Gene: MMP7

4316
MMP-7|MPSL1|PUMP-1
matrix metallopeptidase 7
protein-coding
11q22.2
Ensembl:ENSG00000137673 MIM:178990 Vega:OTTHUMG00000048193 UniprotKB:P09237
NC_000011.10
PubMed
0   ANCO-SNPs
ND
10   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.399e-1 (AD)  3.787e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KLK20.691
TGM40.678
ACPP0.676
MSMB0.661
KLK30.642
OR5B30.57
CRISP30.56
CTSG0.553
SLC44A40.55
CEACAM80.547

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TUBA8-0.284
TBR1-0.269
GPR150-0.266
SLC22A9-0.263
DBH-0.258
EIF4E1B-0.256
CDHR2-0.254
NOS1AP-0.253
EFNA5-0.252
EMX1-0.251

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00786MarimastatSmall Molecule154039-60-8Approved|InvestigationalTarget
DB08170(1R)-N,6-DIHYDROXY-7-METHOXY-2-[(4-METHOXYPHENYL)SULFONYL]-1,2,3,4-TETRAHYDROISOQUINOLINE-1-CARBOXAMIDESmall MoleculeExperimentalTarget
DB08489N4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDESmall MoleculeExperimentalTarget
DB084935-METHYL-3-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YLCARBAMOYL)-HEXANOIC ACIDSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C52148710-nitro-oleic acid10-nitro-oleic acid results in increased activity of MMP7 protein21454668
C5691071-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one"1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one results in decreased expression of MMP7 mRNA"23826121
C0389831,3-dimethylthiourea"1,3-dimethylthiourea inhibits the reaction [Coal Ash results in increased expression of MMP7 mRNA]"14569496
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of MMP7 mRNA"23146750
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MMP7 mRNA"15059925
C5240423,5-bis(2-fluorobenzylidene)piperidin-4-one"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of MMP7 mRNA]"23452621
D000082AcetaminophenAcetaminophen results in decreased expression of MMP7 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of MMP7 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of MMP7 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MMP7 mRNA]17585979
D000111AcetylcysteineAcetylcysteine inhibits the reaction [epigallocatechin gallate results in increased expression of MMP7 protein]17928719
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Tretinoin results in increased expression of MMP7 mRNA]17928719
D016604Aflatoxin B1Aflatoxin B1 affects the expression of MMP7 protein20106945
C526957alisol B 23-acetatealisol B 23-acetate inhibits the reaction [AGT protein results in increased expression of MMP7 protein]28578904
C526957alisol B 23-acetatealisol B 23-acetate inhibits the reaction [AGT protein results in increased expression of MMP7 protein]28578904
C038491allyl sulfideallyl sulfide results in decreased expression of MMP7 protein21695758
D013196DihydrotestosteroneDihydrotestosterone results in decreased expression of MMP7 mRNA8798622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MMP7 mRNA16483693
C030419andrographolideandrographolide results in decreased expression of and results in decreased activity of MMP7 protein19426720
C030419andrographolideandrographolide results in decreased expression of MMP7 mRNA19426720
C061374antimoniteantimonite results in increased expression of MMP7 mRNA17400267
C061374antimonitetyrphostin AG 1478 inhibits the reaction [antimonite results in increased expression of MMP7 mRNA]17400267
C006632arsenic trioxidearsenic trioxide results in decreased expression of MMP7 mRNA19128835|2696637
C015001arsenitearsenite results in increased expression of MMP7 mRNA17400267
C015001arsenitetyrphostin AG 1478 inhibits the reaction [arsenite results in increased expression of MMP7 mRNA]17400267
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of MMP7 mRNA"16574944
D001205Ascorbic Acid[Quercetin co-treated with Ascorbic Acid] results in increased expression of MMP7 mRNA17639512
D001241AspirinAspirin inhibits the reaction [Azoxymethane results in increased expression of MMP7 mRNA]20043115
D001241AspirinAspirin results in decreased expression of MMP7 mRNA12800193
D001397AzoxymethaneAzoxymethane results in increased activity of MMP7 protein20681671
D001397AzoxymethaneAzoxymethane results in increased expression of MMP7 mRNA20681671
D001397Azoxymethanepterostilbene inhibits the reaction [Azoxymethane results in increased activity of MMP7 protein]20681671
D001397Azoxymethanepterostilbene inhibits the reaction [Azoxymethane results in increased expression of MMP7 mRNA]20681671
D001397AzoxymethaneAspirin inhibits the reaction [Azoxymethane results in increased expression of MMP7 mRNA]20043115
D001397AzoxymethaneAzoxymethane results in increased expression of MMP7 mRNA20043115
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MMP7 mRNA20106945
C031403benzyl isothiocyanatebenzyl isothiocyanate inhibits the reaction [epigallocatechin gallate results in increased expression of MMP7 protein]17928719
C031403benzyl isothiocyanatebenzyl isothiocyanate inhibits the reaction [Tretinoin results in increased expression of MMP7 mRNA]17928719
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of MMP7 mRNA20660070
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased secretion of MMP7 protein16009159
D004958EstradiolEstradiol results in increased secretion of MMP7 protein16009159
D004958EstradiolEstradiol results in increased expression of MMP7 mRNA15289156
D004958Estradiol[Estradiol co-treated with Plant Preparations] results in increased expression of MMP7 mRNA26945725
D004958Estradiol[Estradiol co-treated with Testosterone] results in increased expression of MMP7 mRNA11375906
D004958Estradiol[Estradiol co-treated with Testosterone] results in increased expression of MMP7 protein11375906
D004958EstradiolEstradiol results in increased expression of MMP7 mRNA26945725
D004958EstradiolPlant Preparations inhibits the reaction [Estradiol results in increased expression of MMP7 mRNA]26945725
D004958EstradiolPlant Preparations promotes the reaction [Estradiol results in increased expression of MMP7 mRNA]26945725
C006780bisphenol Abisphenol A affects the expression of MMP7 mRNA25181051
C086539BQ 788[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP7 protein]12875994
C086539BQ 788BQ 788 inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP7 protein]12875994
D002087ButyratesButyrates results in decreased expression of MMP7 mRNA16042588
D020148Butyric AcidButyric Acid results in increased expression of MMP7 mRNA12800193
D002110Caffeine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MMP7 mRNA"20230807
D002110Caffeine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MMP7 mRNA]"20230807
D002251Carbon Tetrachloride[Carbon Tetrachloride co-treated with Folic Acid] results in increased expression of MMP7 mRNA18156304
C097658CGS 27023ACGS 27023A affects the activity of MMP7 protein22017477
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of MMP7 mRNA23650126
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of MMP7 mRNA28472532
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of MMP7 mRNA17585979
D002994ClofibrateClofibrate results in increased expression of MMP7 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MMP7 mRNA]17585979
D003024ClozapineClozapine results in decreased expression of MMP7 mRNA17346280
D060729Coal Ash"1,3-dimethylthiourea inhibits the reaction [Coal Ash results in increased expression of MMP7 mRNA]"14569496
D060729Coal AshCoal Ash results in increased expression of MMP7 mRNA14569496
D003474CurcuminCurcumin inhibits the reaction [epigallocatechin gallate results in increased expression of MMP7 protein]17928719
D003474CurcuminCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of MMP7 mRNA]23452621
D003474CurcuminCurcumin inhibits the reaction [Tretinoin results in increased expression of MMP7 mRNA]17928719
D016572CyclosporineCyclosporine results in decreased expression of MMP7 mRNA20106945
C072247cyclo(Trp-Asp-Pro-Val-Leu)[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP7 protein]12875994
C072247cyclo(Trp-Asp-Pro-Val-Leu)cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP7 protein]12875994
C010902decabromobiphenyl etherdecabromobiphenyl ether analog results in decreased expression of MMP7 mRNA26854739
C107676deguelindeguelin results in decreased expression of MMP7 mRNA25322282
D003907DexamethasoneDexamethasone results in increased expression of MMP7 mRNA25047013
C028009diallyl disulfidediallyl disulfide results in decreased expression of MMP7 protein21695758
C042577diallyl trisulfidediallyl trisulfide results in decreased expression of MMP7 protein21695758
D002945CisplatinCisplatin results in decreased expression of MMP7 mRNA27392435
D004041Dietary FatsDietary Fats results in increased expression of MMP7 mRNA25016146
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of MMP7 mRNA15289156
