Gene: MSH2

4436
COCA1|FCC1|HNPCC|HNPCC1|LCFS2
mutS homolog 2
protein-coding
2p21-p16.3
Ensembl:ENSG00000095002 MIM:609309 Vega:OTTHUMG00000128861 UniprotKB:P43246
NG_007110.2
PubMed|SNP Mapped
0   ANCO-SNPs
ND|AD
12   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.718e-1 (AD)  4.799e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CUL20.965
SLC25A460.964
COL4A3BP0.962
GMPS0.961
KLHL420.961
VPS350.958
NAPG0.957
AVL90.957
ZDHHC210.956
C2CD50.955

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.499
OR4F29-0.458
CSAG1-0.45
HEY2-0.403
MTRNR2L10-0.403
MTRNR2L6-0.398
EVC2-0.397
MTRNR2L9-0.397
WDR38-0.396
MYL3-0.393

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether affects the expression of MSH2 mRNA"24680724
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of MSH2 mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"MSH2 protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"11593414
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"MSH2 protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"12901791
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of MSH2 mRNA"18648102
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to MSH2 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to MSH2 protein]26598702
C0067574-biphenylamine4-biphenylamine results in decreased expression of MSH2 mRNA24857880
C5538177-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one"7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one results in decreased expression of MSH2 mRNA"19936915
D000082AcetaminophenAcetaminophen results in increased expression of MSH2 mRNA22230336
D020106AcrylamideAcrylamide results in increased expression of MSH2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of MSH2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MSH2 mRNA22100608|2715375
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of MSH2 mRNA"23195993
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MSH2 mRNA16483693
D001115ArecolineArecoline results in decreased expression of MSH2 mRNA17682004
D001151ArsenicArsenic affects the expression of MSH2 mRNA17450239
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to MSH2 protein]26598702
D001205Ascorbic AcidMSH2 protein promotes the reaction [Ascorbic Acid results in increased susceptibility to chromium hexavalent ion]17301063
D001205Ascorbic AcidMSH2 protein results in increased susceptibility to [chromium hexavalent ion co-treated with Ascorbic Acid]17169990
D001379AzathioprineAzathioprine results in decreased expression of MSH2 mRNA22623647
D001379AzathioprineMSH2 gene mutant form affects the susceptibility to Azathioprine20923998
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MSH2 mRNA20064835
D001564Benzo(a)pyreneMSH2 protein affects the susceptibility to Benzo(a)pyrene22382310
D004958EstradiolEstradiol results in decreased expression of MSH2 mRNA22082530
D004958Estradiol[Estradiol results in increased expression of MSH2 mRNA] which results in increased susceptibility to Cisplatin28323900
D004958Estradiol[Estradiol results in increased expression of MSH2 mRNA] which results in increased susceptibility to Doxorubicin28323900
C006780bisphenol Abisphenol A affects the expression of MSH2 mRNA21786754
C006780bisphenol Abisphenol A affects the methylation of MSH2 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of MSH2 mRNA25181051
C027561butylbenzyl phthalatebutylbenzyl phthalate results in decreased expression of MSH2 mRNA26472102
D002101Cacodylic AcidCacodylic Acid results in decreased expression of MSH2 mRNA17481689
D002104CadmiumCadmium results in decreased expression of MSH226130599
D002104CadmiumCadmium results in decreased expression of MSH2 mRNA23143036
D002104CadmiumCadmium results in decreased activity of MSH2 protein16677676
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of MSH2 mRNA22112500|2647268
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of MSH2 protein22112500
D019256Cadmium Chloride[Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in decreased expression of MSH2 mRNA22112500
D019256Cadmium Chloride[Cadmium Chloride results in increased activity of [DNMT1 protein co-treated with DNMT3A protein]] which results in increased methylation of MSH2 promoter22112500
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MSH2 protein26220685
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of MSH2 promoter22112500
