Gene info: ID 4322

Gene: MMP13

GENE ID: 4322

Synonyms: CLG3|MANDP1|MDST|MMP-13

Description: matrix metallopeptidase 13

Gene type: protein-coding

Location: 11q22.2

dbXrefs: Ensembl:ENSG00000137745 MIM:600108 Vega:OTTHUMG00000165850 UniprotKB:P45452

RefSeq: NG_021404.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.717e-1 (AD) 8.615e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OLIG3	0.89
INSL4	0.889
OR4C5	0.886
OR2W5	0.866
IL22RA2	0.856
OR4C12	0.852
KRTAP6-2	0.852
OR5T2	0.852
TSPY3	0.852
OR5F1	0.852

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FUT9	-0.356
OMG	-0.309
PLA2G6	-0.293
PCYT1B	-0.288
TPCN1	-0.286
ACSL6	-0.282
ERBB4	-0.28
B3GALT1	-0.279
TMEM221	-0.274
CDH20	-0.273

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00786	Marimastat	Small Molecule	154039-60-8	Approved\|Investigational	Target
DB01996	3-Methylpyridine	Small Molecule	108-99-6	Experimental	Target
DB02049	2-{4-[4-(4-Chloro-Phenoxy)-Benzenesulfonyl]-Tetrahydro-Pyran-4-Yl}-N-Hydroxy-Acetamide	Small Molecule		Experimental	Target
DB02071	WAY-151693	Small Molecule	-	Experimental	Target
DB02697	Hydroxyaminovaline	Small Molecule		Experimental	Target
DB03033	1-Methyloxy-4-Sulfone-Benzene	Small Molecule		Experimental	Target
DB04759	PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-(3-METHYL-BENZYLAMIDE)	Small Molecule		Experimental	Target
DB04760	PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-(4-FLUORO-3-METHYL-BENZYLAMIDE)	Small Molecule		Experimental	Target
DB04761	PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-[(PYRIDIN-3-YLMETHYL)-AMIDE]	Small Molecule		Experimental	Target
DB07013	TERT-BUTYL 4-({[4-(BUT-2-YN-1-YLAMINO)PHENYL]SULFONYL}METHYL)-4-[(HYDROXYAMINO)CARBONYL]PIPERIDINE-1-CARBOXYLATE	Small Molecule		Experimental	Target
DB07827	4-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID	Small Molecule		Experimental	Target
DB08388	5-(2-ETHOXYETHYL)-5-[4-(4-FLUOROPHENOXY)PHENOXY]PYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE	Small Molecule		Experimental	Target
DB08490	CTS-1027	Small Molecule	193022-04-7	Experimental\|Investigational	Target
DB08561	BENZYL 6-BENZYL-5,7-DIOXO-6,7-DIHYDRO-5H-[1,3]THIAZOLO[3,2-C]PYRIMIDINE-2-CARBOXYLATE	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C435044	1-((1-O-octadecyl-2-O-methylglycero)phospho)-3-deoxy-myo-inositol	1-((1-O-octadecyl-2-O-methylglycero)phospho)-3-deoxy-myo-inositol inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]	22936809
C070379	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [S100A4 protein results in increased expression of MMP13 protein]"	16948116
C540360	1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6''-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4,-dioxin	"1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6''-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4,-dioxin results in decreased expression of MMP13 mRNA"	19330880
C540360	1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6''-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4,-dioxin	"1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6''-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4,-dioxin results in decreased expression of MMP13 protein"	19330880
C579534	1,3-diacetoxytetradeca-6,12-dien-8,10-diyne	"1,3-diacetoxytetradeca-6,12-dien-8,10-diyne inhibits the reaction [IL1B protein results in increased expression of MMP13]"	21347999
C051246	1-methylanthracene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of MMP13 mRNA	28329830
C051246	1-methylanthracene	SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of MMP13 mRNA]	28329830
C581572	1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea	[Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea] results in increased expression of MMP13 mRNA	25827057
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [S100A4 protein results in increased expression of MMP13 protein]	16948116
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [VEGFA protein results in increased activity of MMP13 protein]	22270366
C104564	2-(4-acetoxyphenyl)-2-chloro-N-methylethylamine	2-(4-acetoxyphenyl)-2-chloro-N-methylethylamine affects the expression of MMP13 mRNA	19997594
C104564	2-(4-acetoxyphenyl)-2-chloro-N-methylethylamine	NR3C1 protein promotes the reaction [2-(4-acetoxyphenyl)-2-chloro-N-methylethylamine results in decreased expression of MMP13 mRNA]	19997594
C010914	2,4-diaminotoluene	"2,4-diaminotoluene results in increased expression of MMP13 mRNA"	20713471
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Chloramphenicol results in increased expression of MMP13 mRNA]	20338993
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [VEGFA protein results in increased activity of MMP13 protein]	22270366
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP13 mRNA]"	16571779
C000594958	3,4,5-trihydroxy-N-(4-(thiazol-2-ylsulfamoyl)-phenyl)-benzamide	"3,4,5-trihydroxy-N-(4-(thiazol-2-ylsulfamoyl)-phenyl)-benzamide inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]"	26107568
C014464	3,4-dichloroaniline	"3,4-dichloroaniline results in increased expression of MMP13 mRNA"	24172598
C532757	4-(4-(4-fluorophenoxy)benzenesulfonylamino)tetrahydropyran-4-carboxylic acid hydroxyamide	4-(4-(4-fluorophenoxy)benzenesulfonylamino)tetrahydropyran-4-carboxylic acid hydroxyamide results in decreased activity of MMP13 protein	23611293
C108123	4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine	"4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]"	22936809
C501474	4-OH-2',3,3',4',5'-pentachlorobiphenyl	"4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in increased expression of MMP13 mRNA]"	21523860
C010643	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]"	21211511
C010643	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]"	21211511
C010643	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]"	21211511
C010643	6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [TNF protein results in increased expression of MMP13 protein]"	21211511
C496492	abrine	abrine results in decreased expression of MMP13 mRNA	22595364
C099958	acanthoic acid	acanthoic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of MMP13 protein]	24802811
D000082	Acetaminophen	Acetaminophen affects the expression of MMP13 mRNA	17562736
C056165	acetovanillone	acetovanillone inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]	21211511
C056165	acetovanillone	acetovanillone inhibits the reaction [TNF protein results in increased expression of MMP13 protein]	21211511
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP13 protein]	17395008
C016601	afimoxifene	afimoxifene results in increased expression of MMP13 mRNA	17640349
C482289	Ageladine A	Ageladine A results in decreased activity of MMP13 protein	21413800
C031143	AICA ribonucleotide	AICA ribonucleotide inhibits the reaction [TGFB1 protein results in decreased expression of MMP13 protein]	27688165
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of MMP13 mRNA	16483693
D000728	Androgens	Androgens results in increased expression of MMP13 mRNA	15138554
D000728	Androgens	Androgens results in increased expression of MMP13 protein	15138554
D000728	Androgens	bicalutamide inhibits the reaction [Androgens results in increased expression of MMP13 mRNA]	15138554
D000728	Androgens	Androgens affects the expression of MMP13 protein	17607299
D000968	Antimycin A	Antimycin A results in increased expression of MMP13 mRNA	19304788
D047310	Apigenin	Apigenin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]	21679050
D016718	Arachidonic Acid	Arachidonic Acid results in increased expression of MMP13 mRNA	16185265
D016718	Arachidonic Acid	Arachidonic Acid results in increased secretion of MMP13 protein	16185265
D016718	Arachidonic Acid	Isotretinoin inhibits the reaction [Arachidonic Acid results in increased expression of MMP13 mRNA]	16185265
D016718	Arachidonic Acid	Isotretinoin inhibits the reaction [Arachidonic Acid results in increased secretion of MMP13 protein]	16185265
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of MMP13 mRNA	26705709
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of MMP13 mRNA"	16574944\|2391707
D001205	Ascorbic Acid	IL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in decreased expression of MMP13 mRNA]	26526931
D001205	Ascorbic Acid	[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in decreased expression of MMP13 mRNA	26526931
D001205	Ascorbic Acid	[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 mRNA	23692848
D001205	Ascorbic Acid	CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 mRNA]	23692848
D001205	Ascorbic Acid	CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 protein]	23692848
D001205	Ascorbic Acid	"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 mRNA]"	23692848
D001205	Ascorbic Acid	"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 protein]"	23692848
D001241	Aspirin	Aspirin results in increased expression of MMP13 mRNA	12800193
C424804	atractylenolide I	atractylenolide I inhibits the reaction [IL1B protein results in increased expression of MMP13]	21347999
C547126	AZM551248	AZM551248 results in increased expression of MMP13 mRNA	22323515
D001554	Benzene	Benzene results in increased expression of MMP13 protein	14673790\|1503611
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in increased expression of MMP13 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MMP13 mRNA	17879257
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MMP13 mRNA	20713471
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [halofuginone results in increased expression of MMP13 mRNA]	16489207
D001599	Berberine	Berberine results in increased expression of MMP13 mRNA	26478571
D004958	Estradiol	Estradiol results in increased expression of MMP13 mRNA	21185374
D004958	Estradiol	Estradiol results in increased expression of MMP13 mRNA	19416213
D004958	Estradiol	Progesterone inhibits the reaction [Estradiol results in increased expression of MMP13 mRNA]	19416213
D004958	Estradiol	ESR2 protein affects the reaction [Estradiol results in decreased expression of MMP13 mRNA]	17612627
D004958	Estradiol	Estradiol inhibits the reaction [ESR2 protein results in increased expression of MMP13 mRNA]	17612627
C023888	beta-hexachlorocyclohexane	beta-hexachlorocyclohexane results in increased expression of MMP13 mRNA	17640349
C002070	betulinic acid	betulinic acid inhibits the reaction [TNF protein results in decreased expression of MMP13 protein]	22285267
C053541	bicalutamide	bicalutamide inhibits the reaction [Androgens results in increased expression of MMP13 mRNA]	15138554
D001663	Bilirubin	Bilirubin results in increased expression of MMP13 mRNA	20196124
C006780	bisphenol A	bisphenol A affects the expression of MMP13 mRNA	25181051
C006780	bisphenol A	bisphenol A inhibits the reaction [Triiodothyronine results in increased expression of MMP13 mRNA]	19228888
C086539	BQ 788	[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP13 protein]	12875994
C086539	BQ 788	BQ 788 inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP13 protein]	12875994
D002101	Cacodylic Acid	Cacodylic Acid results in increased expression of MMP13 mRNA	17441966
D002101	Cacodylic Acid	OGG1 protein inhibits the reaction [Cacodylic Acid results in increased expression of MMP13 mRNA]	17441966
D002104	Cadmium	Cadmium results in decreased expression of MMP13 mRNA	20570719
D002104	Cadmium	Cadmium results in increased expression of MMP13 mRNA	20570719
D002104	Cadmium	Cadmium results in increased expression of MMP13 mRNA	15240111
D002110	Caffeine	Caffeine results in increased expression of MMP13 mRNA	22982570
C081643	candesartan	candesartan results in increased expression of MMP13 protein	19047581
D002211	Capsaicin	Capsaicin results in decreased expression of MMP13 mRNA	16278290
D002211	Capsaicin	Capsaicin results in increased expression of MMP13 protein	22150557
D002211	Capsaicin	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MMP13 protein]	22150557
D002211	Capsaicin	Naproxen inhibits the reaction [Capsaicin results in increased expression of MMP13 protein]	22150557
D002211	Capsaicin	Sumatriptan inhibits the reaction [Capsaicin results in increased expression of MMP13 protein]	22150557
D002220	Carbamazepine	Carbamazepine results in decreased expression of MMP13 mRNA	22982570
D002251	Carbon Tetrachloride	acanthoic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of MMP13 protein]	24802811
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of MMP13 mRNA	17484886
D002251	Carbon Tetrachloride	[Carbon Tetrachloride co-treated with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea] results in increased expression of MMP13 mRNA	25827057
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of MMP13 mRNA	17976157
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of MMP13 mRNA	15056808\|1718743
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of MMP13 protein	17944888\|2480281
D002251	Carbon Tetrachloride	HAS3 protein affects the reaction [Carbon Tetrachloride results in increased expression of MMP13 mRNA]	27042213
D002251	Carbon Tetrachloride	[HAS3 protein affects the susceptibility to Carbon Tetrachloride] which affects the expression of MMP13 protein	27042213
D002251	Carbon Tetrachloride	HGF protein affects the reaction [Carbon Tetrachloride results in decreased expression of MMP13 mRNA]	17976157
D002251	Carbon Tetrachloride	HIF1A protein affects the reaction [Carbon Tetrachloride results in increased expression of MMP13 mRNA]	24639359
D002251	Carbon Tetrachloride	NT5E gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of MMP13 mRNA]	18263696
D002251	Carbon Tetrachloride	NT5E gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of MMP13 protein]	18263696
D002251	Carbon Tetrachloride	PLAT protein affects the reaction [Carbon Tetrachloride results in increased expression of MMP13 protein]	17944888
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of MMP13 mRNA	15963578
D002251	Carbon Tetrachloride	[Carbon Tetrachloride co-treated with Plant Extracts] results in increased expression of MMP13 mRNA	17157831
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of MMP13 mRNA	11903743\|1748585
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased cleavage of MMP13 protein	16484506
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of MMP13 mRNA	17631135
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of MMP13 protein	17631135
D002251	Carbon Tetrachloride	ebselen inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP13 mRNA]	11903743
D002251	Carbon Tetrachloride	pioglitazone affects the reaction [Carbon Tetrachloride results in increased cleavage of MMP13 protein]	16484506
C097658	CGS 27023A	CGS 27023A affects the activity of MMP13 protein	22017477
D002701	Chloramphenicol	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Chloramphenicol results in increased expression of MMP13 mRNA]	20338993
D002701	Chloramphenicol	Chloramphenicol results in increased expression of MMP13 mRNA	20338993
D002701	Chloramphenicol	Chloramphenicol results in increased secretion of MMP13 protein	20338993
D002701	Chloramphenicol	Curcumin inhibits the reaction [Chloramphenicol results in increased expression of MMP13 mRNA]	20338993
D002701	Chloramphenicol	pyrazolanthrone inhibits the reaction [Chloramphenicol results in increased expression of MMP13 mRNA]	20338993
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MMP13 mRNA	20938992
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of MMP13 mRNA	28472532
D002939	Ciprofloxacin	Ciprofloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]	16148020
D002939	Ciprofloxacin	Ciprofloxacin inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]	16148020
D002939	Ciprofloxacin	Ciprofloxacin results in decreased expression of MMP13 mRNA	16148020
D002981	Clindamycin	Clindamycin results in increased expression of MMP13 mRNA	20338993
D002994	Clofibrate	Clofibrate inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]	16572457
D002994	Clofibrate	[Clofibrate promotes the reaction [IL1B protein results in increased expression of IL1RN mRNA]] which results in increased expression of MMP13 mRNA	16572457
D060729	Coal Ash	Coal Ash results in decreased expression of MMP13 mRNA	19000753
D003035	Cobalt	TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA]	23503329
D003035	Cobalt	[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA	23503329
C007095	cobaltiprotoporphyrin	cobaltiprotoporphyrin inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]	23406266
C007095	cobaltiprotoporphyrin	[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in decreased expression of MMP13 mRNA	18200630
C007095	cobaltiprotoporphyrin	[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in decreased expression of MMP13 protein	18200630
C007095	cobaltiprotoporphyrin	HMOX1 mutant form inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]]	23406266
D003042	Cocaine	Cocaine results in decreased expression of MMP13 mRNA	17898221
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of MMP13 mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate affects the expression of MMP13 mRNA	26368670
C495612	CP-471,358	"CP-471,358 results in decreased activity of MMP13 protein"	23611293
D003471	Cuprizone	Cuprizone results in increased expression of MMP13 mRNA	27523638
D003474	Curcumin	Curcumin inhibits the reaction [Chloramphenicol results in increased expression of MMP13 mRNA]	20338993
D003513	Cycloheximide	Cycloheximide results in increased expression of MMP13 mRNA	19684285
D003513	Cycloheximide	[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of MMP13 mRNA	19684285
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Tretinoin results in increased expression of MMP13 mRNA]	16350840
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	[BQ 788 co-treated with cyclo(Trp-Asp-Pro-Val-Leu)] inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP13 protein]	12875994
C072247	cyclo(Trp-Asp-Pro-Val-Leu)	cyclo(Trp-Asp-Pro-Val-Leu) inhibits the reaction [EDN1 protein results in increased secretion of and results in increased activity of MMP13 protein]	12875994
C014347	decitabine	[decitabine co-treated with trichostatin A] results in increased expression of MMP13 mRNA	17891453
C014347	decitabine	[decitabine results in increased expression of LEP mRNA] which results in increased expression of MMP13 mRNA	17502362
C107676	deguelin	deguelin results in decreased expression of MMP13 protein	25322282
D003847	Deoxyglucose	Deoxyglucose analog results in decreased expression of MMP13 protein	27931795
D003847	Deoxyglucose	Deoxyglucose inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]	21211511
D003847	Deoxyglucose	Deoxyglucose inhibits the reaction [TNF protein results in increased expression of MMP13 protein]	21211511
D003907	Dexamethasone	Dexamethasone results in increased activity of MMP13 protein	17728286
D003907	Dexamethasone	Dexamethasone results in increased expression of MMP13 mRNA	17728286
D003907	Dexamethasone	Dexamethasone results in increased expression of MMP13 mRNA	25286332
D003907	Dexamethasone	IL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in decreased expression of MMP13 mRNA]	26526931
D003907	Dexamethasone	[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in decreased expression of MMP13 mRNA	26526931
D003907	Dexamethasone	Dexamethasone results in decreased expression of MMP13 mRNA	19997594
D003907	Dexamethasone	NR3C1 protein promotes the reaction [Dexamethasone results in decreased expression of MMP13 mRNA]	19997594
D003907	Dexamethasone	TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA]	23503329
D003907	Dexamethasone	[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA	23503329
D016264	Dextran Sulfate	Dextran Sulfate results in increased expression of MMP13 mRNA	12105854\|1928509
D016264	Dextran Sulfate	MIF protein affects the reaction [Dextran Sulfate results in increased expression of MMP13 mRNA]	12105854
D016264	Dextran Sulfate	Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP13 mRNA]	19285099
C503840	dieckol	dieckol results in decreased expression of MMP13 mRNA	19330880
C503840	dieckol	dieckol results in decreased expression of MMP13 protein	19330880
D004041	Dietary Fats	Dietary Fats affects the expression of MMP13 mRNA	19680557
D004041	Dietary Fats	Dietary Fats results in increased expression of MMP13 mRNA	22609946
D004041	Dietary Fats	[Vehicle Emissions affects the reaction [APOE gene mutant form affects the susceptibility to Dietary Fats]] which results in decreased expression of MMP13 mRNA	19891982
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of MMP13 mRNA	24535843
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of MMP13 mRNA	16284949\|2453584
D000875	Anthralin	Anthralin results in decreased activity of MMP13 protein	23611293
D002117	Calcitriol	Calcitriol results in decreased expression of MMP13 mRNA	12040012\|2648566
D004110	Diltiazem	Diltiazem promotes the reaction [ferrous sulfate results in increased expression of MMP13 protein]	27095094
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of MMP13 mRNA"	19480007
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of MMP13 protein"	19480007
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of MMP13 mRNA	23197195
D004128	Dimethylnitrosamine	[Dimethylnitrosamine co-treated with gadolinium chloride] results in increased expression of MMP13 mRNA	12493575
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of MMP13 mRNA	23485615
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of MMP13 protein	15504294
D004128	Dimethylnitrosamine	Plant Extracts inhibits the reaction [Dimethylnitrosamine results in increased expression of MMP13 mRNA]	23485615
D004147	Dioxins	Dioxins affects the expression of MMP13 mRNA	20463971
C007517	diphenyleneiodonium	diphenyleneiodonium inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]	21211511
C007517	diphenyleneiodonium	diphenyleneiodonium inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]	21211511
C007517	diphenyleneiodonium	diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]	21211511
C007517	diphenyleneiodonium	diphenyleneiodonium inhibits the reaction [TNF protein results in increased expression of MMP13 protein]	21211511
D004237	Diuron	Diuron metabolite results in increased expression of MMP13 mRNA	24172598
D004237	Diuron	Diuron results in increased expression of MMP13 mRNA	25152437
D004317	Doxorubicin	MMP13 gene mutant form results in decreased susceptibility to Doxorubicin	20407279
D004318	Doxycycline	Doxycycline analog inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]	17267227
D004318	Doxycycline	Doxycycline analog results in decreased activity of MMP13 protein	17267227
D004318	Doxycycline	Doxycycline inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]	17267227
D004318	Doxycycline	Doxycycline results in increased expression of MMP13 mRNA	20338993
C042986	ebselen	ebselen inhibits the reaction [Carbon Tetrachloride results in decreased expression of MMP13 mRNA]	11903743
D004610	Ellagic Acid	Ellagic Acid inhibits the reaction [MMP13 protein results in increased degradation of COL2A1 protein]	23830812
C070609	EMD 53998	EMD 53998 analog results in decreased expression of MMP13 mRNA	24977338
C045651	epigallocatechin gallate	epigallocatechin gallate affects the activity of MMP13 protein	17481882
C007628	esculetin	esculetin inhibits the reaction [Streptozocin results in increased expression of MMP13 mRNA]	21450970
D000431	Ethanol	Ethanol results in decreased expression of MMP13 mRNA	27112526
D000431	Ethanol	Ethanol results in decreased expression of MMP13 mRNA	17920746
C020748	ferrous sulfate	[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 mRNA	23692848
C020748	ferrous sulfate	CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 mRNA]	23692848
C020748	ferrous sulfate	CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 protein]	23692848
C020748	ferrous sulfate	"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 mRNA]"	23692848
C020748	ferrous sulfate	"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 protein]"	23692848
C020748	ferrous sulfate	Diltiazem promotes the reaction [ferrous sulfate results in increased expression of MMP13 protein]	27095094
C020748	ferrous sulfate	ferrous sulfate results in increased expression of MMP13 protein	27095094
C020748	ferrous sulfate	Nimodipine promotes the reaction [ferrous sulfate results in increased expression of MMP13 protein]	27095094
C020748	ferrous sulfate	Verapamil promotes the reaction [ferrous sulfate results in increased expression of MMP13 protein]	27095094
C007738	fluoranthene	[1-methylanthracene co-treated with fluoranthene] results in increased expression of MMP13 mRNA	28329830
C007738	fluoranthene	SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of MMP13 mRNA]	28329830
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MMP13 mRNA	20938992
C039281	furan	furan results in increased expression of MMP13 mRNA	27387713
C038958	gadolinium chloride	[Dimethylnitrosamine co-treated with gadolinium chloride] results in increased expression of MMP13 mRNA	12493575
C038958	gadolinium chloride	gadolinium chloride results in increased expression of MMP13 mRNA	12493575
C038958	gadolinium chloride	SB 203580 inhibits the reaction [gadolinium chloride results in increased expression of MMP13 mRNA]	12493575
C007834	genipin	genipin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP13 mRNA]	22687549
D005938	Glucocorticoids	Glucocorticoids results in decreased expression of MMP13 mRNA	16023836
D005944	Glucosamine	Glucosamine analog affects the expression of MMP13 mRNA	17337215
D005944	Glucosamine	Glucosamine analog inhibits the reaction [IL1B protein results in increased expression of MMP13]	15144122
D005944	Glucosamine	Glucosamine analog inhibits the reaction [IL1B results in increased expression of and results in increased secretion of MMP13 protein]	18080321
D005944	Glucosamine	Glucosamine analog inhibits the reaction [IL1B results in increased expression of MMP13 mRNA]	17337215\|1808032
