Gene: MSH5

4439
G7|MUTSH5|NG23|POF13
mutS homolog 5
protein-coding
6p21.33
Ensembl:ENSG00000204410 MIM:603382 Vega:OTTHUMG00000167551 UniprotKB:O43196
NG_011611.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UVSSA0.826
FCHSD10.823
TTLL30.777
NKTR0.768
KNTC10.764
GANC0.756
MDC10.747
CNTRL0.747
NPHP30.747
AGO40.744

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ADRA2C-0.305
KLRG1-0.304
KCNG1-0.303
EPPIN-0.29
MUC12-0.279
NANOS3-0.272
CRH-0.248
SYT16-0.241
WNT7A-0.241
AKAP14-0.236

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of MSH5 mRNA"27291303
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MSH5 mRNA"19114083
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of MSH5 mRNA"21346803
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of MSH5 mRNA19191707
D000082AcetaminophenAcetaminophen affects the expression of MSH5 mRNA17562736
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in decreased expression of MSH5 mRNA"22863853
C004984apocarotenalapocarotenal results in increased expression of MSH5 mRNA17034753
D001151ArsenicArsenic affects the methylation of MSH5 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MSH5 mRNA25690898
D019207beta Carotenebeta Carotene results in increased expression of MSH5 mRNA17034753
C006780bisphenol Abisphenol A results in decreased expression of MSH5 mRNA24586524
C006780bisphenol Abisphenol A results in increased expression of MSH5 mRNA25181051
D019327Copper SulfateCopper Sulfate results in increased expression of MSH5 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of MSH5 mRNA27523638
D002117CalcitriolCalcitriol results in decreased expression of MSH5 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of MSH5 mRNA21592394
C069837fullerene C60fullerene C60 results in decreased expression of MSH5 mRNA19167457
C029424hydrazinehydrazine results in increased expression of MSH5 mRNA15282401
C544151jinfukangjinfukang results in increased expression of MSH5 mRNA27392435
C008261lead acetatelead acetate results in decreased expression of MSH5 mRNA22609695|2261322
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of MSH5 mRNA21641980
C028007nickel monoxidenickel monoxide results in decreased expression of MSH5 mRNA19167457
C025589ochratoxin Aochratoxin A results in decreased expression of MSH5 mRNA23358140
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MSH5 mRNA19710929
D011794QuercetinQuercetin results in increased expression of MSH5 mRNA21632981
D012643SeleniumSelenium results in decreased expression of MSH5 mRNA19244175
C017947sodium arsenitesodium arsenite results in decreased expression of MSH5 mRNA12377979|2037198
D053260SootSoot results in increased expression of MSH5 mRNA26551751
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of MSH5 mRNA21641980
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of MSH5 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of MSH5 mRNA21592394
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MSH5 mRNA28065790
D014520UrethaneUrethane results in decreased expression of MSH5 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of MSH5 mRNA25979313
D014635Valproic AcidValproic Acid affects the expression of MSH5 mRNA17963808
D014810Vitamin EVitamin E results in decreased expression of MSH5 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003684damaged DNA binding-IBA21873635  
GO:0005515protein binding-IPI16397227  19442657  22401567  
GO:0005524ATP binding-IEA-  
GO:0008094DNA-dependent ATPase activity-IBA21873635  
GO:0030983mismatched DNA binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000712resolution of meiotic recombination intermediates-IBA21873635  
GO:0006298mismatch repair-IBA21873635  
GO:0007131reciprocal meiotic recombination-IBA21873635  
GO:0007292female gamete generation-IBA21873635  
GO:0045143homologous chromosome segregation-IBA21873635  
GO:0051026chiasma assembly-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000228nuclear chromosome-IBA21873635  
GO:0000795synaptonemal complex-IBA21873635  
GO:0032300mismatch repair complex-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474165ReproductionIEA
R-HSA-1500620MeiosisIEA
R-HSA-1640170Cell CycleIEA
R-HSA-912446Meiotic recombinationIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24163739Genetic susceptibility to lung cancer and co-morbidities. (2013 Oct)Yang IAJ Thorac Dis
21537448Candidate variants at 6p21.33 and 6p22.1 and risk of non-small cell lung cancer in a Chinese population. (2010)Zhang MInt J Mol Epidemiol Genet
27323854Tobacco smoking and methylation of genes related to lung cancer development. (2016 Sep 13)Gao XOncotarget
22382497Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer Consortium. (2012 May)Kazma RCarcinogenesis