Gene: MPG

4350
AAG|ADPG|APNG|CRA36.1|MDG|Mid1|PIG11|PIG16|anpg
N-methylpurine DNA glycosylase
protein-coding
16p13.3
Ensembl:ENSG00000103152 MIM:156565 Vega:OTTHUMG00000047887 UniprotKB:P29372
NC_000016.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.872e-1 (AD)  6.998e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MRPS340.914
ARF50.913
CLTA0.912
IMP30.912
POP70.91
TMED30.907
PIN10.906
MRPL40.905
MANBAL0.903
NCBP2-AS20.903

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.664
OR4F29-0.617
MTRNR2L6-0.433
MTRNR2L9-0.433
MTRNR2L10-0.414
EBF1-0.37
KCNJ15-0.352
TTLL10-AS1-0.35
P2RY14-0.349
TTLL10-0.328

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00515CisplatinSmall Molecule15663-27-1ApprovedTarget
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0049811,N(6)-ethenoadenine"MPG protein results in increased metabolism of 1,N(6)-ethenoadenine"10626224
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MPG mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MPG mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MPG mRNA"21346803
C0312782-chloroethyl ethyl sulfideMPG protein results in increased susceptibility to 2-chloroethyl ethyl sulfide17292678
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in increased expression of MPG mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in increased expression of MPG mRNA]28655636
C0259463-methyladenineMPG protein results in increased metabolism of 3-methyladenine10626224
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of MPG mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of MPG mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of MPG mRNA16751229
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MPG mRNA16483693
D001151ArsenicArsenic affects the methylation of MPG gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MPG mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MPG mRNA20504355|2222880
D001629BezafibrateBezafibrate results in increased expression of MPG mRNA15447978
C006780bisphenol Abisphenol A results in decreased expression of MPG mRNA23798566
C006780bisphenol Abisphenol A results in increased expression of MPG mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MPG gene28505145
C016274bromoacetatebromoacetate results in increased expression of MPG mRNA19753638
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of MPG mRNA15336504
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MPG mRNA11958953
D019256Cadmium ChlorideMT1 affects the reaction [Cadmium Chloride results in increased expression of MPG mRNA]11958953
D019256Cadmium ChlorideMT2 affects the reaction [Cadmium Chloride results in increased expression of MPG mRNA]11958953
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of MPG promoter22457795
D002330CarmustineMPG protein results in decreased susceptibility to Carmustine16288039
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of MPG mRNA23650126
D019327Copper SulfateCopper Sulfate results in decreased expression of MPG mRNA19549813
C408982CPG-oligonucleotideCPG-oligonucleotide results in increased expression of MPG mRNA21878529
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of MPG mRNA21878529
D003513CycloheximideCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MPG mRNA]11007951
D003520CyclophosphamideCyclophosphamide affects the expression of MPG mRNA11906922
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MPG mRNA21266533
D002945CisplatinCisplatin analog binds to and affects the activity of MPG protein10891085
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of MPG mRNA27392435
D002945CisplatinCisplatin results in increased expression of MPG mRNA21151649
D004026DieldrinDieldrin results in increased expression of MPG mRNA28385952
C007482dimethyl sulfateMPG protein results in increased susceptibility to dimethyl sulfate15299078
D004237DiuronDiuron results in increased expression of MPG mRNA21551480
D004317DoxorubicinDoxorubicin results in increased expression of MPG mRNA22712078
D052244Endocrine DisruptorsEndocrine Disruptors results in decreased expression of MPG mRNA25198161
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MPG mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MPG mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MPG mRNA17942748
D005027Ethylene OxideEthylene Oxide results in increased expression of MPG protein16051529
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of MPG mRNA21071726
D005020Ethyl MethanesulfonateMPG protein affects the susceptibility to Ethyl Methanesulfonate21071726
C504383fenbuconazolefenbuconazole results in increased expression of MPG mRNA15942997
C039281furanfuran results in decreased expression of MPG mRNA22507866
D006918HydroxyureaHydroxyurea results in increased expression of MPG mRNA12929121
C056493imiquimodimiquimod results in decreased expression of MPG mRNA21878529
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of MPG mRNA27392435
C544151jinfukangjinfukang results in increased expression of MPG mRNA27392435
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in decreased expression of MPG mRNA19564919
D008694MethamphetamineMethamphetamine results in decreased expression of MPG mRNA19564919
C005214methoxyaminemethoxyamine promotes the reaction [MPG protein results in increased susceptibility to Methyl Methanesulfonate]15299078
C005214methoxyaminemethoxyamine promotes the reaction [MPG protein results in increased susceptibility to temozolomide]15299078
C005214methoxyamineMPG protein promotes the reaction [methoxyamine results in increased susceptibility to temozolomide]21377995
C005214methoxyaminePOLB protein inhibits the reaction [MPG protein promotes the reaction [methoxyamine results in increased susceptibility to temozolomide]]21377995
C005223methyleugenolmethyleugenol results in decreased expression of MPG mRNA21659616
D008741Methyl Methanesulfonatemethoxyamine promotes the reaction [MPG protein results in increased susceptibility to Methyl Methanesulfonate]15299078
D008741Methyl MethanesulfonateMPG mutant form results in increased susceptibility to Methyl Methanesulfonate26208482
D008741Methyl MethanesulfonateMPG protein results in decreased susceptibility to Methyl Methanesulfonate16288039
D008741Methyl MethanesulfonateMPG protein results in increased susceptibility to Methyl Methanesulfonate15299078
D008769MethylnitronitrosoguanidineMPG protein results in increased susceptibility to Methylnitronitrosoguanidine15299078
D008770MethylnitrosoureaMPG protein results in decreased susceptibility to Methylnitrosourea16288039
D008770MethylnitrosoureaMPG protein results in increased susceptibility to Methylnitrosourea15299078|1767436
C517284monomethyl phthalatemonomethyl phthalate affects the expression of MPG mRNA26924002
D009151Mustard GasMPG protein results in increased susceptibility to Mustard Gas17292678
C434926N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride"MPG protein promotes the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride results in increased susceptibility to temozolomide]"21377995
C025589ochratoxin Aochratoxin A results in decreased expression of MPG mRNA23358140
D010100OxygenOxygen deficiency results in increased expression of MPG mRNA17914565
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in increased expression of MPG mRNA]28655636
D052638Particulate MatterParticulate Matter results in increased expression of MPG mRNA28655636
C011272perfosfamideperfosfamide results in decreased expression of MPG mRNA11754170
D010634PhenobarbitalPhenobarbital affects the expression of MPG mRNA19159669
D010634PhenobarbitalPhenobarbital results in increased expression of MPG mRNA21335049
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in decreased expression of MPG mRNA19564919
D012834SilverSilver results in decreased expression of MPG mRNA27131904
C016104sodium bichromatesodium bichromate results in increased expression of MPG mRNA22155349
D013311StreptozocinMPG protein affects the susceptibility to Streptozocin17098815
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in decreased expression of MPG mRNA"26680231
C047246temozolomidemethoxyamine promotes the reaction [MPG protein results in increased susceptibility to temozolomide]15299078
C047246temozolomideMPG protein promotes the reaction [methoxyamine results in increased susceptibility to temozolomide]21377995
C047246temozolomide"MPG protein promotes the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride results in increased susceptibility to temozolomide]"21377995
C047246temozolomideMPG protein promotes the reaction [veliparib results in increased susceptibility to temozolomide]21377995
C047246temozolomideMPG protein results in decreased susceptibility to temozolomide16288039
C047246temozolomideMPG protein results in increased susceptibility to temozolomide15299078|1602464
C047246temozolomidePOLB protein inhibits the reaction [MPG protein promotes the reaction [methoxyamine results in increased susceptibility to temozolomide]]21377995
C047246temozolomideMPG affects the reaction [MSH2 results in decreased susceptibility to temozolomide]20025921
D013749TetrachlorodibenzodioxinCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MPG mRNA]11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MPG mRNA11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MPG mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MPG mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MPG mRNA19465110
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MPG mRNA22298810
D014635Valproic AcidValproic Acid affects the expression of MPG mRNA25979313
D014635Valproic AcidValproic Acid results in increased methylation of MPG gene29154799
D014635Valproic AcidValproic Acid affects the expression of MPG mRNA17292431
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in increased expression of MPG mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in increased expression of MPG mRNA28655636
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MPG gene25560391
C521013veliparibMPG protein promotes the reaction [veliparib results in increased susceptibility to temozolomide]21377995
C025643vinclozolinvinclozolin results in decreased expression of MPG mRNA23034163
D014752Vinyl ChlorideVinyl Chloride analog results in increased expression of MPG mRNA10882851
C016829vinyl fluoridevinyl fluoride results in increased expression of MPG mRNA10882851
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of MPG mRNA"25198161

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003684damaged DNA binding-TAS10854423  
GO:0003905alkylbase DNA N-glycosylase activity-IBA21873635  
GO:0005515protein binding-IPI18482256  25416956  
GO:0008725DNA-3-methyladenine glycosylase activity-IEA-  
GO:0019104DNA N-glycosylase activity-TAS-  
GO:0043916DNA-7-methylguanine glycosylase activity-IEA-  
GO:0052821DNA-7-methyladenine glycosylase activity-IEA-  
GO:0052822DNA-3-methylguanine glycosylase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006284base-excision repair-IBA21873635  
GO:0006284base-excision repair-TAS10854423  
GO:0006307DNA dealkylation involved in DNA repair-TAS1645538  
GO:0045007depurination-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0042645mitochondrial nucleoid-IEA-  
KEGG ID KEGG Term
hsa03410Base excision repair
Reactome ID Reactome Term Evidence
R-HSA-110330Recognition and association of DNA glycosylase with site containing an affected purineTAS
R-HSA-110331Cleavage of the damaged purineTAS
R-HSA-110357Displacement of DNA glycosylase by APEX1TAS
R-HSA-73884Base Excision RepairTAS
R-HSA-73894DNA RepairTAS
R-HSA-73927DepurinationTAS
R-HSA-73929Base-Excision Repair, AP Site FormationTAS
R-HSA-73933Resolution of Abasic Sites (AP sites)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22266085Elevated N3-methylpurine-DNA glycosylase DNA repair activity is associated with lung cancer. (2012 Apr 1)Crosbie PAMutat Res