Gene: MSH4

4438
-
mutS homolog 4
protein-coding
1p31.1
Ensembl:ENSG00000057468 MIM:602105 Vega:OTTHUMG00000009788 UniprotKB:O15457
NG_029861.1
SNP Mapped
1   ANCO-SNPs
AD
0   
3.959e-1 (AD)  2.929e-1 (ND)   (Frontal_Cortex)
1.284e-1 (AD)  3.339e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs5745331chr1:75807628 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
QRICH20.609
ZNF6050.596
C15orf620.567
MTRF10.561
TUBA80.555
IMPG20.554
PKNOX10.549
PUS7L0.549
SNRNP480.548
DNASE10.541

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDNF-0.439
CCT6B-0.386
C9orf50-0.385
HSD17B8-0.364
PRSS27-0.361
DPH6-0.352
COPZ2-0.344
RBM3-0.338
PEX11G-0.335
LMOD1-0.334

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MSH4 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MSH4 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MSH4 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MSH4 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MSH4 mRNA"25510870
D004958EstradiolEstradiol results in decreased expression of MSH4 mRNA23804311
D004958Estradiolsodium arsenite promotes the reaction [Estradiol results in decreased expression of MSH4 mRNA]23804311
C006780bisphenol Abisphenol A results in increased expression of MSH4 mRNA20739668
C006780bisphenol Abisphenol A results in decreased expression of MSH4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MSH4 gene28505145
D019327Copper SulfateCopper Sulfate results in decreased expression of MSH4 mRNA19549813
C014347decitabinedecitabine results in increased expression of MSH4 mRNA22082530
D004041Dietary FatsDietary Fats results in increased expression of MSH4 mRNA25016146
D019422Dietary SucroseDietary Sucrose results in increased expression of MSH4 mRNA26033743
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of MSH4 mRNA27432991
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of MSH4 mRNA"25510870
D012715Sesame OilSesame Oil results in increased expression of MSH4 mRNA29191790
C017947sodium arsenitesodium arsenite promotes the reaction [Estradiol results in decreased expression of MSH4 mRNA]23804311
D014635Valproic AcidValproic Acid results in decreased methylation of MSH4 gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of MSH4 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-TAS9299235  
GO:0003684damaged DNA binding-IBA21873635  
GO:0005515protein binding-IPI16397227  22401567  23725059  
GO:0005524ATP binding-IEA-  
GO:0008094DNA-dependent ATPase activity-IBA21873635  
GO:0030983mismatched DNA binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000712resolution of meiotic recombination intermediates-IBA21873635  
GO:0001541ovarian follicle development-IBA21873635  
GO:0001541ovarian follicle development-IEA-  
GO:0006298mismatch repair-IBA21873635  
GO:0007131reciprocal meiotic recombination-IBA21873635  
GO:0007131reciprocal meiotic recombination-TAS9299235  
GO:0007283spermatogenesis-IBA21873635  
GO:0007283spermatogenesis-IEA-  
GO:0007292female gamete generation-IBA21873635  
GO:0007292female gamete generation-IEA-  
GO:0045143homologous chromosome segregation-IBA21873635  
GO:0051026chiasma assembly-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000228nuclear chromosome-IBA21873635  
GO:0000795synaptonemal complex-IBA21873635  
GO:0005634nucleus-TAS9299235  
GO:0005713recombination nodule-IEA-  
GO:0032300mismatch repair complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474165ReproductionIEA
R-HSA-1500620MeiosisIEA
R-HSA-1640170Cell CycleIEA
R-HSA-912446Meiotic recombinationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal