Gene: ETV3L

440695
-
ETS variant 3 like
protein-coding
1q23.1
Ensembl:ENSG00000253831 Vega:OTTHUMG00000041325 UniprotKB:Q6ZN32
NC_000001.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.755e-1 (AD)  8.998e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1571045chr1:157096337 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DRD20.657
HTR1D0.63
OTOF0.62
TNK10.609
DAW10.604
SYNDIG1L0.603
SLC35D30.601
ATG9B0.597
B3GALT50.59
TMPRSS60.589

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GZMB-0.301
TFAP2C-0.298
KLRB1-0.287
FZD10-0.286
MAPKAPK3-0.279
COPZ2-0.279
DDR2-0.274
NKG7-0.273
CCND1-0.273
TMEM71-0.272

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C006780bisphenol Abisphenol A results in decreased expression of ETV3L mRNA25181051
D014520UrethaneUrethane results in increased expression of ETV3L mRNA28818685
C025643vinclozolinvinclozolin results in decreased expression of ETV3L mRNA23869203

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IEA-  
GO:0043565sequence-specific DNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0030154cell differentiation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal