Gene: MMP14

4323
MMP-14|MMP-X1|MT-MMP|MT-MMP 1|MT1-MMP|MT1MMP|MTMMP1|WNCHRS
matrix metallopeptidase 14
protein-coding
14q11.2
Ensembl:ENSG00000157227 MIM:600754 Vega:OTTHUMG00000028704 UniprotKB:P50281
NG_046989.1
PubMed
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.766e-1 (AD)  4.807e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg10576725chr14:23306974MMP146.740e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TGFB10.866
MYD880.862
LTBR0.858
PLP20.851
ANO60.85
ANXA20.847
CLIC10.846
CXCL160.845
EMP30.844
DRAM10.84

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC7A4-0.554
KCNB2-0.517
ABCC12-0.504
BCL11A-0.501
MARCH4-0.498
PPEF1-0.495
NEUROD6-0.49
DRD5-0.489
CALHM1-0.482
B3GALT2-0.479

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00786MarimastatSmall Molecule154039-60-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C4760362-(2-(4-chlorophenyl)ethoxy)adenosine2-(2-(4-chlorophenyl)ethoxy)adenosine results in decreased expression of MMP14 mRNA16783407
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased expression of MMP14 mRNA]19661247
C0388902,3,4,7,8-pentachlorodibenzofuran"2,3,4,7,8-pentachlorodibenzofuran results in decreased expression of MMP14 mRNA"21724226
C0131862,3-pentanedione"2,3-pentanedione results in increased expression of MMP14 mRNA"25710175
C0612822-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine results in decreased activity of MMP14 protein16783407
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MMP14 mRNA"21346803
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of MMP14 protein22326785
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MMP14 mRNA19393235|2232678
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MMP14 protein19393235
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of MMP14 mRNA"23196670
C5446713-caffeoyl-4-dihydrocaffeoylquinic acid3-caffeoyl-4-dihydrocaffeoylquinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP14 mRNA]20599481
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MMP14 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MMP14 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MMP14 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MMP14 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MMP14 mRNA"27188386
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of MMP14 mRNA20829426
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MMP14 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MMP14 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MMP14 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MMP14 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MMP14 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of MMP14 mRNA17562736
D000171Acrolein2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased expression of MMP14 mRNA]19661247
D000171AcroleinAcrolein binds to MMP14 protein19661247
D000171AcroleinAcrolein results in increased activity of MMP14 protein19661247
D000171AcroleinAcrolein results in increased expression of MMP14 mRNA19661247
D000171Acroleinhexaarginine amide inhibits the reaction [Acrolein results in increased activity of MMP14 protein]19661247
D000171AcroleinMMP14 protein affects the reaction [Acrolein results in increased expression of MUC5AC mRNA]19661247
D000171AcroleinN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Acrolein results in increased expression of MMP14 mRNA]19661247
D000171Acroleinpyrazolanthrone inhibits the reaction [Acrolein results in increased expression of MMP14 mRNA]19661247
D000171Acroleintyrphostin AG 1478 inhibits the reaction [Acrolein results in increased expression of MMP14 mRNA]19661247
D000171AcroleinAcrolein results in increased expression of and results in increased activity of MMP14 protein19661247
D000171AcroleinAcrolein results in increased expression of MMP14 mRNA19661247
D000171AcroleinErlotinib Hydrochloride inhibits the reaction [Acrolein results in increased expression of MMP14 mRNA]19661247
D020106AcrylamideAcrylamide results in decreased expression of MMP14 mRNA28959563
C482289Ageladine AAgeladine A results in decreased activity of MMP14 protein21413800
D000629AminopropionitrileAminopropionitrile results in decreased activity of MMP14 protein24014025
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MMP14 mRNA16483693
C006632arsenic trioxidearsenic trioxide affects the expression of MMP14 mRNA21969006
C006632arsenic trioxide[arsenic trioxide co-treated with silybin] results in decreased expression of MMP14 mRNA21969006
C006632arsenic trioxidearsenic trioxide inhibits the reaction [silybin results in increased expression of MMP14 mRNA]21969006
C006632arsenic trioxidearsenic trioxide results in decreased expression of MMP14 mRNA15962302|2703980
C006632arsenic trioxidearsenic trioxide results in decreased expression of MMP14 protein15962302
