mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MITF mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MITF mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of MITF mRNA23489423
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MITF mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MITF mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MITF mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MITF mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MITF mRNA"27188386
C0739467,3',4'-trimethylquercetin"7,3',4'-trimethylquercetin results in increased expression of MITF protein"24853321
C0313909-cis-retinal9-cis-retinal results in increased expression of MITF mRNA23489423
C0313909-cis-retinalALDH1A1 mutant form inhibits the reaction [9-cis-retinal results in increased expression of MITF mRNA]23489423
C542662AC 93253AC 93253 results in decreased expression of MITF mRNA25912555
D000082AcetaminophenAcetaminophen results in decreased expression of MITF mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of MITF mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MITF mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of MITF gene27153756
C477954afzelinafzelin results in increased expression of MITF mRNA27287415
C477954afzelinafzelin results in increased expression of MITF protein27287415
C103303alitretinoinalitretinoin results in increased expression of MITF mRNA23489423
D000638AmiodaroneAmiodarone results in increased expression of MITF mRNA19774075
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MITF mRNA16483693
C047721artemisic acidartemisic acid results in decreased expression of MITF mRNA23063590
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of MITF mRNA"18687144
C010038azelaic acidazelaic acid results in decreased expression of MITF protein20804622
C010038azelaic acid[Taurine co-treated with azelaic acid] results in decreased expression of MITF protein20804622
C012768benzanthronebenzanthrone results in increased expression of MITF protein28029781
D001554BenzeneBenzene results in increased expression of MITF mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MITF mRNA20064835
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MITF mRNA"19150397
D004958Estradiol[Estradiol co-treated with EGF protein] results in increased expression of MITF mRNA24758408
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of MITF mRNA19619570
D004958EstradiolEstradiol results in increased expression of MITF mRNA19619570
D004958EstradiolEstradiol results in increased expression of MITF mRNA19484750
C006780bisphenol Abisphenol A affects the methylation of MITF promoter27334623
C006780bisphenol Abisphenol A affects the expression of MITF mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of MITF mRNA15336504
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of MITF mRNA12160620
D002185Cannabidiol2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cannabidiol results in increased expression of MITF mRNA]28601556
D002185CannabidiolCannabidiol results in increased expression of MITF mRNA28601556
D002185CannabidiolCannabidiol results in increased expression of MITF protein28601556
D002185CannabidiolSB 203580 inhibits the reaction [Cannabidiol results in increased expression of MITF mRNA]28601556
D002220CarbamazepineCarbamazepine affects the expression of MITF mRNA25979313
D012721CarbarylCarbaryl results in decreased expression of MITF mRNA27829164
C002511chaetocin2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [chaetocin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of MITF protein]]26748310
C002511chaetocinchaetocin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of MITF protein]26748310
D002746ChlorpromazineChlorpromazine results in increased expression of MITF protein25449126
D002922CiguatoxinsCiguatoxins affects the expression of MITF mRNA18353800
D005576ColforsinColforsin results in increased expression of MITF mRNA17460731|2860155
D005576ColforsinColforsin results in increased expression of MITF protein17460731|2860155
D003484CyanamideCyanamide results in decreased expression of MITF mRNA23489423
D016572CyclosporineCyclosporine results in decreased expression of MITF mRNA20106945|2798913
D016572CyclosporineCyclosporine results in increased methylation of MITF promoter27989131
C089595cylindrospermopsincylindrospermopsin results in increased expression of MITF mRNA24921660
C014347decitabinedecitabine results in decreased expression of MITF mRNA17785578
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of MITF mRNA27392435
D002117CalcitriolCalcitriol results in decreased expression of MITF mRNA16002434
D004237DiuronDiuron results in decreased expression of MITF mRNA25152437
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of MITF mRNA"23811387
D004365Drugs, Chinese Herbal"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal results in decreased expression of MITF protein]"21816215