D019256Cadmium Chloridedecitabine inhibits the reaction [Cadmium Chloride results in decreased expression of MSH2 mRNA]22112500
D019256Cadmium Chloridedecitabine inhibits the reaction [Cadmium Chloride results in decreased expression of MSH2 protein]22112500
D019256Cadmium Chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MSH2 mRNA12634122
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of MSH2 mRNA15501611
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of MSH2 promoter22457795
D002110CaffeineCaffeine results in decreased expression of MSH2 mRNA12706856
D002330CarmustineMSH2 protein affects the susceptibility to Carmustine18430789
D002746ChlorpromazineChlorpromazine results in decreased expression of MSH2 mRNA15924885
C023600chromic oxide[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MSH2 mRNA12634122
C074702chromium hexavalent ionMSH2 protein promotes the reaction [Ascorbic Acid results in increased susceptibility to chromium hexavalent ion]17301063
C074702chromium hexavalent ionMSH2 protein results in increased susceptibility to chromium hexavalent ion17301063
C074702chromium hexavalent ionMSH2 protein results in increased susceptibility to [chromium hexavalent ion co-treated with Ascorbic Acid]17169990
C017133chromous chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MSH2 mRNA12634122
D002994ClofibrateClofibrate results in increased expression of MSH2 mRNA17585979
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of MSH2 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of MSH2 mRNA19549813
D003375CoumestrolCoumestrol results in increased expression of MSH2 mRNA19167446
D003520CyclophosphamideCyclophosphamide results in decreased expression of MSH2 mRNA11056294|1190692
D016572CyclosporineCyclosporine results in decreased expression of MSH2 mRNA20106945|2556210
D000069439DasatinibDasatinib results in decreased expression of MSH2 mRNA20579391
C014347decitabinedecitabine inhibits the reaction [Cadmium Chloride results in decreased expression of MSH2 mRNA]22112500
C014347decitabinedecitabine inhibits the reaction [Cadmium Chloride results in decreased expression of MSH2 protein]22112500
C014347decitabinedecitabine results in decreased methylation of MSH2 promoter19032668
C014347decitabinedecitabine results in increased expression of MSH2 mRNA19032668|2208253
D016190CarboplatinCarboplatin results in decreased expression of MSH2 mRNA18172885
D003976DiazinonDiazinon affects the expression of MSH2 mRNA22546817
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MSH2 mRNA21266533|2647210
D002945CisplatinCisplatin promotes the reaction [MSH2 protein binds to and affects the localization of ATR protein]21285353
D002945CisplatinCisplatin results in decreased expression of MSH2 protein21696631
D002945CisplatinCisplatin results in increased expression of MSH2 mRNA27594783
D002945Cisplatin[Estradiol results in increased expression of MSH2 mRNA] which results in increased susceptibility to Cisplatin28323900
D002945CisplatinMSH2 protein promotes the reaction [Cisplatin results in increased expression of BBC3 protein]21285353
D002945CisplatinMSH2 protein promotes the reaction [Cisplatin results in increased phosphorylation of CHEK2 protein]21285353
D002945CisplatinMSH2 protein promotes the reaction [Cisplatin results in increased phosphorylation of TP53 protein]21285353
D002945CisplatinMSH2 protein results in increased susceptibility to Cisplatin21285353
D002945Cisplatinsodium arsenite inhibits the reaction [Cisplatin results in decreased expression of MSH2 protein]21696631
D002945CisplatinMSH2 affects the susceptibility to Cisplatin21667017
D002945CisplatinMSH2 protein affects the susceptibility to Cisplatin12185594
D002945CisplatinMSH2 protein promotes the reaction [Cisplatin results in increased expression of BBC3 protein]21285353
D002945CisplatinMSH2 protein promotes the reaction [Cisplatin results in increased phosphorylation of CHEK2 protein]21285353
D002945CisplatinMSH2 protein promotes the reaction [Cisplatin results in increased phosphorylation of TRP53 protein]21285353
D002945CisplatinMSH2 protein results in increased susceptibility to Cisplatin21285353
D002945CisplatinCisplatin results in decreased expression of MSH2 mRNA18172885
C000944dicrotophosdicrotophos results in decreased expression of MSH2 mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of MSH2 mRNA26924002
D004026DieldrinDieldrin affects the expression of MSH2 mRNA22546817
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of MSH2 mRNA26472102
