Gene: MMP15

4324
MMP-15|MT2-MMP|MT2MMP|MTMMP2|SMCP-2
matrix metallopeptidase 15
protein-coding
16q21
Ensembl:ENSG00000102996 MIM:602261 Vega:OTTHUMG00000133466 UniprotKB:P51511
NC_000016.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.833e-1 (AD)  4.462e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11648508chr16:58029609 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM132A0.818
GPR1370.798
TMEM184B0.788
RNF2080.777
GAS2L10.767
RHBDL10.766
B4GALNT40.766
GPSM10.764
WDR240.763
CHPF0.762

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.536
OR4F29-0.476
TFPI2-0.458
CNTF-0.421
NR5A2-0.412
SPTLC3-0.393
CXorf65-0.384
PABPC4L-0.383
GAPT-0.382
DPPA4-0.381

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00786MarimastatSmall Molecule154039-60-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of MMP15 mRNA"22698814
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of MMP15 mRNA]"22698814
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of MMP15 mRNA"25380136
D000082AcetaminophenAcetaminophen affects the expression of MMP15 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of MMP15 gene28458013
D000447AldehydesAldehydes results in increased expression of MMP15 mRNA25014914
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of MMP15 mRNA18585445
D001151ArsenicArsenic results in increased methylation of MMP15 promoter21291286
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of MMP15 mRNA18585445
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of MMP15 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MMP15 mRNA22228805
D004958EstradiolEstradiol results in decreased expression of MMP15 mRNA15072547
C006780bisphenol A[potassium bromate co-treated with bisphenol A] affects the expression of MMP15 mRNA27082013
C006780bisphenol A[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of MMP15 mRNA]27082013
C006780bisphenol Abisphenol A affects the expression of MMP15 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of MMP15 mRNA26079696
C584509C646 compoundC646 compound results in decreased expression of MMP15 mRNA26676548
C081643candesartancandesartan results in increased expression of MMP15 mRNA19047581
D002737ChloropreneChloroprene results in decreased expression of MMP15 mRNA23125180
D019327Copper SulfateCopper Sulfate results in decreased expression of MMP15 mRNA19549813
C030973cupric oxidecupric oxide results in increased expression of MMP15 protein25470785
D016572CyclosporineCyclosporine results in decreased expression of MMP15 mRNA19770486
C014347decitabinedecitabine results in increased expression of MMP15 mRNA27915011
D003976DiazinonDiazinon results in increased methylation of MMP15 gene22964155
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of MMP15 mRNA27392435
D002945CisplatinCisplatin results in increased expression of MMP15 mRNA12066199|2739243
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of MMP15 mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of MMP15 mRNA18042831
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of MMP15 mRNA25380136
C024565ethylene dichlorideethylene dichloride results in decreased expression of MMP15 mRNA28189721
C070081fulvestrantfulvestrant results in increased expression of MMP15 mRNA15072547
D019833GenisteinGenistein results in decreased expression of MMP15 mRNA15754008
C031927hydroquinonehydroquinone affects the expression of MMP15 mRNA15452088
C475919hydroxytamoxifenhydroxytamoxifen results in decreased expression of MMP15 mRNA15072547
D007545IsoproterenolIsoproterenol results in decreased expression of MMP15 mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of MMP15 mRNA27392435
C544151jinfukangjinfukang results in increased expression of MMP15 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of MMP15 mRNA24796395
D008727MethotrexateMethotrexate results in increased expression of MMP15 mRNA21678067
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of MMP15 mRNA"20188158
C517284monomethyl phthalatemonomethyl phthalate affects the expression of MMP15 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MMP15 mRNA"23634900
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MMP15 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MMP15 mRNA"25554681|2562005
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of MMP15 mRNA25380136
C029938nickel sulfatenickel sulfate results in decreased expression of MMP15 mRNA16166746
D009966OrphenadrineOrphenadrine affects the expression of MMP15 mRNA23665939
D000073878Palm OilPalm Oil results in increased expression of MMP15 mRNA18042831
C046012pentanalpentanal results in increased expression of MMP15 mRNA26079696
C019536potassium bromate[potassium bromate co-treated with bisphenol A] affects the expression of MMP15 mRNA27082013
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [[potassium bromate co-treated with bisphenol A] affects the expression of MMP15 mRNA]27082013
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of MMP15 mRNA28903501
C045950propiconazolepropiconazole results in decreased expression of MMP15 mRNA21278054
C005556propionaldehydepropionaldehyde results in increased expression of MMP15 mRNA26079696
D012643SeleniumSelenium results in decreased expression of MMP15 mRNA17390030
D012715Sesame OilSesame Oil results in decreased expression of MMP15 mRNA29191790
D012822Silicon DioxideSilicon Dioxide results in decreased expression of MMP15 mRNA23221170
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MMP15 mRNA19770486|2597527
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MMP15 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MMP15 mRNA21215274
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MMP15 mRNA28065790
D014118Toxins, Biological"Toxins, Biological affects the expression of MMP15 mRNA"19682533
D014212TretinoinTretinoin results in increased expression of MMP15 mRNA23724009
D014212TretinoinTretinoin results in increased expression of MMP15 mRNA20488242
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of MMP15 mRNA19042947
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of MMP15 mRNA17982090
C057693troglitazonetroglitazone results in decreased expression of MMP15 mRNA28973697
D014415TunicamycinTunicamycin results in decreased expression of MMP15 mRNA17127020
D014635Valproic AcidValproic Acid results in increased methylation of MMP15 gene29154799
D014635Valproic AcidValproic Acid affects the expression of MMP15 mRNA17963808
C111237vorinostatvorinostat results in decreased expression of MMP15 mRNA20060208

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004222metalloendopeptidase activity-TAS-  
GO:0005515protein binding-IPI15248212  
GO:0008047enzyme activator activity-TAS7559440  
GO:0008270zinc ion binding-IEA-  
GO:0070006metalloaminopeptidase activity-TAS14645246  
GO ID GO Term Qualifier Evidence PubMed
GO:0006464cellular protein modification process-TAS7559440  
GO:0006508proteolysis-TAS14645246  
GO:0022617extracellular matrix disassembly-TAS-  
GO:0030574collagen catabolic process-TAS-  
GO:0032355response to estradiol-IEA-  
GO:0035987endodermal cell differentiation-IEP23154389  
GO:0043085positive regulation of catalytic activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IEA-  
GO:0031012extracellular matrix-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1442490Collagen degradationTAS
R-HSA-1474228Degradation of the extracellular matrixTAS
R-HSA-1474228Degradation of the extracellular matrixIEA
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1592389Activation of Matrix MetalloproteinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal