Gene: MMP10

4319
SL-2|STMY2
matrix metallopeptidase 10
protein-coding
11q22.2
Ensembl:ENSG00000166670 MIM:185260 Vega:OTTHUMG00000168083 UniprotKB:P09238
NC_000011.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.495e-1 (AD)  7.430e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRRC150.767
CHRNB40.732
CALCA0.726
ARL14EPL0.709
DEC10.694
C2CD4A0.688
ITK0.686
POU4F10.684
PTX30.682
FOXA30.678

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OMG-0.289
LHX6-0.283
SCGB2B2-0.282
CHRM1-0.278
GALNT13-0.277
SCRT1-0.274
SYT15-0.273
CASC15-0.269
ZC3H6-0.267
AGAP2-0.267

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00786MarimastatSmall Molecule154039-60-8Approved|InvestigationalTarget
DB08271N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACIDSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C5691071-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one"1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one results in decreased activity of MMP10 protein"23826121
C5691071-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one"1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one results in decreased expression of MMP10 mRNA"23826121
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of MMP10 mRNA28329830
C5188602-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide"2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide inhibits the reaction [Carbon Tetrachloride results in increased expression of MMP10 mRNA]"26443840
C0144643,4-dichloroaniline"3,4-dichloroaniline results in increased expression of MMP10 mRNA"24172598
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of MMP10 mRNA"18648102
C0022024-oxoretinoic acid4-oxoretinoic acid results in decreased expression of MMP10 mRNA15982314
D000082AcetaminophenAcetaminophen results in increased expression of MMP10 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen affects the expression of MMP10 mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP10 protein]17395008
D016604Aflatoxin B1Aflatoxin B1 affects the expression of MMP10 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MMP10 mRNA22100608|2715375
D000447AldehydesAldehydes results in increased expression of MMP10 mRNA25014914
C103303alitretinoinalitretinoin results in decreased expression of MMP10 mRNA15982314
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MMP10 mRNA16483693
D001379AzathioprineAzathioprine results in decreased expression of MMP10 mRNA19192274
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of MMP10 mRNA20660070
D004958EstradiolEstradiol results in increased expression of MMP10 mRNA20106945
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of MMP10 mRNA20226447
D004958Estradiolbisphenol A inhibits the reaction [Estradiol results in decreased expression of MMP10 mRNA]27312807
D004958EstradiolEstradiol results in decreased expression of MMP10 mRNA27312807
C006780bisphenol Abisphenol A affects the expression of MMP10 mRNA20170705
C006780bisphenol Abisphenol A inhibits the reaction [Estradiol results in decreased expression of MMP10 mRNA]27312807
C006780bisphenol Abisphenol A results in decreased expression of MMP10 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of MMP10 mRNA22079614
C018475butyraldehydebutyraldehyde results in increased expression of MMP10 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of MMP10 mRNA26472689
D002220CarbamazepineCarbamazepine affects the expression of MMP10 mRNA25979313
D002251Carbon Tetrachloride"2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid ethyl amide inhibits the reaction [Carbon Tetrachloride results in increased expression of MMP10 mRNA]"26443840
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of MMP10 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of MMP10 mRNA15056808|2644384
D002701ChloramphenicolChloramphenicol results in decreased expression of MMP10 mRNA20338993
C100187chloropicrinchloropicrin results in increased expression of MMP10 mRNA26352163|2847649
C023676chloroquine diphosphatechloroquine diphosphate results in decreased expression of MMP10 mRNA19192274
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of MMP10 mRNA28472532
D003024ClozapineClozapine results in decreased expression of MMP10 mRNA17346280
C018021cobaltous chloridecobaltous chloride results in increased expression of MMP10 mRNA23052192
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of MMP10 mRNA24690739
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of MMP10 mRNA20971185
D003300Copper[Organoselenium Compounds binds to Copper] which results in increased expression of MMP10 mRNA25167922
D019327Copper SulfateCopper Sulfate results in increased expression of MMP10 mRNA19549813
D003474CurcuminCurcumin results in increased expression of MMP10 mRNA15713895
D016572CyclosporineCyclosporine results in increased expression of MMP10 mRNA20106945
C014347decitabinedecitabine results in decreased expression of MMP10 mRNA27915011
D016264Dextran SulfateDextran Sulfate results in increased expression of MMP10 mRNA20824662
D002945Cisplatin[Cisplatin co-treated with Paclitaxel] results in decreased expression of MMP10 mRNA20705681
D002945CisplatinCisplatin results in increased expression of MMP10 mRNA12066199
C472511dimethylarsinous aciddimethylarsinous acid results in increased expression of MMP10 mRNA23876855
