Gene info: ID 4317

Gene: MMP8

GENE ID: 4317

Synonyms: CLG1|HNC|MMP-8|PMNL-CL

Description: matrix metallopeptidase 8

Gene type: protein-coding

Location: 11q22.2

dbXrefs: Ensembl:ENSG00000118113 MIM:120355 Vega:OTTHUMG00000167587 UniprotKB:P22894

RefSeq: NG_012101.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 7

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.848e-1 (AD) 2.031e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
LCN2	0.748
BPI	0.744
RETN	0.739
LTF	0.727
DEFA3	0.727
CEACAM8	0.721
LILRA5	0.71
S100A12	0.71
S100P	0.706
MMP9	0.7

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SP9	-0.455
PRKCZ	-0.413
KCNC2	-0.409
MAGIX	-0.406
SVOP	-0.402
MYADML2	-0.4
HRH3	-0.398
STAR	-0.396
CORT	-0.388
NNAT	-0.387

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00786	Marimastat	Small Molecule	154039-60-8	Approved\|Investigational	Target
DB02326	1-Hydroxyamine-2-Isobutylmalonic Acid	Small Molecule	-	Experimental	Target
DB02953	2-Thiomethyl-3-Phenylpropanoic Acid	Small Molecule		Experimental	Target
DB03207	2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid	Small Molecule		Experimental	Target
DB03622	2-Hydroxy-5-[4-(2-Hydroxy-Ethyl)-Piperidin-1-Yl]-5-Phenyl-1h-Pyrimidine-4,6-Dione	Small Molecule		Experimental	Target
DB03636	Glycinamid	Small Molecule		Experimental	Target
DB03880	Batimastat	Small Molecule	130370-60-4	Experimental	Target
DB06971	N-{2-[(4'-CYANO-1,1'-BIPHENYL-4-YL)OXY]ETHYL}-N'-HYDROXY-N-METHYLUREA	Small Molecule		Experimental	Target
DB07397	(5S)-5-(2-amino-2-oxoethyl)-4-oxo-N-[(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)methyl]-3,4,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidine-2-carboxamide	Small Molecule		Experimental	Target
DB07713	(1S)-1-{[(4'-methoxy-1,1'-biphenyl-4-yl)sulfonyl]amino}-2-methylpropylphosphonic acid	Small Molecule		Experimental	Target
DB07772	(1R)-1-{[(4'-methoxy-1,1'-biphenyl-4-yl)sulfonyl]amino}-2-methylpropylphosphonic acid	Small Molecule		Experimental	Target
DB07900	3-FORMYL-2-HYDROXY-5-METHYL-HEXANOIC ACID HYDROXYAMIDE	Small Molecule		Experimental	Target
DB08028	BUT-3-ENYL-[5-(4-CHLORO-PHENYL)-3,6-DIHYDRO-[1,3,4]THIADIAZIN-2-YLIDENE]-AMINE	Small Molecule		Experimental	Target
DB08403	METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID	Small Molecule		Experimental	Target
DB08476	3-AMINO-AZACYCLOTRIDECAN-2-ONE	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C025205	1,10-phenanthroline	"1,10-phenanthroline results in decreased activity of MMP8 protein"	15057751
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of MMP8 mRNA"	26377693
C581572	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea results in increased expression of MMP8 mRNA	25827057
C026137	3-hydroxyacetanilide	3-hydroxyacetanilide results in decreased expression of MMP8 mRNA	18544908
C049246	3-hydroxypicolinic acid	3-hydroxypicolinic acid results in decreased activity of MMP8 protein	21189019
D000082	Acetaminophen	Acetaminophen affects the expression of MMP8 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of MMP8 mRNA	18544908
C482289	Ageladine A	Ageladine A results in decreased activity of MMP8 protein	21413800
D000537	Aluminum Oxide	Aluminum Oxide results in decreased expression of MMP8 mRNA	19464052
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of MMP8 mRNA	16483693
D001151	Arsenic	Arsenic affects the expression of MMP8 mRNA	19654921
C030935	benz(a)anthracene	benz(a)anthracene results in increased expression of MMP8 mRNA	26377693
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MMP8 mRNA	27858113
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MMP8 mRNA	27858113
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of MMP8 mRNA	26377693
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in increased expression of MMP8 mRNA	26377693
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MMP8 mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MMP8 mRNA	21569818
C006780	bisphenol A	bisphenol A results in decreased expression of MMP8 mRNA	25594700
C006780	bisphenol A	bisphenol A results in decreased expression of MMP8 mRNA	25181051
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of MMP8 mRNA	15056808\|1650891
C043211	carvedilol	carvedilol results in decreased expression of MMP8 mRNA	15921778
C097658	CGS 27023A	CGS 27023A affects the activity of MMP8 protein	22017477
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MMP8 mRNA	20938992
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of MMP8 mRNA	27858113
D003033	Coal Tar	Coal Tar results in increased expression of MMP8 mRNA	27858113
D003520	Cyclophosphamide	Cyclophosphamide results in increased expression of MMP8 mRNA	27281708
C014347	decitabine	decitabine results in increased expression of MMP8 mRNA	27915011