D000875AnthralinAnthralin results in decreased activity of MMP7 protein23611293
D002117CalcitriolCalcitriol results in increased expression of MMP7 mRNA26485663
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of MMP7 mRNA"19480007
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of MMP7 mRNA"19480007
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of MMP7 protein"19480007
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in increased expression of MMP7 mRNA"27840820
D004726EndosulfanEndosulfan results in increased expression of MMP7 mRNA22677888
C045651epigallocatechin gallateAcetylcysteine inhibits the reaction [epigallocatechin gallate results in increased expression of MMP7 protein]17928719
C045651epigallocatechin gallatebenzyl isothiocyanate inhibits the reaction [epigallocatechin gallate results in increased expression of MMP7 protein]17928719
C045651epigallocatechin gallateCurcumin inhibits the reaction [epigallocatechin gallate results in increased expression of MMP7 protein]17928719
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of MMP7 protein17928719
C045651epigallocatechin gallateGallic Acid inhibits the reaction [epigallocatechin gallate results in increased expression of MMP7 protein]17928719
C015860ergosta-4,6,8(14),22-tetraen-3-one"ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of MMP7 protein]"28578904
C015860ergosta-4,6,8(14),22-tetraen-3-one"ergosta-4,6,8(14),22-tetraen-3-one inhibits the reaction [AGT protein results in increased expression of MMP7 protein]"28578904
C007630estradiol 17 beta-cypionateestradiol 17 beta-cypionate results in increased expression of MMP7 mRNA22497863
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MMP7 mRNA18936297
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MMP7 mRNA17351261
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MMP7 mRNA12655037|1557682
D015025ZearalenoneZearalenone results in increased expression of MMP7 mRNA17557909
D011345FenofibrateFenofibrate results in decreased expression of MMP7 protein25545733
C000499ferric oxideferric oxide results in increased expression of MMP7 protein24885771
D005492Folic AcidFolic Acid results in increased expression of MMP7 mRNA15149334
D005492Folic AcidFolic Acid results in increased expression of MMP7 protein15149334
D005492Folic Acid[Carbon Tetrachloride co-treated with Folic Acid] results in increased expression of MMP7 mRNA18156304
C069837fullerene C60fullerene C60 results in increased expression of MMP7 mRNA20471445
C039281furanfuran results in increased expression of MMP7 mRNA26194646|2738771
D005707Gallic AcidGallic Acid inhibits the reaction [epigallocatechin gallate results in increased expression of MMP7 protein]17928719
D005707Gallic AcidGallic Acid inhibits the reaction [Tretinoin results in increased expression of MMP7 mRNA]17928719
D005707Gallic AcidGallic Acid results in decreased expression of MMP7 mRNA22387266
C054597garcinolgarcinol results in decreased expression of MMP7 protein16052481
D019833GenisteinGenistein inhibits the reaction [Oxygen deficiency results in increased expression of MMP7 mRNA]23452621
D019833GenisteinGenistein results in increased expression of MMP7 mRNA15289156
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of MMP7 mRNA22634610
C412815GW 4064GW 4064 results in decreased expression of MMP7 mRNA26655953
D017313FenretinideFenretinide results in increased expression of MMP7 mRNA28973697
D006861Hydrogen PeroxideCAT protein inhibits the reaction [[SOD2 protein results in increased chemical synthesis of Hydrogen Peroxide] which results in increased expression of MMP7 mRNA]12538496
D006861Hydrogen Peroxide[SOD2 protein results in increased chemical synthesis of Hydrogen Peroxide] which results in increased expression of MMP7 mRNA12538496
C492448ICG 001ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]]28578904
C492448ICG 001Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of MMP7 protein]]28578904
C492448ICG 001ICG 001 inhibits the reaction [AGT protein results in increased expression of MMP7 protein]28578904
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MMP7 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MMP7 mRNA26752646
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of MMP7 mRNA21540303
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of MMP7 mRNA11739494|2372405
D008070Lipopolysaccharidesphenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of MMP7 mRNA]23724058
D018021Lithium ChlorideLithium Chloride results in increased expression of MMP7 protein24244343
D018021Lithium ChlorideMALAT1 protein affects the reaction [Lithium Chloride results in increased expression of MMP7 protein]24244343
D018021Lithium ChlorideMALAT1 protein affects the reaction [resveratrol inhibits the reaction [Lithium Chloride results in increased expression of MMP7 protein]]24244343
D018021Lithium Chlorideresveratrol inhibits the reaction [Lithium Chloride results in increased expression of MMP7 protein]24244343
D019808LosartanICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]]28578904
D019808LosartanLosartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]28578904
D019808LosartanLosartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of MMP7 protein]]28578904
D019808LosartanLosartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]28578904
C551151manganese ferritemanganese ferrite results in increased secretion of MMP7 protein24885771
C013592mangiferinmangiferin results in decreased expression of MMP7 protein23707762
D015122MercaptopurineMercaptopurine results in increased expression of MMP7 mRNA23358152
D008727MethotrexateMethotrexate results in increased expression of MMP7 mRNA21678067
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of MMP7 mRNA21126564
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MMP7 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MMP7 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MMP7 mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MMP7 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MMP7 mRNA]"20230807
C100075miboleronemibolerone results in decreased expression of MMP7 mRNA8798622
D015735MifepristoneMifepristone results in increased expression of MMP7 mRNA17584828
C060893MK-886MK-886 inhibits the reaction [Nicotine results in increased expression of MMP7 mRNA]20061081
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MMP7 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MMP7 mRNA"24911292
D009534NiclosamideNiclosamide results in decreased expression of MMP7 mRNA27338550
D009538NicotineCREB1 protein promotes the reaction [Nicotine results in increased expression of MMP7 mRNA]25847246
D009538NicotineMK-886 inhibits the reaction [Nicotine results in increased expression of MMP7 mRNA]20061081
D009538NicotineMMP7 promoter SNP affects the reaction [Nicotine results in increased expression of MMP7 mRNA]25847246|2584724
D009538NicotineMMP7 promoter SNP affects the susceptibility to Nicotine25847246
D009538NicotineNicotine results in increased expression of MMP7 mRNA20061081|2584724
D009538NicotineNicotine results in increased expression of MMP7 protein25847246
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of MMP7 mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of MMP7 mRNA]"20230807
D005996NitroglycerinNitroglycerin results in increased expression of MMP7 mRNA12084592
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of MMP7 mRNA27935865
C008661nobiletinnobiletin results in decreased expression of MMP7 mRNA15725655
C008661nobiletinnobiletin results in decreased expression of MMP7 protein15725655
D010100Oxygen"3,5-bis(2-fluorobenzylidene)piperidin-4-one inhibits the reaction [Oxygen deficiency results in increased expression of MMP7 mRNA]"23452621
D010100OxygenCurcumin inhibits the reaction [Oxygen deficiency results in increased expression of MMP7 mRNA]23452621
D010100OxygenGenistein inhibits the reaction [Oxygen deficiency results in increased expression of MMP7 mRNA]23452621
D010100OxygenOxygen deficiency results in increased expression of MMP7 mRNA23452621
D010100OxygenPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of MMP7 mRNA]23452621
D010100Oxygenresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of MMP7 mRNA]23452621
C102487pachymic acidpachymic acid analog inhibits the reaction [AGT protein results in increased expression of MMP7 protein]28578904
C102487pachymic acidpachymic acid analog inhibits the reaction [AGT protein results in increased expression of MMP7 protein]28578904
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of MMP7 mRNA23602845
C058305phenethyl isothiocyanatephenethyl isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased expression of MMP7 mRNA]23724058
C049032pinosylvin[pinosylvin affects the localization of and results in decreased activity of CTNNB1 protein] which results in decreased expression of MMP7 mRNA23333577
