Gene info: ID 4329

Gene: ALDH6A1

GENE ID: 4329

Synonyms: MMSADHA|MMSDH

Description: aldehyde dehydrogenase 6 family member A1

Gene type: protein-coding

Location: 14q24.3

dbXrefs: Ensembl:ENSG00000119711 MIM:603178 Vega:OTTHUMG00000171203 UniprotKB:Q02252

RefSeq: NG_012257.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: AD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.420e-1 (AD) 3.551e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RAB31	0.926
ALDH7A1	0.919
GOLIM4	0.915
ALDH9A1	0.913
TP53BP2	0.911
MSI2	0.911
HSDL2	0.906
STOX1	0.906
AMOT	0.902
HADHB	0.899

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.5
OR4F29	-0.492
CACNA1F	-0.449
NRG1	-0.422
OSBPL10	-0.408
GALNT14	-0.406
TRABD2A	-0.406
QRFPR	-0.399
DUSP27	-0.397
ADTRP	-0.396

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of ALDH6A1 mRNA"	17998271\|2249639
C483839	2,2',3,4,4',5',6-heptabromodiphenyl ether	"[2,2',3,4,4',5',6-heptabromodiphenyl ether co-treated with hexabromocyclododecane co-treated with tetrabromobisphenol A co-treated with tetrabromobisphenol-S-bis(2,3-dibromopropyl ether) co-treated with hexabromobenzene] results in decreased expression of ALDH6A1 protein"	18258299
C483839	2,2',3,4,4',5',6-heptabromodiphenyl ether	"[2,2',3,4,4',5',6-heptabromodiphenyl ether co-treated with hexabromocyclododecane co-treated with tetrabromobisphenol A co-treated with tetrabromobisphenol-S-bis(2,3-dibromopropyl ether) co-treated with hexabromobenzene] results in increased expression of ALDH6A1 protein"	18258299
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl results in increased expression of ALDH6A1 mRNA"	23829299
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ALDH6A1 mRNA"	19114083
C063002	2,3-dimethoxy-1,4-naphthoquinone	"2,3-dimethoxy-1,4-naphthoquinone results in decreased expression of ALDH6A1 mRNA"	17547211
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of ALDH6A1 mRNA"	21346803
C009407	2,5,2',5'-tetrachlorobiphenyl	"2,5,2',5'-tetrachlorobiphenyl results in decreased expression of ALDH6A1 mRNA"	23829299
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of ALDH6A1 mRNA"	21346803
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased expression of ALDH6A1 mRNA	19191707
D000082	Acetaminophen	Acetaminophen results in decreased expression of ALDH6A1 mRNA	25704631\|2906747
D000082	Acetaminophen	Acetaminophen affects the expression of ALDH6A1 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of ALDH6A1 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of ALDH6A1 mRNA	22100608\|2715375
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of ALDH6A1 mRNA	19770486
D000393	Air Pollutants	Air Pollutants analog results in decreased expression of ALDH6A1 mRNA	21757418
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin affects the expression of ALDH6A1 protein	26597043
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin analog affects the expression of ALDH6A1 protein	26597043
D000499	Allylamine	Allylamine affects the expression of ALDH6A1 mRNA	15910882
D000638	Amiodarone	Amiodarone results in increased expression of ALDH6A1 mRNA	17991464
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of ALDH6A1 mRNA	16483693
D000965	Antimony	Antimony results in decreased expression of ALDH6A1 mRNA	17547211
D000966	Antimony Potassium Tartrate	Antimony Potassium Tartrate results in decreased expression of ALDH6A1 mRNA	17547211
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of ALDH6A1 mRNA	17547211
D001280	Atrazine	Atrazine results in increased expression of ALDH6A1 mRNA	22378314
C547126	AZM551248	AZM551248 results in decreased expression of ALDH6A1 mRNA	22323515
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ALDH6A1 mRNA	21632981\|2623829
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ALDH6A1 mRNA	22228805
C044887	beta-methylcholine	beta-methylcholine affects the expression of ALDH6A1 mRNA	21179406
C006780	bisphenol A	bisphenol A affects the expression of ALDH6A1 mRNA	21786754
C006780	bisphenol A	[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of ALDH6A1 promoter	23359474
C006780	bisphenol A	[bisphenol A co-treated with Testosterone] results in increased expression of ALDH6A1 mRNA	26496021
C006780	bisphenol A	bisphenol A results in increased methylation of ALDH6A1 gene	28505145
D000069286	Bortezomib	Bortezomib results in decreased expression of ALDH6A1 mRNA	20977926
C013418	bromfenacoum	bromfenacoum results in increased expression of ALDH6A1 protein	28903499
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of ALDH6A1 mRNA	15336504
C018475	butyraldehyde	butyraldehyde results in decreased expression of ALDH6A1 mRNA	26079696
D002104	Cadmium	Cadmium results in decreased expression of ALDH6A1 mRNA	17547211
D002104	Cadmium	Cadmium results in increased oxidation of ALDH6A1 protein	24496640
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of ALDH6A1 mRNA	17547211
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of ALDH6A1 protein	24527689
D002110	Caffeine	Caffeine results in decreased expression of ALDH6A1 mRNA	23774253
D002220	Carbamazepine	Carbamazepine results in decreased expression of ALDH6A1 mRNA	23774253
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of ALDH6A1 mRNA	27339419
D002251	Carbon Tetrachloride	[Olive Oil analog co-treated with Carbon Tetrachloride] affects the expression of ALDH6A1 protein	25303780
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of ALDH6A1 mRNA	23650126
D002995	Clofibric Acid	Clofibric Acid results in increased expression of ALDH6A1 mRNA	17998271
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of ALDH6A1 mRNA	24386269
D003300	Copper	Copper results in decreased expression of ALDH6A1 mRNA	22465980
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of ALDH6A1 mRNA	19549813
D003407	Creosote	Creosote results in increased expression of ALDH6A1 mRNA	19389177
D016572	Cyclosporine	Cyclosporine results in decreased expression of ALDH6A1 mRNA	20106945\|2116390
C014347	decitabine	decitabine results in decreased expression of ALDH6A1 mRNA	19363521
C014347	decitabine	TP53 protein affects the reaction [decitabine results in decreased expression of ALDH6A1 mRNA]	19363521
D064730	Dexrazoxane	[Doxorubicin co-treated with Dexrazoxane] results in increased expression of ALDH6A1 mRNA	26873546
D003993	Dibutyl Phthalate	[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of ALDH6A1 promoter	23359474
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of ALDH6A1 mRNA	21266533
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of ALDH6A1 mRNA	17998271
D004051	Diethylhexyl Phthalate	[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of ALDH6A1 promoter	23359474
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in increased expression of ALDH6A1 mRNA	27638505
D004237	Diuron	Diuron results in decreased expression of ALDH6A1 mRNA	21551480
D004317	Doxorubicin	[Doxorubicin co-treated with Dexrazoxane] results in increased expression of ALDH6A1 mRNA	26873546
D004317	Doxorubicin	Doxorubicin results in decreased expression of ALDH6A1 mRNA	26873546
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of ALDH6A1 protein	20227414
D005411	Flame Retardants	Flame Retardants results in decreased expression of ALDH6A1 protein	18258299
D005411	Flame Retardants	Flame Retardants results in increased expression of ALDH6A1 protein	18258299
D005485	Flutamide	Flutamide results in decreased expression of ALDH6A1 mRNA	24136188\|2479361
C056507	gemcitabine	gemcitabine results in increased expression of ALDH6A1 mRNA	17039268
D005839	Gentamicins	Gentamicins results in decreased expression of ALDH6A1 protein	22061828
D005897	Glafenine	Glafenine results in decreased expression of ALDH6A1 mRNA	24136188
D005947	Glucose	Glucose results in decreased expression of ALDH6A1 mRNA	17178593
C010178	heliotrine	heliotrine results in decreased expression of ALDH6A1 mRNA	26100227
C017363	hexabromobenzene	"[2,2',3,4,4',5',6-heptabromodiphenyl ether co-treated with hexabromocyclododecane co-treated with tetrabromobisphenol A co-treated with tetrabromobisphenol-S-bis(2,3-dibromopropyl ether) co-treated with hexabromobenzene] results in decreased expression of ALDH6A1 protein"	18258299
C017363	hexabromobenzene	"[2,2',3,4,4',5',6-heptabromodiphenyl ether co-treated with hexabromocyclododecane co-treated with tetrabromobisphenol A co-treated with tetrabromobisphenol-S-bis(2,3-dibromopropyl ether) co-treated with hexabromobenzene] results in increased expression of ALDH6A1 protein"	18258299
C089796	hexabromocyclododecane	"[2,2',3,4,4',5',6-heptabromodiphenyl ether co-treated with hexabromocyclododecane co-treated with tetrabromobisphenol A co-treated with tetrabromobisphenol-S-bis(2,3-dibromopropyl ether) co-treated with hexabromobenzene] results in decreased expression of ALDH6A1 protein"	18258299
C089796	hexabromocyclododecane	"[2,2',3,4,4',5',6-heptabromodiphenyl ether co-treated with hexabromocyclododecane co-treated with tetrabromobisphenol A co-treated with tetrabromobisphenol-S-bis(2,3-dibromopropyl ether) co-treated with hexabromobenzene] results in increased expression of ALDH6A1 protein"	18258299
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of ALDH6A1 mRNA	20044591\|2117940
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of ALDH6A1 mRNA	18951874
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ALDH6A1 mRNA	25613284
C410337	K 7174	K 7174 results in decreased expression of ALDH6A1 mRNA	24086573
C482199	lipopolysaccharide, E coli O55-B5	"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ALDH6A1 mRNA"	20371263
D008627	Mercuric Chloride	Mercuric Chloride results in decreased expression of ALDH6A1 mRNA	27188386
D008628	Mercury	Mercury results in decreased expression of ALDH6A1 mRNA	17547211
C004925	methylmercuric chloride	methylmercuric chloride affects the expression of ALDH6A1 protein	27012723
C437683	motexafin gadolinium	motexafin gadolinium results in decreased expression of ALDH6A1 mRNA	16357179
C437683	motexafin gadolinium	Zinc Acetate inhibits the reaction [motexafin gadolinium results in decreased expression of ALDH6A1 mRNA]	16357179
C500085	muraglitazar	muraglitazar results in increased expression of ALDH6A1 mRNA	21515302
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of ALDH6A1 mRNA"	25102311
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of ALDH6A1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of ALDH6A1 mRNA"	25554681
D009532	Nickel	Nickel results in decreased expression of ALDH6A1 mRNA	24768652\|2558310
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in increased expression of ALDH6A1 protein	19716841
D000069463	Olive Oil	[Olive Oil analog co-treated with Carbon Tetrachloride] affects the expression of ALDH6A1 protein	25303780
C046012	pentanal	pentanal results in decreased expression of ALDH6A1 mRNA	26079696
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of ALDH6A1 protein	26879310