D004041	Dietary Fats	[Vehicle Emissions affects the reaction [APOE gene mutant form affects the susceptibility to Dietary Fats]] which results in decreased expression of MMP8 mRNA	19891982
D002117	Calcitriol	Calcitriol results in increased expression of MMP8 mRNA	26485663
D004318	Doxycycline	Doxycycline analog results in decreased activity of MMP8 protein	17267227
D004492	Edetic Acid	Edetic Acid results in decreased activity of MMP8 protein	15057751
C529593	EMD 527040	EMD 527040 results in increased expression of MMP8 mRNA	18221819
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with Megestrol Acetate] results in increased expression of MMP8 protein	22085904
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of MMP8 mRNA	23649840
C049347	fasudil	fasudil affects the expression of MMP8 mRNA	26120273
D005419	Flavonoids	Flavonoids results in decreased expression of MMP8 mRNA	18035473
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MMP8 mRNA	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of MMP8 mRNA	23649840
D007213	Indomethacin	Indomethacin results in increased activity of MMP8 protein	17000239
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of MMP8 mRNA	18625914
D008070	Lipopolysaccharides	Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP8 mRNA]	18625914
D019290	Megestrol Acetate	[Ethinyl Estradiol co-treated with Megestrol Acetate] results in increased expression of MMP8 protein	22085904
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MMP8 mRNA	20938992
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of MMP8 mRNA	23649840
C523799	MRK 003	MMP8 results in increased susceptibility to MRK 003	19903844
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog affects the expression of MMP8 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of MMP8 mRNA"	24664304\|2555468
C012655	nimesulide	nimesulide results in decreased expression of MMP8 protein	12166616
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of MMP8 mRNA	27935865
C572573	N-nitroso-tris-chloroethylurea	[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of MMP8 mRNA	27935865
C484027	oligofectamine	oligofectamine results in increased expression of MMP8 mRNA	14668052
D010100	Oxygen	[Paraquat co-treated with Oxygen] results in decreased expression of MMP8 mRNA	12882763
D010126	Ozone	Ozone results in increased expression of MMP8 mRNA	17460151
D010269	Paraquat	Paraquat results in increased expression of MMP8 mRNA	17215068
D010269	Paraquat	[Paraquat co-treated with Oxygen] results in decreased expression of MMP8 mRNA	12882763
D010634	Phenobarbital	Phenobarbital results in increased expression of MMP8 mRNA	12832660
C060836	pioglitazone	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of MMP8 mRNA	27935865
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MMP8 mRNA	19710929
C113282	prinomastat	prinomastat results in decreased activity of MMP8 protein	17267227
D011374	Progesterone	Progesterone results in increased expression of MMP8 mRNA	21770760
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of MMP8 mRNA	23221170
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of MMP8 mRNA	21602193
D019821	Simvastatin	Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP8 mRNA]	18625914
D012906	Smoke	Smoke results in increased expression of MMP8 mRNA	20937366
D053260	Soot	Soot results in increased expression of MMP8 mRNA	22461453\|2655175
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MMP8 mRNA	26377647\|2892240
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MMP8 mRNA	24035824
D013752	Tetracycline	Tetracycline analog results in decreased activity of MMP8 protein	17267227
C117153	tetracycline CMT-8	tetracycline CMT-8 results in decreased expression of MMP8 protein	11172683
D013755	Tetradecanoylphorbol Acetate	[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of MMP8 mRNA	16979875
D013853	Thioacetamide	POMC protein alternative form promotes the reaction [Thioacetamide results in increased expression of MMP8 mRNA]	16511523
D013853	Thioacetamide	Thioacetamide results in increased expression of MMP8 mRNA	16511523
C009495	titanium dioxide	titanium dioxide results in increased expression of MMP8 mRNA	23557971\|2776080
D014028	Tobacco Smoke Pollution	NFE2L2 protein affects the reaction [Tobacco Smoke Pollution affects the expression of MMP8 mRNA]	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of MMP8 mRNA	20133372
D014635	Valproic Acid	Valproic Acid affects the expression of MMP8 mRNA	17963808
D001335	Vehicle Emissions	[Vehicle Emissions affects the reaction [APOE gene mutant form affects the susceptibility to Dietary Fats]] which results in decreased expression of MMP8 mRNA	19891982
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of MMP8 gene	25560391
C581157	XL147	[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of MMP8 mRNA	27935865
D015032	Zinc	[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of MMP8 mRNA	16979875

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004222	metalloendopeptidase activity	-	TAS	-
GO:0004252	serine-type endopeptidase activity	-	IDA	2164002 16192646
GO:0004252	serine-type endopeptidase activity	-	TAS	-
GO:0008270	zinc ion binding	-	TAS	2164002

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006508	proteolysis	-	IDA	2164002
GO:0022617	extracellular matrix disassembly	-	TAS	-
GO:0030574	collagen catabolic process	-	TAS	-
GO:0035987	endodermal cell differentiation	-	IEP	23154389
GO:0043312	neutrophil degranulation	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IDA	2164002 24784232
GO:0031012	extracellular matrix	-	IEA	-
GO:0035580	specific granule lumen	-	TAS	-
GO:1904724	tertiary granule lumen	-	TAS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1442490	Collagen degradation	TAS
R-HSA-1474228	Degradation of the extracellular matrix	TAS
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-1592389	Activation of Matrix Metalloproteinases	TAS
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-6798695	Neutrophil degranulation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29599337	The Association of Matrix Metalloproteinase-8 Promoter Genotypes in Breast Cancer. (2018 Apr)	Hsiao CL	Anticancer Res
24757528	MMP7 and MMP8 genetic polymorphisms in bladder cancer patients. (2014)	Wieczorek E	Cent European J Urol
23383243	Cigarette smoke-induced collagen destruction; key to chronic neutrophilic airway inflammation? (2013)	Overbeek SA	PLoS One
26656474	Elevated Matrix Metalloproteinase Levels in Bronchi Infected with Periodontopathogenic Bacteria. (2015)	Bernasconi L	PLoS One
29744169	Inflammatory mediator polymorphisms associate with initial periodontitis in adolescents. (2016 Dec)	Heikkinen AM	Clin Exp Dent Res
22122519	Cigarette smoke extract induces select matrix metalloproteinases and integrin expression in periodontal ligament fibroblasts. (2012 Jun)	Bulmanski Z	J Periodontol
17254561	Correlates of serum matrix metalloproteinase-8 (MMP-8) concentrations in nondiabetic subjects without cardiovascular disease. (2007 Apr)	Aquilante CL	Clin Chim Acta