Gene: UNC13C

440279
-
unc-13 homolog C
protein-coding
15q21.3
Ensembl:ENSG00000137766 MIM:614568 Vega:OTTHUMG00000172542 UniprotKB:Q8NB66
NC_000015.10
SNP Mapped
2   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.189e-1 (AD)  9.585e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4430687chr15:54310022 (GRCh38.p7)C>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs8036265chr15:54183938 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAPGEF40.809
KIF5A0.759
SYTL20.745
MCF2L20.727
KIF5C0.712
RIMS20.712
RB1CC10.7
ZEB10.651
MYRIP0.648
KIF1B0.632

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.493
OR4F29-0.468
ISL1-0.304
LHX8-0.301
GAGE10-0.296
SLC18A3-0.295
TH-0.282
ERAS-0.281
SLC5A7-0.279
SLC35D3-0.272

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of UNC13C mRNA19933214
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of UNC13C mRNA"18343893
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of UNC13C gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of UNC13C mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of UNC13C mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of UNC13C gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of UNC13C mRNA21839799
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of UNC13C mRNA25566086
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydeMYBPC3 protein affects the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of UNC13C mRNA]25566086
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of UNC13C mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of UNC13C mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of UNC13C mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of UNC13C protein24552547
D003471CuprizoneCuprizone results in decreased expression of UNC13C mRNA26577399
D003703DemecolcineDemecolcine results in decreased expression of UNC13C mRNA23649840
D003976DiazinonDiazinon results in increased expression of UNC13C mRNA29108742
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of UNC13C mRNA23649840
D005557FormaldehydeFormaldehyde results in decreased expression of UNC13C mRNA23649840
C039281furanfuran results in decreased expression of UNC13C mRNA27387713
C039281furanfuran results in decreased methylation of UNC13C gene22079235
C412815GW 4064GW 4064 results in increased expression of UNC13C mRNA26655953
D008344Maneb[Paraquat co-treated with Maneb] affects the expression of UNC13C mRNA22563483
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of UNC13C mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of UNC13C mRNA"20188158
C028577monobutyl phthalatemonobutyl phthalate results in increased expression of UNC13C mRNA29162477
D010269Paraquat[Paraquat co-treated with Maneb] affects the expression of UNC13C mRNA22563483
D010269ParaquatParaquat results in increased expression of UNC13C mRNA22563483
D010936Plant ExtractsPlant Extracts results in decreased expression of UNC13C mRNA23557933
D059808PolyphenolsPolyphenols results in decreased expression of UNC13C mRNA16293270
D011189Potassium ChloridePotassium Chloride results in decreased expression of UNC13C mRNA16412482
D011374ProgesteroneProgesterone results in increased expression of UNC13C mRNA19690047
C428725pyridabenpyridaben results in increased expression of UNC13C mRNA22563483
D012402RotenoneRotenone results in increased expression of UNC13C mRNA19013527
D013739TestosteroneTestosterone results in decreased expression of UNC13C mRNA20403060
C010792testosterone undecanoatetestosterone undecanoate results in increased expression of UNC13C mRNA19074003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UNC13C mRNA18343893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of UNC13C mRNA19933214

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO:0005516calmodulin binding-IBA21873635  
GO:0005543phospholipid binding-IEA-  
GO:0017075syntaxin-1 binding-IBA21873635  
GO:0019992diacylglycerol binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007268chemical synaptic transmission-ISS-  
GO:0007528neuromuscular junction development-IBA21873635  
GO:0016081synaptic vesicle docking-IBA21873635  
GO:0016082synaptic vesicle priming-IBA21873635  
GO:0016188synaptic vesicle maturation-IBA21873635  
GO:0031914negative regulation of synaptic plasticity-IEA-  
GO:0035249synaptic transmission, glutamatergic-IBA21873635  
GO:0035556intracellular signal transduction-IEA-  
GO:0061789dense core granule priming-IBA21873635  
GO:0099525presynaptic dense core vesicle exocytosis-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-ISS-  
GO:0030054cell junction-IEA-  
GO:0030672synaptic vesicle membrane-IBA21873635  
GO:0031594neuromuscular junction-IBA21873635  
GO:0042734presynaptic membrane-IBA21873635  
GO:0042734presynaptic membrane-IEA-  
GO:0043195terminal bouton-IBA21873635  
GO:0044305calyx of Held-IEA-  
GO:0048786presynaptic active zone-IBA21873635  
GO:0048786presynaptic active zone-TAS15217342  
GO:0098831presynaptic active zone cytoplasmic component-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal