Gene: MOG

4340
BTN6|BTNL11|MOGIG2|NRCLP7
myelin oligodendrocyte glycoprotein
protein-coding
6p22.1
Ensembl:ENSG00000204655 MIM:159465 Vega:OTTHUMG00000031099 UniprotKB:Q16653
NG_031873.1
PubMed
0   ANCO-SNPs
CD|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAG0.967
MYRF0.961
TF0.959
ENPP20.948
FOLH10.946
TMEM1440.94
CAPN30.939
PLEKHH10.933
GJB10.931
CLDN110.928

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.378
CHRNA2-0.363
WTIP-0.362
NEUROD1-0.35
PAX2-0.344
CALB2-0.342
LTK-0.337
SHISA8-0.333
NPBWR1-0.319
GPR153-0.319

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of MOG protein"21673325
D000082AcetaminophenAcetaminophen affects the expression of MOG mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MOG mRNA16483693
D001151ArsenicArsenic affects the methylation of MOG gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of MOG gene25435355
C006780bisphenol Abisphenol A results in decreased expression of MOG mRNA28641223
C006780bisphenol Abisphenol A results in decreased expression of MOG mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of MOG protein28903499
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of MOG promoter22457795
D002211CapsaicinCapsaicin results in increased expression of MOG mRNA20349343
D004390ChlorpyrifosChlorpyrifos affects the expression of MOG mRNA17452286
D007464ClioquinolClioquinol inhibits the reaction [MOG protein results in increased activity of MMP9 protein]23360710
D003300CopperCopper deficiency results in increased expression of MOG mRNA26033743
D003471CuprizoneCuprizone results in decreased expression of MOG mRNA26577399|2752363
D004041Dietary FatsDietary Fats results in increased expression of MOG mRNA8858961
D005557FormaldehydeFormaldehyde results in increased expression of MOG mRNA23649840
D006220HaloperidolHaloperidol results in decreased expression of MOG mRNA17177202
D007649KetamineKetamine results in increased expression of MOG mRNA20080153
D008383MargarineMargarine affects the expression of MOG mRNA12168687
D008727MethotrexateMethotrexate results in decreased expression of MOG mRNA24449571
D008727MethotrexateMethotrexate affects the expression of MOG mRNA18502557
C025589ochratoxin Aochratoxin A results in decreased expression of MOG mRNA24792326
C025589ochratoxin Aochratoxin A results in decreased expression of MOG protein24792326
C025589ochratoxin ASHH protein inhibits the reaction [ochratoxin A results in decreased expression of MOG mRNA]24792326
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of MOG mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of MOG mRNA19162173
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MOG mRNA19710929
D011441PropylthiouracilPropylthiouracil results in decreased expression of MOG mRNA24780913
C089730rosiglitazone[rosiglitazone binds to and results in increased activity of PPARG protein] which results in increased expression of MOG mRNA18543250
D018030Silver CompoundsSilver Compounds results in decreased expression of MOG protein27427492
D018030Silver CompoundsSilver Compounds results in increased expression of MOG mRNA27427492
D012999SomanSoman results in decreased expression of MOG mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MOG mRNA21296121
D014635Valproic AcidValproic Acid results in increased expression of MOG mRNA23665938
D001335Vehicle EmissionsVehicle Emissions affects the methylation of MOG gene25560391
C025643vinclozolinvinclozolin affects the expression of MOG mRNA19015723
D014810Vitamin EVitamin E results in decreased expression of MOG mRNA19244175
D019287Zinc SulfateZinc Sulfate results in decreased expression of MOG mRNA16330358

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IEA-  
GO:0005102signaling receptor binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001817regulation of cytokine production-IBA21873635  
GO:0007155cell adhesion-IEA-  
GO:0007417central nervous system development-TAS1373175  
GO:0046718viral entry into host cell-IEA-  
GO:0050776regulation of immune response-IBA21873635  
GO:0050852T cell receptor signaling pathway-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IEA-  
GO:0009897external side of plasma membrane-IBA21873635  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17291372Oligodendroglial abnormalities in schizophrenia, mood disorders and substance abuse. Comorbidity, shared traits, or molecular phenocopies? (2007 Aug)Sokolov BPInt J Neuropsychopharmacol
25655461Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms. (2015 Apr 15)Manzardo AMGene