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of MSH2 mRNA26472102
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of MSH2 mRNA17854601
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of MSH2 protein17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MSH2 mRNA]17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of MSH2 protein]17854601
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of MSH2 mRNA26472102
C024629dimethyl phthalatedimethyl phthalate affects the expression of MSH2 mRNA26924002
C034171di-n-pentyl phthalatedi-n-pentyl phthalate results in decreased expression of MSH2 mRNA26472102
C034171di-n-pentyl phthalatedi-n-pentyl phthalate results in increased expression of MSH2 mRNA26472102
D004317Doxorubicin[Estradiol results in increased expression of MSH2 mRNA] which results in increased susceptibility to Doxorubicin28323900
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of MSH2 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MSH2 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of MSH2 mRNA12655037
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of MSH2 gene16495775
D005467FloxuridineMSH2 protein results in decreased susceptibility to Floxuridine22194930
D005467Floxuridineolaparib inhibits the reaction [MSH2 protein results in decreased susceptibility to Floxuridine]22194930
D005472FluorouracilFluorouracil results in decreased expression of MSH2 mRNA16557594|1670924
D005472FluorouracilMSH2 protein affects the susceptibility to Fluorouracil18949393
C039281furanfuran results in increased expression of MSH2 mRNA22079235
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of MSH2 mRNA21782745
D005839GentamicinsGentamicins results in increased expression of MSH2 mRNA22061828
C071834glycidamideglycidamide affects the expression of MSH2 protein21978862
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of MSH2 mRNA23143036
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of MSH2 mRNA26519223
D006861Hydrogen Peroxide[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of MSH2 protein15081873
D006861Hydrogen PeroxidePergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of MSH2 protein]15081873
D006861Hydrogen PeroxideSN50 peptide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of MSH2 protein]15081873
C475919hydroxytamoxifenhydroxytamoxifen results in increased expression of MSH2 mRNA16849584
C492448ICG 001ICG 001 results in decreased expression of MSH2 mRNA26191083
C056493imiquimodimiquimod results in decreased expression of MSH2 mRNA21878529
C027185indirubinindirubin results in decreased expression of MSH2 mRNA15056799
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MSH2 mRNA25613284
C051890irinotecanirinotecan metabolite results in decreased expression of MSH2 mRNA15956246
C051890irinotecanirinotecan results in decreased expression of MSH2 mRNA15956246
C051890irinotecanMSH2 protein affects the susceptibility to irinotecan18949393
C410337K 7174K 7174 results in decreased expression of MSH2 mRNA24086573
C008261lead acetate[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MSH2 mRNA12634122
D001556LindaneLindane results in decreased expression of MSH2 mRNA17785943
C015329lycopenelycopene results in increased expression of MSH2 mRNA16886892
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of MSH2 mRNA21641980
D008466MechlorethamineMSH2 protein affects the susceptibility to Mechlorethamine12185594
D008715MethionineMethionine deficiency results in decreased expression of MSH2 mRNA24036140
D008715MethionineMethionine results in decreased expression of MSH2 mRNA24036140
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of MSH2 mRNA21782745
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of MSH2 mRNA12634122
D008770MethylnitrosoureaMethylnitrosourea promotes the reaction [MSH2 protein binds to MLH1 protein binds to PMS2 protein]16204460
D008770MethylnitrosoureaMethylnitrosourea promotes the reaction [MSH2 protein binds to PCNA protein binds to MSH6 protein]16204460
D008770MethylnitrosoureaMSH2 protein affects the susceptibility to Methylnitrosourea12185594
D008770MethylnitrosoureaMSH2 protein promotes the reaction [Methylnitrosourea affects the localization of ATR protein]21285353
D008770MethylnitrosoureaMSH2 protein promotes the reaction [Methylnitrosourea results in increased phosphorylation of CHEK2 protein]21285353
D008770MethylnitrosoureaMSH2 protein promotes the reaction [Methylnitrosourea results in increased phosphorylation of TRP53 protein]21285353
D008770MethylnitrosoureaMSH2 protein results in increased susceptibility to Methylnitrosourea21285353
C020300monomethylarsonic acidmonomethylarsonic acid results in decreased expression of MSH2 mRNA17481689
C517284monomethyl phthalatemonomethyl phthalate affects the expression of MSH2 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of MSH2 mRNA"25554681
D009532NickelNickel results in decreased expression of MSH2 mRNA23195993
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of MSH2 mRNA20971185
C064976O(6)-benzylguanine[temozolomide co-treated with O(6)-benzylguanine] affects the expression of MSH2 protein20980775
C531550olaparibolaparib inhibits the reaction [MSH2 protein results in decreased susceptibility to Floxuridine]22194930
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of MSH2 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of MSH2 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of MSH2 protein25030372
D010126OzoneOzone results in increased expression of MSH2 mRNA16716893
D010269ParaquatParaquat results in decreased expression of MSH2 mRNA23143036
D010479PergolidePergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of MSH2 protein]15081873
D010634PhenobarbitalPhenobarbital affects the expression of MSH2 mRNA19159669
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MSH2 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of MSH2 mRNA23811191
D010894PiroxicamPiroxicam results in decreased expression of MSH2 mRNA21858171
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MSH2 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of MSH2 mRNA22079256
D011743PyrimidinesMSH2 protein results in increased susceptibility to Pyrimidines15611052
D011743PyrimidinesMSH2 protein results in increased susceptibility to Pyrimidines15611052
D011794QuercetinQuercetin results in decreased expression of MSH2 mRNA21632981
D011794QuercetinQuercetin results in increased expression of MSH2 mRNA14715546
D011794QuercetinQuercetin results in increased expression of MSH2 mRNA18095365
C059514resveratrolresveratrol results in increased expression of MSH2 protein25505154
C547185riccardin Driccardin D results in decreased expression of MSH2 mRNA24069304
D012822Silicon DioxideSilicon Dioxide results in increased expression of MSH2 mRNA23221170
C118258SN50 peptideSN50 peptide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of MSH2 protein]15081873
C017947sodium arsenite[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of MSH2 mRNA12634122
C017947sodium arsenitesodium arsenite inhibits the reaction [Cisplatin results in decreased expression of MSH2 protein]21696631
C017947sodium arsenitesodium arsenite results in decreased expression of MSH2 mRNA25787150
C016104sodium bichromatesodium bichromate results in increased expression of MSH2 mRNA22155349
C016104sodium bichromatesodium bichromate results in increased expression of MSH2 mRNA22561333
D013241SterigmatocystinSterigmatocystin results in increased expression of MSH2 mRNA23296099
D013241SterigmatocystinSterigmatocystin results in increased expression of MSH2 protein23296099
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of MSH2 mRNA21641980
C047246temozolomideMSH2 protein affects the susceptibility to temozolomide18430789
C047246temozolomideMSH2 results in decreased susceptibility to temozolomide20025921
C047246temozolomide[temozolomide co-treated with O(6)-benzylguanine] affects the expression of MSH2 protein20980775
C047246temozolomideMPG affects the reaction [MSH2 results in decreased susceptibility to temozolomide]20025921
C047246temozolomideMSH2 gene mutant form promotes the reaction [temozolomide results in increased mutagenesis of B4GALNT2]20025921
C047246temozolomideMSH2 results in decreased susceptibility to temozolomide20025921
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MSH2 mRNA19465110
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of MSH2 mRNA25613284
D013866ThioguanineMSH2 results in increased susceptibility to Thioguanine20025921
C009495titanium dioxidetitanium dioxide results in decreased expression of MSH2 mRNA27760801
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of MSH2 mRNA25729387
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of MSH2 mRNA"17951470
D014212TretinoinTretinoin results in decreased expression of MSH2 mRNA18230668
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MSH2 mRNA"26179874
