Gene: MAP3K11

4296
MEKK11|MLK-3|MLK3|PTK1|SPRK
mitogen-activated protein kinase kinase kinase 11
protein-coding
11q13.1
Ensembl:ENSG00000173327 MIM:600050 Vega:OTTHUMG00000166529 UniprotKB:Q16584
NC_000011.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.516e-1 (AD)  3.737e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DNM20.845
TMEM1890.838
SHROOM10.837
RNH10.818
CDR2L0.816
LZTS20.811
RALY0.81
CYTH10.806
AXIN10.806
TBC1D20.806

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.58
OR4F5-0.57
CNGB1-0.19
CHRNA6-0.184
HDC-0.183
FAM216B-0.182
CNTN5-0.181
NMBR-0.179
NPBWR1-0.179
PKP2-0.175

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MAP3K11 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MAP3K11 mRNA"21346803
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MAP3K11 mRNA27153756
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of MAP3K11 mRNA24449571
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of MAP3K11 mRNA"17331233
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to MAP3K11 promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MAP3K11 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MAP3K11 mRNA21839799
C006780bisphenol Abisphenol A affects the expression of MAP3K11 mRNA25181051
C584509C646 compoundC646 compound results in decreased expression of MAP3K11 mRNA26191083
D019327Copper SulfateCopper Sulfate results in decreased expression of MAP3K11 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of MAP3K11 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of MAP3K11 mRNA20106945|2556210
D003976DiazinonDiazinon results in increased methylation of MAP3K11 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MAP3K11 mRNA21266533
C070081fulvestrantfulvestrant results in increased expression of MAP3K11 mRNA12154049
C039281furanfuran results in increased methylation of MAP3K11 gene22079235
C401858GW 7604GW 7604 results in increased expression of MAP3K11 mRNA12154049
D008070LipopolysaccharidesLipopolysaccharides results in increased phosphorylation of MAP3K11 protein17698565
D008070Lipopolysaccharides[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased methylation of MAP3K11 gene21212295
C025340manganese chloridemanganese chloride results in increased phosphorylation of MAP3K11 protein15342272
C424427NEPP11 compoundNEPP11 compound results in increased phosphorylation of MAP3K11 protein15342272
C487513NSC 23766NSC 23766 inhibits the reaction [Zinc Oxide results in increased expression of MAP3K11 protein]22166487
D011070Poly I-CPoly I-C results in increased phosphorylation of MAP3K11 protein17698565
D011441PropylthiouracilPropylthiouracil results in decreased expression of MAP3K11 mRNA24780913
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of MAP3K11 mRNA12154049
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of MAP3K11 mRNA21427059
D012645SelenomethionineSelenomethionine affects the expression of MAP3K11 mRNA17222674
D013431SulfatesSulfates affects the methylation of MAP3K11 promoter25395096
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MAP3K11 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Lipopolysaccharides] results in increased methylation of MAP3K11 gene21212295
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to MAP3K11 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MAP3K11 mRNA15652763
D013849ThimerosalThimerosal results in decreased expression of MAP3K11 mRNA27188386
D014118Toxins, Biological"Toxins, Biological affects the expression of MAP3K11 mRNA"19682533
D014520UrethaneUrethane results in increased expression of MAP3K11 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of MAP3K11 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MAP3K11 mRNA28001369
D014635Valproic AcidValproic Acid results in increased methylation of MAP3K11 gene29154799
D014635Valproic AcidValproic Acid affects the expression of MAP3K11 mRNA17963808
D014635Valproic AcidValproic Acid results in decreased expression of MAP3K11 mRNA21427059
D014635Valproic AcidValproic Acid results in increased expression of MAP3K11 mRNA21427059
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MAP3K11 gene25560391
D015034Zinc OxideNSC 23766 inhibits the reaction [Zinc Oxide results in increased expression of MAP3K11 protein]22166487
D015034Zinc OxideZinc Oxide results in increased expression of MAP3K11 protein22166487

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-TAS8183572  10799501  
GO:0004674protein serine/threonine kinase activity-IBA21873635  
GO:0004674protein serine/threonine kinase activity-IDA8195146  
GO:0004706JUN kinase kinase kinase activity-IBA21873635  
GO:0004706JUN kinase kinase kinase activity-ISS-  
GO:0005515protein binding-IPI9003777  20890305  23857585  25241761  
GO:0005524ATP binding-IEA-  
GO:0031434mitogen-activated protein kinase kinase binding-IEA-  
GO:0031435mitogen-activated protein kinase kinase kinase binding-IPI17584736  
GO:0042802identical protein binding-IPI9829970  
GO:0042803protein homodimerization activity-IPI9829970  
GO:0048365Rac GTPase binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-IBA21873635  
GO:0000187activation of MAPK activity-IMP15258589  
GO:0006468protein phosphorylation-IDA11053428  
GO:0007017microtubule-based process-IBA21873635  
GO:0007017microtubule-based process-IMP12529434  
GO:0007254JNK cascade-TAS10799501  
GO:0007256activation of JNKK activity-IEA-  
GO:0007257activation of JUN kinase activity-IBA21873635  
GO:0007257activation of JUN kinase activity-IMP15258589  
GO:0008219cell death-IEA-  
GO:0008283cell proliferation-IMP15258589  
GO:0043065positive regulation of apoptotic process-IBA21873635  
GO:0043507positive regulation of JUN kinase activity-IMP17584736  
GO:0043525positive regulation of neuron apoptotic process-IEA-  
GO:0046330positive regulation of JNK cascade-IMP17584736  
GO:0046777protein autophosphorylation-IDA8195146  
GO ID GO Term Qualifier Evidence PubMed
GO:0005813centrosome-IBA21873635  
GO:0005813centrosome-IDA12529434  
GO:0005874microtubule-IDA12529434  
GO:0016020membrane-HDA19946888  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673000RAF activationTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6802946Signaling by moderate kinase activity BRAF mutantsTAS
R-HSA-6802949Signaling by RAS mutantsTAS
R-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAFTAS
R-HSA-6802957Oncogenic MAPK signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23027623MAP kinase genes and colon and rectal cancer. (2012 Dec)Slattery MLCarcinogenesis