D004137DinitrochlorobenzeneDinitrochlorobenzene affects the expression of MMP10 mRNA22302311
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of MMP10 mRNA24690739
D004237DiuronDiuron metabolite results in increased expression of MMP10 mRNA24172598
C521792DMU-212DMU-212 affects the expression of MMP10 mRNA26428916
D004281Docosahexaenoic AcidsDocosahexaenoic Acids results in decreased expression of and results in decreased secretion of and results in decreased activity of MMP10 protein22285823
D004281Docosahexaenoic AcidsDocosahexaenoic Acids results in decreased expression of MMP10 mRNA22285823
D015118Eicosapentaenoic AcidEicosapentaenoic Acid results in decreased expression of and results in decreased secretion of and results in decreased activity of MMP10 protein22285823
D015118Eicosapentaenoic AcidEicosapentaenoic Acid results in decreased expression of MMP10 mRNA22285823
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MMP10 mRNA20170705|2686566
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of MMP10 mRNA18936297
D005419FlavonoidsFlavonoids results in decreased expression of MMP10 mRNA18035473
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of MMP10 mRNA28329830
D005557FormaldehydeFormaldehyde results in increased expression of MMP10 mRNA12679049
D019833GenisteinGenistein affects the expression of MMP10 mRNA26865667
D019833Genistein[Genistein co-treated with Methoxychlor] results in increased expression of MMP10 mRNA21782745
D019833GenisteinGenistein results in increased expression of MMP10 mRNA21782745
D005944GlucosamineGlucosamine inhibits the reaction [IL1B results in increased expression of MMP10 mRNA]17109745
D005944GlucosamineGlucosamine results in increased expression of MMP10 mRNA17109745
D005944GlucosamineIL1B promotes the reaction [Glucosamine results in increased expression of MMP10 mRNA]17109745
D006052Gold Sodium ThiomalateGold Sodium Thiomalate results in decreased expression of MMP10 mRNA19192274
C080043hexyl cinnamic aldehydehexyl cinnamic aldehyde affects the expression of MMP10 mRNA22302311
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of MMP10 mRNA17183730
D006851Hydrochloric AcidHydrochloric Acid results in increased expression of MMP10 protein18339021
D006851Hydrochloric AcidOxygen inhibits the reaction [Hydrochloric Acid results in increased expression of MMP10 protein]18339021
D006861Hydrogen PeroxideCAT protein inhibits the reaction [[SOD2 protein results in increased chemical synthesis of Hydrogen Peroxide] which results in increased expression of MMP10 mRNA]12538496
D006861Hydrogen Peroxide[SOD2 protein results in increased chemical synthesis of Hydrogen Peroxide] which results in increased expression of MMP10 mRNA12538496
D007213IndomethacinIndomethacin results in increased expression of MMP10 mRNA16771604
C561695(+)-JQ1 compound[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of MMP10 mRNA25119042
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MMP10 mRNA26644586
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of MMP10 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of MMP10 mRNA26378955
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP10 protein]17395008
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin results in decreased expression of and results in decreased secretion of MMP10 protein17395008
D008466MechlorethamineMechlorethamine results in increased expression of MMP10 mRNA26273949
D015122MercaptopurineMercaptopurine results in increased expression of MMP10 mRNA23358152
D008687MetforminMetformin inhibits the reaction [IL13 protein results in increased expression of MMP10 mRNA]26497364
D008727MethotrexateMethotrexate results in decreased expression of MMP10 mRNA19192274
D008727MethotrexateMethotrexate results in increased expression of MMP10 mRNA21678067
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in increased expression of MMP10 mRNA21782745
D008731MethoxychlorMethoxychlor results in increased expression of MMP10 mRNA21782745
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MMP10 mRNA20061341
D008775MethylprednisoloneMethylprednisolone results in decreased expression of MMP10 mRNA19192274
D015735MifepristoneMifepristone results in increased expression of MMP10 mRNA17584828
D015735MifepristoneMifepristone results in increased expression of MMP10 mRNA19439560
C500085muraglitazarmuraglitazar results in decreased expression of MMP10 mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MMP10 mRNA"25102311
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MMP10 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MMP10 mRNA"25554681
D009532NickelNickel results in increased expression of MMP10 mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in increased expression of MMP10 mRNA16780908
D0151124-Nitroquinoline-1-oxide4-Nitroquinoline-1-oxide results in increased expression of MMP10 mRNA22561872
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of MMP10 mRNA27935865
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of MMP10 mRNA"12888634
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of MMP10 mRNA20971185
C558013NSC 689534NSC 689534 results in increased expression of MMP10 mRNA20971185
D016566Organoselenium Compounds[Organoselenium Compounds binds to Copper] which results in increased expression of MMP10 mRNA25167922
