Gene: MPI

4351
CDG1B|PMI|PMI1
mannose phosphate isomerase
protein-coding
15q24.1
Ensembl:ENSG00000178802 MIM:154550 Vega:OTTHUMG00000142826 UniprotKB:P34949
NG_008921.1
PubMed
0   ANCO-SNPs
ND|AD
7   
4.320e-1 (AD)  3.864e-1 (ND)   (Frontal_Cortex)
1.517e-1 (AD)  3.933e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg13828047chr15:75182130MPI7.950e-8Maternal smoking in pregnancy27040690
cg13828047chr15:75182130MPI2.500e-14Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC25A110.929
ACTR1A0.925
VPS110.922
UQCRC10.917
ARMC60.917
COPS7A0.915
PDHA10.914
DGCR20.913
TOM10.913
MANBAL0.912

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.69
OR4F29-0.634
MTRNR2L6-0.418
TFPI2-0.415
MTRNR2L9-0.401
PABPC4L-0.385
KCNJ15-0.383
EBF1-0.382
MTRNR2L10-0.381
CLEC2B-0.379

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0245661,1,1-trichloroethane"1,1,1-trichloroethane results in increased expression of MPI mRNA"25270620
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MPI mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MPI mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MPI mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MPI mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of MPI mRNA29067470
D000638AmiodaroneAmiodarone results in increased expression of MPI mRNA19774075
D001151ArsenicArsenic results in increased methylation of MPI promoter21291286
D001280AtrazineAtrazine results in decreased expression of MPI mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of MPI mRNA28651000
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with Copper] results in decreased expression of MPI protein24211336
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MPI protein24211336
C006780bisphenol Abisphenol A results in increased expression of MPI mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of MPI mRNA25270620
C006780bisphenol Abisphenol A affects the expression of MPI mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of MPI mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of MPI protein28903499
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MPI mRNA22767353
D019256Cadmium Chloride[Methyl Parathion co-treated with Cadmium Chloride] results in increased expression of MPI mRNA22767353
D019256Cadmium Chloride[Methyl Parathion co-treated with Cadmium Chloride] results in increased expression of MPI protein22767353
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MPI mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of MPI mRNA26272509
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of MPI mRNA20971185
D003300Copper[Benzo(a)pyrene co-treated with Copper] results in decreased expression of MPI protein24211336
D003300CopperCopper results in decreased expression of MPI protein24211336
D019327Copper SulfateCopper Sulfate results in decreased expression of MPI mRNA19789285
D016572CyclosporineCyclosporine results in decreased expression of MPI mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of MPI mRNA27989131
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MPI mRNA17361019
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of MPI mRNA27392435
D002945CisplatinCisplatin results in increased expression of MPI mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of MPI mRNA28302478
D004026DieldrinDieldrin results in increased expression of MPI mRNA28385952
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MPI mRNA22079256
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of MPI mRNA23649840
C007738fluoranthene[fluoranthene co-treated with Permethrin] results in increased expression of MPI mRNA22406618
D005485FlutamideFlutamide results in decreased expression of MPI mRNA24793618
D005557FormaldehydeFormaldehyde results in decreased expression of MPI mRNA23649840
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of MPI mRNA27392435
C544151jinfukangjinfukang results in increased expression of MPI mRNA27392435
C027693mannose-6-phosphateMPI protein results in increased metabolism of mannose-6-phosphate21539312
C027693mannose-6-phosphatePMM2 protein inhibits the reaction [MPI protein results in increased metabolism of mannose-6-phosphate]21539312
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to MPI promoter]20348232
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of MPI mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MPI mRNA23649840
D008743Methyl Parathion[Methyl Parathion co-treated with Cadmium Chloride] results in increased expression of MPI mRNA22767353
D008743Methyl Parathion[Methyl Parathion co-treated with Cadmium Chloride] results in increased expression of MPI protein22767353
D008743Methyl ParathionMethyl Parathion results in increased expression of MPI mRNA22767353
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of MPI mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of MPI mRNA"25554681
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of MPI mRNA20971185
D026023Permethrin[fluoranthene co-treated with Permethrin] results in increased expression of MPI mRNA22406618
D026023PermethrinPermethrin results in decreased expression of MPI mRNA22406618
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MPI mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of MPI mRNA26272509
C006253pirinixic acidpirinixic acid results in decreased expression of MPI mRNA17426115
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MPI mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of MPI mRNA22079256
D013849ThimerosalThimerosal results in decreased expression of MPI mRNA27188386
C012589trichostatin Atrichostatin A results in increased expression of MPI mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MPI mRNA"26179874
D014520UrethaneUrethane results in decreased expression of MPI mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of MPI mRNA15901671

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004476mannose-6-phosphate isomerase activity-IBA21873635  
GO:0004476mannose-6-phosphate isomerase activity-TAS-  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000032cell wall mannoprotein biosynthetic process-IBA21873635  
GO:0006486protein glycosylation-IBA21873635  
GO:0009298GDP-mannose biosynthetic process-IBA21873635  
GO:0009298GDP-mannose biosynthetic process-IEA-  
GO:0009298GDP-mannose biosynthetic process-TAS-  
GO:0061611mannose to fructose-6-phosphate metabolic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa00051Fructose and mannose metabolism
hsa00520Amino sugar and nucleotide sugar metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-3781865Diseases of glycosylationTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-4043916Defective MPI causes MPI-CDG (CDG-1b)TAS
R-HSA-446193Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-446205Synthesis of GDP-mannoseTAS
R-HSA-446219Synthesis of substrates in N-glycan biosythesisTAS
R-HSA-5609975Diseases associated with glycosylation precursor biosynthesisTAS
R-HSA-597592Post-translational protein modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23189925Acute and chronic effects of smoking on myocardial function in healthy heavy smokers: a study of Doppler flow, Doppler tissue velocity, and two-dimensional speckle tracking echocardiography. (2013 Mar)Farsalinos KEchocardiography
24379127Long-term mortality following normal exercise myocardial perfusion SPECT according to coronary disease risk factors. (2014 Apr)Rozanski AJ Nucl Cardiol
26582040The prognostic value of regadenoson SPECT myocardial perfusion imaging in patients with end-stage renal disease. (2017 Feb)Doukky RJ Nucl Cardiol
17380191C-reactive protein and vulnerability to mental stress-induced myocardial ischemia. (2006 Nov-Dec)Shah RMol Med
29500790Predictors of severe stenosis at invasive coronary angiography in patients with normal myocardial perfusion imaging. (2018 Apr)Yokota SNeth Heart J
26161249The impact of smoking and previous periodontal disease on peri-implant microbiota and health: a retrospective study up to 7-year follow-up. (2015 Jan-Mar)Quaranta AAnn Stomatol (Roma)
22565239Safety and feasibility of regadenoson use for suboptimal heart rate response during symptom-limited standard Bruce exercise stress test. (2012 Oct)Partington SLJ Nucl Cardiol