Gene: MPL

4352
C-MPL|CD110|MPLV|THCYT2|TPOR
MPL proto-oncogene, thrombopoietin receptor
protein-coding
1p34.2
Ensembl:ENSG00000117400 MIM:159530 Vega:OTTHUMG00000007429 UniprotKB:P40238
NG_007525.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.580e-2 (AD)  6.888e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NPBWR10.692
FREM30.682
GPR260.675
RELN0.659
HCRTR10.645
FBLN70.637
HS6ST30.636
GALNTL60.631
PIK3C2G0.631
PRLHR0.622

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEBP2-0.448
ROM1-0.416
AZGP1-0.398
OTOS-0.389
AQP1-0.381
PLIN2-0.374
TGFB3-0.369
KIF19-0.36
ANG-0.349
IFITM2-0.349

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05332RomiplostimBiotechDrug267639-76-9ApprovedTarget
DB05930SB-559448Small Molecule-InvestigationalTarget
DB06210EltrombopagSmall Molecule496775-61-2ApprovedTarget
DB06534ThrombopoietinBiotechDrug9014-42-0InvestigationalTarget
ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of MPL mRNA"18648102
C021139anagrelideanagrelide inhibits the reaction [THPO protein results in increased expression of MPL mRNA]20586925
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MPL mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of MPL mRNA15761015
D001280AtrazineAtrazine results in increased expression of MPL mRNA25929836
C037689benzamidebenzamide analog binds to and results in increased activity of MPL protein18396041
D001554BenzeneBenzene results in decreased expression of MPL mRNA19162166
D001554BenzeneBenzene results in decreased expression of MPL mRNA15120971
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of MPL mRNA26377693
C006780bisphenol Abisphenol A results in increased methylation of MPL promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of MPL mRNA25181051
D002104CadmiumCadmium results in decreased expression of MPL mRNA24376830
C014347decitabinedecitabine promotes the reaction [hydroquinone results in increased expression of MPL mRNA]22245671
C520809eltrombopageltrombopag binds to and results in increased activity of MPL protein21646437
C031927hydroquinonedecitabine promotes the reaction [hydroquinone results in increased expression of MPL mRNA]22245671
C031927hydroquinonehydroquinone results in decreased methylation of MPL gene22245671
C031927hydroquinonehydroquinone results in increased expression of MPL mRNA22245671
D008748Methylcholanthrene"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of MPL mRNA"25926378
C059539midostaurinmidostaurin results in increased expression of MPL protein19573588
D037742Nanotubes, Carbon"[Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of MPL mRNA"25926378
D009532NickelNickel results in decreased expression of MPL mRNA24768652|2558310
D052638Particulate MatterParticulate Matter results in decreased expression of MPL mRNA15046786
D010416PentachlorophenolPentachlorophenol results in increased expression of MPL mRNA23892564
D011192Potassium DichromatePotassium Dichromate results in decreased expression of MPL mRNA23608068
C045950propiconazolepropiconazole results in increased expression of MPL mRNA21278054
D014118Toxins, Biological"Toxins, Biological affects the expression of MPL mRNA"19682533
D014520UrethaneUrethane results in decreased expression of MPL mRNA28818685
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of MPL mRNA15046786

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-TAS8020956  
GO:0005515protein binding-IPI24931576  
GO:0038164thrombopoietin receptor activity-IMP25538044  
GO ID GO Term Qualifier Evidence PubMed
GO:0001780neutrophil homeostasis-IEA-  
GO:0007166cell surface receptor signaling pathway-TAS8020956  
GO:0008283cell proliferation-TAS8020956  
GO:0035702monocyte homeostasis-IEA-  
GO:0038163thrombopoietin-mediated signaling pathway-IEA-  
GO:0050671positive regulation of lymphocyte proliferation-IEA-  
GO:0070527platelet aggregation-IEA-  
GO:0071456cellular response to hypoxia-IEA-  
GO:1905221positive regulation of platelet formation-IEA-  
GO:1990959eosinophil homeostasis-IEA-  
GO:1990960basophil homeostasis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005794Golgi apparatus-IDA25538044  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS8020956  
GO:0009986cell surface-IDA25538044  
GO:0043005neuron projection-IEA-  
GO:0043025neuronal cell body-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisIEA
R-HSA-76002Platelet activation, signaling and aggregationIEA
R-HSA-76009Platelet Aggregation (Plug Formation)IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20849660Risk factors for development of left ventricular thrombus after first acute anterior myocardial infarction-association with anticardiolipin antibodies. (2010 Sep 19)Okuyan EThromb J
14633783Chronic myeloproliferative disorders. (2003)Spivak JLHematology Am Soc Hematol Educ Program
9478297Anticardiolipin antibodies in pre-eclampsia and intrauterine growth retardation. (1997)D'Anna RClin Exp Obstet Gynecol
10436101Elevated anticardiolipin antibody titer is a stroke risk factor in a multiethnic population independent of isotype or degree of positivity. (1999 Aug)Tuhrim SStroke