Gene: MOBP

4336
-
myelin-associated oligodendrocyte basic protein
protein-coding
3p22.1
Ensembl:ENSG00000168314 MIM:600948 Vega:OTTHUMG00000131347 UniprotKB:Q13875
NC_000003.12
PubMed
0   ANCO-SNPs
CD|AD
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.632e-1 (AD)  9.789e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MBP0.961
BCAS10.946
ERMN0.941
LPAR10.937
PAIP2B0.932
TP53INP20.92
SLCO1A20.92
CTNNA30.916
SEPT40.897
RASSF20.886

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.528
PCDH8-0.503
LTK-0.495
NEUROD1-0.492
HCN4-0.48
CNGB1-0.473
SHROOM3-0.469
GRB14-0.463
WNT2-0.462
SP8-0.461

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MOBP mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MOBP mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MOBP mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MOBP mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MOBP mRNA"25510870
D000082AcetaminophenAcetaminophen affects the expression of MOBP mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MOBP mRNA16483693
D001554BenzeneBenzene affects the expression of MOBP mRNA15878777
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MOBP mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to MOBP promoter]19654925
D004958EstradiolEstradiol results in increased expression of MOBP mRNA20068009
C006780bisphenol Abisphenol A results in decreased expression of MOBP mRNA28641223
C006780bisphenol Abisphenol A results in decreased expression of MOBP mRNA25181051
D002211CapsaicinCapsaicin results in increased expression of MOBP mRNA20349343
D004390ChlorpyrifosChlorpyrifos results in decreased expression of MOBP mRNA17452286
D003024ClozapineClozapine results in increased expression of MOBP mRNA15542763|1726610
D003042CocaineCocaine affects the expression of MOBP mRNA20187946
D003471CuprizoneCuprizone results in decreased expression of MOBP mRNA26577399|2752363
D013759DronabinolDronabinol results in decreased expression of MOBP mRNA17578508
D013759DronabinolDronabinol results in increased expression of MOBP mRNA11015613
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MOBP mRNA21266533
D000431EthanolEthanol results in decreased expression of MOBP mRNA29018328
D005419FlavonoidsFlavonoids results in decreased expression of MOBP mRNA18035473
C004312glycidolglycidol results in decreased expression of MOBP mRNA24915197
D002112CalcifediolCalcifediol deficiency results in decreased expression of MOBP mRNA17293106
D008466MechlorethamineMechlorethamine results in decreased expression of MOBP mRNA17107856
D008627Mercuric ChlorideMercuric Chloride results in increased expression of MOBP mRNA27188386
D008727MethotrexateMethotrexate results in decreased expression of MOBP mRNA24449571
C028007nickel monoxidenickel monoxide results in increased expression of MOBP mRNA19167457
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MOBP mRNA"25510870
D010622PhencyclidinePhencyclidine results in increased expression of MOBP mRNA17266109
C006253pirinixic acidpirinixic acid results in decreased expression of MOBP mRNA20813756|2381119
D011441PropylthiouracilPropylthiouracil results in decreased expression of MOBP mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of MOBP mRNA23806026
C017947sodium arsenitesodium arsenite affects the methylation of MOBP gene28589171
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MOBP mRNA22298810
D014241TrichloroethyleneTrichloroethylene results in increased methylation of MOBP gene27618143
D014635Valproic AcidValproic Acid results in decreased methylation of MOBP gene29154799
D014635Valproic AcidValproic Acid results in increased expression of MOBP mRNA23665938
C025643vinclozolinvinclozolin affects the expression of MOBP mRNA19015723

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-IBA21873635  
GO:0005515protein binding-IPI25416956  26871637  
GO:0017022myosin binding-IBA21873635  
GO:0017137Rab GTPase binding-IBA21873635  
GO:0019911structural constituent of myelin sheath-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007399nervous system development-TAS7989345  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IEA-  
GO:0030864cortical actin cytoskeleton-IBA21873635  
GO:0043209myelin sheath-IEA-  
GO:0048471perinuclear region of cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17291372Oligodendroglial abnormalities in schizophrenia, mood disorders and substance abuse. Comorbidity, shared traits, or molecular phenocopies? (2007 Aug)Sokolov BPInt J Neuropsychopharmacol
15009677Gene expression profile of the nucleus accumbens of human cocaine abusers: evidence for dysregulation of myelin. (2004 Mar)Albertson DNJ Neurochem
15849025Gene expression profiling in the brains of human cocaine abusers. (2005 Mar)Bannon MAddict Biol
25655461Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms. (2015 Apr 15)Manzardo AMGene
18357522Expression of transcripts for myelin related genes in postmortem brain from cocaine abusers. (2009 Jan)Kristiansen LVNeurochem Res