Gene info: ID 4314

Gene: MMP3

GENE ID: 4314

Synonyms: CHDS6|MMP-3|SL-1|STMY|STMY1|STR1

Description: matrix metallopeptidase 3

Gene type: protein-coding

Location: 11q22.2

dbXrefs: Ensembl:ENSG00000149968 MIM:185250 Vega:OTTHUMG00000048254 UniprotKB:P08254

RefSeq: NG_012100.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 19

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.931e-1 (AD) 6.745e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
KRT33A	0.47
PTX3	0.452
FBXW10	0.451
RBM46	0.445
ZCCHC13	0.444
SLC36A2	0.443
DEC1	0.441
CRX	0.428
SBK3	0.427
MBD3L1	0.426

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
KLRC3	-0.205
CYP8B1	-0.202
DHRS4L2	-0.2
PON3	-0.2
JRKL-AS1	-0.186
KLRC2	-0.184
SCGB1D2	-0.18
GOLGA6B	-0.173
WFDC13	-0.173
CCNO	-0.172

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00786	Marimastat	Small Molecule	154039-60-8	Approved\|Investigational	Target
DB01877	N-Hydroxy 1n(4-Methoxyphenyl)Sulfonyl-4-(Z,E-N-Methoxyimino)Pyrrolidine-2r-Carboxamide	Small Molecule		Experimental	Target
DB01996	3-Methylpyridine	Small Molecule	108-99-6	Experimental	Target
DB02090	A Disubstituted Succinyl Caprolactam Hydroxymate Mmp3inhibitor	Small Molecule		Experimental	Target
DB02350	N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl]-2,2-Dimethyl-Hexahydro-1,4-Thiazepine-3(S)-Carboxamide	Small Molecule		Experimental	Target
DB02367	(1n)-4-N-Butoxyphenylsulfonyl-(2r)-N-Hydroxycarboxamido-(4s)-Methanesulfonylamino-Pyrrolidine	Small Molecule		Experimental	Target
DB02449	3-(1h-Indol-3-Yl)-2-[4-(4-Phenyl-Piperidin-1-Yl)-Benzenesulfonylamino]-Propionic Acid	Small Molecule		Experimental	Target
DB02697	Hydroxyaminovaline	Small Molecule		Experimental	Target
DB03033	1-Methyloxy-4-Sulfone-Benzene	Small Molecule		Experimental	Target
DB03368	5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine-2,4,6-Trione	Small Molecule		Experimental	Target
DB04140	1-Benzyl-3-(4-Methoxy-Benzenesulfonyl)-6-Oxo-Hexahydro-Pyrimidine-4-Carboxylic Acid Hydroxyamide	Small Molecule		Experimental	Target
DB04232	N-Hydroxy-1-(4-Methoxyphenyl)Sulfonyl-4-Benzyloxycarbonyl-Piperazine-2-Carboxamide	Small Molecule		Experimental	Target
DB04416	R-2-{[4'-Methoxy-(1,1'-Biphenyl)-4-Yl]-Sulfonyl}-Amino-6-Methoxy-Hex-4-Ynoic Acid	Small Molecule		Experimental	Target
DB07390	2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YL)-UREIDO]-N-METHYL-3-PHENYL-PROPIONAMIDE	Small Molecule		Experimental	Target
DB07986	[4-(4-PHENYL-PIPERIDIN-1-YL)-BENZENESULFONYLAMINO]-ACETIC ACID	Small Molecule		Experimental	Target
DB07987	[2-(5-MERCAPTO-[1,3,4]THIADIAZOL-2-YLCARBAMOYL)-1-PHENYL-ETHYL]-CARBAMIC ACID BENZYL ESTER	Small Molecule		Experimental	Target
DB07988	2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2YL)-UREIDO]-N-METHYL-3-PENTAFLUOROPHENYL-PROPIONAMIDE	Small Molecule		Experimental	Target
DB08029	N~2~-(biphenyl-4-ylsulfonyl)-N-hydroxy-N~2~-(2-hydroxyethyl)glycinamide	Small Molecule		Experimental	Target
DB08030	3-[(4'-cyanobiphenyl-4-yl)oxy]-N-hydroxypropanamide	Small Molecule		Experimental	Target
DB08271	N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID	Small Molecule		Experimental	Target
DB08507	N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT-4-YL-N]-BENZYL-P-[PHENYL]-P-[METHYL]PHOSPHINAMID	Small Molecule		Experimental	Target
DB08643	2-(2-{2-[(BIPHENYL-4-YLMETHYL)-AMINO]-3-MERCAPTO-PENTANOYLAMINO}-ACETYLAMINO)-3-METHYL-BUTYRIC ACID METHYL ESTER	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C540360	1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6''-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4,-dioxin	"1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6''-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4,-dioxin results in decreased expression of MMP3 mRNA"	19330880
C540360	1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6''-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4,-dioxin	"1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6''-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4,-dioxin results in decreased expression of MMP3 protein"	19330880
C082486	13-hydroxy-10-oxo-11-octadecenoic acid	13-hydroxy-10-oxo-11-octadecenoic acid inhibits the reaction [DDT results in increased expression of MMP3 mRNA]	20865247
C082486	13-hydroxy-10-oxo-11-octadecenoic acid	13-hydroxy-10-oxo-11-octadecenoic acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP3 mRNA]	20865247
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of MMP3 mRNA	28329830
C581572	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea results in increased expression of MMP3 mRNA	25827057
C417207	2,2',4,6,6'-pentachlorobiphenyl	"2,2',4,6,6'-pentachlorobiphenyl results in increased expression of MMP3 mRNA"	16778083
C417207	2,2',4,6,6'-pentachlorobiphenyl	"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in increased expression of MMP3 mRNA]"	16778083
C417207	2,2',4,6,6'-pentachlorobiphenyl	"pyrazolanthrone inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in increased expression of MMP3 mRNA]"	16778083
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in increased expression of MMP3 mRNA]"	16778083
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein]	19765281
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MMP3 mRNA"	19114083
C010914	2,4-diaminotoluene	"2,4-diaminotoluene results in increased expression of MMP3 mRNA"	20713471
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of MMP3 mRNA]	23328930
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of MMP3 protein]	23328930
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased secretion of MMP3 protein]	23328930
C012796	2-butenal	2-butenal results in increased expression of MMP3 mRNA	20471460
C014464	3,4-dichloroaniline	"3,4-dichloroaniline results in increased expression of MMP3 mRNA"	24172598
C049246	3-hydroxypicolinic acid	3-hydroxypicolinic acid results in decreased activity of MMP3 protein	21189019
C090942	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole	4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein]	19765281
C517041	(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of MMP3 mRNA"	19561079
C034214	5-iodotubercidin	5-iodotubercidin results in increased expression of MMP3 mRNA	26953159
C550547	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	"[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] promotes the reaction [IL1B protein results in increased expression of MMP3 protein]"	20426787
C550547	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	"[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased expression of MMP3 mRNA"	20426787
C550547	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	"[6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT1 protein] which results in increased expression of MMP3 protein"	20426787
