Gene: TRPM1

4308
CSNB1C|LTRPC1|MLSN1
transient receptor potential cation channel subfamily M member 1
protein-coding
15q13.3
Ensembl:ENSG00000134160 MIM:603576 Vega:OTTHUMG00000129267 UniprotKB:Q7Z4N2
NG_016453.2
PubMed
0   ANCO-SNPs
ND
1   
8.458e-1 (AD)  9.772e-1 (ND)   (Frontal_Cortex)
7.126e-1 (AD)  3.990e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SVEP10.445
PLEKHH10.407
C1QTNF80.388
CARNS10.381
KRTAP13-10.379
MAG0.376
P2RY80.375
SGK20.375
SLC31A20.371
CERCAM0.369

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZSCAN5B-0.223
CALB2-0.207
HGFAC-0.206
KLRC2-0.205
AVPR2-0.203
OR52W1-0.202
ASCL2-0.193
NPBWR1-0.185
C19orf33-0.174
PYDC1-0.172

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TRPM1 gene27153756
C006780bisphenol Abisphenol A results in decreased expression of TRPM1 mRNA25181051
D003033Coal TarCoal Tar results in decreased expression of TRPM1 mRNA27858113
D003300CopperCopper deficiency results in increased expression of TRPM1 mRNA26033743
D004041Dietary FatsDietary Fats results in increased expression of TRPM1 mRNA25016146
D019422Dietary SucroseDietary Sucrose results in increased expression of TRPM1 mRNA26033743
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of TRPM1 mRNA17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of TRPM1 mRNA]17942915
C039281furanfuran results in decreased expression of TRPM1 mRNA25539665
C008261lead acetatelead acetate results in decreased expression of TRPM1 mRNA22641619
C002385linsidominelinsidomine results in increased oxidation of TRPM1 protein28086193
D008345ManganeseManganese results in increased expression of TRPM1 mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of TRPM1 mRNA17175027
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TRPM1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of TRPM1 mRNA"25554681
D010795Phthalic AcidsPhthalic Acids results in increased expression of TRPM1 mRNA21061450
D010936Plant ExtractsPlant Extracts results in decreased expression of TRPM1 mRNA23557933
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TRPM1 mRNA21570461
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of TRPM1 mRNA19969065
D014635Valproic AcidValproic Acid results in decreased methylation of TRPM1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TRPM1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005262calcium channel activity-IDA23452348  
GO:0005262calcium channel activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007216G-protein coupled glutamate receptor signaling pathway-IMP23452348  
GO:0007601visual perception-IMP19878917  
GO:0046548retinal rod cell development-IEA-  
GO:0051262protein tetramerization-IEA-  
GO:0060402calcium ion transport into cytosol-IDA23452348  
GO:0070588calcium ion transmembrane transport-TAS-  
GO:0071482cellular response to light stimulus-IMP19896109  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS9806836  
GO:0035841new growing cell tip-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-3295583TRP channelsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21970977Multiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia. (2012 Feb)Stephens SHPsychiatr Genet