D010100OxygenOxygen inhibits the reaction [Hydrochloric Acid results in increased expression of MMP10 protein]18339021
D017239Paclitaxel[Cisplatin co-treated with Paclitaxel] results in decreased expression of MMP10 mRNA20705681
D052638Particulate MatterParticulate Matter results in increased expression of MMP10 mRNA28341207
C506614PD 0325901[PD 0325901 co-treated with (+)-JQ1 compound] results in decreased expression of MMP10 mRNA25119042
C046012pentanalpentanal results in increased expression of MMP10 mRNA26079696
D010634PhenobarbitalPhenobarbital affects the expression of MMP10 mRNA19159669
D010894PiroxicamPiroxicam results in decreased expression of MMP10 mRNA19192274
D010936Plant ExtractsPlant Extracts results in decreased expression of MMP10 mRNA23557933
D011137PolystyrenesPolystyrenes analog results in increased expression of MMP10 mRNA25102311
D011239PrednisolonePrednisolone results in decreased expression of MMP10 mRNA19192274
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of MMP10 mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of MMP10 mRNA20226447
D011374ProgesteroneProgesterone results in increased expression of MMP10 mRNA20226447
C005556propionaldehydepropionaldehyde results in increased expression of MMP10 mRNA26079696
D011794QuercetinQuercetin results in decreased expression of MMP10 protein23645742
D011794QuercetinQuercetin results in increased expression of MMP10 mRNA21632981
D015474IsotretinoinIsotretinoin results in decreased expression of MMP10 mRNA15982314
C089730rosiglitazonerosiglitazone results in decreased expression of MMP10 mRNA21515302
C010327salinomycinsalinomycin results in decreased expression of MMP10 mRNA19682730
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of MMP10 mRNA"23917077
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of MMP10 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of MMP10 mRNA25351596
D019821SimvastatinSimvastatin results in increased expression of MMP10 mRNA17428261
C017947sodium arsenitesodium arsenite results in increased expression of MMP10 mRNA16014739
C016104sodium bichromatesodium bichromate results in increased expression of MMP10 mRNA22561333
C517409statticstattic results in decreased expression of MMP10 mRNA22285823
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of MMP10 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of MMP10 mRNA26378955
C025462sulindac sulfidesulindac sulfide results in increased expression of MMP10 mRNA16184548
C501413tesaglitazartesaglitazar results in decreased expression of MMP10 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MMP10 mRNA23152189|2457672
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MMP10 protein24576722
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MMP10 mRNA16962184|2157046
C009495titanium dioxidetitanium dioxide results in increased expression of MMP10 mRNA19695317
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MMP10 mRNA27865774
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of MMP10 mRNA27404394
D014212TretinoinTretinoin metabolite results in increased expression of MMP10 mRNA15982314
D014212TretinoinTretinoin results in decreased expression of MMP10 mRNA15982314
D014212TretinoinTretinoin results in decreased expression of MMP10 mRNA16604517
D014241TrichloroethyleneTrichloroethylene results in decreased methylation of MMP10 gene27618143
C012589trichostatin Atrichostatin A results in increased expression of MMP10 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride affects the expression of MMP10 mRNA22302311
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of MMP10 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of MMP10 mRNA21515302
D017973Tungsten CompoundsTungsten Compounds results in increased expression of MMP10 mRNA28666766
C113580U 0126U 0126 results in decreased expression of MMP10 mRNA22285823
D014520UrethaneUrethane results in increased expression of MMP10 protein22022614
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of MMP10 mRNA17183730
D014635Valproic AcidValproic Acid results in increased expression of MMP10 mRNA28001369|2915479
D014800VitalliumVitallium analog results in increased expression of MMP10 mRNA23825117
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of MMP10 mRNA27935865
C088658zoledronic acidzoledronic acid results in increased expression of MMP10 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004222metalloendopeptidase activity-TAS-  
GO:0004252serine-type endopeptidase activity-TAS-  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO:0022617extracellular matrix disassembly-TAS-  
GO:0030334regulation of cell migration-IEA-  
GO:0030574collagen catabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-TAS2844164  
GO:0031012extracellular matrix-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1442490Collagen degradationIEA
R-HSA-1442490Collagen degradationTAS
R-HSA-1474228Degradation of the extracellular matrixIEA
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1592389Activation of Matrix MetalloproteinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23936596Matrix metalloproteinase 10 gene polymorphism and atherothrombotic cerebral infarction risk in a Han Chinese population. (2013)Zhu FInt J Clin Exp Med