D000082	Acetaminophen	Acetaminophen results in increased expression of MMP3 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of MMP3 mRNA	17562736
C006358	acetohydroxamic acid	acetohydroxamic acid binds to and results in decreased activity of MMP3 protein	15237990\|1652209
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [TNF protein results in increased expression of MMP3 mRNA]	10336562
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP3 protein]	17395008
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of MMP3 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of MMP3 mRNA	21641981\|2210060
D013196	Dihydrotestosterone	Dihydrotestosterone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA]	8798622
C011512	alpha-naphthoflavone	alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP3 mRNA]	19022365
D000537	Aluminum Oxide	Aluminum Oxide results in increased expression of MMP3 mRNA	16488289
D000622	Aminolevulinic Acid	Aminolevulinic Acid affects the expression of MMP3 mRNA	12542540
D000622	Aminolevulinic Acid	Aminolevulinic Acid affects the expression of MMP3 protein	12542540
D000622	Aminolevulinic Acid	Sodium Azide inhibits the reaction [Aminolevulinic Acid affects the expression of MMP3 protein]	12542540
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of MMP3 mRNA	16483693
C059765	amphotericin B, deoxycholate drug combination	"amphotericin B, deoxycholate drug combination results in increased expression of MMP3 mRNA"	22863853
C078814	anandamide	anandamide results in increased expression of MMP3 mRNA	16330497
D018501	Antirheumatic Agents	[Antirheumatic Agents co-treated with Methotrexate] results in decreased expression of MMP3 protein	23146660
C015001	arsenite	arsenite results in decreased expression of MMP3 mRNA	18929588
C015001	arsenite	TRP53 protein affects the reaction [arsenite results in decreased expression of MMP3 mRNA]	18929588
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of MMP3 mRNA"	24160326
D001241	Aspirin	Aspirin inhibits the reaction [Azoxymethane results in increased expression of MMP3 mRNA]	20043115
D001379	Azathioprine	Azathioprine results in increased expression of MMP3 mRNA	22623647
C547126	AZM551248	AZM551248 results in decreased activity of MMP3 protein	22323515
C547126	AZM551248	AZM551248 results in increased expression of MMP3 mRNA	22323515
D001397	Azoxymethane	Aspirin inhibits the reaction [Azoxymethane results in increased expression of MMP3 mRNA]	20043115
D001397	Azoxymethane	Azoxymethane results in increased expression of MMP3 mRNA	20043115
D001554	Benzene	Benzene results in increased expression of MMP3 mRNA	19446245
D001564	Benzo(a)pyrene	"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] results in increased expression of MMP3 mRNA"	17690111
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MMP3 mRNA	21632981
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MMP3 mRNA	22228805
D001564	Benzo(a)pyrene	alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP3 mRNA]	19022365
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MMP3 mRNA	19022365
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of MMP3 mRNA"	20382639
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased secretion of MMP3 protein	16009159
D004958	Estradiol	Estradiol inhibits the reaction [IL1B protein results in increased expression of MMP3 protein modified form]	22219637
D004958	Estradiol	Estradiol results in decreased expression of MMP3 mRNA	25878060
D004958	Estradiol	Estradiol results in increased expression of MMP3 mRNA	20106945
D004958	Estradiol	Estradiol results in increased secretion of MMP3 protein	16009159
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in decreased expression of MMP3 mRNA	17404688
D004958	Estradiol	bisphenol A inhibits the reaction [Estradiol results in decreased expression of MMP3 mRNA]	27312807
D004958	Estradiol	Estradiol results in decreased expression of MMP3 mRNA	19693291\|2731280
D004958	Estradiol	Estradiol results in increased expression of MMP3 mRNA	19416213\|1948475
D004958	Estradiol	Progesterone inhibits the reaction [Estradiol results in increased expression of MMP3 mRNA]	19416213
C074212	bis(maltolato)oxovanadium(IV)	bis(maltolato)oxovanadium(IV) results in decreased expression of MMP3 mRNA	17696279
C006780	bisphenol A	bisphenol A results in increased expression of MMP3 mRNA	26604029
C006780	bisphenol A	bisphenol A inhibits the reaction [Estradiol results in decreased expression of MMP3 mRNA]	27312807
C006780	bisphenol A	bisphenol A affects the expression of MMP3 mRNA	25181051
C006780	bisphenol A	[enzacamene co-treated with octylmethoxycinnamate co-treated with bisphenol A co-treated with butylparaben] results in increased expression of MMP3 mRNA	25305543
D001761	Bleomycin	Bleomycin results in increased expression of MMP3 mRNA	28434932
D001761	Bleomycin	Dinoprostone inhibits the reaction [Bleomycin results in increased expression of MMP3 mRNA]	28434932
D001761	Bleomycin	MMP3 protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]]	28434932
D001761	Bleomycin	[MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of CTGF mRNA]	28434932
D001761	Bleomycin	[MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB1 mRNA]	28434932
D001761	Bleomycin	[MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA]	28434932
D001761	Bleomycin	[MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]	28434932
D001761	Bleomycin	[MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA]	28434932
C086539	BQ 788	[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP3 protein]	12875994
C086539	BQ 788	BQ 788 inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP3 protein]	12875994
C038091	butylparaben	[enzacamene co-treated with octylmethoxycinnamate co-treated with bisphenol A co-treated with butylparaben] results in increased expression of MMP3 mRNA	25305543
C055494	caffeic acid phenethyl ester	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of MMP3 mRNA	20360939
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of MMP3 mRNA	17484886
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of MMP3 mRNA	15056808
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of MMP3 mRNA	18481824
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of MMP3 protein	17094476
D002251	Carbon Tetrachloride	PLAU protein promotes the reaction [Carbon Tetrachloride results in increased expression of MMP3 mRNA]	18481824
C097658	CGS 27023A	CGS 27023A affects the activity of MMP3 protein	22017477
D002701	Chloramphenicol	Chloramphenicol results in increased expression of MMP3 mRNA	20338993
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MMP3 mRNA	20548288\|2093899
D002809	Chondroitin Sulfates	[Glucosamine co-treated with Chondroitin Sulfates] results in decreased expression of MMP3 mRNA	17605605
