Gene: MME

4311
CALLA|CD10|CMT2T|NEP|SCA43|SFE
membrane metalloendopeptidase
protein-coding
3q25.2
Ensembl:ENSG00000196549 MIM:120520 Vega:OTTHUMG00000158455 UniprotKB:P08473
NG_051105.1
PubMed
0   ANCO-SNPs
OD|ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.856e-1 (AD)  2.251e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COL1A10.645
COL6A30.576
KRT230.575
MPZL30.555
UPK1B0.534
FBN20.533
KLF50.524
COL3A10.522
FBLN50.512
KL0.511

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
S100A1-0.301
NANOS3-0.285
HHATL-0.282
NXPH3-0.264
RLBP1-0.257
FAM151A-0.233
CERS1-0.23
TEX29-0.227
ABHD1-0.225
NUDT8-0.225

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00616CandoxatrilSmall Molecule123122-55-4ExperimentalTarget
DB00886OmapatrilatSmall Molecule167305-00-2InvestigationalTarget
DB02062N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]AlanineSmall MoleculeExperimentalTarget
DB02557PhosphoramidonSmall Molecule36357-77-4ExperimentalTarget
DB02558N-(3-Phenyl-2-Sulfanylpropanoyl)PhenylalanylalanineSmall MoleculeExperimentalTarget
DB02597[2(R,S)-2-Sulfanylheptanoyl]-Phe-AlaSmall MoleculeExperimentalTarget
DB05796DaglutrilSmall Molecule182821-27-8InvestigationalTarget
DB085752-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUMSmall MoleculeExperimentalTarget
DB08626ThiorphanSmall Molecule76721-89-6ExperimentalTarget
DB09292SacubitrilSmall Molecule149709-62-6ApprovedTarget
DB11623CandoxatrilatSmall Molecule123122-54-3ExperimentalTarget
DB06655LiraglutideBiotechDrug204656-20-2ApprovedEnzyme
DB13928SemaglutideSmall Molecule910463-68-2Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of MME mRNA"22698814
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of MME mRNA]"22698814
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of MME mRNA"21920950
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MME mRNA"19114083
C5850042-monochloropropanediol2-monochloropropanediol results in decreased expression of MME mRNA28522335
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of MME mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MME mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MME mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MME mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MME mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MME mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MME mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of MME mRNA29067470
C109238acylineacyline results in decreased expression of MME mRNA17510436
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MME mRNA27153756
D000517alpha-Chlorohydrinalpha-Chlorohydrin affects the expression of MME mRNA28522335
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of MME mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MME mRNA16483693
D018927Anti-Asthmatic AgentsAnti-Asthmatic Agents results in increased expression of MME protein9160837
D001151ArsenicArsenic affects the expression of MME mRNA28793237
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of MME mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MME mRNA20064835
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of MME mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MME mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MME mRNA21839799
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of MME mRNA19619570
D004958EstradiolEstradiol results in decreased expression of MME mRNA16202921|1961957
D001623BetamethasoneBetamethasone inhibits the reaction [Mustard Gas results in decreased activity of MME protein]7501459
C053541bicalutamidebicalutamide results in increased expression of MME mRNA15790403
C006780bisphenol Abisphenol A results in decreased expression of MME mRNA20678512
C006780bisphenol Abisphenol A results in increased expression of MME mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of MME mRNA22079614
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of MME mRNA15336504
C062766candoxatrilcandoxatril results in decreased activity of MME protein16085334|8149689
C060942candoxatrilatcandoxatrilat results in decreased activity of MME protein18084312
C060942candoxatrilatcandoxatrilat results in decreased activity of MME protein16085334
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of MME protein16449355
C086164CGS 24592CGS 24592 results in decreased activity of MME protein16364833
C089987CGS 26303CGS 26303 analog results in decreased activity of MME protein10669576
C089987CGS 26303CGS 26303 results in decreased activity of MME protein10669576
C404931CGS 34043CGS 34043 results in decreased activity of MME protein10669576
C404932CGS 35066CGS 35066 results in decreased activity of MME protein10669576
C511403CGS 35601CGS 35601 results in decreased activity of MME protein16364833
D002994ClofibrateClofibrate results in decreased expression of MME mRNA22300585
C018021cobaltous chloridecobaltous chloride promotes the reaction [HIF1A protein binds to MME gene]23138928
C018021cobaltous chloridecobaltous chloride results in decreased expression of MME mRNA19320972|2313892
C018021cobaltous chloridecobaltous chloride results in decreased expression of MME protein23138928
