Gene: MSI1

4440
-
musashi RNA binding protein 1
protein-coding
12q24.31
Ensembl:ENSG00000135097 MIM:603328 Vega:OTTHUMG00000169344 UniprotKB:O43347
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.924e-1 (AD)  7.109e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDC42EP40.88
OAF0.866
EZR0.862
RFX20.859
MLC10.852
SFXN50.846
FGFR30.841
BMP70.838
SLC7A100.833
FAM167A0.833

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ENPP6-0.43
RSPO3-0.428
OR4F5-0.424
FOXP2-0.408
NRG1-0.398
CCDC68-0.398
PROKR2-0.394
SLC7A14-0.394
ARHGEF28-0.394
DACH1-0.393

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide affects the expression of MSI1 mRNA"25670856
D000082AcetaminophenAcetaminophen affects the expression of MSI1 mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MSI1 mRNA16483693
D004958EstradiolEstradiol results in increased expression of MSI1 mRNA27271280
D004958EstradiolEstradiol results in increased expression of MSI1 protein27271280
C006780bisphenol Abisphenol A results in decreased expression of MSI1 mRNA27271280
C006780bisphenol Abisphenol A results in decreased expression of MSI1 protein27271280
C006780bisphenol AIGF1 protein inhibits the reaction [bisphenol A results in decreased expression of MSI1 mRNA]27271280
C006780bisphenol Abisphenol A results in decreased expression of MSI1 mRNA22687993
C006780bisphenol Abisphenol A results in decreased expression of MSI1 mRNA25181051
D002104CadmiumCadmium results in increased expression of MSI1 mRNA24376830
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MSI1 gene20938992
C014347decitabinedecitabine results in decreased expression of MSI1 mRNA19363521
C014347decitabineTP53 protein affects the reaction [decitabine results in decreased expression of MSI1 mRNA]19363521
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of MSI1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of MSI1 mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of MSI1 mRNA26924002
D002117CalcitriolCalcitriol results in increased expression of MSI1 mRNA26485663
C060311eckoleckol results in decreased expression of MSI1 protein21514314
C574336excavatolide Bexcavatolide B results in decreased expression of MSI1 protein26790859
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MSI1 gene20938992
D005839GentamicinsGentamicins results in decreased expression of MSI1 mRNA22061828
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of MSI1 mRNA27392435
D007854LeadLead affects the expression of MSI1 mRNA28903495
D007854LeadLead affects the splicing of MSI1 mRNA28903495
D007854LeadLead results in decreased expression of MSI1 mRNA24519525
D018021Lithium ChlorideLithium Chloride results in increased expression of MSI1 protein20069066
D008713MethimazoleMethimazole results in increased expression of MSI1 mRNA17403546
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of MSI1 gene20938992
C494474perchlorateperchlorate results in increased expression of MSI1 mRNA17403546
D011441PropylthiouracilPropylthiouracil results in increased expression of MSI1 mRNA17403546
C059514resveratrolresveratrol results in decreased expression of MSI1 protein23651583
D053260SootSoot results in increased expression of MSI1 mRNA26551751
C061133tamibarotenetamibarotene affects the expression of MSI1 mRNA15498508
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MSI1 mRNA19490992
D014212TretinoinTretinoin affects the expression of MSI1 mRNA15498508
D014635Valproic AcidValproic Acid results in increased methylation of MSI1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of MSI1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22681889  
GO:0003723RNA binding-IBA21873635  
GO:0008266poly(U) RNA binding-IEA-  
GO:0042802identical protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007399nervous system development-TAS9790759  
GO:0051252regulation of RNA metabolic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IEA-  
GO:0005654nucleoplasm-IBA21873635  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IEA-  
GO:0005844polysome-IBA21873635  
GO:0005844polysome-IEA-  
KEGG ID KEGG Term
hsa03015mRNA surveillance pathway
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyIEA
R-HSA-376176Signaling by ROBO receptorsIEA
R-HSA-422475Axon guidanceIEA
R-HSA-9010553Regulation of expression of SLITs and ROBOsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28542447Exploratory plasma proteomic analysis in a randomized crossover trial of aspirin among healthy men and women. (2017)Wang XPLoS One