D005944	Glucosamine	Glucosamine analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP13 mRNA]	19656660
D005944	Glucosamine	Glucosamine inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]	17925024
D005944	Glucosamine	Glucosamine inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]	17925024
D005944	Glucosamine	Glucosamine inhibits the reaction [IL1B results in increased expression of MMP13 mRNA]	17109745
D005944	Glucosamine	Glucosamine results in increased expression of MMP13 mRNA	17109745
D005944	Glucosamine	IL1B promotes the reaction [Glucosamine results in increased expression of MMP13 mRNA]	17109745
C508665	gold (III) porphyrin 1a	gold (III) porphyrin 1a results in decreased expression of MMP13 mRNA	16206274
D006145	Guanethidine	Guanethidine results in increased expression of MMP13 mRNA	14527964
C010176	halofuginone	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [halofuginone results in increased expression of MMP13 mRNA]	16489207
C010176	halofuginone	halofuginone promotes the reaction [Thioacetamide results in increased expression of MMP13 mRNA]	16489207
C010176	halofuginone	halofuginone results in increased expression of MMP13 mRNA	16489207
C010176	halofuginone	halofuginone results in increased expression of MMP13 protein	16489207
C010176	halofuginone	SB 203580 inhibits the reaction [halofuginone results in increased expression of MMP13 mRNA]	16489207
D006820	Hyaluronic Acid	[Hyaluronic Acid co-treated with resveratrol] results in decreased expression of MMP13 mRNA	23595953
D006820	Hyaluronic Acid	Hyaluronic Acid metabolite results in increased expression of MMP13 mRNA	23692848
D006820	Hyaluronic Acid	Hyaluronic Acid metabolite results in increased expression of MMP13 protein	23692848
D006854	Hydrocortisone	Hydrocortisone results in increased activity of MMP13 protein	17728286
D006854	Hydrocortisone	Hydrocortisone results in increased expression of MMP13 mRNA	17728286
D006861	Hydrogen Peroxide	CAT protein inhibits the reaction [[SOD2 protein results in increased chemical synthesis of Hydrogen Peroxide] which results in increased expression of MMP13 mRNA]	12538496
D006861	Hydrogen Peroxide	[SOD2 protein results in increased chemical synthesis of Hydrogen Peroxide] which results in increased expression of MMP13 mRNA	12538496
D015056	1-Methyl-3-isobutylxanthine	TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA]	23503329
D015056	1-Methyl-3-isobutylxanthine	[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA	23503329
D007529	Isoflavones	Isoflavones results in decreased expression of MMP13 mRNA	16365062
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of MMP13 mRNA	26324948
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of MMP13 protein	26324948
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of MMP13 mRNA]	26582142
C482199	lipopolysaccharide, E coli O55-B5	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of MMP13 mRNA"	18930950
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of MMP13 protein	17303203
D008070	Lipopolysaccharides	genipin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP13 mRNA]	22687549
D008070	Lipopolysaccharides	(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of MMP13 mRNA]	26582142
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Zymosan] results in decreased activity of MMP13 protein	15259001
D008070	Lipopolysaccharides	[Lipopolysaccharides co-treated with Zymosan] results in increased activity of MMP13 protein	15259001
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of MMP13 mRNA	22687549\|2658214
D018021	Lithium Chloride	Lithium Chloride results in decreased expression of MMP13 mRNA	22982570
D018021	Lithium Chloride	Lithium Chloride results in increased expression of MMP13 mRNA	22982570
D047311	Luteolin	Luteolin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]	21679050
D008345	Manganese	Manganese results in increased expression of MMP13 mRNA	26745496
C025340	manganese chloride	manganese chloride results in increased expression of MMP13 mRNA	26745496
C097284	manganese(III)-tetrakis(4-benzoic acid)porphyrin	manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of and results in increased activity of MMP13 protein]	17395008
C097284	manganese(III)-tetrakis(4-benzoic acid)porphyrin	manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [S100A4 protein results in increased expression of MMP13 mRNA]	16948116
C097284	manganese(III)-tetrakis(4-benzoic acid)porphyrin	manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [S100A4 protein results in increased expression of MMP13 protein]	16948116
C054474	manumycin	manumycin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]	21211511
C054474	manumycin	manumycin inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]	21211511
C054474	manumycin	manumycin inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]	21211511
C054474	manumycin	manumycin inhibits the reaction [TNF protein results in increased expression of MMP13 protein]	21211511
D009637	Masoprocol	Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP13 protein]	17395008
D009637	Masoprocol	Masoprocol inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]	21211511
D009637	Masoprocol	Masoprocol inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]	21211511
D009637	Masoprocol	Masoprocol inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]	21211511
D009637	Masoprocol	Masoprocol inhibits the reaction [TNF protein results in increased expression of MMP13 protein]	21211511
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MMP13 mRNA	20938992
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of MMP13 mRNA	20713471
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of MMP13 mRNA	20061341
C000873	methylprednisolone acetate	methylprednisolone acetate results in decreased expression of MMP13 mRNA	15693093
D008911	Minocycline	Minocycline results in increased expression of MMP13 mRNA	20338993
D008911	Minocycline	Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP13 mRNA]	19285099
C502230	Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin	"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 mRNA]"	23692848
C502230	Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin	"Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 protein]"	23692848
D009268	Nalidixic Acid	Nalidixic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]	16148020
D009268	Nalidixic Acid	Nalidixic Acid results in decreased expression of MMP13 mRNA	16148020