C018021cobaltous chlorideHIF1A protein promotes the reaction [cobaltous chloride results in decreased expression of MME mRNA]23138928
C018021cobaltous chlorideHIF1A protein promotes the reaction [cobaltous chloride results in decreased expression of MME protein]23138928
D003042Cocainenaltrindole inhibits the reaction [[Thiorphan binds to and results in decreased activity of MME protein] which results in increased susceptibility to Cocaine]19279569
D003042Cocaine[Thiorphan binds to and results in decreased activity of MME protein] which results in increased susceptibility to Cocaine19279569
D003300CopperCopper results in decreased expression of MME mRNA22465980
D003474CurcuminCurcumin results in decreased expression of MME mRNA17198877
D016572CyclosporineCyclosporine results in decreased expression of MME mRNA20106945
D002945Cisplatin[Cisplatin co-treated with RELB mutant form co-treated with TNF protein] results in decreased expression of MME mRNA23625948
D002945CisplatinCisplatin results in decreased expression of MME mRNA22023808
D004008DiclofenacDiclofenac results in decreased expression of MME mRNA26934552
D004041Dietary FatsDietary Fats affects the expression of MME mRNA19680557
D004041Dietary FatsDietary Fats results in decreased expression of MME mRNA18042831
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of MME mRNA18164116
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of MME mRNA"19480007
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of MME mRNA"27840820
D004317DoxorubicinDoxorubicin results in decreased expression of MME protein16997790
D004317DoxorubicinMME protein affects the susceptibility to Doxorubicin16217747
D004391DustDust results in decreased expression of MME21877416
D004745EnkephalinsMME protein results in increased metabolism of Enkephalins17906961
C118739entinostatentinostat results in increased expression of MME mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MME mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MME mRNA28196854
C024565ethylene dichlorideethylene dichloride results in decreased expression of MME mRNA28189721
C082360fipronilfipronil results in increased expression of MME mRNA23962444
D005419FlavonoidsFlavonoids results in increased expression of MME mRNA18035473
D005492Folic AcidFolic Acid affects the expression of MME mRNA17320366
C070081fulvestrantfulvestrant results in increased expression of MME mRNA16202921
D005947GlucoseGlucose results in decreased expression of MME mRNA17178593
D017313FenretinideFenretinide results in decreased expression of MME mRNA28973697
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of MME mRNA17183730
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of MME protein17337753
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MME mRNA24796395
C549068LCZ 696LCZ 696 results in decreased activity of MME protein28315356
D007854LeadLead affects the folding of MME protein25673500
D007854LeadLead results in decreased expression of and results in decreased activity of MME protein21315759
D007854LeadLead results in decreased expression of MME mRNA21315759
D008070LipopolysaccharidesLipopolysaccharides affects the activity of MME protein21114838
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of MME mRNA12057914|2111483
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of MME protein21114838
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of MME mRNA12738685
D008628MercuryMercury affects the folding of and results in decreased activity of MME protein25673500
D008628MercuryMercury results in increased expression of MME protein25673500
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of MME mRNA"26251327
D015741MetriboloneMetribolone promotes the reaction [NDRG1 protein binds to MME protein]17220478
D016685MitomycinMME protein affects the susceptibility to Mitomycin16217747
D009020MorphineMorphine results in increased activity of MME protein10070497
D009020MorphineNaloxone inhibits the reaction [Morphine results in increased activity of MME protein]10070497
D009020Morphinephosphoramidon inhibits the reaction [Morphine results in increased activity of MME protein]10070497
D009151Mustard GasBetamethasone inhibits the reaction [Mustard Gas results in decreased activity of MME protein]7501459
D009151Mustard GasMustard Gas results in decreased activity of MME protein7501459
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of MME mRNA"29244179
D009270NaloxoneNaloxone inhibits the reaction [Morphine results in increased activity of MME protein]10070497
C055382naltrindolenaltrindole inhibits the reaction [[Thiorphan binds to and results in decreased activity of MME protein] which results in increased susceptibility to Cocaine]19279569
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of MME protein"21135415
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MME mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MME mRNA"25620056
C005274naringinnaringin inhibits the reaction [Tobacco Smoke Pollution results in decreased activity of MME protein]24085318
D009538NicotineNicotine results in increased expression of MME mRNA23825647
D026423S-Nitroso-N-AcetylpenicillamineS-Nitroso-N-Acetylpenicillamine results in decreased expression of MME mRNA12102619
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of MME mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of MME mRNA27935865
C025589ochratoxin Aochratoxin A results in decreased expression of MME mRNA12700408
C106266omapatrilatomapatrilat results in decreased activity of MME protein18084312
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of MME mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of MME mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of MME mRNA23138928
D010100OxygenOxygen deficiency results in decreased expression of MME protein23138928
D010100OxygenOxygen deficiency results in increased expression of MME mRNA24236059
D000073878Palm OilPalm Oil affects the expression of MME mRNA19680557
D000073878Palm OilPalm Oil results in decreased expression of MME mRNA18042831
D052638Particulate MatterMME protein affects the susceptibility to Particulate Matter21877416
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of MME mRNA27153767
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of MME mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of MME mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of MME mRNA19270015|1948288
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MME mRNA"27188386
C008890phosphoramidonphosphoramidon inhibits the reaction [Morphine results in increased activity of MME protein]10070497
C008890phosphoramidonphosphoramidon results in decreased activity of MME protein10070497|1219306
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of MME mRNA27935865
C006253pirinixic acidpirinixic acid results in decreased expression of MME mRNA23811191
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of MME mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in increased expression of MME protein23718831
D017035PravastatinPravastatin results in decreased expression of MME mRNA27225895
D017035PravastatinPravastatin affects the expression of MME mRNA27225895
D011285Pregnenolone CarbonitrileNR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in decreased expression of MME mRNA]22698814
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of MME mRNA22698814
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of MME mRNA19162173
D011374ProgesteroneProgesterone results in decreased expression of MME mRNA18070364
D011374ProgesteroneProgesterone results in increased expression of MME mRNA21795739
D011374ProgesteroneProgesterone affects the expression of MME mRNA17251523
C045950propiconazolepropiconazole results in decreased expression of MME mRNA21278054
D011441PropylthiouracilPropylthiouracil results in decreased expression of MME mRNA24780913
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in decreased expression of MME protein19885019
C049331racecadotrilracecadotril results in decreased activity of MME protein1624154|3481337
C049331racecadotrilracecadotril results in decreased activity of MME protein16085334|9808682
C059514resveratrolresveratrol results in increased activity of MME protein16162502
D012643SeleniumSelenium deficiency affects the expression of and affects the localization of MME protein17109141
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of MME protein24831964
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of MME protein24831964
C017947sodium arsenitesodium arsenite results in increased expression of MME mRNA22714537
D012969Sodium FluorideSodium Fluoride results in increased expression of MME protein28918527
C075117squalestatin 1squalestatin 1 results in decreased expression of MME mRNA27225895
C075117squalestatin 1squalestatin 1 results in increased expression of MME mRNA27225895
D013311StreptozocinStreptozocin results in decreased expression of MME protein19634143
D013311StreptozocinTrientine inhibits the reaction [Streptozocin results in decreased expression of MME protein]19634143
C013698tallowtallow affects the expression of MME mRNA19680557
D013629TamoxifenTamoxifen affects the expression of MME mRNA20937368
D013739TestosteroneTestosterone results in decreased expression of MME mRNA21669218
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of MME mRNA25172293
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of MME mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MME mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MME mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MME mRNA16704738
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MME mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MME mRNA17586704
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of MME mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MME mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MME mRNA21215274
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased expression of MME protein16997790
D013792ThalidomideThalidomide results in decreased expression of MME mRNA26217789
D013853ThioacetamideThioacetamide results in increased expression of MME mRNA23411599
D015244ThiorphanThiorphan results in decreased activity of MME protein16405511
D015244Thiorphan[Thiorphan results in decreased activity of MME protein] which affects the activity of AKT1 protein16405511