C027579	periodate-oxidized adenosine	periodate-oxidized adenosine affects the expression of ALDH6A1 mRNA	17097637
D010578	Petroleum	Petroleum affects the expression of ALDH6A1 mRNA	25208076
D010695	Phlorhizin	Phlorhizin results in decreased expression of ALDH6A1 mRNA	22538082
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ALDH6A1 mRNA	19710929
C006253	pirinixic acid	pirinixic acid results in decreased expression of ALDH6A1 mRNA	19162173
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of ALDH6A1 mRNA	27413110
D011374	Progesterone	Progesterone results in increased expression of ALDH6A1 mRNA	20726854
D011794	Quercetin	Quercetin results in decreased expression of ALDH6A1 mRNA	21632981
C089730	rosiglitazone	rosiglitazone results in decreased expression of ALDH6A1 mRNA	21515302
C541923	sandostatinLAR	sandostatinLAR results in decreased expression of ALDH6A1 mRNA	17210224
C009237	senecionine	senecionine results in increased expression of ALDH6A1 mRNA	26100227
C009238	senkirkine	senkirkine results in decreased expression of ALDH6A1 mRNA	26100227
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of ALDH6A1 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of ALDH6A1 mRNA	25351596
C080703	SK&F 83959	SK&F 83959 results in decreased expression of ALDH6A1 protein	25852303
C009277	sodium arsenate	sodium arsenate results in decreased expression of ALDH6A1 mRNA	23922661
C016104	sodium bichromate	sodium bichromate results in decreased expression of ALDH6A1 mRNA	25993096
C041711	St. Thomas' Hospital cardioplegic solution	St. Thomas' Hospital cardioplegic solution results in increased expression of ALDH6A1 mRNA	16214533
D013467	Sulindac	"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of ALDH6A1 mRNA"	20371263
D013739	Testosterone	[bisphenol A co-treated with Testosterone] results in increased expression of ALDH6A1 mRNA	26496021
C020806	tetrabromobisphenol A	"[2,2',3,4,4',5',6-heptabromodiphenyl ether co-treated with hexabromocyclododecane co-treated with tetrabromobisphenol A co-treated with tetrabromobisphenol-S-bis(2,3-dibromopropyl ether) co-treated with hexabromobenzene] results in decreased expression of ALDH6A1 protein"	18258299
C020806	tetrabromobisphenol A	"[2,2',3,4,4',5',6-heptabromodiphenyl ether co-treated with hexabromocyclododecane co-treated with tetrabromobisphenol A co-treated with tetrabromobisphenol-S-bis(2,3-dibromopropyl ether) co-treated with hexabromobenzene] results in increased expression of ALDH6A1 protein"	18258299
C555802	tetrabromobisphenol-S-bis(2,3-dibromopropyl ether)	"[2,2',3,4,4',5',6-heptabromodiphenyl ether co-treated with hexabromocyclododecane co-treated with tetrabromobisphenol A co-treated with tetrabromobisphenol-S-bis(2,3-dibromopropyl ether) co-treated with hexabromobenzene] results in decreased expression of ALDH6A1 protein"	18258299
C555802	tetrabromobisphenol-S-bis(2,3-dibromopropyl ether)	"[2,2',3,4,4',5',6-heptabromodiphenyl ether co-treated with hexabromocyclododecane co-treated with tetrabromobisphenol A co-treated with tetrabromobisphenol-S-bis(2,3-dibromopropyl ether) co-treated with hexabromobenzene] results in increased expression of ALDH6A1 protein"	18258299
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ALDH6A1 mRNA	17101203
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ALDH6A1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ALDH6A1 mRNA	19770486
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ALDH6A1 mRNA	18178546\|2095900
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ALDH6A1 mRNA	25613284
D019284	Thapsigargin	Thapsigargin results in increased expression of ALDH6A1 mRNA	22378314
D013849	Thimerosal	Thimerosal results in decreased expression of ALDH6A1 mRNA	27188386
D013893	Thiram	Thiram results in decreased expression of ALDH6A1 mRNA	20530235
C009495	titanium dioxide	titanium dioxide affects the expression of ALDH6A1 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of ALDH6A1 protein	22595367
D014212	Tretinoin	Tretinoin results in decreased expression of ALDH6A1 mRNA	23774253
D014415	Tunicamycin	Tunicamycin results in increased expression of ALDH6A1 mRNA	22378314
D014520	Urethane	Urethane results in decreased expression of ALDH6A1 mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of ALDH6A1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of ALDH6A1 mRNA	26272509
D014635	Valproic Acid	Valproic Acid results in increased expression of ALDH6A1 mRNA	19136453
D014640	Vancomycin	Vancomycin results in increased expression of ALDH6A1 mRNA	18930951
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of ALDH6A1 gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of ALDH6A1 mRNA	19015723
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of ALDH6A1 mRNA	26682919
D014810	Vitamin E	Vitamin E results in decreased expression of ALDH6A1 mRNA	19244175
D024483	Vitamin K 3	Vitamin K 3 affects the expression of ALDH6A1 mRNA	20044591
C111237	vorinostat	vorinostat results in decreased expression of ALDH6A1 mRNA	27188386
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical affects the expression of ALDH6A1 mRNA"	25208076
D015032	Zinc	Zinc deficiency results in increased expression of ALDH6A1 mRNA	22171008
D015032	Zinc	Zinc deficiency results in decreased expression of ALDH6A1 protein	15671213
D019345	Zinc Acetate	Zinc Acetate inhibits the reaction [motexafin gadolinium results in decreased expression of ALDH6A1 mRNA]	16357179
D019345	Zinc Acetate	Zinc Acetate results in increased expression of ALDH6A1 mRNA	16357179

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000062	fatty-acyl-CoA binding	-	ISS	-
GO:0003723	RNA binding	-	HDA	22658674
GO:0004491	methylmalonate-semialdehyde dehydrogenase (acylating) activity	-	IBA	21873635
GO:0004491	methylmalonate-semialdehyde dehydrogenase (acylating) activity	-	IMP	23835272
GO:0004491	methylmalonate-semialdehyde dehydrogenase (acylating) activity	-	ISS	-
GO:0004491	methylmalonate-semialdehyde dehydrogenase (acylating) activity	-	TAS	-
GO:0018478	malonate-semialdehyde dehydrogenase (acetylating) activity	-	IBA	21873635
GO:0018478	malonate-semialdehyde dehydrogenase (acetylating) activity	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006210	thymine catabolic process	-	IBA	21873635
GO:0006210	thymine catabolic process	-	IMP	23835272
GO:0006573	valine metabolic process	-	IBA	21873635
GO:0006573	valine metabolic process	-	ISS	-
GO:0006574	valine catabolic process	-	IBA	21873635
GO:0006574	valine catabolic process	-	IMP	23835272
GO:0009083	branched-chain amino acid catabolic process	-	TAS	-
GO:0019859	thymine metabolic process	-	ISS	-
GO:0050873	brown fat cell differentiation	-	IEA	-
GO:0055114	oxidation-reduction process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005654	nucleoplasm	-	IDA	-
GO:0005739	mitochondrion	-	IBA	21873635
GO:0005739	mitochondrion	-	IDA	-
GO:0005739	mitochondrion	-	NAS	1527093
GO:0005759	mitochondrial matrix	-	TAS	-

KEGG ID	KEGG Term
hsa00280	Valine, leucine and isoleucine degradation
hsa00562	Inositol phosphate metabolism
hsa00640	Propanoate metabolism
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-70895	Branched-chain amino acid catabolism	TAS
R-HSA-71291	Metabolism of amino acids and derivatives	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
10971205	Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease. (2000 Sep)	Vasiliou V	Pharmacology