D002809	Chondroitin Sulfates	[Glucosamine co-treated with Chondroitin Sulfates] results in decreased expression of MMP3 mRNA	20110869
D002809	Chondroitin Sulfates	[Glucosamine co-treated with Chondroitin Sulfates] results in decreased secretion of MMP3 protein	20110869
D002939	Ciprofloxacin	Ciprofloxacin promotes the reaction [IL1B protein results in increased expression of MMP3 mRNA]	12428247
D002939	Ciprofloxacin	Ciprofloxacin promotes the reaction [IL1B protein results in increased secretion of MMP3 protein]	12428247
D002939	Ciprofloxacin	Ciprofloxacin results in increased expression of MMP3 mRNA	12428247
D002953	Citrinin	Citrinin results in increased expression of MMP3 mRNA	19361540
D002953	Citrinin	pyrazolanthrone inhibits the reaction [Citrinin results in increased expression of MMP3 mRNA]	19361540
D007464	Clioquinol	[Clioquinol co-treated with Copper] results in increased expression of and results in increased activity of MMP3 protein	16648635
D002994	Clofibrate	Clofibrate inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]	16572457
D002994	Clofibrate	[Clofibrate promotes the reaction [IL1B protein results in increased expression of IL1RN mRNA]] which results in increased expression of MMP3 mRNA	16572457
D003035	Cobalt	TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of MMP3 mRNA]	23503329
D003035	Cobalt	[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of MMP3 mRNA	23503329
C007095	cobaltiprotoporphyrin	cobaltiprotoporphyrin inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]	20110250\|2215530
C007095	cobaltiprotoporphyrin	HMOX1 protein promotes the reaction [cobaltiprotoporphyrin inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]]	20110250
C007095	cobaltiprotoporphyrin	HMOX1 protein promotes the reaction [cobaltiprotoporphyrin inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]]	20110250
D003300	Copper	[Clioquinol co-treated with Copper] results in increased expression of and results in increased activity of MMP3 protein	16648635
D003300	Copper	[Disulfiram binds to Copper] which results in decreased expression of MMP3 mRNA	24690739
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of MMP3 mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in increased expression of MMP3 mRNA	19549813
D003474	Curcumin	Curcumin inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]	16807698
D003474	Curcumin	Curcumin results in increased expression of MMP3 mRNA	15713895\|1832173
D003474	Curcumin	[resveratrol co-treated with Curcumin] inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]	19889203
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of MMP3 mRNA	15331540
D016572	Cyclosporine	Cyclosporine results in increased expression of MMP3 mRNA	20106945\|2163298
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP3 protein]	12875994
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP3 protein]	12875994
D003634	DDT	13-hydroxy-10-oxo-11-octadecenoic acid inhibits the reaction [DDT results in increased expression of MMP3 mRNA]	20865247
D003634	DDT	DDT results in increased expression of MMP3 mRNA	20865247
D003634	DDT	zerumbone inhibits the reaction [DDT results in increased expression of MMP3 mRNA]	20865247
D013759	Dronabinol	Dronabinol results in increased expression of MMP3 mRNA	16330497
D003907	Dexamethasone	Dexamethasone inhibits the reaction [TNF protein results in increased expression of MMP3 mRNA]	10336562
D003907	Dexamethasone	Dexamethasone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA]	20858459
D003907	Dexamethasone	Dexamethasone results in decreased expression of MMP3 mRNA	25047013
D003907	Dexamethasone	TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of MMP3 mRNA]	23503329
D003907	Dexamethasone	[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of MMP3 mRNA	23503329
D016264	Dextran Sulfate	Dextran Sulfate results in increased expression of MMP3 mRNA	19285099\|2082466
D016264	Dextran Sulfate	Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP3 mRNA]	19285099
C041517	dibenzo(a,l)pyrene	"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] results in increased expression of MMP3 mRNA"	17690111
C041517	dibenzo(a,l)pyrene	"dibenzo(a,l)pyrene results in decreased expression of MMP3 mRNA"	25908611
D002945	Cisplatin	[Cisplatin co-treated with Paclitaxel] results in increased expression of MMP3 mRNA	20705681
D002945	Cisplatin	MMP3 promoter polymorphism affects the susceptibility to [Fluorouracil co-treated with Cisplatin]	15102660
C503840	dieckol	dieckol results in decreased expression of MMP3 mRNA	19330880
C503840	dieckol	dieckol results in decreased expression of MMP3 protein	19330880
D004041	Dietary Fats	Dietary Fats results in decreased expression of MMP3 mRNA	18042831
D004041	Dietary Fats	[Ethanol co-treated with Dietary Fats] results in increased expression of MMP3 mRNA	21051528
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of MMP3 mRNA	20360939
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of MMP3 mRNA	20360939
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of MMP3 mRNA	22504913
D000875	Anthralin	Anthralin results in decreased activity of MMP3 protein	23611293
D002117	Calcitriol	Calcitriol results in increased expression of MMP3 mRNA	12040012\|1600243
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of MMP3 mRNA	20146380
D004221	Disulfiram	[Disulfiram binds to Copper] which results in decreased expression of MMP3 mRNA	24690739
D004237	Diuron	Diuron metabolite results in increased expression of MMP3 mRNA	24172598
D004237	Diuron	Diuron results in increased expression of MMP3 mRNA	25152437
C063533	dofetilide	dofetilide binds to MMP3 protein	21634430
D004317	Doxorubicin	Doxorubicin results in increased expression of MMP3 mRNA	28710503
D004317	Doxorubicin	Lovastatin inhibits the reaction [Doxorubicin results in increased expression of MMP3 mRNA]	28710503
D004317	Doxorubicin	NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of MMP3 mRNA]	28710503
D004318	Doxycycline	Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]	17267227
D004318	Doxycycline	Doxycycline results in decreased activity of MMP3 protein	17267227
D004318	Doxycycline	Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MMP3 mRNA]	18089841
D004656	Enalapril	Enalapril results in decreased expression of MMP3 mRNA	25037058
D004726	Endosulfan	Endosulfan results in increased expression of MMP3 mRNA	28108160
D004726	Endosulfan	Endosulfan results in increased expression of MMP3 protein	28108160
C038939	enzacamene	[enzacamene co-treated with octylmethoxycinnamate co-treated with bisphenol A co-treated with butylparaben] results in increased expression of MMP3 mRNA	25305543
D004967	Estrogens	[Estrogens co-treated with IL1B protein] results in increased expression of MMP3 mRNA	18570937
D004967	Estrogens	[Estrogens co-treated with Progesterone co-treated with IL1B protein] results in increased expression of MMP3 mRNA	18570937
D000431	Ethanol	CNR1 gene mutant form inhibits the reaction [[Ethanol co-treated with Thioacetamide] results in increased expression of MMP3 mRNA]	21863215
D000431	Ethanol	[Ethanol co-treated with Thioacetamide] results in increased expression of MMP3 mRNA	21863215
D000431	Ethanol	[Ethanol co-treated with Dietary Fats] results in increased expression of MMP3 mRNA	21051528
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of MMP3 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of MMP3 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MMP3 mRNA	17942748
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with Megestrol Acetate] results in increased expression of MMP3 protein	22085904
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of MMP3 mRNA	28329830
D005472	Fluorouracil	MMP3 promoter polymorphism affects the susceptibility to [Fluorouracil co-treated with Cisplatin]	15102660
D005492	Folic Acid	Folic Acid affects the expression of MMP3 mRNA	17320366
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MMP3 mRNA	20548288\|2093899
D005557	Formaldehyde	Formaldehyde results in decreased expression of MMP3 mRNA	28937961
D005557	Formaldehyde	Formaldehyde results in increased expression of MMP3 mRNA	27664576
C067584	formosanin C	formosanin C results in decreased expression of MMP3 protein	21304274
C007789	fucoidan	fucoidan inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein]	16364234
C069837	fullerene C60	fullerene C60 results in increased expression of MMP3 mRNA	20064541
C056507	gemcitabine	gemcitabine results in decreased expression of MMP3 protein	20531411
D019833	Genistein	Genistein results in decreased expression of MMP3 mRNA	22504913
D019833	Genistein	Genistein results in decreased expression of MMP3 protein	24552547
D005944	Glucosamine	[Glucosamine co-treated with Chondroitin Sulfates] results in decreased expression of MMP3 mRNA	17605605
D005944	Glucosamine	Glucosamine analog inhibits the reaction [IL1B protein results in increased expression of MMP3]	15144122
D005944	Glucosamine	Glucosamine analog inhibits the reaction [IL1B results in increased expression of and results in increased secretion of MMP3 protein]	18080321
D005944	Glucosamine	Glucosamine analog inhibits the reaction [IL1B results in increased expression of MMP3 mRNA]	18080321
D005944	Glucosamine	Glucosamine analog results in decreased expression of MMP3 mRNA	16300972
D005944	Glucosamine	[Glucosamine co-treated with Chondroitin Sulfates] results in decreased expression of MMP3 mRNA	20110869
D005944	Glucosamine	[Glucosamine co-treated with Chondroitin Sulfates] results in decreased secretion of MMP3 protein	20110869
D005944	Glucosamine	Glucosamine inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]	17925024
D005944	Glucosamine	Glucosamine inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein]	17925024
D005944	Glucosamine	Glucosamine inhibits the reaction [IL1B results in increased expression of MMP3 mRNA]	18340449
D005944	Glucosamine	Glucosamine inhibits the reaction [IL1B results in increased expression of MMP3 protein]	18340449
D005944	Glucosamine	Glucosamine results in decreased expression of and results in decreased activity of MMP3 protein	12801482
D005944	Glucosamine	Glucosamine inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]	11229466
D005944	Glucosamine	Glucosamine inhibits the reaction [IL1B results in increased expression of MMP3 mRNA]	17109745
D005944	Glucosamine	Glucosamine results in increased expression of MMP3 mRNA	17109745
D005944	Glucosamine	IL1B promotes the reaction [Glucosamine results in increased expression of MMP3 mRNA]	17109745
C065632	glucosamine 3-O-sulfate	glucosamine 3-O-sulfate results in decreased expression of MMP3 mRNA	16300972
D005947	Glucose	[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of MMP3	24840287
D005947	Glucose	resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of MMP3]	24840287
C086566	glycitein	glycitein results in decreased expression of MMP3 mRNA	20188714
C086566	glycitein	glycitein results in decreased expression of MMP3 protein	20188714
C010176	halofuginone	halofuginone promotes the reaction [Thioacetamide results in increased expression of MMP3 mRNA]	16489207
C010176	halofuginone	halofuginone results in increased expression of MMP3 mRNA	16489207
C010176	halofuginone	halofuginone results in increased expression of MMP3 protein	16489207
D006820	Hyaluronic Acid	[Hyaluronic Acid co-treated with resveratrol] results in decreased expression of MMP3 mRNA	23595953
D006861	Hydrogen Peroxide	CAT protein inhibits the reaction [[SOD2 protein results in increased chemical synthesis of Hydrogen Peroxide] which results in increased expression of MMP3 mRNA]	12538496
D006861	Hydrogen Peroxide	[SOD2 protein results in increased chemical synthesis of Hydrogen Peroxide] which results in increased expression of MMP3 mRNA	12538496
C031927	hydroquinone	hydroquinone affects the expression of MMP3 mRNA	15452088
D006877	Hydroxamic Acids	Hydroxamic Acids analog binds to and results in decreased activity of MMP3 protein	15237990
D007052	Ibuprofen	Ibuprofen inhibits the reaction [TNF protein results in increased expression of MMP3 mRNA]	10336562
D007052	Ibuprofen	Ibuprofen results in increased expression of MMP3 mRNA	16580899
C041508	indeno(1,2,3-cd)pyrene	"indeno(1,2,3-cd)pyrene results in decreased expression of MMP3 mRNA"	26377693
D007213	Indomethacin	Indomethacin inhibits the reaction [TNF protein results in increased expression of MMP3 mRNA]	10336562
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MMP3 mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of MMP3 mRNA]	23503329
D015056	1-Methyl-3-isobutylxanthine	[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of MMP3 mRNA	23503329
D007545	Isoproterenol	Doxycycline inhibits the reaction [Isoproterenol results in increased expression of MMP3 mRNA]	18089841
D007545	Isoproterenol	Isoproterenol results in increased expression of MMP3 mRNA	18089841\|2000320
D007545	Isoproterenol	Isoproterenol results in increased expression of MMP3	12883319
D007545	Isoproterenol	SI 27 inhibits the reaction [Isoproterenol results in increased expression of MMP3]	12883319
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of MMP3 mRNA	26324948
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of MMP3 protein	26324948
C433788	lipopolysaccharide, E. coli O26-B6	"lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP3 mRNA]"	18986645
C433788	lipopolysaccharide, E. coli O26-B6	"lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP3 mRNA"	18986645
C433788	lipopolysaccharide, E. coli O26-B6	"Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP3 mRNA]"	18986645
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of MMP3 protein	17303203
D008070	Lipopolysaccharides	Melitten inhibits the reaction [Lipopolysaccharides results in increased expression of MMP3 protein]	17303203
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of MMP3 mRNA	25613284
D008148	Lovastatin	Lovastatin inhibits the reaction [Doxorubicin results in increased expression of MMP3 mRNA]	28710503
C008316	maltol	maltol analog binds to and results in decreased activity of MMP3 protein	15237990
C008316	maltol	maltol binds to and results in decreased activity of MMP3 protein	16522091
D008345	Manganese	Manganese results in increased expression of MMP3 mRNA	26745496
C025340	manganese chloride	manganese chloride results in increased expression of MMP3 mRNA	26745496
C097284	manganese(III)-tetrakis(4-benzoic acid)porphyrin	manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP3 protein]	17395008
C097284	manganese(III)-tetrakis(4-benzoic acid)porphyrin	manganese(III)-tetrakis(4-benzoic acid)porphyrin results in decreased expression of and results in decreased secretion of MMP3 protein	17395008
D061965	Matrix Metalloproteinase Inhibitors	Matrix Metalloproteinase Inhibitors inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]	19765281
D061965	Matrix Metalloproteinase Inhibitors	Matrix Metalloproteinase Inhibitors inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein]	19765281
D019290	Megestrol Acetate	[Ethinyl Estradiol co-treated with Megestrol Acetate] results in increased expression of MMP3 protein	22085904
D008555	Melitten	Melitten inhibits the reaction [Lipopolysaccharides results in increased expression of MMP3 protein]	17303203
C088155	methanandamide	methanandamide results in increased expression of MMP3 mRNA	16330497
C088155	methanandamide	methanandamide results in increased expression of MMP3 protein	16330497
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MMP3 mRNA	20548288\|2093899
D008727	Methotrexate	[Antirheumatic Agents co-treated with Methotrexate] results in decreased expression of MMP3 protein	23146660
D008727	Methotrexate	Methotrexate results in decreased expression of MMP3 mRNA	15476228
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of MMP3 mRNA	20713471
D008770	Methylnitrosourea	Methylnitrosourea results in increased expression of MMP3 mRNA	17412507
C000873	methylprednisolone acetate	methylprednisolone acetate results in decreased expression of MMP3 mRNA	15693093
D015741	Metribolone	Metribolone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA]	8798622
C100075	mibolerone	mibolerone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA]	8798622
D015735	Mifepristone	Mifepristone results in increased expression of MMP3 mRNA	17584828
D015735	Mifepristone	Mifepristone results in increased expression of MMP3 mRNA	19439560
D015735	Mifepristone	Mifepristone inhibits the reaction [Progesterone results in decreased expression of MMP3 mRNA]	27264040
D008911	Minocycline	Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP3 mRNA]	19285099
C523799	MRK 003	MMP3 results in decreased susceptibility to MRK 003	19903844
C500085	muraglitazar	muraglitazar results in decreased expression of MMP3 mRNA	21515302
D019810	Sodium Azide	Sodium Azide inhibits the reaction [Aminolevulinic Acid affects the expression of MMP3 protein]	12542540
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of MMP3 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of MMP3 mRNA"	25554681
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of MMP3 mRNA	15913567
D009532	Nickel	Nickel results in increased expression of MMP3 mRNA	25583101
D009532	Nickel	TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of MMP3 mRNA]	23503329
D009532	Nickel	[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of MMP3 mRNA	23503329
C029938	nickel sulfate	nickel sulfate results in increased expression of MMP3 mRNA	16780908
C029938	nickel sulfate	nickel sulfate results in increased expression of MMP3 mRNA	16166746
D009538	Nicotine	"lipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP3 mRNA]"	18986645
D009538	Nicotine	"Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP3 mRNA]"	18986645
D009538	Nicotine	Nicotine results in increased expression of MMP3 mRNA	17151781\|1898664
D009538	Nicotine	Nicotine results in increased expression of MMP3 protein	17151781
C012655	nimesulide	nimesulide results in decreased expression of MMP3 protein	12166616
C500716	N-isobutyl-N-(4-methoxyphenylsulfonyl)glycylhydroxamic acid	N-isobutyl-N-(4-methoxyphenylsulfonyl)glycylhydroxamic acid results in decreased activity of MMP3 protein	12972402
D009569	Nitric Oxide	Nitric Oxide results in increased expression of MMP3	24840287
D009569	Nitric Oxide	[NOC 18 results in increased abundance of Nitric Oxide] inhibits the reaction [resveratrol inhibits the reaction [Nitric Oxide results in increased expression of MMP3]]	24840287
D009569	Nitric Oxide	resveratrol inhibits the reaction [Nitric Oxide results in increased expression of MMP3]	24840287
D017672	Nitrogen Compounds	Nitrogen Compounds analog binds to and results in decreased activity of MMP3 protein	16522091
D015112	4-Nitroquinoline-1-oxide	4-Nitroquinoline-1-oxide results in increased expression of MMP3 mRNA	22561872
C093285	NOC 18	[NOC 18 results in increased abundance of Nitric Oxide] inhibits the reaction [resveratrol inhibits the reaction [Nitric Oxide results in increased expression of MMP3]]	24840287
C487513	NSC 23766	NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of MMP3 mRNA]	28710503
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of MMP3 mRNA	20971185
C118580	octylmethoxycinnamate	[enzacamene co-treated with octylmethoxycinnamate co-treated with bisphenol A co-treated with butylparaben] results in increased expression of MMP3 mRNA	25305543
D015242	Ofloxacin	Ofloxacin results in increased expression of MMP3 mRNA	21903125\|2306772
D015242	Ofloxacin	Ofloxacin results in increased expression of MMP3 mRNA	20688128
D010100	Oxygen	[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of MMP3	24840287
D010100	Oxygen	resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of MMP3]	24840287
D010126	Ozone	Ozone results in increased expression of MMP3 mRNA	20980218
D017239	Paclitaxel	[Cisplatin co-treated with Paclitaxel] results in increased expression of MMP3 mRNA	20705681
D017239	Paclitaxel	Paclitaxel results in increased expression of MMP3	18754875
D017239	Paclitaxel	Paclitaxel results in increased expression of MMP3 mRNA	18754875
D000073878	Palm Oil	Palm Oil results in decreased expression of MMP3 mRNA	18042831
D010269	Paraquat	Paraquat affects the expression of MMP3 mRNA	26345256
D010269	Paraquat	Paraquat results in increased expression of MMP3 mRNA	17215068\|2610857
D010269	Paraquat	Paraquat results in increased expression of MMP3 protein	26988026
C497431	PD-0200347	PD-0200347 results in decreased expression of MMP3 protein	15693013
D010455	Peptides	Peptides inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA]	20004183
D010455	Peptides	Peptides inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 protein]	20004183
D015232	Dinoprostone	Dinoprostone inhibits the reaction [Bleomycin results in increased expression of MMP3 mRNA]	28434932
D015232	Dinoprostone	MMP3 protein affects the reaction [Dinoprostone inhibits the reaction [Bleomycin results in increased expression of TGFB3 mRNA]]	28434932
D015232	Dinoprostone	[MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of CTGF mRNA]	28434932
D015232	Dinoprostone	[MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB1 mRNA]	28434932
D015232	Dinoprostone	[MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFB2 mRNA]	28434932
D015232	Dinoprostone	[MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR1 mRNA]	28434932
D015232	Dinoprostone	[MMP3 protein co-treated with Dinoprostone] affects the reaction [Bleomycin results in increased expression of TGFBR2 mRNA]	28434932
D010634	Phenobarbital	Phenobarbital affects the expression of MMP3 mRNA	19159669
D010672	Phenytoin	Phenytoin results in decreased expression of MMP3 mRNA	15948689
D064801	Phospholipase A2 Inhibitors	Phospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]	19765281
D064801	Phospholipase A2 Inhibitors	Phospholipase A2 Inhibitors inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein]	19765281
D064801	Phospholipase A2 Inhibitors	Phospholipase A2 Inhibitors results in decreased expression of MMP3 mRNA	19765281
C030614	picolinic acid	picolinic acid binds to and results in decreased activity of MMP3 protein	16522091
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MMP3 mRNA	19710929
D010938	Plant Oils	Plant Oils results in increased expression of MMP3 mRNA	23370395
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls affects the expression of MMP3 mRNA	21334430
C113831	poly-N-acetyl glucosamine	poly-N-acetyl glucosamine results in increased expression of MMP3 mRNA	19638916
D017035	Pravastatin	MMP3 promoter polymorphism affects the susceptibility to Pravastatin	8662692
C113282	prinomastat	prinomastat results in decreased activity of MMP3 protein	17267227
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased secretion of MMP3 protein	16009159
D011374	Progesterone	[Estrogens co-treated with Progesterone co-treated with IL1B protein] results in increased expression of MMP3 mRNA	18570937
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in decreased expression of MMP3 mRNA	17404688
D011374	Progesterone	Progesterone inhibits the reaction [IL1B protein results in increased expression of MMP3 protein modified form]	22219637
D011374	Progesterone	Progesterone results in decreased expression of MMP3 mRNA	26604029
D011374	Progesterone	Progesterone results in decreased secretion of MMP3 protein	16009159
D011374	Progesterone	Tetrachlorodibenzodioxin inhibits the reaction [Progesterone results in decreased secretion of MMP3 protein]	16009159
D011374	Progesterone	Triclosan inhibits the reaction [Progesterone results in decreased expression of MMP3 mRNA]	26604029
D011374	Progesterone	Progesterone affects the expression of MMP3 protein	17118170
D011374	Progesterone	Mifepristone inhibits the reaction [Progesterone results in decreased expression of MMP3 mRNA]	27264040
D011374	Progesterone	Progesterone inhibits the reaction [Estradiol results in increased expression of MMP3 mRNA]	19416213
D011374	Progesterone	Progesterone results in decreased expression of MMP3 mRNA	27264040
C432165	pyrazolanthrone	"pyrazolanthrone inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in increased expression of MMP3 mRNA]"	16778083
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Citrinin results in increased expression of MMP3 mRNA]	19361540
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of MMP3 mRNA]	12832416
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 protein]	20004183
C014175	pyrazolo(3,4-d)pyrimidine	"pyrazolo(3,4-d)pyrimidine analog affects the expression of MMP3 mRNA"	21152443
C014175	pyrazolo(3,4-d)pyrimidine	"pyrazolo(3,4-d)pyrimidine analog affects the expression of MMP3 mRNA"	21152443
D011725	Pyridines	Pyridines analog binds to and results in decreased activity of MMP3 protein	15237990
D011728	Pyridones	Pyridones analog binds to and results in decreased activity of MMP3 protein	15237990
D011753	Pyrones	Pyrones analog binds to and results in decreased activity of MMP3 protein	15237990
D011794	Quercetin	Quercetin inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]	22592909
D011794	Quercetin	Quercetin inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]	22592909
D011794	Quercetin	Quercetin results in decreased expression of MMP3 mRNA	22592909
D011794	Quercetin	Quercetin results in decreased expression of MMP3 protein	22592909
D011794	Quercetin	Quercetin results in increased expression of MMP3 mRNA	21632981
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in decreased expression of MMP3 mRNA	17582780
C059514	resveratrol	resveratrol inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein]	18759268
C059514	resveratrol	resveratrol inhibits the reaction [TNF protein results in increased expression of MMP3 mRNA]	23257246
C059514	resveratrol	[resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]	20426787
C059514	resveratrol	[Hyaluronic Acid co-treated with resveratrol] results in decreased expression of MMP3 mRNA	23595953
C059514	resveratrol	[NOC 18 results in increased abundance of Nitric Oxide] inhibits the reaction [resveratrol inhibits the reaction [Nitric Oxide results in increased expression of MMP3]]	24840287
C059514	resveratrol	resveratrol affects the expression of MMP3	24066520
C059514	resveratrol	[resveratrol co-treated with Curcumin] inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]	19889203
C059514	resveratrol	resveratrol inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]	18606398
C059514	resveratrol	resveratrol inhibits the reaction [Nitric Oxide results in increased expression of MMP3]	24840287
C059514	resveratrol	resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of MMP3]	24840287
C059514	resveratrol	resveratrol inhibits the reaction [TNF protein results in increased expression of MMP3 mRNA]	23328930
C059514	resveratrol	resveratrol inhibits the reaction [TNF protein results in increased expression of MMP3 protein]	23328930
C059514	resveratrol	resveratrol inhibits the reaction [TNF protein results in increased secretion of MMP3 protein]	23328930
C116926	rofecoxib	rofecoxib results in increased expression of MMP3 mRNA	16580899
C089730	rosiglitazone	rosiglitazone results in decreased expression of MMP3 mRNA	21515302
C093642	SB 203580	SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 protein]	20004183
C078903	seocalcitol	seocalcitol results in increased expression of MMP3 mRNA	12040012
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of MMP3 mRNA"	24160326
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in decreased expression of MMP3 mRNA"	16251409
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of MMP3 mRNA"	23917077
C421267	SI 27	SI 27 inhibits the reaction [Isoproterenol results in increased expression of MMP3]	12883319
D012834	Silver	Silver results in increased expression of MMP3 mRNA	19969064
D019821	Simvastatin	Simvastatin results in decreased expression of MMP3	19801495
D019821	Simvastatin	Simvastatin results in decreased expression of MMP3 mRNA	16414398
D012980	Sodium Salicylate	Sodium Salicylate inhibits the reaction [TNF protein results in increased expression of MMP3 mRNA]	10336562
D012999	Soman	Soman results in increased expression of MMP3 mRNA	19281266
D053260	Soot	Soot results in increased expression of MMP3 mRNA	22461453\|2655175
D013311	Streptozocin	PRDX4 protein inhibits the reaction [Streptozocin results in increased expression of MMP3 mRNA]	20446767
D013311	Streptozocin	Streptozocin results in increased expression of MMP3 mRNA	20446767
D013311	Streptozocin	Streptozocin results in decreased expression of MMP3 mRNA	18246672
D012460	Sulfasalazine	Sulfasalazine inhibits the reaction [IL1B protein results in increased expression of and results in increased activity of MMP3 protein]	16684522
D012460	Sulfasalazine	Sulfasalazine inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]	16684522
D012460	Sulfasalazine	Sulfasalazine results in decreased expression of and results in decreased activity of MMP3 protein	16684522
D013605	T-2 Toxin	T-2 Toxin results in increased expression of MMP3 mRNA	22800716
D013629	Tamoxifen	Tamoxifen affects the expression of MMP3 mRNA	17555576
C501413	tesaglitazar	tesaglitazar results in decreased expression of MMP3 mRNA	21515302
D013739	Testosterone	Testosterone results in decreased expression of MMP3 mRNA	19693291
D013739	Testosterone	Testosterone results in increased expression of MMP3 mRNA	19693291
D013749	Tetrachlorodibenzodioxin	13-hydroxy-10-oxo-11-octadecenoic acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP3 mRNA]	20865247
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [Progesterone results in decreased secretion of MMP3 protein]	16009159
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MMP3 mRNA	20865247\|2315218
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MMP3 protein	15531779
D013749	Tetrachlorodibenzodioxin	zerumbone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP3 mRNA]	20865247
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MMP3 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MMP3 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MMP3 mRNA	21354282
D013750	Tetrachloroethylene	Tetrachloroethylene results in decreased expression of MMP3 mRNA	16010555
D013752	Tetracycline	Tetracycline inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]	17267227
D013752	Tetracycline	Tetracycline results in decreased activity of MMP3 protein	17267227
D013752	Tetracycline	Tetracycline results in decreased expression of MMP3 mRNA	24489787
D013755	Tetradecanoylphorbol Acetate	BAG1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA]	20858459
D013755	Tetradecanoylphorbol Acetate	Dexamethasone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA]	20858459
D013755	Tetradecanoylphorbol Acetate	Dihydrotestosterone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA]	8798622
D013755	Tetradecanoylphorbol Acetate	Metribolone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA]	8798622
D013755	Tetradecanoylphorbol Acetate	mibolerone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA]	8798622
D013755	Tetradecanoylphorbol Acetate	Peptides inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA]	20004183
D013755	Tetradecanoylphorbol Acetate	Peptides inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 protein]	20004183
D013755	Tetradecanoylphorbol Acetate	pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 protein]	20004183
D013755	Tetradecanoylphorbol Acetate	SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 protein]	20004183
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA	16176868\|2000418
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of MMP3 protein	20004183
D013755	Tetradecanoylphorbol Acetate	Tretinoin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA]	16176868
D013755	Tetradecanoylphorbol Acetate	U 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 protein]	20004183
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MMP3 mRNA	25613284
D013853	Thioacetamide	CNR1 gene mutant form inhibits the reaction [[Ethanol co-treated with Thioacetamide] results in increased expression of MMP3 mRNA]	21863215
D013853	Thioacetamide	[Ethanol co-treated with Thioacetamide] results in increased expression of MMP3 mRNA	21863215
D013853	Thioacetamide	halofuginone promotes the reaction [Thioacetamide results in increased expression of MMP3 mRNA]	16489207
D013853	Thioacetamide	Thioacetamide results in increased expression of MMP3 mRNA	16489207
D008063	Thioctic Acid	Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]	24975507
D008063	Thioctic Acid	Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]	24975507
C009495	titanium dioxide	titanium dioxide results in increased expression of MMP3 mRNA	23557971\|2776080
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of MMP3 mRNA	27865774
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of MMP3 mRNA	10836612\|2740439
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of MMP3 protein	27480279
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of MMP3 mRNA	23967268
C024746	tobacco tar	tobacco tar results in increased expression of MMP3 mRNA	19559774
C479163	tofacitinib	tofacitinib results in decreased expression of MMP3 mRNA	25398374
C513941	tongxinluo	tongxinluo results in decreased expression of MMP3	19801495
D014118	Toxins, Biological	"Toxins, Biological affects the expression of MMP3 mRNA"	19682533
D014212	Tretinoin	Tretinoin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 mRNA]	16176868
D014212	Tretinoin	Tretinoin results in increased expression of MMP3 mRNA	16249480
D014260	Triclosan	Triclosan inhibits the reaction [Progesterone results in decreased expression of MMP3 mRNA]	26604029
D014260	Triclosan	Triclosan results in increased expression of MMP3 mRNA	26604029
