Gene: MLH1

4292
COCA2|FCC2|HNPCC|HNPCC2|hMLH1
mutL homolog 1
protein-coding
3p22.2
Ensembl:ENSG00000076242 MIM:120436 Vega:OTTHUMG00000130797 UniprotKB:P40692
NG_007109.2
PubMed
0   ANCO-SNPs
ND
23   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.419e-1 (AD)  2.062e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GLT8D10.904
TSN0.903
SMU10.901
CHTOP0.901
XPNPEP10.895
UNC500.892
GDI20.891
SAR1A0.89
XRCC60.888
KHDRBS10.888

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.724
OR4F29-0.688
C8orf74-0.234
MTRNR2L9-0.216
MTRNR2L6-0.211
HMHB1-0.199
MTRNR2L10-0.191
OR4F16-0.188
KRT73-0.187
UGT2B7-0.183

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MLH1 mRNA"19114083
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of MLH1 mRNA"20702594
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MLH1 mRNA"19167446
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MLH1 mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"MLH1 protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"11425520
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"MLH1 protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"16256150
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of MLH1 mRNA12419474
D000082AcetaminophenAcetaminophen results in increased expression of MLH1 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of MLH1 mRNA17562736
D001115ArecolineArecoline results in decreased expression of MLH1 mRNA17682004
D001152ArsenicalsArsenicals results in increased methylation of MLH1 promoter23073540
D001205Ascorbic AcidAscorbic Acid promotes the reaction [MLH1 gene mutant form results in decreased susceptibility to chromium hexavalent ion]15831465
D001205Ascorbic AcidMLH1 protein promotes the reaction [Ascorbic Acid results in increased susceptibility to chromium hexavalent ion]17301063
D001205Ascorbic AcidMLH1 protein results in increased susceptibility to [chromium hexavalent ion co-treated with Ascorbic Acid]17169990
D001280AtrazineAtrazine results in increased expression of MLH1 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of MLH1 mRNA22378314
C487081belinostatbelinostat promotes the reaction [decitabine results in increased expression of MLH1 protein]19259094
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MLH1 mRNA28461126
D004958Estradioldecitabine affects the reaction [Estradiol results in decreased expression of MLH1 mRNA]22082530
D004958Estradiol[Estradiol co-treated with sodium arsenite] results in decreased expression of MLH1 mRNA23804311
D004958EstradiolEstradiol results in decreased expression of MLH1 mRNA22082530|2380431
D004958EstradiolEstradiol results in decreased expression of MLH1 protein23804311
D004958Estradiol[Estradiol results in increased expression of MLH1 mRNA] which results in increased susceptibility to Cisplatin28323900
D004958Estradiol[Estradiol results in increased expression of MLH1 mRNA] which results in increased susceptibility to Doxorubicin28323900
D004958Estradiol[sodium arsenite co-treated with Estradiol] results in decreased expression of MLH1 protein23804311
D004958Estradiol[sodium arsenite co-treated with Estradiol] results in increased methylation of MLH1 promoter23804311
C006780bisphenol Abisphenol A results in decreased expression of MLH1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of MLH1 mRNA22121209
C006780bisphenol Abisphenol A results in increased methylation of MLH1 gene28582417
C006780bisphenol Abisphenol A results in decreased methylation of MLH1 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of MLH1 mRNA25181051
C016274bromoacetatebromoacetate results in increased expression of MLH1 mRNA19753638
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of MLH1 mRNA12419474
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MLH1 mRNA23741332
D002330CarmustineMLH1 protein affects the susceptibility to Carmustine18430789
C074702chromium hexavalent ionAscorbic Acid promotes the reaction [MLH1 gene mutant form results in decreased susceptibility to chromium hexavalent ion]15831465
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of MLH1 mRNA19376149
C074702chromium hexavalent ionMLH1 gene mutant form results in decreased susceptibility to chromium hexavalent ion15831465
C074702chromium hexavalent ionMLH1 protein affects the reaction [chromium hexavalent ion affects the activity of CASP3 protein]15831465
C074702chromium hexavalent ionMLH1 protein affects the reaction [chromium hexavalent ion results in increased activity of CASP2 protein]15831465
C074702chromium hexavalent ionMLH1 protein affects the reaction [chromium hexavalent ion results in increased activity of CASP7 protein]15831465
C074702chromium hexavalent ionMLH1 protein affects the reaction [chromium hexavalent ion results in increased cleavage of PARP1 protein]15831465
C074702chromium hexavalent ionMLH1 protein promotes the reaction [Ascorbic Acid results in increased susceptibility to chromium hexavalent ion]17301063
C074702chromium hexavalent ionMLH1 protein results in increased susceptibility to chromium hexavalent ion17301063
C074702chromium hexavalent ionMLH1 protein results in increased susceptibility to [chromium hexavalent ion co-treated with Ascorbic Acid]17169990
C074702chromium hexavalent ionMLH1 protein results in increased susceptibility to chromium hexavalent ion15831465
D019327Copper SulfateCopper Sulfate results in decreased expression of MLH1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MLH1 mRNA"19167446
D003375CoumestrolCoumestrol results in increased expression of MLH1 mRNA19167446
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of MLH1 mRNA21878529
D003520CyclophosphamideCyclophosphamide results in decreased expression of MLH1 mRNA11906922
D016572CyclosporineCyclosporine results in increased expression of MLH1 mRNA20106945|2556210
C017160cypermethrincypermethrin results in increased expression of MLH1 mRNA21142847
C017160cypermethrincypermethrin results in increased expression of MLH1 mRNA25569846
C014347decitabinebelinostat promotes the reaction [decitabine results in increased expression of MLH1 protein]19259094
C014347decitabinedecitabine affects the methylation of MLH1 promoter18069755
C014347decitabinedecitabine affects the reaction [Estradiol results in decreased expression of MLH1 mRNA]22082530
C014347decitabine[decitabine co-treated with trichostatin A] affects the methylation of MLH1 promoter18069755
C014347decitabinedecitabine inhibits the reaction [Oxygen deficiency results in decreased expression of MLH1 mRNA]25043185
C014347decitabinedecitabine inhibits the reaction [Oxygen deficiency results in increased methylation of MLH1 promoter]25043185
C014347decitabinedecitabine results in decreased methylation of MLH121875463
C014347decitabinedecitabine results in decreased methylation of MLH1 promoter19032668|1908063
C014347decitabinedecitabine results in increased expression of MLH119080631
C014347decitabinedecitabine results in increased expression of MLH1 mRNA19032668|1941713
C014347decitabinedecitabine results in increased expression of MLH1 protein19259094|2187546
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MLH1 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MLH1 mRNA21266533
D002945CisplatinCisplatin affects the localization of MLH1 protein21064154
D002945CisplatinCisplatin results in increased expression of MLH1 mRNA27392435|2759478
D002945Cisplatin[Estradiol results in increased expression of MLH1 mRNA] which results in increased susceptibility to Cisplatin28323900
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of MLH1 mRNA26924002
D004052Diethylnitrosamine[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of MLH1 mRNA18253720
D004052Diethylnitrosamine[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of MLH1 mRNA18775883
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of MLH1 mRNA15766595
D004054DiethylstilbestrolMLH1 gene mutant form affects the susceptibility to Diethylstilbestrol15700306
D0198131,2-Dimethylhydrazine"[NFE2L2 protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of MLH1 mRNA"26388957
C024629dimethyl phthalatedimethyl phthalate affects the expression of MLH1 mRNA26924002
D004317Doxorubicin[Estradiol results in increased expression of MLH1 mRNA] which results in increased susceptibility to Doxorubicin28323900
D004726EndosulfanEndosulfan results in increased expression of MLH1 mRNA25569846
C045651epigallocatechin gallateepigallocatechin gallate results in decreased methylation of MLH1 promoter14633667
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of MLH1 mRNA14633667
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of MLH1 protein14633667
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MLH1 mRNA22079256
D005038EthylnitrosoureaEthylnitrosourea results in increased expression of MLH121154115
D005038EthylnitrosoureaPhytic Acid inhibits the reaction [Ethylnitrosourea results in increased expression of MLH1]21154115
D015025ZearalenoneZearalenone results in increased expression of MLH1 mRNA28552778
D015025ZearalenoneZearalenone results in increased expression of MLH1 protein28552778
D011345Fenofibrate[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of MLH1 mRNA18253720
D011345Fenofibrate[Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of MLH1 mRNA18775883
D011345FenofibrateFenofibrate results in increased expression of MLH1 mRNA17264098|1877588
D005467FloxuridineMLH1 protein results in decreased susceptibility to Floxuridine22194930
D005467Floxuridineolaparib inhibits the reaction [MLH1 protein results in decreased susceptibility to Floxuridine]22194930
D005472FluorouracilMLH1 mRNA affects the susceptibility to Fluorouracil18497967
D005472FluorouracilMLH1 protein affects the susceptibility to Fluorouracil18949393
D005472FluorouracilMLH1 protein results in increased susceptibility to Fluorouracil17914563
C419708gefitinibgefitinib results in decreased expression of MLH1 mRNA16685379
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of MLH1 mRNA15458575
C056493imiquimodimiquimod results in decreased expression of MLH1 mRNA21878529
C051890irinotecanMLH1 protein affects the susceptibility to irinotecan18949393
D007545IsoproterenolIsoproterenol results in increased expression of MLH1 mRNA21335049
D007854LeadLead affects the expression of MLH1 mRNA28903495
D007854LeadLead affects the splicing of MLH1 mRNA28903495
C015329lycopenelycopene results in increased expression of MLH1 mRNA16886892
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in decreased expression of MLH1 protein17671175
D008770MethylnitrosoureaMethylnitrosourea promotes the reaction [MSH2 protein binds to MLH1 protein binds to PMS2 protein]16204460
D008770MethylnitrosoureaMLH1 affects the reaction [MGMT protein affects the reaction [Methylnitrosourea results in increased activity of CASP3 protein]]13679151
D008770MethylnitrosoureaMLH1 protein affects the susceptibility to Methylnitrosourea12967659
D008770MethylnitrosoureaMLH1 protein promotes the reaction [MGMT protein results in decreased susceptibility to Methylnitrosourea]13679151
C517284monomethyl phthalatemonomethyl phthalate affects the expression of MLH1 mRNA26924002
C066471NCS 382NCS 382 results in increased expression of MLH1 mRNA28119166
D009532NickelNickel analog results in increased expression of MLH1 mRNA24579805
D009532NickelNickel analog results in increased expression of MLH1 protein24579805
C022838nickel chloridenickel chloride results in decreased expression of MLH1 mRNA28472268
C022838nickel chloridenickel chloride results in decreased expression of MLH1 protein28472268
C022838nickel chloridenickel chloride affects the expression of MLH1 mRNA22546817
C064976O(6)-benzylguanine[temozolomide co-treated with O(6)-benzylguanine] affects the expression of MLH1 protein20980775
C531550olaparibolaparib inhibits the reaction [MLH1 protein results in decreased susceptibility to Floxuridine]22194930
D010100Oxygendecitabine inhibits the reaction [Oxygen deficiency results in decreased expression of MLH1 mRNA]25043185
