Gene: CD200

4345
MOX1|MOX2|MRC|OX-2
CD200 molecule
protein-coding
3q13.2
Ensembl:ENSG00000091972 MIM:155970 Vega:OTTHUMG00000159248 UniprotKB:P41217
NC_000003.12
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.249e-1 (AD)  1.722e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
INPP5F0.975
NECAP10.968
NSF0.966
RTN10.966
BTBD100.963
OLA10.962
GPRASP20.962
SYT40.961
PRKACB0.961
ATP1B10.961

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.499
CSAG1-0.487
OR4F29-0.464
FZD10-0.461
RNF135-0.455
RUNX3-0.441
MAGEA12-0.44
ASB4-0.438
HEY2-0.438
SYDE1-0.438

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of CD200 mRNA"26377693
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of CD200 mRNA"20206263
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CD200 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CD200 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CD200 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CD200 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CD200 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of CD200 mRNA29067470
C000188alachloralachlor results in increased expression of CD200 mRNA12419858
D000452AldrinAldrin results in increased expression of CD200 mRNA18579281
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CD200 mRNA16483693
D000661AmphetamineAmphetamine results in increased expression of CD200 mRNA20223277
C547126AZM551248AZM551248 results in decreased expression of CD200 mRNA22323515
C028559bathocuproine sulfonate[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD200 mRNA]15477007
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CD200 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CD200 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of CD200 mRNA26377693
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CD200 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CD200 mRNA21569818|2222880
C006780bisphenol Abisphenol A results in decreased expression of CD200 mRNA27685785
C006780bisphenol Abisphenol A results in increased expression of CD200 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of CD200 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of CD200 mRNA17484886
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CD200 mRNA27858113
D003033Coal TarCoal Tar results in decreased expression of CD200 mRNA27858113
D003345CorticosteroneCorticosterone results in decreased expression of CD200 mRNA15755911
D003703DemecolcineDemecolcine results in increased expression of CD200 mRNA23649840
D004041Dietary FatsDietary Fats results in increased expression of CD200 mRNA18042831
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of CD200 mRNA15171707
C118739entinostatentinostat results in decreased expression of CD200 mRNA27188386
D000431EthanolEthanol results in decreased expression of CD200 mRNA28986285
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CD200 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CD200 mRNA17942748
D005419FlavonoidsFlavonoids results in increased expression of CD200 mRNA18035473
D005557FormaldehydeFormaldehyde results in increased expression of CD200 mRNA23649840
C039281furanfuran results in increased expression of CD200 mRNA27387713
C010176halofuginonehalofuginone results in increased expression of CD200 mRNA17180598
D017313FenretinideFenretinide results in increased expression of CD200 mRNA28973697
D015759Ionomycin[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD200 mRNA]15477007
D015759Ionomycinpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD200 mRNA]15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD200 mRNA15477007
C561695(+)-JQ1 compound(+)-JQ1 compound affects the expression of CD200 mRNA26733615
C561695(+)-JQ1 compound(+)-JQ1 compound promotes the reaction [panobinostat affects the expression of CD200 mRNA]26733615
C561695(+)-JQ1 compoundpanobinostat promotes the reaction [(+)-JQ1 compound affects the expression of CD200 mRNA]26733615
D007854LeadLead affects the splicing of CD200 mRNA28903495
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CD200 mRNA23649840
D015741MetriboloneMetribolone results in decreased expression of CD200 mRNA17010675
D009532NickelNickel results in decreased expression of CD200 mRNA25583101
C017557nickel subsulfidenickel subsulfide results in increased expression of CD200 mRNA21086188
C029938nickel sulfatenickel sulfate results in decreased expression of CD200 mRNA22714537
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] affects the expression of CD200 mRNA25729387
D000073878Palm OilPalm Oil results in increased expression of CD200 mRNA18042831
C496932panobinostat(+)-JQ1 compound promotes the reaction [panobinostat affects the expression of CD200 mRNA]26733615
C496932panobinostatpanobinostat affects the expression of CD200 mRNA26733615
C496932panobinostatpanobinostat promotes the reaction [(+)-JQ1 compound affects the expression of CD200 mRNA]26733615
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CD200 mRNA17560707
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of CD200 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of CD200 mRNA19482888
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CD200 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of CD200 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CD200 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of CD200 mRNA19162173
D059808PolyphenolsPolyphenols results in decreased expression of CD200 mRNA16293270
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of CD200 mRNA22714537
D011374ProgesteroneProgesterone results in increased expression of CD200 mRNA22238285
D011441PropylthiouracilPropylthiouracil results in increased expression of CD200 mRNA24780913
C020972pyrrolidine dithiocarbamic acid[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD200 mRNA]15477007
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD200 mRNA]15477007
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in decreased expression of CD200 mRNA15576828
D053260SootSoot results in decreased expression of CD200 mRNA26551751
D013739TestosteroneTestosterone affects the expression of CD200 mRNA20403060
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of CD200 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CD200 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CD200 mRNA17942748
D013755Tetradecanoylphorbol Acetate[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD200 mRNA]15477007
D013755Tetradecanoylphorbol Acetatepyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD200 mRNA]15477007
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD200 mRNA15477007
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of CD200 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of CD200 mRNA28111298
D019772Topotecan[oxaliplatin co-treated with Topotecan] affects the expression of CD200 mRNA25729387
D019772TopotecanTopotecan results in increased expression of CD200 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of CD200 mRNA21934132
D014212TretinoinTretinoin results in decreased expression of CD200 mRNA20488242
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CD200 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of CD200 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of CD200 mRNA23179753|2438349
D014638VanadatesVanadates results in increased expression of CD200 mRNA22714537
D014750VincristineVincristine results in increased expression of CD200 mRNA23649840
C111237vorinostatvorinostat results in decreased expression of CD200 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21982860  
GO ID GO Term Qualifier Evidence PubMed
GO:0043031negative regulation of macrophage activation-IEA-  
GO:0050776regulation of immune response-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS3032785  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27929051Reduced expression of monocyte CD200R is associated with enhanced proinflammatory cytokine production in sarcoidosis. (2016 Dec 8)Fraser SDSci Rep
27710895CD200Fc attenuates inflammatory responses and maintains barrier function by suppressing NF-kappaB pathway in cigarette smoke extract induced endothelial cells. (2016 Dec)Xu JBiomed Pharmacother