Gene: MAP3K10

4294
MEKK10|MLK2|MST
mitogen-activated protein kinase kinase kinase 10
protein-coding
19q13.2
Ensembl:ENSG00000130758 MIM:600137 Vega:OTTHUMG00000182591 UniprotKB:Q02779
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.508e-1 (AD)  1.192e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
JPH30.972
PDZD40.963
PPP1R9B0.958
FBXL190.952
BRSK10.951
BAP10.95
FBXL160.947
AGAP30.945
KCNN10.944
CBX60.942

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.676
OR4F29-0.636
TFPI2-0.397
C9orf135-0.385
IGF2BP2-0.383
SGMS2-0.381
KCNJ15-0.381
C1orf87-0.379
IL18RAP-0.377
CLEC2B-0.37

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of MAP3K10 mRNA"23829299
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MAP3K10 mRNA"19114083
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of MAP3K10 mRNA"28973690
C4771875-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole"5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxyphenyl)-5'-benzimidazolyl)benzimidazole results in decreased expression of MAP3K10 mRNA"22745752
D000082AcetaminophenAcetaminophen affects the expression of MAP3K10 mRNA17562736
C015001arsenitearsenite results in increased methylation of MAP3K10 promoter23974009
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of MAP3K10 mRNA"17331233
D001280AtrazineAtrazine results in decreased expression of MAP3K10 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of MAP3K10 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MAP3K10 mRNA26001963
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of MAP3K10 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of MAP3K10 mRNA25181051
D002994ClofibrateClofibrate results in decreased expression of MAP3K10 mRNA23811191
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of MAP3K10 mRNA28628672
D003976DiazinonDiazinon affects the expression of MAP3K10 mRNA22546817
D004026DieldrinDieldrin affects the expression of MAP3K10 mRNA22546817
D002117CalcitriolCalcitriol results in increased expression of MAP3K10 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of MAP3K10 mRNA21592394
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MAP3K10 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAP3K10 mRNA17942748
C069837fullerene C60fullerene C60 results in decreased expression of MAP3K10 mRNA19167457
D007052IbuprofenIbuprofen results in increased expression of MAP3K10 mRNA28201806
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of MAP3K10 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MAP3K10 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of MAP3K10 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MAP3K10 mRNA23086925
D007854LeadLead affects the expression of MAP3K10 mRNA28903495
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MAP3K10 mRNA26011545
C022838nickel chloridenickel chloride affects the expression of MAP3K10 mRNA22546817
D019319Okadaic AcidOkadaic Acid results in decreased expression of MAP3K10 mRNA25270620
C045362prochlorazprochloraz results in increased expression of MAP3K10 mRNA21470553
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of MAP3K10 mRNA25895662
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of MAP3K10 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of MAP3K10 mRNA21592394
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MAP3K10 mRNA17942748
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of MAP3K10 mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MAP3K10 mRNA25613284
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of MAP3K10 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of MAP3K10 mRNA17963808

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003714transcription corepressor activity-ISS-  
GO:0004672protein kinase activity-TAS8536694  10801775  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA19801649  
GO:0004706JUN kinase kinase kinase activity-IBA21873635  
GO:0004706JUN kinase kinase kinase activity-ISS-  
GO:0005524ATP binding-IEA-  
GO:0042803protein homodimerization activity-ISS8195146  
GO:0043425bHLH transcription factor binding-IPI19801649  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-IBA21873635  
GO:0006915apoptotic process-TAS10801775  
GO:0007165signal transduction-TAS10801775  
GO:0007224smoothened signaling pathway-IMP18455992  
GO:0007254JNK cascade-TAS10801775  
GO:0007256activation of JNKK activity-IEA-  
GO:0007257activation of JUN kinase activity-IBA21873635  
GO:0007257activation of JUN kinase activity-ISS8195146  
GO:0018105peptidyl-serine phosphorylation-IDA19801649  
GO:0018107peptidyl-threonine phosphorylation-IDA19801649  
GO:0043065positive regulation of apoptotic process-IBA21873635  
GO:0043433negative regulation of DNA-binding transcription factor activity-IMP19801649  
GO:0043507positive regulation of JUN kinase activity-IMP17584736  
GO:0045892negative regulation of transcription, DNA-templated-IMP19801649  
GO:0045892negative regulation of transcription, DNA-templated-ISS-  
GO:0046330positive regulation of JNK cascade-IMP17584736  
GO:0046777protein autophosphorylation-ISS8195146  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA18455992  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23027623MAP kinase genes and colon and rectal cancer. (2012 Dec)Slattery MLCarcinogenesis