D010100Oxygendecitabine inhibits the reaction [Oxygen deficiency results in increased methylation of MLH1 promoter]25043185
D010100Oxygen[KDM1A protein binds to RCOR1 protein] promotes the reaction [Oxygen deficiency results in decreased expression of MLH1 mRNA]25043185
D010100Oxygen[KDM1A protein binds to RCOR1 protein] promotes the reaction [Oxygen deficiency results in decreased expression of MLH1 protein]25043185
D010100Oxygen[KDM1A protein binds to RCOR1 protein] promotes the reaction [Oxygen deficiency results in increased methylation of MLH1 promoter]25043185
D010100OxygenKDM1A protein promotes the reaction [Oxygen deficiency results in decreased expression of MLH1 mRNA]25043185
D010100OxygenKDM1A protein promotes the reaction [Oxygen deficiency results in increased methylation of MLH1 promoter]25043185
D010100OxygenKDM5B protein promotes the reaction [Oxygen deficiency results in decreased expression of MLH1 mRNA]25043185
D010100OxygenOxygen deficiency promotes the reaction [KDM1A protein binds to MLH1 promoter]25043185
D010100OxygenOxygen deficiency results in decreased expression of MLH1 mRNA25043185|2847226
D010100OxygenOxygen deficiency results in decreased expression of MLH1 protein25043185|2847226
D010100OxygenOxygen deficiency results in increased methylation of MLH1 promoter25043185
D010100OxygenRCOR1 protein promotes the reaction [Oxygen deficiency results in increased methylation of MLH1 promoter]25043185
D010269ParaquatParaquat results in increased expression of MLH1 mRNA15458575
D052638Particulate MatterParticulate Matter results in increased expression of MLH1 mRNA24769257
C011272perfosfamideperfosfamide results in decreased expression of MLH1 mRNA11754170
D010575PesticidesPesticides results in decreased methylation of MLH1 gene28396702
D010833Phytic AcidPhytic Acid affects the methylation of MLH1 promoter21154115
D010833Phytic AcidPhytic Acid inhibits the reaction [Ethylnitrosourea results in increased expression of MLH1]21154115
C006253pirinixic acidpirinixic acid results in increased expression of MLH1 mRNA19162173|2012707
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MLH1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of MLH1 mRNA22079256|2271453
D011192Potassium DichromatePotassium Dichromate results in increased expression of MLH1 mRNA23628323
C045362prochlorazprochloraz results in increased expression of MLH1 mRNA29038839
D011794QuercetinQuercetin results in increased expression of MLH1 mRNA25862958
C037219quinolinequinoline analog results in increased expression of MLH1 mRNA19417133
C547185riccardin Driccardin D results in increased expression of MLH1 mRNA24069304
C017947sodium arsenite[Estradiol co-treated with sodium arsenite] results in decreased expression of MLH1 mRNA23804311
C017947sodium arsenite[sodium arsenite co-treated with Estradiol] results in decreased expression of MLH1 protein23804311
C017947sodium arsenite[sodium arsenite co-treated with Estradiol] results in increased methylation of MLH1 promoter23804311
C017947sodium arsenitesodium arsenite results in decreased expression of MLH1 mRNA23804311|2847226
C017947sodium arsenitesodium arsenite results in decreased expression of MLH1 protein23804311
C017947sodium arsenitesodium arsenite results in increased expression of MLH1 mRNA12634122
C016104sodium bichromatesodium bichromate results in increased expression of MLH1 mRNA22155349
D013241SterigmatocystinMLH1 protein affects the reaction [Sterigmatocystin results in increased expression of CCNB1 protein]23296099
D013241SterigmatocystinMLH1 protein affects the reaction [Sterigmatocystin results in increased expression of CDC25C protein]23296099
D013241SterigmatocystinMLH1 protein affects the reaction [Sterigmatocystin results in increased expression of CDC25C protein modified form]23296099
D013241SterigmatocystinMLH1 protein affects the reaction [Sterigmatocystin results in increased expression of CDK1 protein]23296099
D013241SterigmatocystinMLH1 protein affects the reaction [Sterigmatocystin results in increased expression of CDK1 protein modified form]23296099
D013241SterigmatocystinMLH1 protein affects the susceptibility to Sterigmatocystin23296099
D013241SterigmatocystinSterigmatocystin results in increased expression of MLH1 mRNA23296099
D013241SterigmatocystinSterigmatocystin results in increased expression of MLH1 protein23296099
C047246temozolomideMLH1 protein affects the susceptibility to temozolomide18430789
C047246temozolomide[temozolomide co-treated with O(6)-benzylguanine] affects the expression of MLH1 protein20980775
C047246temozolomideMLH1 protein affects the susceptibility to temozolomide12967659
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MLH1 mRNA20702594
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MLH1 mRNA19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MLH1 mRNA21215274
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased methylation of MLH1 promoter25214829
C012589trichostatin A[decitabine co-treated with trichostatin A] affects the methylation of MLH1 promoter18069755
D014415TunicamycinTunicamycin results in increased expression of MLH1 mRNA15458575
D014520UrethaneUrethane results in decreased expression of MLH1 protein25168426
D014635Valproic AcidValproic Acid affects the expression of MLH1 mRNA25979313
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MLH1 gene25560391
D014800VitalliumVitallium analog results in decreased expression of MLH1 mRNA23825117

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-IEA-  
GO:0003697single-stranded DNA binding-IBA21873635  
GO:0003697single-stranded DNA bindingcontributes_toIDA11809883  
GO:0005515protein binding-IPI2414623  8942985  11427529  11429708  11793469  14676842  
16189514  16403449  17581638  17715146  17967441  19060904  
20603015  20603073  20706999  21516116  25416956  25910212  
26496610  27107012  27107014  
GO:0005515protein bindingcontributes_toIPI16403449  
GO:0005524ATP binding-IEA-  
GO:0016887ATPase activity-IBA21873635  
GO:0032137guanine/thymine mispair binding-IEA-  
GO:0032407MutSalpha complex bindingcontributes_toIDA16403449  
GO ID GO Term Qualifier Evidence PubMed
GO:0000289nuclear-transcribed mRNA poly(A) tail shortening-IEA-  
GO:0000712resolution of meiotic recombination intermediates-IEA-  
GO:0006298mismatch repair-IBA21873635  
GO:0006298mismatch repair-IGI23603115  
GO:0006298mismatch repair-TAS-  
GO:0006303double-strand break repair via nonhomologous end joining-IEA-  
GO:0007060male meiosis chromosome segregation-IEA-  
GO:0007129synapsis-IEA-  
GO:0007283spermatogenesis-IEA-  
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage-IEA-  
GO:0016321female meiosis chromosome segregation-IEA-  
GO:0016446somatic hypermutation of immunoglobulin genes-IBA21873635  
GO:0043060meiotic metaphase I plate congression-IEA-  
GO:0045141meiotic telomere clustering-IEA-  
GO:0045190isotype switching-IEA-  
GO:0045950negative regulation of mitotic recombination-IEA-  
GO:0048298positive regulation of isotype switching to IgA isotypes-IEA-  
GO:0048304positive regulation of isotype switching to IgG isotypes-IEA-  
GO:0048477oogenesis-IEA-  
GO:0051257meiotic spindle midzone assembly-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000795synaptonemal complex-IBA21873635  
GO:0001673male germ cell nucleus-IEA-  
GO:0005634nucleus-IC11809883  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005712chiasma-IBA21873635  
GO:0005715late recombination nodule-IEA-  
GO:0016020membrane-HDA19946888  
GO:0032300mismatch repair complex-IBA21873635  
GO:0032389MutLalpha complex-IBA21873635  
KEGG ID KEGG Term
hsa03430Mismatch repair
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05213Endometrial cancer
Reactome ID Reactome Term Evidence
R-HSA-1474165ReproductionIEA
R-HSA-1500620MeiosisIEA
R-HSA-1640170Cell CycleIEA
R-HSA-1643685DiseaseTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5358508Mismatch RepairTAS
R-HSA-5358508Mismatch RepairIEA
R-HSA-5358565Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)TAS
R-HSA-5358606Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)IEA
R-HSA-5423599Diseases of Mismatch Repair (MMR)TAS
R-HSA-5545483Defective Mismatch Repair Associated With MLH1TAS
R-HSA-5632987Defective Mismatch Repair Associated With PMS2TAS
R-HSA-6796648TP53 Regulates Transcription of DNA Repair GenesTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73894DNA RepairTAS
R-HSA-73894DNA RepairIEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-912446Meiotic recombinationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28674222Small suitability of the DLEC1, MLH1 and TUSC4 mRNA expression analysis as potential prognostic or differentiating markers for NSCLC patients in the Polish population. (2017 Jun)Kordiak JJ Genet
27693945Repair genes expression profile of MLH1, MSH2 and ATM in the normal oral mucosa of chronic smokers. (2017 Jan)Alves MGArch Oral Biol
21559014Body mass index in early adulthood and colorectal cancer risk for carriers and non-carriers of germline mutations in DNA mismatch repair genes. (2011 Jun 28)Win AKBr J Cancer
17509026Aberrant DNA methylation in non-neoplastic gastric mucosa of H. Pylori infected patients and effect of eradication. (2007 Jul)Perri FAm J Gastroenterol
28676214DNA mismatch repair deficiency in surgically resected lung adenocarcinoma: Microsatellite instability analysis using the Promega panel. (2017 Aug)Takamochi KLung Cancer
21875327MLH1 promoter methylation, diet, and lifestyle factors in mismatch repair deficient colorectal cancer patients from EPIC-Norfolk. (2011)Gay LJNutr Cancer
20301390Lynch Syndrome (1993)Kohlmann W-
23539450Genomic aberrations occurring in subsets of serrated colorectal lesions but not conventional adenomas. (2013 May 1)Burnett-Hartman ANCancer Res
28693228Expression of methylation-modulated tumor-related genes in endoscopically resected early esophageal squamous neoplasia. (2017 Jul)Hosoda KOncol Lett
25791328DNA methylation analysis of cancer-related genes in oral epithelial cells of healthy smokers. (2015 Jun)De Oliveira SRArch Oral Biol
17064992Expression of DNA mismatch repair proteins in transformed non-Hodgkin's lymphoma: relationship to smoking. (2006 Sep)Nandi SLeuk Lymphoma
27732944Germline mutations in Japanese familial pancreatic cancer patients. (2016 Nov 8)Takai EOncotarget
23504373Significant frequency of allelic imbalance in 3p region covering RARbeta and MLH1 loci seems to be essential in molecular non-small cell lung cancer diagnosis. (2013 Jun)Antczak AMed Oncol
18523027Mismatch repair polymorphisms and risk of colon cancer, tumour microsatellite instability and interactions with lifestyle factors. (2009 May)Campbell PTGut
25252713Factors modifying the risk for developing acute skin toxicity after whole-breast intensity modulated radiotherapy. (2014 Sep 25)De Langhe SBMC Cancer
28927526Putative biomarkers for cervical cancer: SNVs, methylation and expression profiles. (2017 Jul)Cardoso MFSMutat Res
29334683Epigenetic Silencing of the MLH1 Promoter in Relation to the Development of Gastric Cancer and its use as a Biomarker for Patients with Microsatellite Instability: a Systematic Analysis. (2018)Hu GCell Physiol Biochem
29108386Single nucleotide polymorphisms in MLH1 predict poor prognosis of hepatocellular carcinoma in a Chinese population. (2017 Oct 3)Zhu XOncotarget
21938565[Bladder cancer at an early age in father and son]. (2011 Dec)Ovsiannikov DUrologe A
23787767Reduced expression of mutS homolog 2 and mutL homolog 1 affects overall survival in laryngeal squamous cell carcinoma patients: Investigation into a potential cause. (2013 Sep)Gong HLOncol Rep
28622040Analysis of differential genetic expression in endometrial polyps of postmenopausal women. (2017 Oct)Troncon JKClimacteric
25249451Association of DCC, MLH1, GSTT1, GSTM1, and TP53 gene polymorphisms with colorectal cancer in Kazakhstan. (2015 Jan)Djansugurova LTumour Biol
21093954Polymorphisms of MLH1 and MSH2 genes and the risk of lung cancer among never smokers. (2011 Jun)Lo YLLung Cancer