D017973	Tungsten Compounds	Tungsten Compounds results in increased expression of MMP3 mRNA	28666766
C113580	U 0126	U 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 protein]	20004183
D014638	Vanadates	Vanadates results in increased expression of MMP3 mRNA	22714537
C545088	varespladib methyl	varespladib methyl inhibits the reaction [IL1B protein results in increased expression of MMP3 mRNA]	19765281
C545088	varespladib methyl	varespladib methyl inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein]	19765281
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of MMP3 mRNA	17065432
C403304	zerumbone	zerumbone inhibits the reaction [DDT results in increased expression of MMP3 mRNA]	20865247
C403304	zerumbone	zerumbone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP3 mRNA]	20865247
D015032	Zinc	Zinc results in increased secretion of MMP3 protein	12972402
D015032	Zinc	TNF protein inhibits the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of MMP3 mRNA]	23503329
D015032	Zinc	[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of MMP3 mRNA	23503329
D015054	Zymosan	NCF1 protein affects the reaction [Zymosan results in increased expression of MMP3 mRNA]	14507659
D015054	Zymosan	Zymosan results in increased expression of MMP3 mRNA	14507659

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004175	endopeptidase activity	-	IDA	15863497 19022250 20969476
GO:0004222	metalloendopeptidase activity	-	TAS	-
GO:0004252	serine-type endopeptidase activity	-	TAS	-
GO:0005515	protein binding	-	IPI	9573338 25416956
GO:0008237	metallopeptidase activity	-	IDA	9573338
GO:0008270	zinc ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006508	proteolysis	-	IDA	12867428 15863497 19022250 20969476
GO:0010727	negative regulation of hydrogen peroxide metabolic process	-	IDA	20969476
GO:0019221	cytokine-mediated signaling pathway	-	TAS	-
GO:0022617	extracellular matrix disassembly	-	TAS	-
GO:0030574	collagen catabolic process	-	TAS	-
GO:0032461	positive regulation of protein oligomerization	-	IDA	19022250
GO:0071732	cellular response to nitric oxide	-	TAS	15863497
GO:1903209	positive regulation of oxidative stress-induced cell death	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	TAS	3360803
GO:0031012	extracellular matrix	-	IEA	-

KEGG ID	KEGG Term
hsa05323	Rheumatoid arthritis

Reactome ID	Reactome Term	Evidence
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-1442490	Collagen degradation	TAS
R-HSA-1442490	Collagen degradation	IEA
R-HSA-1474228	Degradation of the extracellular matrix	TAS
R-HSA-1474228	Degradation of the extracellular matrix	IEA
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-1474244	Extracellular matrix organization	IEA
R-HSA-1474290	Collagen formation	TAS
R-HSA-1592389	Activation of Matrix Metalloproteinases	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-168256	Immune System	TAS
R-HSA-2022090	Assembly of collagen fibrils and other multimeric structures	TAS
R-HSA-2179392	EGFR Transactivation by Gastrin	IEA
R-HSA-2179392	EGFR Transactivation by Gastrin	TAS
R-HSA-372790	Signaling by GPCR	IEA
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-388396	GPCR downstream signalling	IEA
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-416476	G alpha (q) signalling events	IEA
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-449147	Signaling by Interleukins	TAS
R-HSA-6785807	Interleukin-4 and 13 signaling	TAS
R-HSA-881907	Gastrin-CREB signalling pathway via PKC and MAPK	IEA
R-HSA-881907	Gastrin-CREB signalling pathway via PKC and MAPK	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
12485468	Interaction between smoking and the stromelysin-1 (MMP3) gene 5A/6A promoter polymorphism and risk of coronary heart disease in healthy men. (2002 Nov)	Humphries SE	Ann Hum Genet
15767859	The genetics of stroke. (2005 Apr)	Morgan L	Curr Opin Lipidol
22776467	Age at onset of rheumatoid arthritis: association with polymorphisms in the vascular endothelial growth factor A(VEGFA) gene and an intergenic locus between matrix metalloproteinase (MMP) 1 and 3 genes. (2012 Nov-Dec)	Chen Y	Clin Exp Rheumatol
24489939	Association of matrix metalloproteinase-3 -1171(5A>6A) polymorphism with cancer risk: a meta-analysis of 41 studies. (2014)	Yang X	PLoS One
15823277	Matrix metalloproteinase3 and 9 gene promoter polymorphisms: joint action of two loci as a risk factor for coronary artery complicated plaques. (2005 May)	Pollanen PJ	Atherosclerosis
12204805	Coronary artery calcification is related to functional polymorphism of matrix metalloproteinase 3: the Helsinki Sudden Death Study. (2002 Oct)	Pollanen PJ	Atherosclerosis
27989222	Pilot Study on the Genetic Background of an Active Matrix Metalloproteinase-8 Test in Finnish Adolescents. (2017 May)	Heikkinen AM	J Periodontol
15039035	Genetic risk factors for stroke and carotid atherosclerosis: insights into pathophysiology from candidate gene approaches. (2004 Apr)	Humphries SE	Lancet Neurol
29744169	Inflammatory mediator polymorphisms associate with initial periodontitis in adolescents. (2016 Dec)	Heikkinen AM	Clin Exp Dent Res
19221176	Matrix metalloproteinase-1 and matrix metalloproteinase-3 gene promoter polymorphisms are associated with mortality in haemodialysis patients. (2009 Jul)	Cozzolino M	Nephrol Dial Transplant
22122519	Cigarette smoke extract induces select matrix metalloproteinases and integrin expression in periodontal ligament fibroblasts. (2012 Jun)	Bulmanski Z	J Periodontol
19843588	Polymorphisms in the promoter regions of matrix metalloproteinases 1 and 3 and cancer risk: a meta-analysis of 50 case-control studies. (2010 Jan)	Peng B	Mutagenesis
22371740	Genetic variability and the risk of myocardial infarction in Poles under 45 years of age. (2010 Apr 30)	Sakowicz A	Arch Med Sci
26771213	Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease. (2016 Jul 1)	Hobbs BD	Am J Respir Crit Care Med
15319302	The functional SNP in the matrix metalloproteinase-3 promoter modifies susceptibility and lymphatic metastasis in esophageal squamous cell carcinoma but not in gastric cardiac adenocarcinoma. (2004 Dec)	Zhang J	Carcinogenesis
19321798	Matrix metalloproteinase 1, 3 and 12 polymorphisms and esophageal adenocarcinoma risk and prognosis. (2009 May)	Bradbury PA	Carcinogenesis
24638860	SIRT6 regulates the cigarette smoke-induced signalling in rheumatoid arthritis synovial fibroblasts. (2014 Jul)	Engler A	J Mol Med (Berl)
22888638	[Association of the MMP3, MMP9, ADAM33 and TIMP3 genes polymorphic markers with development and progression of chronic obstructive pulmonary disease]. (2012 May-Jun)	Korytina GF	Mol Biol (Mosk)
15528217	Polymorphisms in the MMP1 and MMP3 promoter and non-small cell lung carcinoma in North China. (2005 Feb)	Fang S	Carcinogenesis