D014501UraniumUranium affects the expression of MSH2 mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of MSH2 mRNA15672453
D014520UrethaneUrethane results in decreased expression of MSH2 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of MSH2 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of MSH2 mRNA29154799
D024483Vitamin K 3Vitamin K 3 affects the expression of MSH2 mRNA20044591
C088658zoledronic acidzoledronic acid affects the localization of MSH2 protein17070308
C088658zoledronic acidzoledronic acid results in decreased expression of MSH2 protein17070308

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion bindingCONTRIBUTES_TOIBA21873635  
GO:0000287magnesium ion bindingcontributes_toIDA16403449  
GO:0000400four-way junction DNA binding-IBA21873635  
GO:0000400four-way junction DNA bindingcontributes_toIDA12034830  
GO:0000403Y-form DNA binding-IBA21873635  
GO:0000404heteroduplex DNA loop binding-IBA21873635  
GO:0000406double-strand/single-strand DNA junction binding-IBA21873635  
GO:0003677DNA binding-IDA7923193  
GO:0003684damaged DNA binding-IBA21873635  
GO:0003690double-stranded DNA bindingcontributes_toIDA11809883  
GO:0003697single-stranded DNA bindingCONTRIBUTES_TOIBA21873635  
GO:0003697single-stranded DNA bindingcontributes_toIDA11809883  
GO:0005515protein binding-IPI8942985  9207118  9774676  10856833  12414623  14657349  
15014079  16025128  18675275  19377479  19596235  22157815  
22179786  25241761  26496610  
GO:0005515protein bindingcontributes_toIPI16403449  
GO:0005524ATP bindingCONTRIBUTES_TOIBA21873635  
GO:0005524ATP bindingcontributes_toIDA15105434  
GO:0008022protein C-terminus binding-IPI14706347  
GO:0008094DNA-dependent ATPase activity-IBA21873635  
GO:0016887ATPase activitycontributes_toIDA16403449  
GO:0019237centromeric DNA binding-IEA-  
GO:0019899enzyme binding-IPI9788596  10856833  11427529  11429708  12414623  14676842  
17715146  
GO:0019901protein kinase binding-IBA21873635  
GO:0019901protein kinase binding-IPI14657349  
GO:0030983mismatched DNA binding-IBA21873635  
GO:0030983mismatched DNA bindingcontributes_toIDA8942985  11756455  11801590  
GO:0032137guanine/thymine mispair binding-IBA21873635  
GO:0032137guanine/thymine mispair bindingcontributes_toIDA8942985  11809883  
GO:0032137guanine/thymine mispair binding-IMP16713580  
GO:0032138single base insertion or deletion binding-IBA21873635  
GO:0032139dinucleotide insertion or deletion bindingcontributes_toIDA8942985  
GO:0032142single guanine insertion bindingCONTRIBUTES_TOIBA21873635  
GO:0032142single guanine insertion bindingcontributes_toIDA8942985  
GO:0032143single thymine insertion bindingCONTRIBUTES_TOIBA21873635  
GO:0032143single thymine insertion bindingcontributes_toIDA8942985  
GO:0032181dinucleotide repeat insertion bindingCONTRIBUTES_TOIBA21873635  
GO:0032181dinucleotide repeat insertion bindingcontributes_toIDA8942985  
GO:0032357oxidized purine DNA bindingCONTRIBUTES_TOIBA21873635  
GO:0032357oxidized purine DNA bindingcontributes_toIDA11756455  11801590  
GO:0032405MutLalpha complex bindingCONTRIBUTES_TOIBA21873635  
GO:0032405MutLalpha complex bindingcontributes_toIDA16403449  
GO:0042803protein homodimerization activity-IBA21873635  
GO:0042803protein homodimerization activity-IDA8942985  
GO:0043531ADP bindingCONTRIBUTES_TOIBA21873635  
GO:0043531ADP bindingcontributes_toIDA15105434  
GO ID GO Term Qualifier Evidence PubMed
GO:0000710meiotic mismatch repair-IBA21873635  
GO:0001701in utero embryonic development-IEA-  
GO:0006119oxidative phosphorylation-IEA-  
GO:0006281DNA repair-IDA8942985  
GO:0006290pyrimidine dimer repair-IBA21873635  
GO:0006298mismatch repair-IBA21873635  
GO:0006298mismatch repair-IDA7923193  11555625  
GO:0006298mismatch repair-IGI23603115  
GO:0006298mismatch repair-TAS-  
GO:0006301postreplication repair-IBA21873635  
GO:0006301postreplication repair-IDA7923193  
GO:0006302double-strand break repair-IBA21873635  
GO:0006311meiotic gene conversion-IBA21873635  
GO:0006312mitotic recombination-IBA21873635  
GO:0007050cell cycle arrest-IBA21873635  
GO:0007050cell cycle arrest-IEA-  
GO:0007281germ cell development-IBA21873635  
GO:0007281germ cell development-IEA-  
GO:0007283spermatogenesis-IBA21873635  
GO:0008340determination of adult lifespan-IBA21873635  
GO:0008340determination of adult lifespan-IEA-  
GO:0008584male gonad development-IBA21873635  
GO:0008584male gonad development-ISS-  
GO:0010165response to X-ray-IBA21873635  
GO:0010165response to X-ray-ISS-  
GO:0010224response to UV-B-IBA21873635  
GO:0010224response to UV-B-ISS-  
GO:0016446somatic hypermutation of immunoglobulin genes-IBA21873635  
GO:0016447somatic recombination of immunoglobulin gene segments-ISS-  
GO:0019724B cell mediated immunity-ISS-  
GO:0030183B cell differentiation-IBA21873635  
GO:0030183B cell differentiation-ISS-  
GO:0031573intra-S DNA damage checkpoint-IBA21873635  
GO:0036297interstrand cross-link repair-IBA21873635  
GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator-IBA21873635  
GO:0043111replication fork arrest-IBA21873635  
GO:0043524negative regulation of neuron apoptotic process-IBA21873635  
GO:0043524negative regulation of neuron apoptotic process-ISS-  
GO:0043570maintenance of DNA repeat elements-IBA21873635  
GO:0043570maintenance of DNA repeat elements-IMP16388310  
GO:0045128negative regulation of reciprocal meiotic recombination-IBA21873635  
GO:0045190isotype switching-IBA21873635  
GO:0045190isotype switching-ISS-  
GO:0045910negative regulation of DNA recombination-IDA17715146  
GO:0045910negative regulation of DNA recombination-ISS-  
GO:0048298positive regulation of isotype switching to IgA isotypes-IBA21873635  
GO:0048298positive regulation of isotype switching to IgA isotypes-IEA-  
GO:0048304positive regulation of isotype switching to IgG isotypes-IBA21873635  
GO:0048304positive regulation of isotype switching to IgG isotypes-IEA-  
GO:0051096positive regulation of helicase activity-IBA21873635  
GO:0051096positive regulation of helicase activity-IDA17715146  
GO ID GO Term Qualifier Evidence PubMed
GO:0000228nuclear chromosome-IBA21873635  
GO:0000784nuclear chromosome, telomeric region-HDA19135898  
GO:0005654nucleoplasm-TAS-  
GO:0016020membrane-HDA19946888  
GO:0032300mismatch repair complex-IBA21873635  
GO:0032301MutSalpha complex-IBA21873635  
GO:0032301MutSalpha complex-IDA8942985  23622243  
GO:0032302MutSbeta complex-IBA21873635  
GO:0032302MutSbeta complex-IDA8942985  
KEGG ID KEGG Term
hsa03430Mismatch repair
hsa05200Pathways in cancer
hsa05210Colorectal cancer
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-5358508Mismatch RepairTAS
R-HSA-5358508Mismatch RepairIEA
R-HSA-5358565Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)TAS
R-HSA-5358606Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)IEA
R-HSA-5358606Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)TAS
R-HSA-5423599Diseases of Mismatch Repair (MMR)TAS
R-HSA-5632927Defective Mismatch Repair Associated With MSH3TAS
R-HSA-5632928Defective Mismatch Repair Associated With MSH2TAS
R-HSA-5632968Defective Mismatch Repair Associated With MSH6TAS
R-HSA-6796648TP53 Regulates Transcription of DNA Repair GenesTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73894DNA RepairTAS
R-HSA-73894DNA RepairIEA
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26116372MiR-21: an environmental driver of malignant melanoma? (2015 Jun 27)Melnik BCJ Transl Med
21419447Upper urinary tract carcinoma in Lynch syndrome cases. (2011 May)Crockett DGJ Urol
17064992Expression of DNA mismatch repair proteins in transformed non-Hodgkin's lymphoma: relationship to smoking. (2006 Sep)Nandi SLeuk Lymphoma
28391998Does smoking change expression patterns of the tumor suppressor and DNA repair genes in the prostate gland? (2017 Aug)Boran CUrol Oncol
21938565[Bladder cancer at an early age in father and son]. (2011 Dec)Ovsiannikov DUrologe A
23787767Reduced expression of mutS homolog 2 and mutL homolog 1 affects overall survival in laryngeal squamous cell carcinoma patients: Investigation into a potential cause. (2013 Sep)Gong HLOncol Rep
20301390Lynch Syndrome (1993)Kohlmann W-
27693945Repair genes expression profile of MLH1, MSH2 and ATM in the normal oral mucosa of chronic smokers. (2017 Jan)Alves MGArch Oral Biol
28693228Expression of methylation-modulated tumor-related genes in endoscopically resected early esophageal squamous neoplasia. (2017 Jul)Hosoda KOncol Lett
21559014Body mass index in early adulthood and colorectal cancer risk for carriers and non-carriers of germline mutations in DNA mismatch repair genes. (2011 Jun 28)Win AKBr J Cancer
10690586Chronic inflammatory bowel disease and cancer. (2000 Jan-Feb)Pohl CHepatogastroenterology
21093954Polymorphisms of MLH1 and MSH2 genes and the risk of lung cancer among never smokers. (2011 Jun)Lo YLLung Cancer