Gene: MPP2

4355
DLG2
membrane palmitoylated protein 2
protein-coding
17q21.31
Ensembl:ENSG00000108852 MIM:600723 Vega:OTTHUMG00000133840 UniprotKB:Q14168
NC_000017.11
PubMed|SNP Mapped
0   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.231e-1 (AD)  3.491e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NUDCD30.953
MAPT0.953
MADD0.949
APBB10.949
TRIM30.944
ATP6V0A10.943
USP50.942
TBC1D250.938
FAM131B0.938
IGSF80.938

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.567
OR4F29-0.531
TFPI2-0.5
KCNJ15-0.494
RNF135-0.482
CLEC2B-0.481
SIX1-0.48
MTRNR2L6-0.477
EBF1-0.477
WWTR1-0.467

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of MPP2 mRNA28329830
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of MPP2 mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of MPP2 mRNA"23829299
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of MPP2 mRNA"23829299
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MPP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MPP2 mRNA"27188386
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MPP2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of MPP2 mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MPP2 mRNA22316170
D001564Benzo(a)pyreneAHR affects the reaction [Benzo(a)pyrene results in increased expression of MPP2 mRNA]21995607
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of MPP2 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to MPP2 promoter]21995607
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MPP2 mRNA15034205|2199560
C006780bisphenol Abisphenol A results in increased expression of MPP2 mRNA15223131
D002220CarbamazepineCarbamazepine affects the expression of MPP2 mRNA25979313
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of MPP2 mRNA24763279
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MPP2 gene20938992
D003300CopperCopper deficiency results in increased expression of MPP2 mRNA26033743
D003976DiazinonDiazinon results in increased methylation of MPP2 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MPP2 mRNA21266533
D002945CisplatinMPP2 protein affects the susceptibility to Cisplatin16217747
D002945CisplatinMPP2 results in decreased susceptibility to Cisplatin21652733
D004041Dietary FatsDietary Fats results in increased expression of MPP2 mRNA25016146
D019422Dietary SucroseDietary Sucrose results in increased expression of MPP2 mRNA26033743
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of MPP2 mRNA28329830
C007738fluoranthenefluoranthene results in increased expression of MPP2 mRNA28329830
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MPP2 gene20938992
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of MPP2 mRNA24763279
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MPP2 gene20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of MPP2 mRNA"20188158
D010100OxygenOxygen deficiency results in increased expression of MPP2 mRNA22629407
D010100OxygenOxygen inhibits the reaction [Oxygen deficiency results in increased expression of MPP2 mRNA]22629407
C410127PCB 180PCB 180 results in increased expression of MPP2 mRNA23829299
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MPP2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of MPP2 mRNA26272509
D010938Plant OilsPlant Oils results in decreased expression of MPP2 mRNA23370395
D059808PolyphenolsPolyphenols results in decreased expression of MPP2 mRNA16293270
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of MPP2 mRNA22714537
D011374ProgesteroneProgesterone results in increased expression of MPP2 mRNA19690047
D013749TetrachlorodibenzodioxinAHR affects the reaction [Tetrachlorodibenzodioxin results in increased expression of MPP2 mRNA]21995607
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MPP2 mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MPP2 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MPP2 mRNA15034205|1993321
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MPP2 mRNA28065790
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MPP2 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of MPP2 mRNA19140230
D014635Valproic AcidValproic Acid affects the expression of MPP2 mRNA25979313
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of MPP2 mRNA25423262
C025643vinclozolinvinclozolin results in decreased expression of MPP2 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI19665017  
GO ID GO Term Qualifier Evidence PubMed
GO:0051260protein homooligomerization-ISS-  
GO:0060079excitatory postsynaptic potential-ISS-  
GO:0060291long-term synaptic potentiation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005856cytoskeleton-IDA19665017  
GO:0014069postsynaptic density-ISS-  
GO:0032590dendrite membrane-ISS-  
GO:0032591dendritic spine membrane-IEA-  
GO:0043197dendritic spine-ISS-  
GO:0043198dendritic shaft-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal