Gene: MN1

4330
MGCR|MGCR1|MGCR1-PEN|dJ353E16.2
MN1 proto-oncogene, transcriptional regulator
protein-coding
22q12.1
Ensembl:ENSG00000169184 MIM:156100 Vega:OTTHUMG00000150975 UniprotKB:Q10571
NG_023258.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.787e-1 (AD)  5.457e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SOWAHA0.722
CCDC88C0.698
SLC24A30.694
ECE20.68
GNAL0.674
MEIS20.663
NOG0.652
NECAB20.647
STRIP20.641
DCLK30.638

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.371
CDA-0.319
CTNNA3-0.314
SH2D1B-0.314
ZFP57-0.313
OR4F29-0.308
VSTM1-0.306
SPINK8-0.304
OLFML2B-0.299
ANXA1-0.287

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of MN1 mRNA"27291303
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MN1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MN1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MN1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MN1 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MN1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MN1 mRNA19770486
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of MN1 mRNA21298039
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MN1 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MN1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MN1 mRNA21839799
C006780bisphenol Abisphenol A results in decreased expression of MN1 mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of MN1 mRNA17484886
D002737ChloropreneChloroprene results in increased expression of MN1 mRNA23125180
D016572CyclosporineCyclosporine results in decreased expression of MN1 mRNA27989131
D003609DactinomycinDactinomycin inhibits the reaction [Calcitriol results in increased expression of MN1 mRNA]15890672
C014347decitabinedecitabine results in decreased expression of MN1 mRNA27915011
D003976DiazinonDiazinon results in increased methylation of MN1 gene22964155
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of MN1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of MN1 mRNA27392435
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of MN1 mRNA24535843
D002117CalcitriolCalcitriol results in increased expression of MN1 mRNA15890672|1600243
D002117CalcitriolDactinomycin inhibits the reaction [Calcitriol results in increased expression of MN1 mRNA]15890672
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of MN1 mRNA"22485181
D004397FonofosFonofos results in increased methylation of MN1 promoter22847954
D005557FormaldehydeFormaldehyde results in decreased expression of MN1 mRNA20655997
D006534Heptachlor EpoxideHeptachlor Epoxide results in decreased expression of MN1 mRNA25270620
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of MN1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MN1 mRNA24796395
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in decreased expression of MN1 mRNA19564919
D008694MethamphetamineMethamphetamine results in decreased expression of MN1 mRNA19564919
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MN1 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MN1 mRNA"27188386
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MN1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MN1 mRNA"25554681|2562005
D010100OxygenOxygen deficiency results in increased expression of MN1 mRNA26516004
D010278ParathionParathion results in increased methylation of MN1 promoter22847954
D052638Particulate MatterParticulate Matter results in increased expression of MN1 mRNA22178795
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of MN1 mRNA18593933
D010416PentachlorophenolPentachlorophenol results in decreased expression of MN1 mRNA23892564
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of MN1 mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of MN1 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of MN1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of MN1 mRNA19482888
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MN1 mRNA19710929
D011794QuercetinQuercetin results in increased expression of MN1 mRNA21632981
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MN1 mRNA19059307
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in decreased expression of MN1 mRNA19564919
C078903seocalcitolseocalcitol results in increased expression of MN1 mRNA12040012
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of MN1 mRNA25895662
D012834SilverSilver results in decreased expression of MN1 mRNA27131904
C009277sodium arsenatesodium arsenate results in decreased expression of MN1 mRNA21795629
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of MN1 mRNA"26680231
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of MN1 mRNA19059307
D013629TamoxifenTamoxifen results in increased expression of MN1 mRNA25123088
C012568terbufosterbufos results in increased methylation of MN1 promoter22847954
D013739TestosteroneTestosterone results in decreased expression of MN1 mRNA20403060
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MN1 mRNA19465110
D014212TretinoinTretinoin results in decreased expression of MN1 mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of MN1 mRNA24935251
C057693troglitazonetroglitazone results in increased expression of MN1 mRNA19140230
C057693troglitazonetroglitazone results in decreased expression of MN1 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MN1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of MN1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of MN1 mRNA28001369
D014635Valproic AcidValproic Acid results in increased expression of MN1 mRNA23179753|2493525
D000068756ValsartanValsartan inhibits the reaction [AGT protein results in decreased expression of MN1 mRNA]19225232
C029297vinylidene chloridevinylidene chloride results in decreased expression of MN1 mRNA26682919
C111237vorinostatvorinostat results in decreased expression of MN1 mRNA27188386
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of MN1 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001957intramembranous ossification-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IEA-  
GO:0007275multicellular organism development-IEA-  
GO:0008150biological_process-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005575cellular_component-ND-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22409215Genetic and environmental risk factors for submucous cleft palate. (2012 Apr)Reiter REur J Oral Sci
25189868Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study. (2015 Mar)Sung YJAm J Hypertens