Gene: MAP3K9

4293
MEKK9|MLK1|PRKE1
mitogen-activated protein kinase kinase kinase 9
protein-coding
14q24.2
Ensembl:ENSG00000006432 MIM:600136 Vega:OTTHUMG00000171249 UniprotKB:P80192
NC_000014.9
PubMed
0   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.448e-1 (AD)  4.247e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNB10.974
AAK10.969
ADD20.968
TLN20.965
HECW10.964
HCN10.963
KIAA1549L0.962
PRKCE0.962
RASGRF10.962
ARHGAP440.961

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
YES1-0.624
RAB13-0.613
MYL3-0.608
HEY2-0.607
COPZ2-0.6
REST-0.592
RAI14-0.59
SNHG18-0.585
WWTR1-0.584
RNF135-0.574

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB0870312-(2-hydroxyethyl)-2-(1-methylethoxy)-13,14-dihydronaphtho[2,1-a]pyrrolo[3,4-c]carbazol-5(12H)-oneSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C5696701-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one"1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno(3,2-d)pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one results in decreased activity of MAP3K9 protein"21981714
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of MAP3K9 mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAP3K9 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAP3K9 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of MAP3K9 mRNA29067470
D020106AcrylamideAcrylamide results in increased expression of MAP3K9 mRNA28959563
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of MAP3K9 mRNA"17331233
C006780bisphenol Abisphenol A results in decreased expression of MAP3K9 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of MAP3K9 mRNA29097150
C006780bisphenol Abisphenol A results in increased methylation of MAP3K9 gene28505145
D016572CyclosporineCyclosporine results in increased expression of MAP3K9 mRNA25562108
C000944dicrotophosdicrotophos results in increased expression of MAP3K9 mRNA28302478
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MAP3K9 mRNA29097150
D005557FormaldehydeFormaldehyde results in decreased expression of MAP3K9 mRNA20655997
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of MAP3K9 mRNA24796395
D008727MethotrexateMethotrexate affects the expression of MAP3K9 mRNA18502557
D011441PropylthiouracilPropylthiouracil results in increased expression of MAP3K9 mRNA24780913
D011794QuercetinQuercetin results in increased expression of MAP3K9 mRNA21632981
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of MAP3K9 mRNA21427059
D012999SomanSoman results in increased expression of MAP3K9 mRNA19281266
D013853ThioacetamideThioacetamide results in increased expression of MAP3K9 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of MAP3K9 mRNA28065790
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MAP3K9 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of MAP3K9 mRNA24935251|2627250
D014520UrethaneUrethane results in increased expression of MAP3K9 mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of MAP3K9 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of MAP3K9 mRNA21427059

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA15610029  
GO:0004706JUN kinase kinase kinase activity-IBA21873635  
GO:0004706JUN kinase kinase kinase activity-ISS-  
GO:0004708MAP kinase kinase activity-NAS8477742  
GO:0005515protein binding-IPI22939624  
GO:0005524ATP binding-IEA-  
GO:0042803protein homodimerization activity-ISS8195146  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-IBA21873635  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0006468protein phosphorylation-IDA15610029  
GO:0006915apoptotic process-IEA-  
GO:0007256activation of JNKK activity-IEA-  
GO:0007257activation of JUN kinase activity-IBA21873635  
GO:0007257activation of JUN kinase activity-ISS8195146  
GO:0043065positive regulation of apoptotic process-IEA-  
GO:0046777protein autophosphorylation-IDA15610029  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24993294Diet and lifestyle factors interact with MAPK genes to influence survival: the Breast Cancer Health Disparities Study. (2014 Sep)Slattery MLCancer Causes Control
25629224MAPK genes interact with diet and lifestyle factors to alter risk of breast cancer: the Breast Cancer Health Disparities Study. (2015)Slattery MLNutr Cancer
23027623MAP kinase genes and colon and rectal cancer. (2012 Dec)Slattery MLCarcinogenesis
25278008Genome-wide association discoveries of alcohol dependence. (2014 Nov-Dec)Zuo LAm J Addict