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of MMP13 mRNA"	23845593
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of MMP13 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of MMP13 mRNA"	25554681
D009288	Naproxen	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MMP13 protein]	22150557
D009288	Naproxen	Naproxen inhibits the reaction [Capsaicin results in increased expression of MMP13 protein]	22150557
D009532	Nickel	TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA]	23503329
D009532	Nickel	[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA	23503329
D009538	Nicotine	Nicotine results in increased expression of MMP13 mRNA	17151781
D009538	Nicotine	Nicotine results in increased expression of MMP13 protein	17151781
D009553	Nimodipine	Nimodipine promotes the reaction [ferrous sulfate results in increased expression of MMP13 protein]	27095094
D015112	4-Nitroquinoline-1-oxide	4-Nitroquinoline-1-oxide results in decreased expression of MMP13 mRNA	22561872
D009643	Norfloxacin	Norfloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]	16148020
D009643	Norfloxacin	Norfloxacin inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]	16148020
D009643	Norfloxacin	Norfloxacin results in decreased expression of MMP13 mRNA	16148020
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of MMP13 mRNA	20971185
D015242	Ofloxacin	Ofloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]	16148020
D015242	Ofloxacin	Ofloxacin results in decreased expression of MMP13 mRNA	16148020
D015242	Ofloxacin	Ofloxacin results in increased expression of MMP13 mRNA	21903125\|2306772
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of MMP13 mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in decreased expression of MMP13 mRNA	20193091
D010100	Oxygen	Oxygen deficiency results in decreased expression of MMP13 protein	20193091
D010100	Oxygen	Oxygen deficiency results in increased expression of MMP13 mRNA	25931318
D010100	Oxygen	[Paraquat co-treated with Oxygen] results in decreased expression of MMP13 mRNA	12882763
D010100	Oxygen	sarpogrelate inhibits the reaction [Oxygen deficiency results in increased expression of MMP13 mRNA]	25931318
D000073878	Palm Oil	Palm Oil affects the expression of MMP13 mRNA	19680557
D010269	Paraquat	Paraquat results in increased expression of MMP13 mRNA	26108578
D010269	Paraquat	[Paraquat co-treated with Oxygen] results in decreased expression of MMP13 mRNA	12882763
D052638	Particulate Matter	Particulate Matter results in decreased expression of MMP13 mRNA	27851901
C497431	PD-0200347	PD-0200347 results in decreased expression of MMP13 mRNA	15693013
C497431	PD-0200347	PD-0200347 results in decreased expression of MMP13 protein	15693013
D010424	Pentobarbital	Pentobarbital results in increased expression of MMP13 mRNA	22982570
D010455	Peptides	Peptides inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP13 mRNA]	20004183
D010455	Peptides	Peptides inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP13 protein]	20004183
D010578	Petroleum	Petroleum affects the expression of MMP13 mRNA	25208076
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of MMP13 mRNA	24535843
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of MMP13 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of MMP13 mRNA	19482888
C004479	pimagedine	pimagedine results in increased expression of MMP13 mRNA	18380797
C060836	pioglitazone	pioglitazone affects the reaction [Carbon Tetrachloride results in increased cleavage of MMP13 protein]	16484506
D010936	Plant Extracts	[Carbon Tetrachloride co-treated with Plant Extracts] results in increased expression of MMP13 mRNA	17157831
D010936	Plant Extracts	Plant Extracts inhibits the reaction [Dimethylnitrosamine results in increased expression of MMP13 mRNA]	23485615
D010972	Platelet Activating Factor	Platelet Activating Factor results in increased expression of MMP13 mRNA	16386258
C113282	prinomastat	prinomastat results in decreased activity of MMP13 protein	17267227
D011374	Progesterone	Progesterone inhibits the reaction [Estradiol results in increased expression of MMP13 mRNA]	19416213
C115642	punicalagin	punicalagin inhibits the reaction [MMP13 protein results in increased degradation of COL2A1 protein]	23830812
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Chloramphenicol results in increased expression of MMP13 mRNA]	20338993
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [S100A4 protein results in increased expression of MMP13 protein]	16948116
C432165	pyrazolanthrone	pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP13 protein]	20004183
C014175	pyrazolo(3,4-d)pyrimidine	"pyrazolo(3,4-d)pyrimidine analog affects the expression of MMP13 mRNA"	21152443
C030984	pyrene	pyrene results in decreased expression of MMP13 mRNA	15963578
D011794	Quercetin	Quercetin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]	21211511
D011794	Quercetin	Quercetin inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]	21211511
D011794	Quercetin	Quercetin inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]	21211511
D011794	Quercetin	Quercetin inhibits the reaction [TNF protein results in increased expression of MMP13 protein]	21211511
C059514	resveratrol	resveratrol inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]	19011540
C059514	resveratrol	resveratrol inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]	21211511\|2652693
C059514	resveratrol	resveratrol inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]	21211511
C059514	resveratrol	resveratrol inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]	18759268
C059514	resveratrol	resveratrol inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]	21211511\|2325724
C059514	resveratrol	resveratrol inhibits the reaction [TNF protein results in increased expression of MMP13 protein]	21211511
C059514	resveratrol	resveratrol results in decreased secretion of MMP13 protein	18759268
C059514	resveratrol	SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]]	23257246
C059514	resveratrol	[Hyaluronic Acid co-treated with resveratrol] results in decreased expression of MMP13 mRNA	23595953
C059514	resveratrol	resveratrol results in decreased expression of MMP13 mRNA	23772162
C059514	resveratrol	resveratrol results in decreased activity of MMP13 protein	20825639
C059514	resveratrol	resveratrol results in decreased expression of MMP13 mRNA	20825639
C059514	resveratrol	resveratrol inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]	22936809