C006632arsenic trioxidearsenic trioxide promotes the reaction [Berberine results in decreased expression of MMP14 protein]18294404
D001241AspirinAspirin inhibits the reaction [AGT protein modified form results in increased expression of MMP14 mRNA]22306536
C547126AZM551248AZM551248 results in increased expression of MMP14 mRNA22323515
D001464BariumBarium results in increased expression of MMP14 protein23804419
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MMP14 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MMP14 mRNA27858113
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of MMP14 mRNA18164116
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MMP14 mRNA27858113
D001599Berberinearsenic trioxide promotes the reaction [Berberine results in decreased expression of MMP14 protein]18294404
D001599BerberineBerberine results in decreased expression of MMP14 protein18294404
D004958EstradiolEstradiol affects the expression of MMP14 mRNA22574217
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of MMP14 protein18829229
D004958EstradiolEstradiol inhibits the reaction [Progesterone results in increased expression of MMP14 mRNA]18692832
D004958EstradiolEstradiol results in increased expression of MMP14 mRNA18829229
D004958EstradiolEstradiol results in increased expression of MMP14 protein18829229
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of MMP14 mRNA17404688
D004958EstradiolEstradiol results in increased expression of MMP14 mRNA19484750
C095105bexarotenebexarotene results in decreased expression of MMP14 mRNA16648578
C004541biochanin Abiochanin A results in decreased expression of MMP14 protein16598420
C034786bis(4-hydroxycinnamoyl)methanebis(4-hydroxycinnamoyl)methane results in decreased expression of MMP14 protein18495463
C006780bisphenol Abisphenol A results in increased expression of MMP14 mRNA25619500|2768578
C006780bisphenol Abisphenol A affects the methylation of MMP14 promoter27334623
C006780bisphenol Abisphenol A affects the expression of MMP14 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MMP14 gene28505145
D002101Cacodylic AcidCacodylic Acid results in increased expression of MMP14 mRNA17441966
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of MMP14 mRNA26238599
D002211CapsaicinCapsaicin inhibits the reaction [EGF results in increased expression of MMP14]21462327
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of MMP14 mRNA15056808|1826369
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of MMP14 mRNA15963342
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of MMP14 mRNA19395590
C097658CGS 27023ACGS 27023A affects the activity of MMP14 protein22017477
D002713Chlorine[Ozone co-treated with Chlorine] results in decreased expression of MMP14 mRNA18636392
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of MMP14 mRNA27858113
D002922CiguatoxinsCiguatoxins affects the expression of MMP14 mRNA18353800
D060729Coal AshCoal Ash results in increased expression of MMP14 mRNA19000753
C018021cobaltous chloridecobaltous chloride results in decreased expression of MMP14 mRNA19320972
C018021cobaltous chloridecobaltous chloride results in decreased expression of MMP14 mRNA24386269
D003042CocaineCocaine affects the expression of MMP14 mRNA20187946
C015763cumene[cumene co-treated with KRAS gene mutant form] results in decreased expression of MMP14 mRNA18648096
D003471CuprizoneCuprizone results in increased expression of MMP14 mRNA26577399
D003474CurcuminCurcumin results in decreased expression of MMP14 protein18495463
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP14 mRNA]18200517
D003474CurcuminCurcumin inhibits the reaction [Indomethacin results in decreased expression of MMP14 protein]16934674
D016572CyclosporineCyclosporine results in increased expression of MMP14 mRNA20106945
D003543CysteamineCysteamine results in increased expression of MMP14 mRNA22532830
D003543CysteamineCysteamine results in increased expression of MMP14 protein22532830
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of MMP14 mRNA23640034
C014347decitabinedecitabine results in increased expression of MMP14 mRNA27915011
C050229demethoxycurcumindemethoxycurcumin results in decreased expression of MMP14 protein18495463
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MMP14 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MMP14 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MMP14 mRNA21266533
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of MMP14 mRNA18164116
C039060dihydroartemisinindihydroartemisinin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP14 mRNA]20152819
C039060dihydroartemisinindihydroartemisinin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP14 protein]20152819
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of MMP14 mRNA"19480007
D004128Dimethylnitrosamine[Dimethylnitrosamine co-treated with gadolinium chloride] results in increased expression of MMP14 mRNA12493575
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of MMP14 protein18371158
D004128Dimethylnitrosamine"Drugs, Chinese Herbal inhibits the reaction [Dimethylnitrosamine results in increased expression of MMP14 protein]"18371158
D004237DiuronDiuron results in decreased expression of MMP14 mRNA25152437
D004317DoxorubicinDoxorubicin results in increased activity of MMP14 protein19782292
D004317DoxorubicinDoxorubicin results in increased expression of MMP14 mRNA19782292
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal inhibits the reaction [Dimethylnitrosamine results in increased expression of MMP14 protein]"18371158
D004391DustDust results in increased expression of MMP14 mRNA17805423
D000069347Erlotinib HydrochlorideErlotinib Hydrochloride inhibits the reaction [Acrolein results in increased expression of MMP14 mRNA]19661247
D004967Estrogens[Estrogens co-treated with Progesterone co-treated with IL1B protein] results in increased expression of MMP14 mRNA18570937
D004967EstrogensEstrogens results in increased expression of MMP14 protein18570937
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MMP14 mRNA15576828
C024565ethylene dichlorideethylene dichloride results in increased expression of MMP14 mRNA28189721
D018120FinasterideFinasteride results in increased expression of MMP14 mRNA24136188
D005485FlutamideFlutamide results in decreased expression of MMP14 mRNA24136188
C067584formosanin Cformosanin C results in decreased expression of MMP14 protein21304274
C039281furanfuran results in increased methylation of MMP14 gene22079235
C038958gadolinium chloride[Dimethylnitrosamine co-treated with gadolinium chloride] results in increased expression of MMP14 mRNA12493575
C038958gadolinium chloridegadolinium chloride results in increased expression of MMP14 mRNA12493575
C038958gadolinium chloridegadolinium chloride results in increased expression of MMP14 protein12493575
D019833GenisteinGenistein results in decreased expression of MMP14 mRNA15754008
D019833GenisteinGenistein results in decreased expression of MMP14 protein16598420
D019833GenisteinGenistein results in increased expression of MMP14 mRNA22228119
D005947GlucoseGlucose results in decreased expression of MMP14 protein21367880
D005947Glucoseisoangustone A inhibits the reaction [Glucose results in decreased expression of MMP14 protein]21367880
D006493HeparinHeparin analog results in decreased expression of MMP14 mRNA26476401
C492739hexaarginine amidehexaarginine amide inhibits the reaction [Acrolein results in increased activity of MMP14 protein]19661247
D017313FenretinideFenretinide results in increased expression of MMP14 mRNA28973697
C031927hydroquinone[MMP14 protein co-treated with TIMP2 protein] inhibits the reaction [hydroquinone results in decreased activity of MMP2 protein]18055817
C031927hydroquinoneMMP14 protein inhibits the reaction [hydroquinone results in decreased activity of MMP2 protein]18055817
C031927hydroquinoneMMP14 protein inhibits the reaction [hydroquinone results in increased expression of COL1A1 protein]18055817
C031927hydroquinoneMMP14 protein inhibits the reaction [hydroquinone results in increased expression of COL4A1 protein]18055817
C031927hydroquinoneMMP14 protein inhibits the reaction [hydroquinone results in increased expression of LAMA4 protein]18055817
C031927hydroquinone[TIMP2 protein co-treated with MMP14 protein] inhibits the reaction [hydroquinone results in increased expression of COL1A1 protein]18055817
C031927hydroquinone[TIMP2 protein co-treated with MMP14 protein] inhibits the reaction [hydroquinone results in increased expression of COL4A1 protein]18055817
C031927hydroquinone[TIMP2 protein co-treated with MMP14 protein] inhibits the reaction [hydroquinone results in increased expression of LAMA4 protein]18055817
C079053IH 764-3IH 764-3 inhibits the reaction [Paraquat results in increased expression of MMP14 mRNA]22804981
C016517indole-3-carbinolindole-3-carbinol affects the expression of MMP14 mRNA21396975
D007213IndomethacinCurcumin inhibits the reaction [Indomethacin results in decreased expression of MMP14 protein]16934674
D007213IndomethacinIndomethacin results in decreased expression of MMP14 protein16934674
D007213IndomethacinMelatonin inhibits the reaction [Indomethacin results in decreased expression of MMP14 protein]16934674
D007213IndomethacinOmeprazole inhibits the reaction [Indomethacin results in decreased expression of MMP14 protein]16934674
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MMP14 mRNA25613284
C551631isoangustone Aisoangustone A inhibits the reaction [Glucose results in decreased expression of MMP14 protein]21367880
D007545IsoproterenolIsoproterenol results in increased expression of MMP14 mRNA21335049
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MMP14 mRNA24796395|2596192
D007649KetamineKetamine results in decreased expression of MMP14 mRNA20080153
C572783kuguacin Jkuguacin J results in decreased expression of MMP14 mRNA22266361
C008261lead acetatelead acetate results in decreased expression of MMP14 mRNA22641619
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of MMP14 mRNA12057914
D019808LosartanLosartan inhibits the reaction [AGT protein modified form results in increased expression of MMP14 mRNA]22306536
C100796lysine tyrosylquinonelysine tyrosylquinone results in increased activity of MMP14 protein24014025
D008345ManganeseManganese results in decreased expression of MMP14 protein17043766
D061965Matrix Metalloproteinase InhibitorsMatrix Metalloproteinase Inhibitors inhibits the reaction [sodium arsenite results in increased expression of MMP14 protein]24816914
D008550MelatoninMelatonin inhibits the reaction [Indomethacin results in decreased expression of MMP14 protein]16934674
C042720mercuric bromidemercuric bromide results in increased expression of MMP14 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MMP14 mRNA"27188386
D008687MetforminMetformin inhibits the reaction [IL13 protein results in increased expression of MMP14 mRNA]26497364
D008731MethoxychlorMethoxychlor affects the expression of MMP14 mRNA20829426
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MMP14 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MMP14 mRNA28001369
D015735MifepristoneMifepristone results in increased expression of MMP14 mRNA17584828
D016685MitomycinMitomycin results in decreased expression of MMP14 mRNA12760830
C078131N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamideN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Acrolein results in increased expression of MMP14 mRNA]19661247
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of MMP14 mRNA"23845593
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MMP14 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MMP14 mRNA"25554681|2562005
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of MMP14 mRNA15913567
D0150581-Naphthylisothiocyanate"O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of MMP14 mRNA]"15913567
C017096n-butoxyethanoln-butoxyethanol results in increased expression of MMP14 mRNA19812364
C029938nickel sulfatenickel sulfate results in increased expression of MMP14 mRNA16100012
C107010O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate"O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of MMP14 mRNA]"15913567
D009853OmeprazoleOmeprazole inhibits the reaction [Indomethacin results in decreased expression of MMP14 protein]16934674
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of MMP14 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of MMP14 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of MMP14 mRNA24205000
D010100OxygenOxygen deficiency results in increased expression of MMP14 mRNA16980344
D010100OxygenOxygen deficiency results in increased expression of MMP14 protein16980344
D010126Ozone[Ozone co-treated with Chlorine] results in decreased expression of MMP14 mRNA18636392
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MMP14 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of MMP14 mRNA26272509
D010269ParaquatParaquat results in increased expression of MMP14 mRNA26345256
D010269ParaquatIH 764-3 inhibits the reaction [Paraquat results in increased expression of MMP14 mRNA]22804981
D010269ParaquatParaquat results in increased expression of MMP14 mRNA22804981
C074968pentaacetyl geniposidepentaacetyl geniposide results in decreased expression of MMP14 mRNA19464279
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of MMP14 mRNA19162173
D010634PhenobarbitalPhenobarbital affects the expression of MMP14 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of MMP14 mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MMP14 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of MMP14 mRNA26272509
C004479pimagedinepimagedine results in increased expression of MMP14 mRNA18380797
C008922piperinepiperine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP14 mRNA]21354279
C008922piperinepiperine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP14 protein]21354279
C006253pirinixic acidpirinixic acid results in decreased expression of MMP14 mRNA19162173
D010936Plant ExtractsPlant Extracts results in decreased expression of MMP14 mRNA23557933
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of MMP14 mRNA27989595
D011192Potassium DichromatePotassium Dichromate results in increased expression of MMP14 protein23718831
D017035PravastatinPravastatin results in decreased expression of MMP14 mRNA16935385
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of MMP14 mRNA19162173
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of MMP14 protein18829229
D011374ProgesteroneEstradiol inhibits the reaction [Progesterone results in increased expression of MMP14 mRNA]18692832
D011374Progesterone[Estrogens co-treated with Progesterone co-treated with IL1B protein] results in increased expression of MMP14 mRNA18570937
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of MMP14 mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of MMP14 mRNA18692832|2660402
C045950propiconazolepropiconazole results in decreased expression of MMP14 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in increased expression of MMP14 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of MMP14 mRNA27029645
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Acrolein results in increased expression of MMP14 mRNA]19661247
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of MMP14 mRNA21427059
C010327salinomycinsalinomycin results in decreased expression of MMP14 mRNA19682730
D012643SeleniumSelenium results in decreased expression of MMP14 mRNA17390030
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of MMP14 mRNA"21514415
D012822Silicon DioxideSilicon Dioxide results in decreased expression of MMP14 mRNA23623845
C440975silybin[arsenic trioxide co-treated with silybin] results in decreased expression of MMP14 mRNA21969006
C440975silybinarsenic trioxide inhibits the reaction [silybin results in increased expression of MMP14 mRNA]21969006
D012906SmokeSmoke results in decreased expression of MMP14 mRNA21095227
C017947sodium arseniteMatrix Metalloproteinase Inhibitors inhibits the reaction [sodium arsenite results in increased expression of MMP14 protein]24816914
C017947sodium arsenitesodium arsenite results in increased expression of MMP14 mRNA24816914
C017947sodium arsenitesodium arsenite results in increased expression of MMP14 protein24816914
C017947sodium arsenitesodium arsenite results in decreased expression of MMP14 mRNA16014739
C017947sodium arsenitesodium arsenite results in increased expression of MMP14 protein18569616
C017947sodium arsenite[sodium arsenite results in increased expression of MMP14 protein] which results in increased activity of MMP2 protein18569616
C017947sodium arsenite[sodium arsenite results in increased expression of MMP14 protein] which results in increased expression of MMP2 protein modified form18569616
D053260SootSoot results in increased expression of MMP14 mRNA22461453|2655175
D013467SulindacSulindac results in decreased expression of MMP14 mRNA24136188
D013629TamoxifenTamoxifen results in decreased expression of MMP14 mRNA19393235
D013629TamoxifenTamoxifen results in decreased expression of MMP14 protein19393235
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MMP14 mRNA21570461|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MMP14 mRNA16120747
C117155tetracycline CMT-3tetracycline CMT-3 inhibits the reaction [MMP14 protein results in increased metabolism of and results in increased activity of MMP2 protein]11172680
C117155tetracycline CMT-3tetracycline CMT-3 results in decreased activity of MMP14 protein11172680
D013755Tetradecanoylphorbol Acetate3-caffeoyl-4-dihydrocaffeoylquinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP14 mRNA]20599481
D013755Tetradecanoylphorbol Acetatedihydroartemisinin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP14 mRNA]20152819
D013755Tetradecanoylphorbol Acetatedihydroartemisinin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP14 protein]20152819
D013755Tetradecanoylphorbol Acetatepiperine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP14 mRNA]21354279
D013755Tetradecanoylphorbol Acetatepiperine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP14 protein]21354279
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of MMP14 mRNA20152819|2059948
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of MMP14 protein20152819|2135427
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MMP14 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of MMP14 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of MMP14 mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MMP14 mRNA28111298
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of and results in increased activity of MMP14 protein19661247
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of MMP14 mRNA25729387
D019772TopotecanTopotecan results in increased expression of MMP14 mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of MMP14 mRNA"19682533
D014192TrapidilTrapidil affects the reaction [PTH protein affects the expression of MMP14 mRNA]18635661
C012589trichostatin Atrichostatin A affects the expression of MMP14 mRNA28542535
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MMP14 mRNA]18200517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of MMP14 mRNA18200517
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [Acrolein results in increased expression of MMP14 mRNA]19661247
C113580U 0126U 0126 results in decreased activity of MMP14 protein22326785
C113580U 0126U 0126 results in decreased expression of MMP14 mRNA19393235|2232678
C113580U 0126U 0126 results in decreased expression of MMP14 protein19393235
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MMP14 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of MMP14 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MMP14 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of MMP14 mRNA26272509
D014635Valproic AcidValproic Acid results in increased methylation of MMP14 gene29154799
D014635Valproic AcidValproic Acid affects the expression of MMP14 mRNA17292431
D014635Valproic AcidValproic Acid results in decreased expression of MMP14 mRNA20546886|2142705
D014638VanadatesVanadates results in increased expression of MMP14 mRNA22714537
D014639VanadiumVanadium results in increased expression of MMP14 mRNA19000753
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MMP14 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of MMP14 mRNA26272509
C087958YM 529YM 529 results in decreased expression of and results in decreased activity of MMP14 protein22326785
C087958YM 529YM 529 results in decreased expression of MMP14 mRNA22326785
C521292YSNSG cyclopeptideYSNSG cyclopeptide results in decreased activity of MMP14 protein19551865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004222metalloendopeptidase activity-ISS-  
GO:0004222metalloendopeptidase activity-TAS-  
GO:0004252serine-type endopeptidase activity-TAS-  
GO:0005178integrin binding-IEA-  
GO:0005515protein binding-IPI12220632  14718544  18164686  20608975  20798051  21219645  
21572390  22065321  24112707  25304424  25416956  
GO:0008270zinc ion binding-IEA-  
GO:0016504peptidase activator activity-IEA-  
GO:0070006metalloaminopeptidase activity-IDA24970228  
GO:0070006metalloaminopeptidase activity-TAS14645246  
GO ID GO Term Qualifier Evidence PubMed
GO:0001525angiogenesis-IEA-  
GO:0001541ovarian follicle development-IEA-  
GO:0001666response to hypoxia-IEA-  
GO:0001935endothelial cell proliferation-IEA-  
GO:0001958endochondral ossification-IEA-  
GO:0006508proteolysis-IDA15863497  24970228  
GO:0006508proteolysis-TAS14645246  
GO:0006979response to oxidative stress-IEA-  
GO:0008584male gonad development-IEA-  
GO:0009612response to mechanical stimulus-IEA-  
GO:0009725response to hormone-IEA-  
GO:0010831positive regulation of myotube differentiation-ISS-  
GO:0010952positive regulation of peptidase activity-IEA-  
GO:0014070response to organic cyclic compound-IEA-  
GO:0016485protein processing-TAS24970228  
GO:0022617extracellular matrix disassembly-TAS-  
GO:0030307positive regulation of cell growth-IDA22065321  
GO:0030324lung development-IEA-  
GO:0030335positive regulation of cell migration-IDA22065321  
GO:0030574collagen catabolic process-TAS-  
GO:0031638zymogen activation-IEA-  
GO:0035987endodermal cell differentiation-IEP23154389  
GO:0035988chondrocyte proliferation-IEA-  
GO:0043615astrocyte cell migration-IEA-  
GO:0043627response to estrogen-IEA-  
GO:0045579positive regulation of B cell differentiation-ISS-  
GO:0045746negative regulation of Notch signaling pathway-ISS-  
GO:0048701embryonic cranial skeleton morphogenesis-IEA-  
GO:0048754branching morphogenesis of an epithelial tube-IEA-  
GO:0048771tissue remodeling-IEA-  
GO:0048870cell motility-TAS14645246  
GO:0051895negative regulation of focal adhesion assembly-IEA-  
GO:0060322head development-IEA-  
GO:0097094craniofacial suture morphogenesis-IEA-  
GO:1905523positive regulation of macrophage migration-IEA-  
GO:1990834response to odorant-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IMP24784232  
GO:0005634nucleus-IMP24784232  
GO:0005737cytoplasmcolocalizes_withIDA22065321  
GO:0005796Golgi lumen-TAS-  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA15351710  24859005  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS8015608  
GO:0005925focal adhesion-HDA21423176  
GO:0031012extracellular matrix-IEA-  
GO:0031410cytoplasmic vesicle-IDA24859005  
GO:0042470melanosome-IEA-  
GO:0044354macropinosome-IDA24859005  
GO:0045111intermediate filament cytoskeleton-IDA-  
KEGG ID KEGG Term
hsa04912GnRH signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1442490Collagen degradationIEA
R-HSA-1442490Collagen degradationTAS
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474228Degradation of the extracellular matrixIEA
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1592389Activation of Matrix MetalloproteinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19661247Matrix metalloproteinase-14 mediates a phenotypic shift in the airways to increase mucin production. (2009 Nov 1)Deshmukh HSAm J Respir Crit Care Med
23499464Novel proteolytic microvesicles released from human macrophages after exposure to tobacco smoke. (2013 May)Li CJAm J Pathol