Gene: KLK12

43849
KLK-L5|KLKL5
kallikrein related peptidase 12
protein-coding
19q13.41
Ensembl:ENSG00000186474 MIM:605539 Vega:OTTHUMG00000165806 UniprotKB:Q9UKR0
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.023e-2 (AD)  3.907e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPINK50.629
TMPRSS11B0.625
SERPINB30.597
MUC210.589
FGFBP10.588
KRT40.581
ADH70.58
SPRR2F0.573
DAZ10.555
KRT150.553

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TDRD9-0.226
SPC24-0.211
ACVR1C-0.198
OTC-0.196
ZRANB3-0.195
LANCL3-0.194
LURAP1L-0.19
CHIT1-0.189
THEGL-0.189
EIF2A-0.188

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of KLK12 mRNA24449571
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of KLK12 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of KLK12 gene25435355
C006780bisphenol Abisphenol A results in decreased expression of KLK12 mRNA25181051
D002922CiguatoxinsCiguatoxins affects the expression of KLK12 mRNA18353800
D002945CisplatinKLK12 protein affects the susceptibility to Cisplatin16217747
D011192Potassium DichromatePotassium Dichromate results in increased expression of KLK12 mRNA23608068
D012969Sodium FluorideSodium Fluoride results in increased expression of KLK12 mRNA27257137
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KLK12 mRNA23152189

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-NAS11054574  
GO:0008233peptidase activity-IDA21628462  
GO:0008236serine-type peptidase activity-IDA15300858  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IDA21628462  
GO:0070268cornification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-NAS21628462  
GO:0030141secretory granule-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-6805567KeratinizationTAS
R-HSA-6809371Formation of the cornified envelopeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18316555A multiparametric serum kallikrein panel for diagnosis of non-small cell lung carcinoma. (2008 Mar 1)Planque CClin Cancer Res