Gene: MMP12

4321
HME|ME|MME|MMP-12
matrix metallopeptidase 12
protein-coding
11q22.2
Ensembl:ENSG00000262406 MIM:601046 Vega:OTTHUMG00000165848 UniprotKB:P39900
NG_032936.1
PubMed
0   ANCO-SNPs
ND
28   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.591e-1 (AD)  6.424e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RGS210.768
SULT1C30.756
OR5H10.749
OR10Z10.733
MMP200.72
PRAMEF10.706
ABCB50.703
OR4C120.699
OR5T20.699
OR5M10.699

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADCY2-0.218
TMEM116-0.212
PPP5D1-0.199
MYBPC1-0.197
PCDH9-0.196
SFTPD-0.192
GALR3-0.192
ENPP5-0.191
CDKL3-0.19
PTCHD1-0.188

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00551Acetohydroxamic AcidSmall Molecule546-88-3ApprovedTarget
DB00786MarimastatSmall Molecule154039-60-8Approved|InvestigationalTarget
DB02118CP-271485Small Molecule-ExperimentalTarget
DB03367PF-00356231Small MoleculeExperimentalTarget
DB03880BatimastatSmall Molecule130370-60-4ExperimentalTarget
DB044052-[2-(1,3-Dioxo-1,3-Dihydro-2h-Isoindol-2-Yl)Ethyl]-4-(4'-Ethoxy-1,1'-Biphenyl-4-Yl)-4-Oxobutanoic AcidSmall MoleculeExperimentalTarget
DB05387AE-941Small Molecule-InvestigationalTarget
DB07026(1S,5S,7R)-N~7~-(BIPHENYL-4-YLMETHYL)-N~3~-HYDROXY-6,8-DIOXA-3-AZABICYCLO[3.2.1]OCTANE-3,7-DICARBOXAMIDESmall MoleculeExperimentalTarget
DB07446N-(biphenyl-4-ylsulfonyl)-D-leucineSmall MoleculeExperimentalTarget
DB07556N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDESmall MoleculeExperimentalTarget
DB07683N-(dibenzo[b,d]thiophen-3-ylsulfonyl)-L-valineSmall MoleculeExperimentalTarget
DB07920N-oxo-2-[(4-phenylphenyl)sulfonylamino]ethanamideSmall MoleculeExperimentalTarget
DB079212-[(4-fluorophenyl)sulfonylamino]-N-oxo-ethanamideSmall MoleculeExperimentalTarget
DB07922N-oxo-2-(phenylsulfonylamino)ethanamideSmall MoleculeExperimentalTarget
DB08271N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACIDSmall MoleculeExperimentalTarget
DB08599N-[(4-methoxyphenyl)sulfonyl]-D-alanineSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IL1B protein results in increased activity of MMP12 protein]16359550
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA]16359550
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL1B protein results in increased activity of MMP12 protein]16359550
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA]16359550
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP12 mRNA]"16571779
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MMP12 mRNA"15059925
C0807553-(2-methoxybenzylamino)-2-phenylpiperidine3-(2-methoxybenzylamino)-2-phenylpiperidine inhibits the reaction [TAC1 protein results in increased expression of MMP12 mRNA]18441096
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of MMP12 mRNA"20959002
C4340033-(4-methylphenylsulfonyl)-2-propenenitrile3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Ethanol results in increased expression of MMP12 mRNA]23978445
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in decreased expression of MMP12 mRNA18544908
C0917683'-methoxy-4'-nitroflavone3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP12 mRNA]21441140
D000082AcetaminophenAcetaminophen affects the expression of MMP12 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of MMP12 mRNA18544908
D000082AcetaminophenMMP12 mRNA affects the susceptibility to Acetaminophen26512990
C006358acetohydroxamic acidacetohydroxamic acid binds to and results in decreased activity of MMP12 protein17269766
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Ethanol results in increased expression of MMP12 mRNA]23978445
C016601afimoxifeneafimoxifene results in decreased expression of MMP12 mRNA17640349
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MMP12 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MMP12 mRNA23630614
C482289Ageladine AAgeladine A results in decreased activity of MMP12 protein21413800
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of MMP12 mRNA"21730038
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MMP12 mRNA16483693
C114556aprepitantaprepitant inhibits the reaction [TAC1 protein results in increased expression of MMP12 mRNA]18441096
C006632arsenic trioxidearsenic trioxide results in decreased expression of MMP12 mRNA19128835
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of MMP12 mRNA"16574944
D001379AzathioprineAzathioprine results in decreased expression of MMP12 mRNA19192274
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of MMP12 mRNA22687991
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MMP12 mRNA22228805
D004958EstradiolESR2 protein affects the reaction [Estradiol results in increased expression of MMP12 mRNA]14699072
D004958EstradiolEstradiol affects the expression of MMP12 mRNA14699072
C023888beta-hexachlorocyclohexanebeta-hexachlorocyclohexane results in increased expression of MMP12 mRNA17640349
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in increased expression of MMP12 mRNA15912405
C006780bisphenol Abisphenol A affects the expression of MMP12 mRNA25181051
C584509C646 compoundC646 compound results in increased expression of MMP12 mRNA26921506
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MMP12 mRNA25993096
D002211CapsaicinCapsaicin results in decreased expression of MMP12 mRNA18441096
D002211CapsaicinCapsaicin results in decreased expression of MMP12 protein18441096
D002244Carbon"[Carbon co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of MMP12 mRNA"26880698
D002244CarbonCarbon results in increased expression of MMP12 mRNA26880698
D002244Carbon"lipopolysaccharide, E coli O55-B5 promotes the reaction [Carbon results in increased expression of MMP12 mRNA]"26880698
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of MMP12 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of MMP12 mRNA18038451|2733941
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of MMP12 mRNA]18038451
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of MMP12 mRNA15963342|1623916
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of MMP12 mRNA17056239
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of MMP12 mRNA22223197
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of MMP12 protein22223197
C034221catecholcatechol results in increased expression of MMP12 mRNA10216232
D002509CephaloridineCephaloridine results in increased expression of MMP12 mRNA18500788
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MMP12 mRNA20938992
D003300CopperCopper deficiency results in increased expression of MMP12 mRNA17418555
D019327Copper SulfateCopper Sulfate results in increased expression of MMP12 mRNA19549813
D003345CorticosteroneCorticosterone results in decreased expression of MMP12 mRNA15755911
D016572CyclosporineCyclosporine results in decreased methylation of MMP12 promoter27989131
D016572CyclosporineCyclosporine results in increased expression of MMP12 mRNA20106945
D003543CysteamineCysteamine results in increased expression of MMP12 mRNA22532830
D003543CysteamineCysteamine results in increased expression of MMP12 protein22532830
D003907DexamethasoneDexamethasone inhibits the reaction [IL1B protein results in increased activity of MMP12 protein]16359550
D003907DexamethasoneDexamethasone inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA]16359550
D002945CisplatinCisplatin results in decreased expression of MMP12 mRNA22023808
D004008DiclofenacDiclofenac results in decreased expression of MMP12 mRNA19192274
D004041Dietary FatsDietary Fats affects the expression of MMP12 mRNA19680557
D004041Dietary FatsDietary Fats results in increased expression of MMP12 mRNA22609946
C014476diethyl maleatediethyl maleate results in increased expression of MMP12 mRNA10216232
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of MMP12 mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MMP12 mRNA23830814
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of MMP12 mRNA23830814
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of MMP12 mRNA21658437
D002117CalcitriolCalcitriol results in increased expression of MMP12 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of MMP12 mRNA21592394
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of MMP12 mRNA"19480007
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in increased expression of MMP12 mRNA"27840820
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of MMP12 mRNA10216232
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [Ethanol results in increased expression of MMP12 mRNA]23978445
C007517diphenyleneiodoniumdiphenyleneiodonium results in decreased expression of MMP12 mRNA23978445
D004237DiuronDiuron results in decreased expression of MMP12 mRNA21551480
D004317DoxorubicinDoxorubicin results in increased expression of MMP12 mRNA15033991
D000431Ethanol3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Ethanol results in increased expression of MMP12 mRNA]23978445
D000431EthanolAcetylcysteine inhibits the reaction [Ethanol results in increased expression of MMP12 mRNA]23978445
D000431EthanolCYBB mutant form inhibits the reaction [Ethanol results in increased expression of MMP12 mRNA]23978445
D000431EthanolCYBB mutant form inhibits the reaction [Ethanol results in increased expression of MMP12 protein]23978445
D000431Ethanoldiphenyleneiodonium inhibits the reaction [Ethanol results in increased expression of MMP12 mRNA]23978445
D000431EthanolEthanol results in increased expression of MMP12 mRNA23978445
D000431EthanolEthanol results in increased expression of MMP12 protein23978445
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Megestrol Acetate] results in increased expression of MMP12 protein22085904
C504383fenbuconazolefenbuconazole results in increased expression of MMP12 mRNA15942997
C000499ferric oxide[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of MMP12 mRNA20540983
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MMP12 mRNA20938992
C069837fullerene C60fullerene C60 results in increased expression of MMP12 mRNA20471445
C039281furanfuran results in increased expression of MMP12 mRNA26194646|2738771
D005944GlucosamineGlucosamine inhibits the reaction [IL1B results in increased expression of MMP12 mRNA]17109745
D005944GlucosamineGlucosamine results in increased expression of MMP12 mRNA17109745
D005944GlucosamineIL1B promotes the reaction [Glucosamine results in increased expression of MMP12 mRNA]17109745
D006861Hydrogen PeroxideCAT protein inhibits the reaction [[SOD2 protein results in increased chemical synthesis of Hydrogen Peroxide] which results in increased expression of MMP12 mRNA]12538496
D006861Hydrogen Peroxide[SOD2 protein results in increased chemical synthesis of Hydrogen Peroxide] which results in increased expression of MMP12 mRNA12538496
C016517indole-3-carbinolindole-3-carbinol affects the expression of MMP12 mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MMP12 mRNA25613284
D008055Lipids[Methotrexate analog binds to Lipids] which results in decreased expression of MMP12 mRNA24065615
C482199lipopolysaccharide, E coli O55-B5"[Carbon co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of MMP12 mRNA"26880698
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 promotes the reaction [Carbon results in increased expression of MMP12 mRNA]"26880698
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of MMP12 mRNA25106431
D058185Magnetite Nanoparticles[Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of MMP12 mRNA20540983
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of MMP12 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of MMP12 mRNA26378955
D019290Megestrol Acetate[Ethinyl Estradiol co-treated with Megestrol Acetate] results in increased expression of MMP12 protein22085904
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MMP12 mRNA20938992
D008727MethotrexateMethotrexate results in decreased expression of MMP12 mRNA19192274
D008727Methotrexate[Methotrexate analog binds to Lipids] which results in decreased expression of MMP12 mRNA24065615
D008775MethylprednisoloneMethylprednisolone results in decreased expression of MMP12 mRNA19192274
C523799MRK 003MMP12 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of MMP12 mRNA"23845593
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MMP12 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MMP12 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MMP12 mRNA"19836432|2491129
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MMP12 protein"24911292
D009532NickelNickel affects the expression of MMP12 mRNA14575637
D009532NickelNickel results in increased expression of MMP12 mRNA25583101
D009532Nickeltrichostatin A inhibits the reaction [Nickel affects the expression of MMP12 mRNA]14575637
C028007nickel monoxidenickel monoxide results in increased expression of MMP12 mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of MMP12 mRNA16166746
D0151124-Nitroquinoline-1-oxide4-Nitroquinoline-1-oxide results in decreased expression of MMP12 mRNA22561872
D0151124-Nitroquinoline-1-oxide4-Nitroquinoline-1-oxide results in increased expression of MMP12 mRNA22561872
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of MMP12 mRNA27935865
D009966OrphenadrineOrphenadrine affects the expression of MMP12 mRNA23665939
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of MMP12 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of MMP12 mRNA25729387
D010126OzoneOzone results in increased expression of MMP12 mRNA12763052
D000073878Palm OilPalm Oil affects the expression of MMP12 mRNA19680557
D010269ParaquatParaquat results in increased expression of MMP12 mRNA17215068
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of MMP12 mRNA27935865
D011239PrednisolonePrednisolone results in decreased expression of MMP12 mRNA19192274
D011374ProgesteroneProgesterone affects the expression of MMP12 mRNA17251523
D011441PropylthiouracilPropylthiouracil results in increased expression of MMP12 mRNA24780913
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [IL1B protein results in increased activity of MMP12 protein]16359550
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA]16359550
D011791QuartzQuartz results in increased expression of MMP12 mRNA19836432
D011794QuercetinQuercetin results in increased expression of MMP12 mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of MMP12 mRNA14699072
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MMP12 mRNA19059307
C085746rottlerin"rottlerin inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP12 mRNA]"16571779
D017632Asbestos, Serpentine"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP12 mRNA]"16571779
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased activity of MMP12 protein"16571779
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of MMP12 mRNA"16251409|1657177
D017632Asbestos, Serpentine"PRKDC protein affects the reaction [Asbestos, Serpentine results in increased expression of MMP12 mRNA]"16571779
D017632Asbestos, Serpentine"rottlerin inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP12 mRNA]"16571779
D017632Asbestos, Serpentine"U 0126 inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP12 mRNA]"16571779
D012822Silicon DioxideSilicon Dioxide results in increased expression of MMP12 mRNA26345256
D012822Silicon DioxideSilicon Dioxide results in increased expression of MMP12 mRNA22431001
D019821SimvastatinSimvastatin results in increased expression of MMP12 mRNA17428261
D012969Sodium FluorideSodium Fluoride results in decreased expression of MMP12 mRNA27257137
D053260SootSoot results in increased expression of MMP12 mRNA22461453|2655175
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of MMP12 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of MMP12 mRNA26378955
D013605T-2 ToxinT-2 Toxin results in increased expression of MMP12 mRNA22800716
C013698tallowtallow affects the expression of MMP12 mRNA19680557
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of MMP12 mRNA19059307
C501413tesaglitazartesaglitazar results in decreased expression of MMP12 mRNA21515302
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of MMP12 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of MMP12 mRNA21592394
D013749Tetrachlorodibenzodioxin3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP12 mRNA]21441140
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MMP12 mRNA21441140
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MMP12 protein15531779
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MMP12 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MMP12 mRNA18606429|1937224
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MMP12 mRNA20959002|2121527
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MMP12 mRNA25613284
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MMP12 mRNA23830814
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of MMP12 mRNA23830814
D013853ThioacetamideThioacetamide results in increased expression of MMP12 mRNA23411599
D008063Thioctic Acid[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MMP12 mRNA23830814
C009495titanium dioxidetitanium dioxide results in increased expression of MMP12 mRNA19464567|2125934
D014028Tobacco Smoke PollutionNFE2L2 protein affects the reaction [Tobacco Smoke Pollution affects the expression of MMP12 mRNA]20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of MMP12 mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of MMP12 protein20215583
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of MMP12 mRNA25729387
D019772TopotecanTopotecan results in increased expression of MMP12 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of MMP12 mRNA"19682533
C012589trichostatin Atrichostatin A inhibits the reaction [Nickel affects the expression of MMP12 mRNA]14575637
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of MMP12 mRNA16141432
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of MMP12 mRNA17982090
C113580U 0126"U 0126 inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP12 mRNA]"16571779
D017974Uranium CompoundsUranium Compounds results in decreased expression of MMP12 mRNA19654044
C009687wortmanninwortmannin inhibits the reaction [IL1B protein results in increased activity of MMP12 protein]16359550
C009687wortmanninwortmannin inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA]16359550

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001047core promoter binding-IMP24784232  
GO:0004175endopeptidase activity-TAS8226919  
GO:0004222metalloendopeptidase activity-IDA24784232  
GO:0004222metalloendopeptidase activity-IMP19932771  
GO:0004222metalloendopeptidase activity-TAS8226919  
GO:0004252serine-type endopeptidase activity-TAS-  
GO:0005509calcium ion binding-IMP11575928  
GO:0005518collagen binding-IPI19932771  
GO:0008270zinc ion binding-IMP11575928  
GO:0043565sequence-specific DNA binding-IMP24784232  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0006508proteolysis-IDA24784232  
GO:0006508proteolysis-IMP19932771  
GO:0006606protein import into nucleus-IMP24784232  
GO:0022617extracellular matrix disassembly-TAS-  
GO:0030574collagen catabolic process-TAS-  
GO:0035313wound healing, spreading of epidermal cells-IDA15802269  
GO:0045944positive regulation of transcription by RNA polymerase II-IMP24784232  
GO:0050691regulation of defense response to virus by host-IEA-  
GO:0060054positive regulation of epithelial cell proliferation involved in wound healing-IDA15802269  
GO:0060339negative regulation of type I interferon-mediated signaling pathway-IEA-  
GO:0060340positive regulation of type I interferon-mediated signaling pathway-IEA-  
GO:0098586cellular response to virus-IEA-  
GO:1902741positive regulation of interferon-alpha secretion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IMP24784232  
GO:0005634nucleus-IMP24784232  
GO:0005737cytoplasm-IDA24784232  
GO:0031012extracellular matrix-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1442490Collagen degradationTAS
R-HSA-1474228Degradation of the extracellular matrixIEA
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1474244Extracellular matrix organizationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28692348The G allele of MMP12 -82 A > G promoter polymorphism as a protective factor for COPD in Bulgarian population. (2017 Dec)Tacheva TArch Physiol Biochem
24828142Airway mucus obstruction triggers macrophage activation and matrix metalloproteinase 12-dependent emphysema. (2014 Nov)Trojanek JBAm J Respir Cell Mol Biol
29722565MMP-12 activates protease activated receptor (PAR)-1, upregulates placenta growth factor and leads to pulmonary emphysema. (2018 May 3)Hou HHAm J Physiol Lung Cell Mol Physiol
26917578Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12. (2016 Jun)Jackson VEThorax
22209925Metalloproteases/anti-metalloproteases imbalance in chronic obstructive pulmonary disease: genetic factors and treatment implications. (2011 Dec)Mocchegiani ECurr Opin Pulm Med
29616282A large lung gene expression study identifying IL1B as a novel player in airway inflammation in COPD airway epithelial cells. (2018 Jun)Yi GInflamm Res
11875051The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function. (2002 Mar 1)Joos LHum Mol Genet
16676616[Study on matrix metalloproteinase 1, 9, 12 polymorphisms and susceptibility to chronic obstructive pulmonary disease among Han nationality in northern China]. (2005 Nov)Zhang RBZhonghua Liu Xing Bing Xue Za Zhi
26351771Cigarette smoke modulates PC3 prostate cancer cell migration by altering adhesion molecules and the extracellular matrix. (2015 Nov)Yang SMol Med Rep
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