Gene: MPST

4357
MST|TST2|TUM1
mercaptopyruvate sulfurtransferase
protein-coding
22q12.3
Ensembl:ENSG00000128309 MIM:602496 Vega:OTTHUMG00000150543 UniprotKB:P25325
NC_000022.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.315e-1 (AD)  5.714e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HMG20B0.876
SLC25A10.871
TSC22D40.868
COMT0.845
CYP27A10.841
TMED10.823
SERF20.823
RFXANK0.822
MID1IP10.81
EFHD10.81

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NCR3LG1-0.541
CDH7-0.532
HS6ST3-0.524
MCHR2-0.521
PCDHAC1-0.521
KCNH1-0.515
EPHA3-0.514
KCNH5-0.511
ZNF860-0.51
SCN8A-0.509

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of MPST mRNA"19162173
C0083663-mercaptopyruvic acidMPST protein results in increased metabolism of [Cyanides co-treated with 3-mercaptopyruvic acid]20705081
C0083663-mercaptopyruvic acid[MPST protein results in increased metabolism of [Cyanides co-treated with 3-mercaptopyruvic acid]] which results in increased chemical synthesis of and results in increased abundance of Pyruvic Acid20705081
C0083663-mercaptopyruvic acid[MPST protein results in increased metabolism of [Cyanides co-treated with 3-mercaptopyruvic acid]] which results in increased chemical synthesis of and results in increased abundance of thiocyanate20705081
D000082AcetaminophenAcetaminophen results in decreased expression of MPST mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of MPST mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of MPST protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MPST mRNA22100608|2715375
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in decreased expression of MPST protein26597043
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of MPST protein26597043
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of MPST mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MPST mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MPST mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MPST mRNA27195522
C006780bisphenol A[Fructose co-treated with bisphenol A] results in decreased expression of MPST protein26930160
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MPST protein24527689
D002330CarmustineMPST mRNA affects the susceptibility to Carmustine16365179
D002509CephaloridineCephaloridine results in decreased expression of MPST mRNA18500788
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MPST mRNA20938992
D002994ClofibrateClofibrate results in decreased expression of MPST protein16470657
C018021cobaltous chloridecobaltous chloride results in decreased expression of MPST mRNA24386269
D003300CopperCopper results in decreased expression of MPST mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of MPST mRNA19549813
D003486CyanidesMPST protein results in increased metabolism of Cyanides23929717
D003486CyanidesMPST protein results in increased metabolism of [Cyanides co-treated with 3-mercaptopyruvic acid]20705081
D003486Cyanides[MPST protein results in increased metabolism of [Cyanides co-treated with 3-mercaptopyruvic acid]] which results in increased chemical synthesis of and results in increased abundance of Pyruvic Acid20705081
D003486Cyanides[MPST protein results in increased metabolism of [Cyanides co-treated with 3-mercaptopyruvic acid]] which results in increased chemical synthesis of and results in increased abundance of thiocyanate20705081
D003486Cyanides[MPST protein results in increased metabolism of Cyanides] which results in increased abundance of thiocyanate23929717
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MPST mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of MPST mRNA27392435
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of MPST mRNA"22485181
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of MPST protein23301498
D005419FlavonoidsFlavonoids results in decreased expression of MPST mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MPST mRNA20938992
D005632Fructose[Fructose co-treated with bisphenol A] results in decreased expression of MPST protein26930160
C039281furanfuran binds to MPST protein22240984
C039281furanfuran results in increased expression of MPST mRNA26194646
D006581HexachlorobenzeneHexachlorobenzene results in increased expression of MPST mRNA15159207
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of MPST mRNA17183730
D006862Hydrogen SulfideMPST results in increased chemical synthesis of Hydrogen Sulfide25205294
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MPST mRNA25613284
C051890irinotecanirinotecan results in decreased expression of MPST mRNA20185912
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of MPST mRNA27392435
C544151jinfukangjinfukang results in increased expression of MPST mRNA27392435
C017461lead nitratelead nitrate results in increased expression of MPST protein22525307
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of MPST mRNA16507785
D008627Mercuric ChlorideMercuric Chloride results in decreased activity of MPST protein21605701
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of MPST mRNA20938992
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of MPST protein19059321
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of MPST protein24806433
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of MPST mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MPST mRNA"25554681
C051752nefazodonenefazodone results in decreased expression of MPST mRNA24136188
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of MPST mRNA25729387
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of MPST protein26879310
D010575PesticidesPesticides results in increased expression of MPST protein19059321
D010634PhenobarbitalPhenobarbital results in decreased expression of MPST mRNA19270015
D010795Phthalic AcidsPhthalic Acids results in decreased expression of MPST mRNA21061450
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MPST mRNA19710929
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MPST mRNA19710929
D011190Potassium CyanidePotassium Cyanide results in decreased activity of MPST protein23929717
D019289Pyruvic Acid[MPST protein results in increased metabolism of [Cyanides co-treated with 3-mercaptopyruvic acid]] which results in increased chemical synthesis of and results in increased abundance of Pyruvic Acid20705081
C059514resveratrolresveratrol results in increased expression of MPST mRNA22610192
C059514resveratrolresveratrol results in increased expression of MPST protein25505154
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of MPST mRNA19244175
D012643SeleniumSelenium results in increased expression of MPST mRNA19244175
D013605T-2 ToxinT-2 Toxin affects the expression of MPST protein26141394
D013629TamoxifenTamoxifen affects the expression of MPST mRNA20937368
C047246temozolomideMPST mRNA affects the susceptibility to temozolomide16365179
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MPST mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MPST mRNA25613284
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in decreased expression of MPST protein"25852303
C031760thiocyanate[MPST protein results in increased metabolism of [Cyanides co-treated with 3-mercaptopyruvic acid]] which results in increased chemical synthesis of and results in increased abundance of thiocyanate20705081
C031760thiocyanate[MPST protein results in increased metabolism of Cyanides] which results in increased abundance of thiocyanate23929717
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MPST protein22595367
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of MPST protein22609517
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of MPST mRNA25729387
D019772TopotecanTopotecan results in decreased expression of MPST mRNA25729387
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of MPST mRNA17183730
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MPST gene25560391
C025643vinclozolinvinclozolin results in decreased expression of MPST mRNA23034163
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of MPST mRNA19244175
D014810Vitamin EVitamin E results in increased expression of MPST mRNA19244175
D015032ZincZinc results in decreased expression of MPST mRNA17074742
D019287Zinc SulfateZinc Sulfate results in decreased expression of MPST mRNA17074742

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004792thiosulfate sulfurtransferase activity-IEA-  
GO:00167843-mercaptopyruvate sulfurtransferase activity-ISS-  
GO:00167843-mercaptopyruvate sulfurtransferase activity-TAS-  
GO:0042802identical protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000098sulfur amino acid catabolic process-TAS-  
GO:0001822kidney development-IEA-  
GO:0001889liver development-IEA-  
GO:0009440cyanate catabolic process-TAS9070219  
GO:0009636response to toxic substance-TAS9070219  
GO:0019346transsulfuration-IEA-  
GO:0021510spinal cord development-IEA-  
GO:0070814hydrogen sulfide biosynthetic process-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005759mitochondrial matrix-TAS-  
GO:0005829cytosol-IEA-  
GO:0030054cell junction-IEA-  
GO:0043005neuron projection-ISS-  
GO:0045202synapse-IEA-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
hsa00270Cysteine and methionine metabolism
hsa01100Metabolic pathways
hsa04122Sulfur relay system
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1614558Degradation of cysteine and homocysteineTAS
R-HSA-1614635Sulfur amino acid metabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29743070The anti-proliferative and anti-inflammatory response of COPD airway smooth muscle cells to hydrogen sulfide. (2018 May 9)Perry MMRespir Res