D015474	Isotretinoin	Isotretinoin inhibits the reaction [Arachidonic Acid results in increased expression of MMP13 mRNA]	16185265
D015474	Isotretinoin	Isotretinoin inhibits the reaction [Arachidonic Acid results in increased secretion of MMP13 protein]	16185265
D015474	Isotretinoin	Isotretinoin results in decreased expression of MMP13 protein	16185265
C089032	rimonabant	rimonabant results in decreased expression of MMP13 mRNA	21863215
D012402	Rotenone	Rotenone inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP13 protein]	17395008
D012402	Rotenone	Rotenone results in increased expression of MMP13 mRNA	19304788
C085746	rottlerin	"rottlerin inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP13 mRNA]"	16571779
C064294	sarpogrelate	sarpogrelate inhibits the reaction [Oxygen deficiency results in increased expression of MMP13 mRNA]	25931318
C093642	SB 203580	SB 203580 analog inhibits the reaction [IL1B results in increased expression of MMP13 mRNA]	19656660
C093642	SB 203580	SB 203580 inhibits the reaction [S100A4 protein results in increased expression of MMP13 protein]	16948116
C093642	SB 203580	SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP13 protein]	20004183
C093642	SB 203580	SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of MMP13 mRNA]	28329830
C093642	SB 203580	SB 203580 inhibits the reaction [gadolinium chloride results in increased expression of MMP13 mRNA]	12493575
C093642	SB 203580	SB 203580 inhibits the reaction [halofuginone results in increased expression of MMP13 mRNA]	16489207
C410733	scriptaid	scriptaid affects the expression of MMP13 mRNA	18813790
D012643	Selenium	Selenium inhibits the reaction [T-2 Toxin results in increased expression of MMP13 mRNA]	21144892
D012643	Selenium	Selenium inhibits the reaction [T-2 Toxin results in increased expression of MMP13 protein]	21144892
C078903	seocalcitol	seocalcitol results in decreased expression of MMP13 mRNA	12040012
D017632	Asbestos, Serpentine	"2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP13 mRNA]"	16571779
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in increased expression of MMP13 mRNA"	16571779\|2391707
D017632	Asbestos, Serpentine	"PRKDC protein affects the reaction [Asbestos, Serpentine results in increased expression of MMP13 mRNA]"	16571779
D017632	Asbestos, Serpentine	"rottlerin inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP13 mRNA]"	16571779
D017632	Asbestos, Serpentine	"tyrphostin AG 1478 inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP13 mRNA]"	16571779
D017632	Asbestos, Serpentine	"U 0126 inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP13 mRNA]"	16571779
D012834	Silver	Silver results in decreased expression of MMP13 mRNA	27131904
D019821	Simvastatin	Simvastatin results in increased expression of MMP13 mRNA	17428261
D019821	Simvastatin	Simvastatin results in increased expression of MMP13 mRNA	16274305
C017947	sodium arsenite	sodium arsenite results in decreased expression of MMP13 mRNA	12679051
C017947	sodium arsenite	sodium arsenite results in increased expression of MMP13 mRNA	16014739
D013311	Streptozocin	esculetin inhibits the reaction [Streptozocin results in increased expression of MMP13 mRNA]	21450970
D013311	Streptozocin	Streptozocin results in increased expression of MMP13 mRNA	21450970
D010042	Ouabain	Ouabain results in decreased expression of MMP13 mRNA	28795476
D012460	Sulfasalazine	Sulfasalazine inhibits the reaction [[IL1A protein co-treated with OSM protein] results in increased expression of MMP13 mRNA]	19690126
D012460	Sulfasalazine	Sulfasalazine inhibits the reaction [[IL1A protein co-treated with OSM protein] results in increased expression of MMP13 protein]	19690126
D018170	Sumatriptan	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of MMP13 protein]	22150557
D018170	Sumatriptan	Sumatriptan inhibits the reaction [Capsaicin results in increased expression of MMP13 protein]	22150557
D014284	Triiodothyronine	"4-OH-2',3,3',4',5'-pentachlorobiphenyl inhibits the reaction [Triiodothyronine results in increased expression of MMP13 mRNA]"	21523860
D014284	Triiodothyronine	bisphenol A inhibits the reaction [Triiodothyronine results in increased expression of MMP13 mRNA]	19228888
D014284	Triiodothyronine	Triiodothyronine results in increased expression of MMP13 mRNA	19228888\|2152386
D013605	T-2 Toxin	Selenium inhibits the reaction [T-2 Toxin results in increased expression of MMP13 mRNA]	21144892
D013605	T-2 Toxin	Selenium inhibits the reaction [T-2 Toxin results in increased expression of MMP13 protein]	21144892
D013605	T-2 Toxin	T-2 Toxin results in increased expression of MMP13 mRNA	21144892
D013605	T-2 Toxin	T-2 Toxin results in increased expression of MMP13 protein	21144892
D013605	T-2 Toxin	T-2 Toxin results in increased expression of MMP13 mRNA	22800716
C013698	tallow	tallow affects the expression of MMP13 mRNA	19680557
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of MMP13 mRNA	20728951
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MMP13 mRNA	17003102
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of MMP13 mRNA	19684285
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MMP13 mRNA	19684285
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MMP13 protein	15531779
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MMP13 mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to MMP13 promoter]	19654925
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MMP13	17003102
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MMP13 mRNA	16120747\|1797511
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MMP13	17003102
D013752	Tetracycline	Tetracycline analog inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]	17267227
D013752	Tetracycline	Tetracycline analog results in decreased activity of MMP13 protein	17267227
D013752	Tetracycline	Tetracycline inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]	17267227
C117153	tetracycline CMT-8	tetracycline CMT-8 results in decreased expression of MMP13 protein	11172683
D013755	Tetradecanoylphorbol Acetate	Glucosamine analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP13 mRNA]	19656660
D013755	Tetradecanoylphorbol Acetate	Peptides inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP13 mRNA]	20004183
D013755	Tetradecanoylphorbol Acetate	Peptides inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP13 protein]	20004183
D013755	Tetradecanoylphorbol Acetate	pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP13 protein]	20004183
