Gene info: ID 4342

Gene: MOS

GENE ID: 4342

Synonyms: MSV

Description: MOS proto-oncogene, serine/threonine kinase

Gene type: protein-coding

Location: 8q12.1

dbXrefs: Ensembl:ENSG00000172680 MIM:190060 Vega:OTTHUMG00000164299 UniprotKB:P00540

RefSeq: NC_000008.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 12

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.209e-1 (AD) 9.080e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4A47	0.414
TRAIP	0.399
XAGE1A	0.398
NPAP1	0.393
MYO3A	0.393
GPR1	0.384
FAT2	0.382
TSPAN18	0.376
KPRP	0.375
CCDC38	0.373

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HSPB6	-0.218
KCNJ16	-0.201
HPSE2	-0.193
MTRNR2L9	-0.192
ASCL1	-0.19
HIC1	-0.189
OR5C1	-0.186
CDR1	-0.186
SLC38A11	-0.184
SLC13A2	-0.184

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C012606	4-vinyl-1-cyclohexene dioxide	4-vinyl-1-cyclohexene dioxide affects the expression of MOS mRNA	20829426
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of MOS gene	27153756
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of MOS mRNA	21298039
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of MOS mRNA	16483693
C015001	arsenite	arsenite results in increased methylation of MOS promoter	23974009
D001280	Atrazine	Atrazine results in increased expression of MOS mRNA	22378314
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the expression of MOS mRNA	22641617
D019256	Cadmium Chloride	Cadmium Chloride affects the methylation of MOS promoter	22457795
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of MOS mRNA	19789285
D019327	Copper Sulfate	Copper Sulfate results in increased expression of MOS mRNA	19789285
D015084	2,4-Dichlorophenoxyacetic Acid	"2,4-Dichlorophenoxyacetic Acid inhibits the reaction [Progesterone results in increased expression of MOS protein]"	14694440\|1705569
D015084	2,4-Dichlorophenoxyacetic Acid	"2,4-Dichlorophenoxyacetic Acid inhibits the reaction [Progesterone results in increased metabolism of MOS mRNA]"	17055699
D002945	Cisplatin	[Cisplatin co-treated with Quercetin] results in increased expression of MOS mRNA	27514524
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of MOS mRNA	26924002
D004026	Dieldrin	Dieldrin results in decreased expression of MOS mRNA	23041725
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of MOS mRNA	26924002
D004147	Dioxins	Dioxins affects the expression of MOS mRNA	20463971
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of MOS mRNA	23550701
D005419	Flavonoids	Flavonoids results in increased expression of MOS mRNA	18035473
C008261	lead acetate	lead acetate results in decreased expression of MOS mRNA	22609695
D008713	Methimazole	Methimazole results in decreased expression of MOS mRNA	17403546
D008731	Methoxychlor	Methoxychlor affects the expression of MOS mRNA	20829426
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of MOS mRNA	26011545
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of MOS mRNA"	20188158
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of MOS mRNA	26924002
D010100	Oxygen	Oxygen deficiency results in increased expression of MOS mRNA	17914565
C494474	perchlorate	perchlorate results in decreased expression of MOS mRNA	17403546
D010634	Phenobarbital	Phenobarbital results in decreased expression of MOS mRNA	21896655
D010936	Plant Extracts	Plant Extracts results in decreased expression of MOS mRNA	23557933
D011374	Progesterone	"2,4-Dichlorophenoxyacetic Acid inhibits the reaction [Progesterone results in increased expression of MOS protein]"	14694440\|1705569
D011374	Progesterone	"2,4-Dichlorophenoxyacetic Acid inhibits the reaction [Progesterone results in increased metabolism of MOS mRNA]"	17055699
D011374	Progesterone	Progesterone results in increased expression of MOS protein	17055699
D011374	Progesterone	Progesterone results in increased metabolism of MOS mRNA	17055699
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of MOS mRNA	24780913
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of MOS mRNA	17403546
D011794	Quercetin	[Cisplatin co-treated with Quercetin] results in increased expression of MOS mRNA	27514524
C059514	resveratrol	resveratrol results in increased expression of MOS mRNA	24314921
C410733	scriptaid	scriptaid affects the expression of MOS mRNA	18813790
D012839	Simazine	Simazine results in increased expression of MOS mRNA	22984576
D013974	Thyroxine	Thyroxine results in decreased expression of MOS mRNA	17403546
D013974	Thyroxine	Thyroxine results in increased expression of MOS mRNA	17403546
C402769	tipifarnib	tipifarnib results in increased expression of MOS mRNA	16403772
D014635	Valproic Acid	Valproic Acid results in increased methylation of MOS gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of MOS gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004674	protein serine/threonine kinase activity	-	ISS	-
GO:0004709	MAP kinase kinase kinase activity	-	ISS	-
GO:0005515	protein binding	-	IPI	21516116 25416956
GO:0005524	ATP binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000165	MAPK cascade	-	IEA	-
GO:0000186	activation of MAPKK activity	-	ISS	-
GO:0000187	activation of MAPK activity	-	ISS	-
GO:0000212	meiotic spindle organization	-	ISS	-
GO:0006325	chromatin organization	-	ISS	-
GO:0046777	protein autophosphorylation	-	ISS	-
GO:0051296	establishment of meiotic spindle orientation	-	ISS	-
GO:1902103	negative regulation of metaphase/anaphase transition of meiotic cell cycle	-	IBA	21873635
GO:1902103	negative regulation of metaphase/anaphase transition of meiotic cell cycle	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IBA	21873635

KEGG ID	KEGG Term
hsa04010	MAPK signaling pathway
hsa04114	Oocyte meiosis
hsa04810	Regulation of actin cytoskeleton
hsa04914	Progesterone-mediated oocyte maturation

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
28226201	Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms. (2017 May)	Adkins AE	Alcohol Clin Exp Res
24106234	Health-Related Quality of Life in HIV-Infected and At-Risk Women: The Impact of Illicit Drug Use and Hepatitis C on a Community Preference Weighted Measure. (2014 Aug)	Aden B	Med Decis Making
25835344	[Are health district prevalence studies useful in family practice? Report of a case: chronic obstructive pulmonary disease]. (2015 Nov)	Casado Vicente V	Aten Primaria
11322028	[Usefulness of carbohydrate-deficient transferrin (CDT) in the assessment of abuse and abstinence in chronic alcoholism]. (2000 Nov)	Avivar Falcon I	An Med Interna
9374967	Health outcomes of women exposed to household alcohol abuse: a Family Practice Training Site Research Network (FPTSRN) study. (1997 Nov)	Ryan JG	J Fam Pract
16413443	MOS short form 36 and Oswestry Disability Index outcomes in lumbar fusion: a multicenter experience. (2006 Jan-Feb)	Glassman S	Spine J
15740466	Mental disorders, disability and health service use amongst Vietnamese refugees and the host Australian population. (2005 Apr)	Steel Z	Acta Psychiatr Scand
11440825	MOS HIP: McMaster outcome study of hypertension in pregnancy. (2001 Sep)	Ray JG	Early Hum Dev
28549689	Hair Coloring, Stress, and Smoking Increase the Risk of Breast Cancer: A Case-Control Study. (2017 Dec)	Dianatinasab M	Clin Breast Cancer
11788076	Adverse impact of cigarette smoking on dimensions of health-related quality of life in persons with HIV infection. (2001 Dec)	Turner J	AIDS Patient Care STDS
29430733	The relationship between clinical characteristics including presence of exposed lesions and health-related quality of life (HRQoL) in patients with psoriasis: analysis from the nationwide epidemiologic study for psoriasis in Korea (EPI-PSODE study). (2018 Feb 11)	Youn SW	J Eur Acad Dermatol Venereol
16224309	Heritability of SF-36 among middle-age, middle-class, male-male twins. (2005 Nov)	Romeis JC	Med Care