Gene: CDNF

441549
ARMETL1
cerebral dopamine neurotrophic factor
protein-coding
10p13
Ensembl:ENSG00000185267 MIM:611233 Vega:OTTHUMG00000017713 UniprotKB:Q49AH0
NC_000010.11
PubMed
0   ANCO-SNPs
CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.073e-1 (AD)  9.576e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCT6B0.743
FAM227B0.69
CCDC150.673
ANXA40.648
LRRCC10.645
SEPSECS0.644
PBLD0.643
SPAG160.633
HAUS60.631
ENOSF10.627

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNG1-0.55
KCNK12-0.51
ADRA2C-0.496
GJB3-0.485
FAM155B-0.484
OPRD1-0.483
PSPN-0.48
PRDM11-0.464
ZNF469-0.457
ZFHX2-0.456

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of CDNF mRNA"22698814
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to CDNF protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CDNF protein]26598702
D000082AcetaminophenAcetaminophen results in decreased expression of CDNF mRNA29067470
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to CDNF protein]26598702
C547126AZM551248AZM551248 results in decreased expression of CDNF mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CDNF mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of CDNF mRNA25181051
D002110CaffeineCaffeine results in decreased expression of CDNF mRNA23774253
D002220CarbamazepineCarbamazepine results in decreased expression of CDNF mRNA23774253
D016572CyclosporineCyclosporine results in decreased methylation of CDNF promoter27989131
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of CDNF mRNA24317228
C016366dibenzothiophenedibenzothiophene results in decreased expression of CDNF mRNA23656968
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of CDNF mRNA27392435
D002945CisplatinCisplatin results in increased expression of CDNF mRNA27392435
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of CDNF mRNA27392435
C544151jinfukangjinfukang results in increased expression of CDNF mRNA27392435
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CDNF mRNA26011545
C005556propionaldehydepropionaldehyde results in increased expression of CDNF mRNA26079696
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CDNF mRNA25895662
C009277sodium arsenatesodium arsenate results in increased expression of CDNF mRNA23922661
D014212TretinoinTretinoin results in decreased expression of CDNF mRNA23774253
D014635Valproic AcidValproic Acid results in decreased expression of CDNF mRNA23774253

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008083growth factor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0031175neuron projection development-IBA21873635  
GO:0071542dopaminergic neuron differentiation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IBA21873635  
GO:0005783endoplasmic reticulum-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19429035Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence. (2009 Apr 10)Lohoff FWNeurosci Lett