D015244ThiorphanThiorphan results in decreased activity of MME protein3519939
D015244Thiorphannaltrindole inhibits the reaction [[Thiorphan binds to and results in decreased activity of MME protein] which results in increased susceptibility to Cocaine]19279569
D015244Thiorphan[Thiorphan binds to and results in decreased activity of MME protein] which results in increased susceptibility to Cocaine19279569
D015244ThiorphanThiorphan results in decreased activity of MME protein3481337|3519939
D015244ThiorphanThiorphan binds to and results in decreased activity of MME protein19279569
D015244ThiorphanThiorphan results in decreased activity of MME protein16085334
D014028Tobacco Smoke Pollutionnaringin inhibits the reaction [Tobacco Smoke Pollution results in decreased activity of MME protein]24085318
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased activity of MME protein24085318
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MME mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of MME mRNA18087596
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of MME mRNA25729387
D019772TopotecanTopotecan results in increased expression of MME mRNA25729387
D014212TretinoinCSF3 protein promotes the reaction [Tretinoin results in increased expression of MME protein]12627849
D014212TretinoinTretinoin results in increased expression of MME mRNA21934132
D014212TretinoinTretinoin results in increased expression of MME protein12627849
C012589trichostatin Atrichostatin A results in increased expression of MME mRNA24935251
D014266TrientineTrientine inhibits the reaction [Streptozocin results in decreased expression of MME protein]19634143
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of MME mRNA19042947
C057693troglitazonetroglitazone results in increased expression of MME mRNA28973697
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of MME mRNA17183730
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MME mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of MME mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in increased expression of MME protein21877416
D001335Vehicle EmissionsMME protein affects the susceptibility to Vehicle Emissions21877416
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of MME21877416
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MME gene25560391
D001335Vehicle EmissionsVehicle Emissions results in decreased activity of MME protein13680092|1591601
D014747VinblastineMME protein affects the susceptibility to Vinblastine16217747
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of MME mRNA27935865
C511404ZD4054ZD4054 results in decreased expression of MME mRNA19943105

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004175endopeptidase activity-IDA8168535  15283675  20876573  
GO:0004175endopeptidase activity-IMP2531377  
GO:0004222metalloendopeptidase activity-IDA15283675  27588448  
GO:0004222metalloendopeptidase activity-IMP2521388  
GO:0005515protein binding-IPI17342744  23289620  
GO:0008237metallopeptidase activity-EXP15283675  
GO:0008238exopeptidase activity-IDA6208535  
GO:0008270zinc ion binding-IDA8168535  
GO:0042277peptide binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001822kidney development-IEP22272689  
GO:0002003angiotensin maturation-TAS-  
GO:0006508proteolysis-IDA8168535  20876573  27588448  
GO:0006518peptide metabolic process-ISS-  
GO:0019233sensory perception of pain-ISS-  
GO:0043312neutrophil degranulation-TAS-  
GO:0046449creatinine metabolic process-IMP22024547  
GO:0050435amyloid-beta metabolic process-ISS-  
GO:0071345cellular response to cytokine stimulus-IDA20876573  
GO:0071492cellular response to UV-A-IDA20876573  
GO:0071493cellular response to UV-B-IDA20876573  
GO:0090399replicative senescence-IEP20876573  
GO:0097242amyloid-beta clearance-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA20876573  22272689  
GO:0005886plasma membrane-IDA20876573  22272689  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-NAS2521388  
GO:0005903brush border-IDA22272689  
GO:0005925focal adhesion-HDA21423176  
GO:0008021synaptic vesicle-ISS-  
GO:0016021integral component of membrane-NAS2968607  
GO:0030424axon-ISS-  
GO:0030425dendrite-ISS-  
GO:0030667secretory granule membrane-TAS-  
GO:0044306neuron projection terminus-ISS-  
GO:0045202synapse-ISS-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
hsa04614Renin-angiotensin system
hsa04640Hematopoietic cell lineage
hsa04974Protein digestion and absorption
hsa05010Alzheimer's disease
Reactome ID Reactome Term Evidence
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-2022377Metabolism of Angiotensinogen to AngiotensinsTAS
R-HSA-2980736Peptide hormone metabolismTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26298082Spatiotemporal expression of endogenous opioid processing enzymes in mouse uterus at peri-implantation. (2016 Feb)Wu WCell Tissue Res
27957625A genome-wide analysis in cluster headache points to neprilysin and PACAP receptor gene variants. (2016 Dec)Bacchelli EJ Headache Pain
27748099BAP1 Tumor Predisposition Syndrome (1993)Pilarski R-
15029091[Psychiatric manifestations of vitamin B12 deficiency: a case report]. (2003 Nov-Dec)Durand CEncephale