Gene: MRC1

4360
CD206|CLEC13D|CLEC13DL|MMR|MRC1L1|bA541I19.1|hMR
mannose receptor C-type 1
protein-coding
10p12.33
Ensembl:ENSG00000260314 MIM:153618 Vega:OTTHUMG00000174646 UniprotKB:P22897
NG_047011.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.472e-1 (AD)  7.719e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GATA60.689
SLC22A20.684
SLC22A80.669
ALX40.66
TRABD2B0.651
SLC13A40.646
INMT0.646
CDC20B0.644
PKHD1L10.64
OR51E10.635

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HPSE2-0.26
GRM3-0.242
EFNA2-0.239
ZNF98-0.238
HHATL-0.238
HES6-0.235
EPHB1-0.231
PDE6B-0.226
GRIN2C-0.222
HDAC11-0.219

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09266Technetium Tc-99m tilmanoceptSmall Molecule1262984-82-6Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MRC1 mRNA"21346803
C4574992-chloro-5-nitrobenzanilide2-chloro-5-nitrobenzanilide inhibits the reaction [[Selenium co-treated with IL4 protein] results in increased expression of MRC1 mRNA]21775527
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of MRC1 mRNA"18648102
C5352117,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acid"7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acid results in increased expression of MRC1 mRNA"24038091
D000082AcetaminophenAcetaminophen affects the expression of MRC1 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of MRC1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MRC1 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of MRC1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MRC1 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of MRC1 mRNA24449571
D001397Azoxymethane[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MRC1 mRNA25026504
D001397Azoxymethane[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MRC1 protein25026504
D001397Azoxymethaneisoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MRC1 mRNA]25026504
D001397Azoxymethaneisoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MRC1 protein]25026504
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MRC1 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MRC1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MRC1 mRNA22300585
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MRC1 mRNA21839799
D004958EstradiolEstradiol results in increased expression of MRC1 mRNA19484750
C095105bexarotene[bexarotene co-treated with Tamoxifen] results in decreased expression of MRC1 mRNA17630414
C006780bisphenol Abisphenol A results in decreased expression of MRC1 mRNA25181051
D001761BleomycinBleomycin results in increased expression of MRC1 mRNA29033951
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of MRC1 mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of MRC1 mRNA24982889
D019256Cadmium ChlorideCadmium Chloride affects the expression of MRC1 mRNA18804290
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of MRC1 mRNA27339419
D002706ChlordanChlordan results in decreased expression of MRC1 mRNA23153324
D003042CocaineCocaine results in decreased expression of MRC1 mRNA17898221
C107676deguelindeguelin promotes the reaction [Oxygen deficiency results in increased expression of MRC1 mRNA]22745725
D016264Dextran Sulfate[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MRC1 mRNA25026504
D016264Dextran Sulfate[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MRC1 protein25026504
D016264Dextran Sulfateisoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MRC1 mRNA]25026504
D016264Dextran Sulfateisoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MRC1 protein]25026504
D004041Dietary FatsHMOX1 protein promotes the reaction [Dietary Fats results in increased expression of MRC1 mRNA]23390531
D004041Dietary FatsDietary Fats results in decreased expression of MRC1 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of MRC1 mRNA23390531
D004237DiuronDiuron results in decreased expression of MRC1 mRNA25152437
D004298DopamineDopamine results in decreased expression of MRC1 mRNA25818600
D004298DopamineDopamine results in decreased expression of MRC1 protein25818600
D052244Endocrine DisruptorsEndocrine Disruptors results in increased expression of MRC1 mRNA25198161
D004726EndosulfanEndosulfan inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of MRC1 mRNA]26159488
C007630estradiol 17 beta-cypionateestradiol 17 beta-cypionate results in increased expression of MRC1 mRNA22497863
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MRC1 mRNA12072388|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MRC1 mRNA17942748
D005047EtoposideEtoposide results in decreased expression of MRC1 mRNA25270620
D005485FlutamideFlutamide results in decreased expression of MRC1 mRNA24793618
C039281furanfuran results in increased methylation of MRC1 gene22079235
D017313FenretinideFenretinide results in decreased expression of MRC1 mRNA28973697
C040920isoliquiritigeninisoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MRC1 mRNA]25026504
C040920isoliquiritigeninisoliquiritigenin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of MRC1 protein]25026504
D007545IsoproterenolIsoproterenol results in increased expression of MRC1 mRNA20003209
C008261lead acetatelead acetate results in increased expression of MRC1 mRNA22641619
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of MRC1 protein"17630318
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of MRC1 protein26918785
D008070Lipopolysaccharides"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Lipopolysaccharides results in increased expression of MRC1 protein]"26918785
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with IL4 protein] results in increased expression of MRC1 mRNA21977998
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of MRC1 mRNA24038091
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with Rutin] results in increased expression of MRC1 protein28693884
D008466MechlorethamineMechlorethamine results in increased expression of MRC1 protein26273949
D008687MetforminMetformin inhibits the reaction [IL13 protein results in increased expression of MRC1 mRNA]26497364
D008687MetforminMetformin inhibits the reaction [IL13 protein results in increased expression of MRC1 protein]26497364
D008687MetforminMetformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MRC1 mRNA]26497364
D008687MetforminMetformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MRC1 protein]26497364
C445068methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate inhibits the reaction [Lipopolysaccharides results in increased expression of MRC1 protein]"26918785
C005219methyl cellosolvemethyl cellosolve results in increased expression of MRC1 mRNA21061450
C523799MRK 003MRC1 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of MRC1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of MRC1 mRNA"25554681
D019829NevirapineNevirapine metabolite results in increased expression of MRC1 mRNA23947594
D009532NickelNickel results in increased expression of MRC1 mRNA25583101
C017557nickel subsulfidenickel subsulfide results in increased expression of MRC1 mRNA21086188
C012655nimesulidenimesulide results in decreased expression of MRC1 mRNA24136188
C025589ochratoxin Aochratoxin A results in increased expression of MRC1 mRNA24792326
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of MRC1 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of MRC1 mRNA25729387
D010100Oxygendeguelin promotes the reaction [Oxygen deficiency results in increased expression of MRC1 mRNA]22745725
D010100OxygenOxygen deficiency results in increased expression of MRC1 mRNA22745725
D017239PaclitaxelPaclitaxel results in increased expression of MRC1 mRNA18754875
D000073878Palm OilPalm Oil results in decreased expression of MRC1 mRNA18042831
D010269ParaquatParaquat results in decreased expression of MRC1 mRNA24521700
D010269ParaquatParaquat results in increased expression of MRC1 mRNA28467894
D052638Particulate MatterParticulate Matter results in increased expression of MRC1 protein17630318
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of MRC1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of MRC1 mRNA19482888
D010795Phthalic AcidsPhthalic Acids results in increased expression of MRC1 mRNA21061450
C006253pirinixic acidpirinixic acid results in decreased expression of MRC1 mRNA18445702
D011192Potassium DichromatePotassium Dichromate results in increased expression of MRC1 mRNA23608068
D011374ProgesteroneProgesterone inhibits the reaction [IL4 protein results in increased expression of MRC1 mRNA]21977998
C059514resveratrolresveratrol results in increased expression of MRC1 mRNA23832548
D012431Rutin[Lipopolysaccharides co-treated with Rutin] results in increased expression of MRC1 protein28693884
D012431RutinRutin results in increased expression of MRC1 protein28693884
D012643Selenium2-chloro-5-nitrobenzanilide inhibits the reaction [[Selenium co-treated with IL4 protein] results in increased expression of MRC1 mRNA]21775527
D012643Selenium[Selenium co-treated with IL4 protein] results in increased expression of MRC1 mRNA21775527
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of MRC1 mRNA23806026
D012822Silicon DioxideSilicon Dioxide results in decreased expression of MRC1 mRNA23221170
C009277sodium arsenatesodium arsenate results in increased expression of MRC1 mRNA21795629
D012969Sodium FluorideSodium Fluoride results in decreased expression of MRC1 mRNA27862939
D018038Sodium SeleniteSodium Selenite results in decreased expression of MRC1 mRNA23274088
D012999SomanSoman results in increased expression of MRC1 mRNA19281266
D053260SootSoot results in increased expression of MRC1 mRNA22461453
D013629Tamoxifen[bexarotene co-treated with Tamoxifen] results in decreased expression of MRC1 mRNA17630414
D013749TetrachlorodibenzodioxinEndosulfan inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of MRC1 mRNA]26159488
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MRC1 mRNA26159488
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MRC1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MRC1 mRNA16267337
D013755Tetradecanoylphorbol AcetateMetformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MRC1 mRNA]26497364
D013755Tetradecanoylphorbol AcetateMetformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MRC1 protein]26497364
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of MRC1 mRNA26497364
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of MRC1 protein26497364
C009495titanium dioxidetitanium dioxide results in increased expression of MRC1 mRNA23409001
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of MRC1 mRNA25729387
D019772TopotecanTopotecan results in increased expression of MRC1 mRNA25729387
D014241TrichloroethyleneTrichloroethylene results in increased methylation of MRC1 gene27618143
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of MRC1 mRNA19042947
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of MRC1 mRNA17982090
C057693troglitazonetroglitazone results in increased expression of MRC1 mRNA28973697
D014635Valproic AcidValproic Acid results in decreased methylation of MRC1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of MRC1 mRNA17292431
D000068756ValsartanValsartan results in decreased expression of MRC1 mRNA22768174
D001335Vehicle EmissionsVehicle Emissions results in increased expression of MRC1 protein17630318
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MRC1 gene25560391
C025643vinclozolinvinclozolin affects the expression of MRC1 mRNA19015723|2303416
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of MRC1 mRNA"25198161

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IEA-  
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0005515protein binding-IPI11222859  
GO:0005537mannose binding-IEA-  
GO:0038024cargo receptor activity-IDA20035344  
GO ID GO Term Qualifier Evidence PubMed
GO:0006898receptor-mediated endocytosis-IDA20035344  
GO:0007165signal transduction-IEA-  
GO:0046718viral entry into host cell-IEA-  
GO:0071222cellular response to lipopolysaccharide-IEA-  
GO:0071346cellular response to interferon-gamma-IEA-  
GO:0071353cellular response to interleukin-4-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA20035344  
GO:0005887integral component of plasma membrane-TAS1294118  
GO:0009986cell surface-IEA-  
GO:0010008endosome membrane-IDA20035344  
KEGG ID KEGG Term
hsa04145Phagosome
Reactome ID Reactome Term Evidence
R-HSA-1236975Antigen processing-Cross presentationTAS
R-HSA-1236975Antigen processing-Cross presentationIEA
R-HSA-1236978Cross-presentation of soluble exogenous antigens (endosomes)TAS
R-HSA-1236978Cross-presentation of soluble exogenous antigens (endosomes)IEA
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1280218Adaptive Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19902202Genetic variants in the mannose receptor gene (MRC1) are associated with asthma in two independent populations. (2009 Dec)Hattori TImmunogenetics