D004365Drugs, Chinese Herbal"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal results in decreased expression of MITF protein]"21816215
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in decreased expression of MITF mRNA"21816215
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in decreased expression of MITF protein"21816215
D004642EmodinEmodin results in decreased expression of MITF protein26972667
C118739entinostatentinostat results in increased expression of MITF mRNA26272509
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MITF mRNA22079256
D011345FenofibrateFenofibrate results in decreased expression of MITF mRNA23872139
D011345FenofibrateFenofibrate results in decreased expression of MITF protein23872139
D005557FormaldehydeFormaldehyde results in decreased expression of MITF mRNA27664576
D017313FenretinideFenretinide results in decreased expression of MITF mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MITF mRNA25613284
D0150561-Methyl-3-isobutylxanthine1-Methyl-3-isobutylxanthine results in increased expression of MITF protein26748310
D0150561-Methyl-3-isobutylxanthine2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [chaetocin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of MITF protein]]26748310
D0150561-Methyl-3-isobutylxanthinechaetocin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of MITF protein]26748310
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of MITF mRNA27392435
C544151jinfukangjinfukang results in decreased expression of MITF mRNA27392435
D007840LatexLatex analog results in decreased expression of MITF mRNA24768652
C008261lead acetatelead acetate results in increased expression of MITF mRNA20542052
C533894LG 100815LG 100815 results in increased expression of MITF mRNA16951191
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of MITF mRNA25613284
D018021Lithium ChlorideLithium Chloride results in increased expression of MITF mRNA23527032
D008558MelphalanMelphalan results in decreased expression of MITF mRNA22363485
C042720mercuric bromidemercuric bromide results in increased expression of MITF mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MITF mRNA"27188386
C538691methyl 3, 5-O-dicaffeoylquinate"methyl 3, 5-O-dicaffeoylquinate results in decreased expression of MITF mRNA"22705713
C538691methyl 3, 5-O-dicaffeoylquinate"methyl 3, 5-O-dicaffeoylquinate results in decreased expression of MITF protein"22705713
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of MITF mRNA"26251327
C008493methylselenic acidmethylselenic acid results in increased expression of MITF mRNA18548127
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MITF mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MITF mRNA"25620056
D009285NaphthoquinonesNaphthoquinones results in increased expression of MITF mRNA23811387
D009532NickelNickel results in decreased expression of MITF mRNA25583101
C028007nickel monoxidenickel monoxide results in increased expression of MITF mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of MITF mRNA16780908
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in increased expression of MITF mRNA"16951191
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MITF mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of MITF mRNA26272509
D010670PhenylthioureaPhenylthiourea results in increased expression of MITF protein26051519
C121565pifithrinpifithrin results in decreased expression of MITF mRNA19098008
C121565pifithrinpifithrin results in decreased expression of MITF protein19098008
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MITF mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of MITF mRNA23811191
D010936Plant ExtractsPlant Extracts results in decreased expression of MITF protein24380755
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MITF mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of MITF mRNA22079256
D011374ProgesteroneProgesterone results in increased expression of MITF mRNA20864642
D011441PropylthiouracilPropylthiouracil results in decreased expression of MITF mRNA24780913
C043680ptaquiloside[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of MITF mRNA23274088
D011794QuercetinQuercetin results in increased expression of MITF mRNA15309432
D011794QuercetinQuercetin analog inhibits the reaction [POMC protein modified form results in increased expression of MITF protein]26586997
C059514resveratrolresveratrol results in increased expression of MITF mRNA25888808
C093642SB 203580SB 203580 inhibits the reaction [Cannabidiol results in increased expression of MITF mRNA]28601556
D012715Sesame OilSesame Oil results in increased expression of MITF mRNA29191790
C017947sodium arsenitesodium arsenite affects the methylation of MITF gene28589171
C017947sodium arsenitesodium arsenite inhibits the reaction [EDN1 protein results in increased expression of MITF]28470405
D018038Sodium Selenite[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of MITF mRNA23274088
D013267StilbenesStilbenes analog results in decreased expression of MITF mRNA29042215
D013267StilbenesStilbenes analog results in decreased expression of MITF protein29042215
C049412sweroside2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sweroside results in increased expression of MITF protein]26051519
C049412swerosideU 0126 inhibits the reaction [sweroside results in increased expression of MITF protein]26051519
D013629TamoxifenTamoxifen results in increased expression of MITF mRNA25123088
D013654Taurine[Taurine co-treated with azelaic acid] results in decreased expression of MITF protein20804622
D013654TaurineTaurine results in decreased expression of MITF protein20804622
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of MITF mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MITF mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MITF mRNA24058054
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MITF protein28029781
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MITF mRNA25613284
C483909torcetrapibtorcetrapib results in increased expression of MITF mRNA23228038
D014212TretinoinTretinoin results in increased expression of MITF mRNA21934132
D014212TretinoinTretinoin results in increased expression of MITF mRNA11851873|1703866
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MITF mRNA"27188386
C012589trichostatin Atrichostatin A affects the expression of MITF mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of MITF mRNA24935251|2627250
C113580U 0126U 0126 inhibits the reaction [sweroside results in increased expression of MITF protein]26051519
C113580U 0126U 0126 results in increased expression of MITF protein26051519
D014520UrethaneUrethane results in increased expression of MITF mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MITF mRNA"27188386
D014635Valproic AcidValproic Acid results in decreased expression of MITF mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of MITF mRNA19101580|2317975
D014635Valproic AcidValproic Acid affects the expression of MITF mRNA17963808
C551177vemurafenibvemurafenib affects the expression of MITF protein26640592
C025643vinclozolinvinclozolin results in decreased expression of MITF mRNA22615374
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MITF mRNA"27188386
D015032ZincZinc deficiency results in decreased expression of MITF protein21893222

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA14737107  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA14737107  20530484  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IMP14737107  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-NAS24769727  
GO:0003682chromatin binding-IEA-  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-IEA-  
GO:0005515protein binding-IPI20530484  21811243  
GO:0046983protein dimerization activity-IEA-  
GO:0070888E-box binding-IDA27889061  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IMP24769727  
GO:0006355regulation of transcription, DNA-templated-IMP27889061  
GO:0006355regulation of transcription, DNA-templated-NAS9647758  10578055  
GO:0006366transcription by RNA polymerase II-IEA-  
GO:0010628positive regulation of gene expression-IDA22234890  
GO:0010628positive regulation of gene expression-IMP22234890  22523078  
GO:0030316osteoclast differentiation-IEA-  
GO:0030318melanocyte differentiation-IBA21873635  
GO:0030318melanocyte differentiation-NAS9647758  
GO:0042127regulation of cell proliferation-IEA-  
GO:0043010camera-type eye development-IEA-  
GO:0044336canonical Wnt signaling pathway involved in negative regulation of apoptotic process-IEA-  
GO:0045165cell fate commitment-IEA-  
GO:0045670regulation of osteoclast differentiation-IEA-  
GO:0045893positive regulation of transcription, DNA-templated-IDA9647758  
GO:0045893positive regulation of transcription, DNA-templated-NAS10578055  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA20530484  21209915  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP14737107  
GO:0046849bone remodeling-IEA-  
GO:0065003protein-containing complex assembly-IDA20530484  
GO:2000144positive regulation of DNA-templated transcription, initiation-IDA8995290  12204775  
GO:2001141regulation of RNA biosynthetic process-IDA16411896  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA27889061  
GO:0005634nucleus-NAS9647758  10578055  
GO:0005654nucleoplasm-TAS-  
GO:0032991protein-containing complex-IDA20530484  
KEGG ID KEGG Term
hsa04380Osteoclast differentiation
hsa04916Melanogenesis
hsa05200Pathways in cancer
hsa05218Melanoma
Reactome ID Reactome Term Evidence
R-HSA-2990846SUMOylationTAS
R-HSA-3108232SUMO E3 ligases SUMOylate target proteinsTAS
R-HSA-3232118SUMOylation of transcription factorsTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22012259A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma. (2011 Oct 19)Bertolotto CNature