Gene: ASL

435
ASAL
argininosuccinate lyase
protein-coding
7q11.21
Ensembl:ENSG00000126522 MIM:608310 Vega:OTTHUMG00000022876 UniprotKB:P04424
NG_009288.1
PubMed
0   ANCO-SNPs
ND|AD
12   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.280e-1 (AD)  4.697e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GSS0.893
ACP20.892
BCKDK0.889
CHMP60.874
TBL30.866
PSEN20.865
WDR610.858
PNKP0.853
RBFA0.853
ACAD90.852

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.536
OR4F29-0.508
MTRNR2L9-0.418
MTRNR2L6-0.409
MIA-0.352
MTRNR2L10-0.349
CYP39A1-0.349
LRRIQ1-0.329
C7orf61-0.326
PPBP-0.318

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00125L-ArginineSmall Molecule74-79-3Approved|NutraceuticalTarget
DB02267ArgininosuccinateSmall MoleculeExperimentalTarget
DB038142-(N-Morpholino)-Ethanesulfonic AcidSmall MoleculeExperimentalTarget
ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ASL mRNA"21346803
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of ASL mRNA]"19467301
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASL mRNA"27188386
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of ASL mRNA19038236
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASL mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ASL mRNA15120968
D000082AcetaminophenAcetaminophen results in increased expression of ASL mRNA11779202
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ASL protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ASL mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ASL mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of ASL mRNA28522335
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of ASL protein26597043
C018824ammonium acetateammonium acetate results in increased activity of ASL protein16009439
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ASL mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ASL mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of ASL mRNA20458559
C006632arsenic trioxideASL protein results in decreased susceptibility to arsenic trioxide20707922
D001241AspirinAspirin results in decreased expression of ASL mRNA15928584
D001280AtrazineAtrazine results in increased expression of ASL mRNA25929836
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of ASL mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ASL mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ASL mRNA"19150397
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ASL mRNA28628672
C006780bisphenol Abisphenol A affects the expression of ASL mRNA21786754
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ASL mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of ASL mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ASL mRNA28628672
D002220CarbamazepineCarbamazepine affects the expression of ASL mRNA24752500
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ASL mRNA26639393|2733941
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ASL mRNA17522070
D002725ChloroformChloroform results in increased expression of ASL mRNA17522070
D002994ClofibrateClofibrate results in increased expression of ASL protein19952500
D002994ClofibrateClofibrate results in decreased expression of ASL mRNA17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of ASL mRNA24612858
C018021cobaltous chloridecobaltous chloride results in decreased expression of ASL mRNA19320972|1937684
C018021cobaltous chloridecobaltous chloride results in decreased expression of ASL mRNA24386269
D019327Copper SulfateCopper Sulfate results in decreased expression of ASL mRNA19549813
D019327Copper SulfateCopper Sulfate results in decreased expression of ASL mRNA18579281
D016572CyclosporineCyclosporine results in decreased expression of ASL mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of ASL mRNA27989131
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ASL mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ASL mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ASL mRNA28628672
D003976DiazinonDiazinon results in increased methylation of ASL gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ASL mRNA17361019|2126653
D002945CisplatinCisplatin results in increased expression of ASL mRNA27594783
D004008DiclofenacDiclofenac affects the expression of ASL mRNA24752500
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of ASL mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of ASL mRNA19467301
C024629dimethyl phthalatedimethyl phthalate affects the expression of ASL mRNA26924002
D004147DioxinsDioxins affects the expression of ASL mRNA20463971
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased methylation of ASL promoter27415467
D005485FlutamideFlutamide results in decreased expression of ASL mRNA21126777
C056933fumonisin B1fumonisin B1 results in decreased expression of ASL mRNA16221962
C039281furanfuran results in increased methylation of ASL gene22079235
D005897GlafenineGlafenine results in decreased expression of ASL mRNA24136188
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ASL mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ASL mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ASL mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ASL mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ASL mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ASL mRNA28628672
D007538Isoniazid[Isoniazid co-treated with Zidovudine] results in increased activity of ASL protein28619387
D007538IsoniazidIsoniazid results in increased activity of ASL protein28619387
D007538Isoniazidsilybin inhibits the reaction [[Isoniazid co-treated with Zidovudine] results in increased activity of ASL protein]28619387
C544151jinfukangjinfukang results in increased expression of ASL mRNA27392435
C008261lead acetatelead acetate results in increased expression of ASL mRNA11578147
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ASL mRNA11779202
D008694MethamphetamineMethamphetamine results in decreased expression of ASL mRNA19564919
D008713MethimazoleMethimazole results in decreased expression of ASL mRNA17403546
D008727MethotrexateMethotrexate affects the expression of ASL mRNA18502557
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of ASL mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ASL mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ASL mRNA"25620056
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of ASL mRNA17522070
C022838nickel chloridenickel chloride affects the expression of ASL mRNA22110744
C002741N-nitrosomorpholineN-nitrosomorpholine affects the expression of ASL protein19716841
C025589ochratoxin Aochratoxin A results in decreased expression of ASL mRNA12700408
D010098OxycodoneOxycodone results in increased expression of ASL mRNA23439660
D010126OzoneOzone results in increased expression of ASL mRNA25838073
C494474perchlorateperchlorate results in decreased expression of ASL mRNA17403546
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ASL mRNA20452409
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ASL mRNA19162173
D010634PhenobarbitalPhenobarbital results in decreased expression of ASL protein19952500
D010634PhenobarbitalPhenobarbital results in decreased expression of ASL mRNA19162173
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ASL mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of ASL mRNA16221962|2081375
C006253pirinixic acidpirinixic acid results in increased expression of ASL mRNA18445702
C006253pirinixic acidpirinixic acid results in decreased expression of ASL mRNA17164430|1916217
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of ASL mRNA28903501
D011441PropylthiouracilPropylthiouracil results in decreased expression of ASL mRNA17403546
D011794QuercetinQuercetin results in increased expression of ASL mRNA16455785
C079198S 1 (combination)ASL protein results in increased susceptibility to S 1 (combination)16734730
D012524SarinSarin results in decreased expression of ASL mRNA19522546
D012643SeleniumSelenium results in increased expression of ASL mRNA19244175
C009250sevofluranesevoflurane affects the expression of ASL mRNA15967596
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ASL mRNA25895662
C440975silybinsilybin inhibits the reaction [[Isoniazid co-treated with Zidovudine] results in increased activity of ASL protein]28619387
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ASL mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of ASL mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ASL mRNA21215274
D013752TetracyclineTetracycline results in increased expression of ASL mRNA17522070
D013806TheophyllineTheophylline results in decreased expression of ASL mRNA17522070
D014212TretinoinTretinoin results in increased expression of ASL mRNA16012519|1721838
C012589trichostatin Atrichostatin A results in increased expression of ASL mRNA15901671
D014635Valproic AcidValproic Acid results in increased expression of ASL mRNA15901671
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASL mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of ASL mRNA23179753|2627250
D014635Valproic AcidValproic Acid affects the expression of ASL mRNA17292431
D014640VancomycinVancomycin results in increased expression of ASL mRNA18930951
C029297vinylidene chloridevinylidene chloride results in decreased expression of ASL mRNA26682919
D015215Zidovudine[Isoniazid co-treated with Zidovudine] results in increased activity of ASL protein28619387
D015215Zidovudinesilybin inhibits the reaction [[Isoniazid co-treated with Zidovudine] results in increased activity of ASL protein]28619387
D015215ZidovudineZidovudine results in increased activity of ASL protein28619387

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004056argininosuccinate lyase activity-EXP2263616  
GO:0004056argininosuccinate lyase activity-IBA21873635  
GO:0005515protein binding-IPI25416956  26871637  
GO:0042802identical protein binding-IPI21988832  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0000050urea cycle-IBA21873635  
GO:0000050urea cycle-IEA-  
GO:0000050urea cycle-TAS-  
GO:0042450arginine biosynthetic process via ornithine-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-TAS282632  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA19056867  
KEGG ID KEGG Term
hsa00250Alanine, aspartate and glutamate metabolism
hsa00330Arginine and proline metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-351202Metabolism of polyaminesTAS
R-HSA-70635Urea cycleTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24106801Cystic fibrosis transmembrane conductance regulator activation by roflumilast contributes to therapeutic benefit in chronic bronchitis. (2014 Mar)Lambert JAAm J Respir Cell Mol Biol
7585737Relationship of cigarette smoking to the severity of coronary and thoracic aortic atherosclerosis. (1995)Inoue TCardiology
23899395Mutant p21ras in vinyl chloride exposed workers. (1998)Li YBiomarkers
28874823Role of Smad3 and p38 Signalling in Cigarette Smoke-induced CFTR and BK dysfunction in Primary Human Bronchial Airway Epithelial Cells. (2017 Sep 5)Sailland JSci Rep
28883932Effect of vitamin D3 on the antimicrobial activity of human airway surface liquid: preliminary results of a randomised placebo-controlled double-blind trial. (2017)Vargas Buonfiglio LGBMJ Open Respir Res
26521141Roflumilast partially reverses smoke-induced mucociliary dysfunction. (2015 Oct 31)Schmid ARespir Res
10390705Plasma p53 protein and anti-p53 antibody expression in vinyl chloride monomer workers in Taiwan. (1999 Jun)Luo JCJ Occup Environ Med
26413475Structural and physiological MRI correlates of occult cerebrovascular disease in late-onset epilepsy. (2015)Hanby MFNeuroimage Clin
18499348Nicotine abstinence-induced cerebral blood flow changes by genotype. (2008 Jun 27)Wang ZNeurosci Lett
8864252Relation of C4b-binding protein to athero-sclerosis of the descending thoracic aorta. (1996)Kimoto KArtery
27569012[Geographic Altitude of Residence and Alcohol Dependence in a Peruvian Population]. (2016 Jul-Sep)Quinones-Laveriano DMRev Colomb Psiquiatr
26528246Mucociliary dysfunction in HIV and smoked substance abuse. (2015)Chinnapaiyan SFront Microbiol