Gene: KLK14

43847
KLK-L6
kallikrein related peptidase 14
protein-coding
19q13.41
Ensembl:ENSG00000129437 MIM:606135 Vega:OTTHUMG00000143721 UniprotKB:Q9P0G3
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.249e-2 (AD)  5.344e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg25263454chr19:51587409KLK14Promoter6.557e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DNASE1L20.807
TLR90.792
PLK10.782
CCNA20.782
QRICH20.756
AOC20.755
SLFNL10.75
CLDN90.729
ZGLP10.727
RAD54L0.726

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TRDN-0.367
CCT6B-0.349
RBM3-0.346
CD36-0.342
CTSO-0.34
DSG1-0.324
PRSS27-0.318
MPEG1-0.309
CASQ2-0.307
DPH6-0.303

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of KLK14 gene27153756
D000638AmiodaroneAmiodarone results in increased expression of KLK14 mRNA19774075
D001280AtrazineAtrazine results in decreased expression of KLK14 mRNA25929836
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of KLK14 mRNA19737606
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KLK14 mRNA23735875
C006780bisphenol Abisphenol A results in decreased expression of KLK14 mRNA25181051
D003671DEET[fipronil co-treated with DEET] results in decreased expression of KLK14 mRNA27091632
C082360fipronil[fipronil co-treated with DEET] results in decreased expression of KLK14 mRNA27091632
C082360fipronilfipronil results in decreased expression of KLK14 mRNA27091632
D004397FonofosFonofos results in increased methylation of KLK14 promoter22847954
D010278ParathionParathion results in increased methylation of KLK14 promoter22847954
C012568terbufosterbufos results in increased methylation of KLK14 promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KLK14 mRNA23152189

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-IDA15654974  16885167  17110383  17158887  
GO:0004252serine-type endopeptidase activity-NAS10969073  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IDA15654974  17110383  17158887  18482984  
GO:0009566fertilization-IDA18482984  
GO:0045744negative regulation of G-protein coupled receptor protein signaling pathway-IDA16885167  
GO:0045745positive regulation of G-protein coupled receptor protein signaling pathway-IDA16885167  
GO:0048730epidermis morphogenesis-IBA21873635  
GO:0048730epidermis morphogenesis-IDA17158887  
GO:0070268cornification-TAS-  
GO:0070684seminal clot liquefaction-IBA21873635  
GO:0070684seminal clot liquefaction-IDA18482984  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA15654974  17110383  
GO:0030141secretory granule-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-6805567KeratinizationTAS
R-HSA-6809371Formation of the cornified envelopeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18316555A multiparametric serum kallikrein panel for diagnosis of non-small cell lung carcinoma. (2008 Mar 1)Planque CClin Cancer Res