Gene: MSH3

4437
DUP|FAP4|MRP1
mutS homolog 3
protein-coding
5q14.1
Ensembl:ENSG00000113318 MIM:600887 Vega:OTTHUMG00000162540 UniprotKB:P20585
NG_016607.1
PubMed|SNP Mapped
4   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.589e-1 (AD)  4.702e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs6874652chr5:80834893 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs3797898chr5:80827492 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs6151896chr5:80825827 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs2306371chr5:80813439 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TTC370.876
SRP720.874
WDR440.871
CEP1700.871
CEP680.87
DHX360.869
ARFGEF10.867
KIDINS2200.865
TAB30.863
UHRF1BP1L0.863

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.454
OR4F5-0.453
CSAG1-0.357
MTRNR2L10-0.314
MTRNR2L6-0.313
S100A14-0.308
FOXJ1-0.301
C7orf61-0.299
HMX1-0.297
NKX6-1-0.293

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of MSH3 mRNA"26377693
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MSH3 mRNA"19114083
D000082AcetaminophenAcetaminophen affects the expression of MSH3 mRNA25064622
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MSH3 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MSH3 mRNA19770486
D000638AmiodaroneAmiodarone affects the expression of MSH3 mRNA25064622
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MSH3 mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MSH3 mRNA19770486
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of MSH3 mRNA28628672
C006780bisphenol Abisphenol A affects the methylation of MSH3 promoter27334623
C006780bisphenol Abisphenol A results in increased expression of MSH3 mRNA25181051
D002104CadmiumCadmium results in decreased activity of MSH3 protein16677676
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MSH3 mRNA11958953
D019256Cadmium ChlorideMT1 affects the reaction [Cadmium Chloride results in increased expression of MSH3 mRNA]11958953
D019256Cadmium ChlorideMT2 affects the reaction [Cadmium Chloride results in increased expression of MSH3 mRNA]11958953
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of MSH3 mRNA17484886
D002273CarcinogensCarcinogens results in decreased expression of MSH3 mRNA22269147
C100187chloropicrinchloropicrin results in increased expression of MSH3 mRNA26352163
D002746ChlorpromazineChlorpromazine affects the expression of MSH3 mRNA25064622
D002994ClofibrateClofibrate results in increased expression of MSH3 mRNA17585979
D019327Copper SulfateCopper Sulfate results in decreased expression of MSH3 mRNA19549813
D003375CoumestrolCoumestrol results in decreased expression of MSH3 mRNA19167446
D003513CycloheximideCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of MSH3 mRNA]11007951
D003520CyclophosphamideCyclophosphamide results in decreased expression of MSH3 mRNA11906922
D016572CyclosporineCyclosporine affects the expression of MSH3 mRNA25064622
D016572CyclosporineCyclosporine results in decreased expression of MSH3 mRNA20106945
C089595cylindrospermopsincylindrospermopsin results in increased expression of MSH3 mRNA23726867
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of MSH3 mRNA28628672
D002945CisplatinMSH3 protein results in decreased susceptibility to Cisplatin21285347
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of MSH3 mRNA25064622
C504383fenbuconazolefenbuconazole results in decreased expression of MSH3 mRNA15942997
C492448ICG 001ICG 001 results in increased expression of MSH3 mRNA26191083
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of MSH3 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of MSH3 mRNA28628672
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of MSH3 mRNA26011545
D009153MutagensMutagens results in decreased expression of MSH3 mRNA22269147
C005246myristicinmyristicin results in decreased expression of MSH3 mRNA24792648
C452423N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amineN-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine results in decreased expression of MSH3 mRNA16052530
C531550olaparibMSH3 protein results in decreased susceptibility to olaparib21285347
C030110oxaliplatinMSH3 protein promotes the reaction [oxaliplatin results in increased expression of TP53BP1 protein]21285347
C030110oxaliplatinMSH3 protein promotes the reaction [oxaliplatin results in increased phosphorylation of and affects the localization of H2AFX protein]21285347
C030110oxaliplatinMSH3 protein results in decreased susceptibility to oxaliplatin21285347
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of MSH3 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of MSH3 mRNA25729387
D010269ParaquatParaquat affects the expression of MSH3 mRNA25064622
D010936Plant ExtractsPlant Extracts results in increased expression of MSH3 mRNA23557933
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of MSH3 mRNA22714537
C045950propiconazolepropiconazole results in decreased expression of MSH3 mRNA21278054
D000952Antigens, Polyomavirus Transforming"Antigens, Polyomavirus Transforming results in increased expression of MSH3 mRNA"26680231
D013749TetrachlorodibenzodioxinCycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of MSH3 mRNA]11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MSH3 mRNA11007951
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MSH3 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MSH3 mRNA16962184
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MSH3 mRNA19465110
D013752TetracyclineTetracycline affects the expression of MSH3 mRNA25064622
D013853ThioacetamideThioacetamide affects the expression of MSH3 mRNA25064622
D014028Tobacco Smoke PollutionMSH3 gene polymorphism affects the susceptibility to Tobacco Smoke Pollution22623965
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of MSH3 mRNA25729387
C057693troglitazonetroglitazone results in decreased expression of MSH3 mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of MSH3 mRNA25064622
D014635Valproic AcidValproic Acid results in decreased methylation of MSH3 gene29154799
D014635Valproic AcidValproic Acid affects the expression of MSH3 mRNA17963808
D014638VanadatesVanadates results in increased expression of MSH3 mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MSH3 gene25560391
C088658zoledronic acidzoledronic acid results in increased expression of MSH3 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000403Y-form DNA binding-IBA21873635  
GO:0000404heteroduplex DNA loop binding-IBA21873635  
GO:0000406double-strand/single-strand DNA junction binding-IBA21873635  
GO:0003684damaged DNA binding-IBA21873635  
GO:0003697single-stranded DNA bindingCONTRIBUTES_TOIBA21873635  
GO:0003697single-stranded DNA bindingcontributes_toIDA11809883  
GO:0005515protein binding-IPI8942985  9774676  11005803  14657349  16025128  19377479  
22179786  25416956  
GO:0005524ATP binding-IEA-  
GO:0008094DNA-dependent ATPase activity-IBA21873635  
GO:0019237centromeric DNA binding-IBA21873635  
GO:0019899enzyme binding-IPI11427529  
GO:0030983mismatched DNA binding-IBA21873635  
GO:0030983mismatched DNA bindingcontributes_toIDA8942985  
GO:0032137guanine/thymine mispair bindingNOTIDA11809883  
GO:0032139dinucleotide insertion or deletion bindingcontributes_toIDA8942985  
GO:0032142single guanine insertion bindingCONTRIBUTES_TOIBA21873635  
GO:0032142single guanine insertion bindingcontributes_toIDA8942985  
GO:0032181dinucleotide repeat insertion bindingCONTRIBUTES_TOIBA21873635  
GO:0032181dinucleotide repeat insertion bindingcontributes_toIDA8942985  
GO:0032357oxidized purine DNA binding-IBA21873635  
GO:0032357oxidized purine DNA bindingNOT contributes_toIDA11756455  
GO:0042803protein homodimerization activityNOTIDA8942985  
GO ID GO Term Qualifier Evidence PubMed
GO:0000710meiotic mismatch repair-IBA21873635  
GO:0000735removal of nonhomologous ends-IBA21873635  
GO:0006281DNA repair-IDA8942985  
GO:0006298mismatch repair-IBA21873635  
GO:0006298mismatch repair-IMP8782829  
GO:0006298mismatch repair-TAS-  
GO:0006312mitotic recombination-IBA21873635  
GO:0007131reciprocal meiotic recombination-IBA21873635  
GO:0016447somatic recombination of immunoglobulin gene segments-IBA21873635  
GO:0043111replication fork arrest-IBA21873635  
GO:0043570maintenance of DNA repeat elements-IBA21873635  
GO:0043570maintenance of DNA repeat elements-IMP16388310  
GO:0045910negative regulation of DNA recombination-IDA17715146  
GO:0051096positive regulation of helicase activity-IBA21873635  
GO:0051096positive regulation of helicase activity-IDA17715146  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
GO:0016020membrane-HDA19946888  
GO:0032300mismatch repair complex-IBA21873635  
GO:0032302MutSbeta complex-IBA21873635  
GO:0032302MutSbeta complex-IDA8942985  
KEGG ID KEGG Term
hsa03430Mismatch repair
hsa05200Pathways in cancer
hsa05210Colorectal cancer
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-5358508Mismatch RepairIEA
R-HSA-5358508Mismatch RepairTAS
R-HSA-5358606Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)IEA
R-HSA-5358606Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)TAS
R-HSA-5423599Diseases of Mismatch Repair (MMR)TAS
R-HSA-5632927Defective Mismatch Repair Associated With MSH3TAS
R-HSA-5632928Defective Mismatch Repair Associated With MSH2TAS
R-HSA-73894DNA RepairIEA
R-HSA-73894DNA RepairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24934723Aberrant methylation of the MSH3 promoter and distal enhancer in esophageal cancer patients exposed to first-hand tobacco smoke. (2014 Nov)Vogelsang MJ Cancer Res Clin Oncol