Gene: MRE11

4361
ATLD|HNGS1|MRE11A|MRE11B
MRE11 homolog, double strand break repair nuclease
protein-coding
11q21
Ensembl:ENSG00000020922 MIM:600814 Vega:OTTHUMG00000167780 UniprotKB:P49959
NG_007261.1
PubMed
0   ANCO-SNPs
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.951e-1 (AD)  2.151e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0319031-UFT protocolMRE11 protein results in decreased susceptibility to 1-UFT protocol16734730
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MRE11 mRNA"19167446
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in decreased expression of MRE11 protein26194647
D000082AcetaminophenAcetaminophen results in increased expression of MRE11 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MRE11 gene27153756
C016274bromoacetatebromoacetate results in increased expression of MRE11 mRNA19753638
D002166CamptothecinCamptothecin results in decreased expression of MRE11 mRNA24792648
D000069287CapecitabineMRE11 protein results in decreased susceptibility to Capecitabine16734730
C099555CD 437CD 437 results in decreased expression of MRE11 protein15059897
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of MRE11 protein25173789
D003300Copper[Thiosemicarbazones binds to Copper] which results in increased expression of MRE11 protein20931265
D019327Copper SulfateCopper Sulfate results in decreased expression of MRE11 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MRE11 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of MRE11 mRNA19167446
D016572CyclosporineCyclosporine results in decreased expression of MRE11 mRNA20106945
C089595cylindrospermopsincylindrospermopsin results in decreased expression of MRE11 mRNA23726867
C014347decitabinedecitabine affects the localization of MRE11 protein modified form17991895
D002945CisplatinCisplatin results in increased expression of MRE11 protein26723870
D004126DimethylformamideDimethylformamide results in increased expression of MRE11 mRNA26387567
D004126DimethylformamideDimethylformamide results in increased expression of MRE11 protein26387567
C025034doxifluridineMRE11 protein results in decreased susceptibility to doxifluridine16734730
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MRE11 mRNA22079256
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of MRE11 mRNA20044591
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MRE11 mRNA25613284
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MRE11 mRNA23649840
C005246myristicinmyristicin results in decreased expression of MRE11 mRNA24792648
D010419PentamidinePentamidine results in decreased activity of MRE11 protein20144237
D010936Plant ExtractsPlant Extracts results in increased expression of MRE11 mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MRE11 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of MRE11 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in increased expression of MRE11 mRNA23628323
D011794QuercetinQuercetin results in decreased expression of MRE11 mRNA21632981
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of MRE11 mRNA19167446
C059514resveratrolresveratrol results in decreased expression of MRE11 protein22644231
C059514resveratrolresveratrol results in decreased expression of [MRE11 protein binds to NBN protein binds to RAD50 protein]22644231
C547185riccardin Driccardin D results in decreased expression of MRE11 mRNA24069304
D012402RotenoneRotenone results in increased expression of MRE11 mRNA18191903
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MRE11 mRNA25613284
D013882Thiosemicarbazones[Thiosemicarbazones binds to Copper] which results in increased expression of MRE11 protein20931265
D014635Valproic AcidValproic Acid results in decreased expression of MRE11 mRNA23179753|2718838
C521013veliparibMRE11 protein results in decreased susceptibility to veliparib21300766
D015032ZincZinc deficiency results in decreased expression of MRE11 mRNA18356318
C023616zinc chromatezinc chromate affects the expression of MRE11 protein25173789
C023616zinc chromatezinc chromate results in increased expression of MRE11 protein19027772

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000014single-stranded DNA endodeoxyribonuclease activity-IBA21873635  
GO:0000014single-stranded DNA endodeoxyribonuclease activity-IDA9705271  
GO:0003677DNA bindingcontributes_toIDA15790808  
GO:0003690double-stranded DNA binding-TAS10802669  
GO:0003691double-stranded telomeric DNA binding-IBA21873635  
GO:0004003ATP-dependent DNA helicase activitycontributes_toIMP15790808  
GO:0004518nuclease activity-TAS15790808  
GO:0004519endonuclease activity-IBA21873635  
GO:0004520endodeoxyribonuclease activity-IDA9705271  
GO:0004520endodeoxyribonuclease activity-TAS-  
GO:0005515protein binding-IPI12419185  15916964  16377563  17428914  17500065  17500595  
17612497  18583988  18716619  19197236  19234442  19609304  
21052091  22078559  22157895  24529708  24534091  24651726  
25558984  25772236  26807646  27568553  
GO:0008022protein C-terminus binding-IPI9590181  
GO:00084083'-5' exonuclease activity-IBA21873635  
GO:00084083'-5' exonuclease activity-IDA9651580  9705271  
GO:0030145manganese ion binding-IBA21873635  
GO:0030145manganese ion binding-IEA-  
GO:0042802identical protein binding-IPI22078559  
GO:0043047single-stranded telomeric DNA binding-IBA21873635  
GO:0045296cadherin binding-HDA25468996  
GO ID GO Term Qualifier Evidence PubMed
GO:0000019regulation of mitotic recombination-TAS8530104  
GO:0000723telomere maintenance-IBA21873635  
GO:0000724double-strand break repair via homologous recombination-TAS-  
GO:0000729DNA double-strand break processing-TAS-  
GO:0006260DNA replication-TAS-  
GO:0006281DNA repair-TAS9705271  9931460  
GO:0006284base-excision repair-IBA21873635  
GO:0006302double-strand break repair-IBA21873635  
GO:0006302double-strand break repair-TAS10612394  
GO:0006303double-strand break repair via nonhomologous end joining-IDA9651580  
GO:0006303double-strand break repair via nonhomologous end joining-TAS-  
GO:0006310DNA recombination-TAS9705271  
GO:0006974cellular response to DNA damage stimulus-IDA17500065  
GO:0007004telomere maintenance via telomerase-TAS9705271  9931460  
GO:0007062sister chromatid cohesion-IBA21873635  
GO:0007062sister chromatid cohesion-IMP15917200  
GO:0007095mitotic G2 DNA damage checkpoint-IBA21873635  
GO:0007095mitotic G2 DNA damage checkpoint-IEA-  
GO:0007129synapsis-IEA-  
GO:0007131reciprocal meiotic recombination-TAS8530104  9931460  
GO:0008283cell proliferation-IEA-  
GO:0016032viral process-IEA-  
GO:0031573intra-S DNA damage checkpoint-IBA21873635  
GO:0031860telomeric 3' overhang formation-IBA21873635  
GO:0031860telomeric 3' overhang formation-IMP16374507  
GO:0031954positive regulation of protein autophosphorylation-IDA15790808  
GO:0032206positive regulation of telomere maintenance-IMP16374507  
GO:0032481positive regulation of type I interferon production-TAS-  
GO:0032508DNA duplex unwinding-IMP15790808  
GO:0032876negative regulation of DNA endoreduplication-IMP15917200  
GO:0033674positive regulation of kinase activity-IDA15790808  
GO:0042138meiotic DNA double-strand break formation-IBA21873635  
GO:0043066negative regulation of apoptotic process-IMP16374507  
GO:0090305nucleic acid phosphodiester bond hydrolysis-IEA-  
GO:0097552mitochondrial double-strand break repair via homologous recombination-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000781chromosome, telomeric regioncolocalizes_withIDA15149599  
GO:0000784nuclear chromosome, telomeric region-HDA19135898  
GO:0000784nuclear chromosome, telomeric regionCOLOCALIZES_WITHIBA21873635  
GO:0000784nuclear chromosome, telomeric region-IDA10811102  
GO:0000784nuclear chromosome, telomeric regioncolocalizes_withIDA24270157  
GO:0000784nuclear chromosome, telomeric regioncolocalizes_withISS-  
GO:0000785chromatin-IBA21873635  
GO:0005634nucleus-TAS10802669  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IDA25468996  
GO:0005829cytosol-TAS-  
GO:0016605PML body-IDA10811102  
GO:0016605PML body-ISS-  
GO:0030870Mre11 complex-IBA21873635  
GO:0030870Mre11 complex-IDA19151086  
GO:0030870Mre11 complex-NAS15790808  
GO:0030870Mre11 complex-TAS27918544  
GO:0035861site of double-strand break-IBA21873635  
GO:0035861site of double-strand break-IDA15916964  
KEGG ID KEGG Term
hsa03440Homologous recombination
hsa03450Non-homologous end-joining
Reactome ID Reactome Term Evidence
R-HSA-1474165ReproductionIEA
R-HSA-1500620MeiosisIEA
R-HSA-1640170Cell CycleIEA
R-HSA-1640170Cell CycleTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-1834941STING mediated induction of host immune responsesTAS
R-HSA-1834949Cytosolic sensors of pathogen-associated DNA TAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceTAS
R-HSA-3270619IRF3-mediated induction of type I IFNTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5633007Regulation of TP53 ActivityTAS
R-HSA-5685938HDR through Single Strand Annealing (SSA)TAS
R-HSA-5685939HDR through MMEJ (alt-NHEJ)TAS
R-HSA-5685942HDR through Homologous Recombination (HRR)TAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693537Resolution of D-Loop StructuresTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693548Sensing of DNA Double Strand BreaksTAS
R-HSA-5693554Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)TAS
R-HSA-5693565Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksTAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693568Resolution of D-loop Structures through Holliday Junction IntermediatesTAS
R-HSA-5693571Nonhomologous End-Joining (NHEJ)TAS
R-HSA-5693579Homologous DNA Pairing and Strand ExchangeTAS
R-HSA-5693606DNA Double Strand Break ResponseTAS
R-HSA-5693607Processing of DNA double-strand break endsTAS
R-HSA-5693616Presynaptic phase of homologous DNA pairing and strand exchangeTAS
R-HSA-6804756Regulation of TP53 Activity through PhosphorylationTAS
R-HSA-69473G2/M DNA damage checkpointTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73894DNA RepairTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-912446Meiotic recombinationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18638378Analysis of variants in DNA damage signalling genes in bladder cancer. (2008 Jul 18)Choudhury ABMC Med Genet
28476809Contribution of Double-strand Break Repair Gene Nijmegen Breakage Syndrome 1 Genotypes, Gender Difference and Smoking Status to Taiwanese Lung Cancer. (2017 May)Chuang CLAnticancer Res
28729482BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity. (2017 Oct)Tacconi EMEMBO Mol Med