D013755	Tetradecanoylphorbol Acetate	SB 203580 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP13 protein]	20004183
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of MMP13 mRNA	19656660\|2000418
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of MMP13 protein	20004183
D013755	Tetradecanoylphorbol Acetate	U 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP13 protein]	20004183
D013806	Theophylline	Theophylline results in increased expression of MMP13 mRNA	22982570
D013853	Thioacetamide	KRT18 protein affects the reaction [Thioacetamide results in increased expression of MMP13 mRNA]	18395095
D013853	Thioacetamide	Thioacetamide results in increased expression of MMP13 mRNA	18395095
D013853	Thioacetamide	halofuginone promotes the reaction [Thioacetamide results in increased expression of MMP13 mRNA]	16489207
D013853	Thioacetamide	Thioacetamide results in increased expression of MMP13 mRNA	16489207
D008063	Thioctic Acid	Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]	24975507
D008063	Thioctic Acid	Thioctic Acid inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]	24975507
D013893	Thiram	Thiram results in decreased expression of MMP13 mRNA	24235232
D013893	Thiram	Thiram results in increased expression of MMP13 mRNA	15899490
D013893	Thiram	VEGFA protein affects the reaction [Thiram results in decreased expression of MMP13 mRNA]	24235232
C003466	thymoquinone	thymoquinone inhibits the reaction [TGFB1 protein results in decreased expression of MMP13 protein]	27688165
C009495	titanium dioxide	titanium dioxide results in increased expression of MMP13 mRNA	19464567
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of MMP13 mRNA	20133372
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of MMP13 mRNA	28111298
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of MMP13 mRNA	25729387
D014212	Tretinoin	[Tretinoin co-treated with OSM protein] results in increased expression of MMP13 mRNA	16467367
D014212	Tretinoin	Cycloheximide inhibits the reaction [Tretinoin results in increased expression of MMP13 mRNA]	16350840
D014212	Tretinoin	Tretinoin results in increased expression of MMP13 mRNA	16350840
D014212	Tretinoin	Tretinoin results in increased expression of MMP13 mRNA	24977338
C012589	trichostatin A	[decitabine co-treated with trichostatin A] results in increased expression of MMP13 mRNA	17891453
C080163	trovafloxacin	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of MMP13 mRNA"	18930950
C406122	tyrphostin A9	tyrphostin A9 inhibits the reaction [S100A4 protein results in increased expression of MMP13 protein]	16948116
C101044	tyrphostin AG 1478	"tyrphostin AG 1478 inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP13 mRNA]"	16571779
C113580	U 0126	U 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP13 protein]	20004183
C113580	U 0126	"U 0126 inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP13 mRNA]"	16571779
D014635	Valproic Acid	Valproic Acid results in increased expression of MMP13 mRNA	22982570
D014635	Valproic Acid	Valproic Acid affects the expression of MMP13 mRNA	25979313
D001335	Vehicle Emissions	[Vehicle Emissions affects the reaction [APOE gene mutant form affects the susceptibility to Dietary Fats]] which results in decreased expression of MMP13 mRNA	19891982
D014700	Verapamil	Verapamil promotes the reaction [ferrous sulfate results in increased expression of MMP13 protein]	27095094
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical affects the expression of MMP13 mRNA"	25208076
C009687	wortmannin	wortmannin inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]	22936809
D015032	Zinc	TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA]	23503329
D015032	Zinc	[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of MMP13 mRNA	23503329
D015034	Zinc Oxide	Zinc Oxide analog results in decreased expression of MMP13 mRNA	27185063
D015054	Zymosan	[Lipopolysaccharides co-treated with Zymosan] results in decreased activity of MMP13 protein	15259001
D015054	Zymosan	[Lipopolysaccharides co-treated with Zymosan] results in increased activity of MMP13 protein	15259001

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004222	metalloendopeptidase activity	-	IDA	8576151 9065415
GO:0004222	metalloendopeptidase activity	-	TAS	-
GO:0004252	serine-type endopeptidase activity	-	TAS	-
GO:0005509	calcium ion binding	-	IDA	23913860
GO:0005518	collagen binding	-	IDA	9065415
GO:0008270	zinc ion binding	-	IDA	23913860

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001958	endochondral ossification	-	IEA	-
GO:0003417	growth plate cartilage development	-	IEA	-
GO:0006508	proteolysis	-	IEA	-
GO:0022617	extracellular matrix disassembly	-	IMP	8576151 9065415
GO:0022617	extracellular matrix disassembly	-	TAS	-
GO:0030282	bone mineralization	-	IEA	-
GO:0030574	collagen catabolic process	-	IDA	8576151 9065415
GO:0030574	collagen catabolic process	-	TAS	-
GO:0044267	cellular protein metabolic process	-	IEA	-
GO:0060349	bone morphogenesis	-	IDA	16167086

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	TAS	8207000
GO:0031012	extracellular matrix	-	IEA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1442490	Collagen degradation	IEA
R-HSA-1442490	Collagen degradation	TAS
R-HSA-1474228	Degradation of the extracellular matrix	TAS
R-HSA-1474228	Degradation of the extracellular matrix	IEA
R-HSA-1474244	Extracellular matrix organization	TAS
R-HSA-1474244	Extracellular matrix organization	IEA
R-HSA-1474290	Collagen formation	TAS
R-HSA-1592389	Activation of Matrix Metalloproteinases	TAS
R-HSA-2022090	Assembly of collagen fibrils and other multimeric structures	TAS
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8878166	Transcriptional regulation by RUNX2	TAS
R-HSA-8941332	RUNX2 regulates genes involved in cell migration	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
19436652	Lipid-soluble cigarette smoking particles induce expression of inflammatory and extracellular-matrix-related genes in rat cerebral arteries. (2009)	Vikman P	Vasc Health Risk Manag
29744169	Inflammatory mediator polymorphisms associate with initial periodontitis in adolescents. (2016 Dec)	Heikkinen AM	Clin Exp Dent Res
26351771	Cigarette smoke modulates PC3 prostate cancer cell migration by altering adhesion molecules and the extracellular matrix. (2015 Nov)	Yang S	Mol Med Rep
20020508	Human cleft lip and palate fibroblasts and normal nicotine-treated fibroblasts show altered in vitro expressions of genes related to molecular signaling pathways and extracellular matrix metabolism. (2010 Mar)	Baroni T	J Cell Physiol