Gene: ASPA

443
ACY2|ASP
aspartoacylase
protein-coding
17p13.2
Ensembl:ENSG00000108381 MIM:608034 Vega:OTTHUMG00000090655 UniprotKB:P45381
NG_008399.1
PubMed
0   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.948e-1 (AD)  7.437e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ST180.937
ERMN0.922
FOLH10.918
FRMD4B0.911
SH3TC20.91
FAM107B0.909
SLC44A10.906
PIEZO20.895
C10orf900.893
LDB30.89

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUX2-0.468
PCDH8-0.46
HCN4-0.46
CALB2-0.458
CHRNA2-0.442
LTK-0.431
CNGB1-0.43
SHISA8-0.43
SDK1-0.417
SP8-0.416

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00128L-Aspartic AcidSmall Molecule56-84-8Approved|NutraceuticalTarget
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0252051,10-phenanthroline"1,10-phenanthroline results in decreased activity of ASPA protein"17027983
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of ASPA mRNA"26377693
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ASPA mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ASPA mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ASPA mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ASPA mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ASPA mRNA"25510870
D000082AcetaminophenAcetaminophen affects the expression of ASPA mRNA25064622
D000082AcetaminophenAcetaminophen results in decreased expression of ASPA mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of ASPA mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ASPA protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ASPA gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ASPA mRNA22100608|2715375
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of ASPA mRNA21298039
D000638AmiodaroneAmiodarone affects the expression of ASPA mRNA25064622
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ASPA mRNA16483693
C547126AZM551248AZM551248 results in decreased expression of ASPA mRNA22323515
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of ASPA mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ASPA mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ASPA mRNA21839799
C099952bifenthrinbifenthrin results in decreased expression of ASPA mRNA21718662
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of ASPA mRNA27685785
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ASPA mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of ASPA mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ASPA mRNA25993096
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ASPA mRNA27339419
D002746ChlorpromazineChlorpromazine affects the expression of ASPA mRNA25064622
D002994ClofibrateClofibrate results in increased expression of ASPA mRNA23811191
D003300CopperCopper results in decreased expression of ASPA mRNA22465980
D003471CuprizoneCuprizone results in decreased expression of ASPA mRNA26577399|2752363
D016572CyclosporineCyclosporine affects the expression of ASPA mRNA25064622
D016572CyclosporineCyclosporine results in decreased expression of ASPA mRNA20106945|2798913
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of ASPA mRNA24317228
D013759DronabinolDronabinol results in decreased expression of ASPA mRNA17578508
D003907DexamethasoneDexamethasone results in increased expression of ASPA mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ASPA mRNA28628672
D003907Dexamethasone[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of ASPA mRNA24848799
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of ASPA mRNA28962523
D004041Dietary FatsDietary Fats results in decreased expression of ASPA mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of ASPA mRNA18042831
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of ASPA mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of ASPA mRNA]19850644
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of ASPA mRNA"22485181
D004492Edetic AcidEdetic Acid results in decreased activity of ASPA protein17027983
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ASPA mRNA25064622
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of ASPA mRNA23649840
C082360fipronilfipronil results in decreased expression of ASPA mRNA22542256
D005419FlavonoidsFlavonoids results in decreased expression of ASPA mRNA18035473
D005557FormaldehydeFormaldehyde results in increased expression of ASPA mRNA23649840
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ASPA mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ASPA mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ASPA mRNA28628672
D0150561-Methyl-3-isobutylxanthine[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of ASPA mRNA24848799
D064704LevofloxacinLevofloxacin results in decreased expression of ASPA mRNA24136188
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of ASPA mRNA25613284
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of ASPA mRNA16507785
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ASPA mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ASPA mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ASPA mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ASPA mRNA"25554681|2562005
D009532NickelNickel results in decreased expression of ASPA mRNA24768652|2558310
C025589ochratoxin Aochratoxin A results in decreased expression of ASPA mRNA12700408
C437127O,O-diethylphosphorylcholine iodide"O,O-diethylphosphorylcholine iodide results in decreased activity of ASPA protein"17027983
D010126OzoneOzone results in increased expression of ASPA mRNA28623178
D000073878Palm OilPalm Oil results in decreased expression of ASPA mRNA18042831
D000073878Palm OilPalm Oil results in increased expression of ASPA mRNA18042831
D010269ParaquatParaquat affects the expression of ASPA mRNA25064622
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ASPA mRNA"25510870
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ASPA mRNA18692542
D010578PetroleumPetroleum affects the expression of ASPA mRNA25208076
D010634PhenobarbitalPhenobarbital results in increased expression of ASPA mRNA19270015
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ASPA mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of ASPA mRNA18301758|2381119
D059808PolyphenolsPolyphenols results in decreased expression of ASPA mRNA16293270
D011441PropylthiouracilPropylthiouracil results in decreased expression of ASPA mRNA24780913
C502851quinocetonequinocetone results in increased expression of ASPA mRNA27046791
C089730rosiglitazonerosiglitazone results in increased expression of ASPA mRNA24848799
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ASPA mRNA23221170
C017947sodium arsenitesodium arsenite affects the methylation of ASPA gene28589171
D053260SootSoot results in decreased expression of ASPA mRNA26551751
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of ASPA mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ASPA mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ASPA mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ASPA promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ASPA mRNA22298810
D013752TetracyclineTetracycline affects the expression of ASPA mRNA25064622
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ASPA mRNA25613284
D013853ThioacetamideThioacetamide affects the expression of ASPA mRNA25064622
D013853ThioacetamideThioacetamide results in decreased expression of ASPA mRNA23411599
C011559tributyltintributyltin results in increased expression of ASPA mRNA24848799
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ASPA mRNA"26743178
C057693troglitazonetroglitazone results in increased expression of ASPA mRNA25572481
D014635Valproic AcidValproic Acid affects the expression of ASPA mRNA25064622
D014635Valproic AcidValproic Acid results in increased expression of ASPA mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of ASPA gene29154799
D014640VancomycinVancomycin results in increased expression of ASPA mRNA18930951
C025643vinclozolinvinclozolin results in increased expression of ASPA mRNA23034163
C029297vinylidene chloridevinylidene chloride results in decreased expression of ASPA mRNA26682919
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of ASPA mRNA"25208076
D015032ZincZinc binds to ASPA protein17027983|1719476
D015032ZincZinc binds to ASPA protein17194761

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004046aminoacylase activity-TAS8252036  
GO:0005515protein binding-IPI22284616  25416956  25910212  
GO:0016788hydrolase activity, acting on ester bonds-IEA-  
GO:0019807aspartoacylase activity-TAS-  
GO:0042802identical protein binding-IPI16189514  17194761  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006533aspartate catabolic process-TAS8252036  
GO:0008652cellular amino acid biosynthetic process-TAS-  
GO:0022010central nervous system myelination-IEA-  
GO:0048714positive regulation of oligodendrocyte differentiation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00250Alanine, aspartate and glutamate metabolism
hsa00340Histidine metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-70614Amino acid synthesis and interconversion (transamination)TAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24890784Exon microarray analysis of human dorsolateral prefrontal cortex in alcoholism. (2014 Jun)Manzardo AMAlcohol Clin Exp Res