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of MMP7 mRNA27935865
C006253pirinixic acidpirinixic acid results in decreased expression of MMP7 mRNA17426115
D010936Plant ExtractsPlant Extracts inhibits the reaction [Oxygen deficiency results in increased expression of MMP7 mRNA]23452621
D028321Plant Preparations[Estradiol co-treated with Plant Preparations] results in increased expression of MMP7 mRNA26945725
D028321Plant PreparationsPlant Preparations inhibits the reaction [Estradiol results in increased expression of MMP7 mRNA]26945725
D028321Plant PreparationsPlant Preparations promotes the reaction [Estradiol results in increased expression of MMP7 mRNA]26945725
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of MMP7 mRNA20660070
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased secretion of MMP7 protein16009159
D011374ProgesteroneProgesterone results in decreased secretion of MMP7 protein16009159
D011374ProgesteroneTetrachlorodibenzodioxin inhibits the reaction [Progesterone results in decreased secretion of MMP7 protein]16009159
D011374ProgesteroneProgesterone affects the expression of MMP7 mRNA17251523
D011374ProgesteroneProgesterone results in decreased expression of MMP7 mRNA22238285
C107773pterostilbenepterostilbene inhibits the reaction [Azoxymethane results in increased activity of MMP7 protein]20681671
C107773pterostilbenepterostilbene inhibits the reaction [Azoxymethane results in increased expression of MMP7 mRNA]20681671
C107773pterostilbenepterostilbene inhibits the reaction [MMP7 protein results in increased activity of MMP2 protein]20681671
C107773pterostilbenepterostilbene inhibits the reaction [MMP7 protein results in increased activity of MMP9 protein]20681671
D011794Quercetin[Quercetin co-treated with Ascorbic Acid] results in increased expression of MMP7 mRNA17639512
D011794QuercetinQuercetin results in decreased expression of MMP7 protein15725655|2364574
C059514resveratrolMALAT1 protein affects the reaction [resveratrol inhibits the reaction [Lithium Chloride results in increased expression of MMP7 protein]]24244343
C059514resveratrolMALAT1 protein inhibits the reaction [resveratrol results in decreased expression of MMP7 protein]24244343
C059514resveratrolresveratrol inhibits the reaction [Lithium Chloride results in increased expression of MMP7 protein]24244343
C059514resveratrolresveratrol inhibits the reaction [Oxygen deficiency results in increased expression of MMP7 mRNA]23452621
C059514resveratrolresveratrol results in decreased expression of MMP7 protein24244343
C013672riddelliineriddelliine results in decreased expression of MMP7 mRNA18047727
D012459SalicylatesSalicylates results in decreased expression of MMP7 protein15725655
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of MMP7"19105532
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of MMP7 mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of MMP7 mRNA23806026
C017947sodium arsenitesodium arsenite results in increased expression of MMP7 mRNA28595984
D013311StreptozocinPRDX4 protein inhibits the reaction [Streptozocin results in increased expression of MMP7 mRNA]20446767
D013311StreptozocinStreptozocin results in increased expression of MMP7 mRNA20446767
D013467SulindacSulindac results in decreased expression of MMP7 mRNA18499699
D013467SulindacSulindac results in decreased expression of MMP7 protein18499699
C025463sulindac sulfonesulindac sulfone results in decreased expression of MMP7 protein15725655
C021751tanshinonetanshinone results in decreased expression of MMP7 mRNA15849732
D013739Testosterone[Estradiol co-treated with Testosterone] results in increased expression of MMP7 mRNA11375906
D013739Testosterone[Estradiol co-treated with Testosterone] results in increased expression of MMP7 protein11375906
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of MMP7 mRNA28300664
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [Progesterone results in decreased secretion of MMP7 protein]16009159
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MMP7 mRNA26377647
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of MMP7 mRNA8798622
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MMP7 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of MMP7 mRNA19695317
C009495titanium dioxidetitanium dioxide results in increased expression of MMP7 mRNA23557971
C082097tocotrienol, delta"tocotrienol, delta results in decreased expression of MMP7 protein"21453743
D014212TretinoinAcetylcysteine inhibits the reaction [Tretinoin results in increased expression of MMP7 mRNA]17928719
D014212Tretinoinbenzyl isothiocyanate inhibits the reaction [Tretinoin results in increased expression of MMP7 mRNA]17928719
D014212TretinoinCurcumin inhibits the reaction [Tretinoin results in increased expression of MMP7 mRNA]17928719
D014212TretinoinGallic Acid inhibits the reaction [Tretinoin results in increased expression of MMP7 mRNA]17928719
D014212TretinoinTretinoin results in increased expression of MMP7 mRNA16249480|1792871
D014212TretinoinTretinoin results in increased expression of MMP7 protein17928719
C021100trichloroacetaldehydetrichloroacetaldehyde metabolite results in increased expression of MMP7 protein17077186
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MMP7 mRNA"26179874
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [antimonite results in increased expression of MMP7 mRNA]17400267
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [arsenite results in increased expression of MMP7 mRNA]17400267
D014635Valproic AcidValproic Acid results in increased expression of MMP7 mRNA19949822
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MMP7 gene25560391
D001335Vehicle EmissionsVehicle Emissions results in increased expression of MMP7 mRNA17065432
C016837zinc chloridezinc chloride results in decreased expression of MMP7 mRNA21540303
D015054ZymosanZymosan results in increased expression of MMP7 mRNA11739494

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004222metalloendopeptidase activity-TAS-  
GO:0004252serine-type endopeptidase activity-TAS-  
GO:0005515protein binding-IPI20812334  
GO:0008201heparin binding-IEA-  
GO:0008237metallopeptidase activity-IBA21873635  
GO:0008237metallopeptidase activity-IDA15297466  26482249  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002779antibacterial peptide secretion-IBA21873635  
GO:0006508proteolysis-IDA15297466  26482249  
GO:0007568aging-IEA-  
GO:0022617extracellular matrix disassembly-TAS-  
GO:0030574collagen catabolic process-TAS-  
GO:0031667response to nutrient levels-IEA-  
GO:0044849estrous cycle-IEA-  
GO:0060135maternal process involved in female pregnancy-IEA-  
GO:0071260cellular response to mechanical stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-TAS1497627  
GO:0009986cell surface-IEA-  
GO:0031012extracellular matrix-IEA-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa04310Wnt signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1442490Collagen degradationTAS
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474228Degradation of the extracellular matrixIEA
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1474290Collagen formationTAS
R-HSA-1592389Activation of Matrix MetalloproteinasesTAS
R-HSA-2022090Assembly of collagen fibrils and other multimeric structuresTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29599326Association of Matrix Metalloproteinase-7 Genotypes to the Risk of Oral Cancer in Taiwan. (2018 Apr)Shih LCAnticancer Res
24757528MMP7 and MMP8 genetic polymorphisms in bladder cancer patients. (2014)Wieczorek ECent European J Urol
19635926Smoking-dependent reprogramming of alveolar macrophage polarization: implication for pathogenesis of chronic obstructive pulmonary disease. (2009 Aug 15)Shaykhiev RJ Immunol
28870920The Contribution of Matrix Metalloproteinase-7 Promoter Genotypes in Breast Cancer in Taiwan. (2017 Sep)Chou AKAnticancer Res
21917606Potential role of HE4 in multimodal screening for epithelial ovarian cancer. (2011 Nov 2)Urban NJ Natl Cancer Inst
26351771Cigarette smoke modulates PC3 prostate cancer cell migration by altering adhesion molecules and the extracellular matrix. (2015 Nov)Yang SMol Med Rep
24043489Functional characterization of a porcine emphysema model. (2013 Dec)Bruun CSLung
23783374Expression of cilium-associated genes defines novel molecular subtypes of idiopathic pulmonary fibrosis. (2013 Dec)Yang IVThorax
22785600The matrix metalloproteinase 2-1575 gene polymorphism is associated with the risk of developing myocardial infarction in Mexican patients. (2012)Perez-Hernandez NJ Atheroscler Thromb
28005264Mucin 4 and matrix metalloproteinase 7 as novel salivary biomarkers for periodontitis. (2017 Mar)Lundmark AJ Clin Periodontol