Gene: ASS1

445
ASS|CTLN1
argininosuccinate synthase 1
protein-coding
9q34.11
Ensembl:ENSG00000130707 MIM:603470 Vega:OTTHUMG00000020806 UniprotKB:P00966
NG_011542.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.633e-1 (AD)  7.940e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AP1S10.878
TPGS20.873
SUMO30.867
GAP430.866
RBP40.866
GGCT0.862
BEX50.861
ZMAT20.859
SPINT20.858
TCEAL60.857

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.591
OR4F29-0.547
CPM-0.402
CTNNA3-0.378
RAI14-0.36
TGFB3-0.355
REST-0.352
DOCK5-0.336
SGMS2-0.335
TRPV5-0.335

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00125L-ArginineSmall Molecule74-79-3Approved|NutraceuticalTarget
DB00128L-Aspartic AcidSmall Molecule56-84-8Approved|NutraceuticalTarget
DB00155L-CitrullineSmall Molecule372-75-8Approved|Investigational|NutraceuticalTarget
DB00171ATPSmall Molecule56-65-5Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of ASS1 mRNA"28903501
C0668412,3,7,8-tetrabromodibenzo-4-dioxin"2,3,7,8-tetrabromodibenzo-4-dioxin affects the expression of ASS1 protein"27604104
C0144643,4-dichloroaniline"3,4-dichloroaniline results in increased expression of ASS1 mRNA"24172598
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASS1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASS1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASS1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASS1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASS1 mRNA"27188386
C5444715-hydroxythalidomide5-hydroxythalidomide binds to ASS1 protein27464947
C5444715-hydroxythalidomide5-hydroxythalidomide binds to ASS1 protein27464947
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASS1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASS1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASS1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASS1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASS1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of ASS1 mRNA17562736
D000082AcetaminophenAcetaminophen affects the expression of ASS1 mRNA17366322
D000082AcetaminophenAcetaminophen affects the expression of ASS1 protein16687475
D000082AcetaminophenAcetaminophen results in increased expression of ASS1 protein15800402|1653804
D000109AcetylcholineASS1 protein results in increased susceptibility to Acetylcholine25033204
D020106AcrylamideAcrylamide results in increased expression of ASS1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ASS1 mRNA19770486
D000447AldehydesAldehydes results in increased expression of ASS1 mRNA25014914
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of ASS1 mRNA28522335
C103505AM 251AM 251 results in increased expression of ASS1 mRNA16500647
C018824ammonium acetateammonium acetate results in increased activity of ASS1 protein16009439
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ASS1 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of ASS1 mRNA15070760|1576101
C006632arsenic trioxidearsenic trioxide results in increased expression of ASS1 mRNA27829220
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in decreased expression of ASS1 mRNA15894607
C015001arsenitearsenite affects the expression of ASS1 mRNA22959463
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of ASS1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ASS1 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ASS1 mRNA21632981
D001564Benzo(a)pyreneAHR protein inhibits the reaction [Benzo(a)pyrene results in decreased expression of ASS1 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ASS1 mRNA15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ASS1 mRNA21569818
D004958EstradiolEstradiol results in increased expression of ASS1 mRNA15757668
D004958EstradiolEstradiol results in increased expression of ASS1 mRNA15289156
C006780bisphenol Abisphenol A results in increased expression of ASS1 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of ASS1 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ASS1 mRNA15336504
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ASS1 protein24394546
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of ASS1 protein24394546
C018475butyraldehydebutyraldehyde results in increased expression of ASS1 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ASS1 mRNA23741332
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ASS1 mRNA24982889
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ASS1 mRNA24982889
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ASS1 mRNA25993096
C459604candoxincandoxin results in decreased expression of ASS1 mRNA16309724
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of ASS1 mRNA17484886|2663939
D002738ChloroquineChloroquine results in decreased expression of ASS1 mRNA19393257
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ASS1 mRNA20938992
D002994ClofibrateClofibrate results in decreased expression of ASS1 protein19952500
D002994ClofibrateClofibrate results in decreased expression of ASS1 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of ASS1 mRNA12851107
D002994ClofibrateClofibrate results in decreased expression of ASS1 protein16470657
C018021cobaltous chloridecobaltous chloride results in decreased expression of ASS1 mRNA19376846
D003300CopperCopper results in decreased expression of ASS1 mRNA22465980
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of ASS1 mRNA17383702
D016572CyclosporineCyclosporine results in decreased expression of ASS1 mRNA20106945
C014347decitabinedecitabine affects the expression of ASS1 mRNA23300844
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ASS1 mRNA]27941970
D003907DexamethasoneDexamethasone results in increased expression of ASS1 mRNA25047013
D003907DexamethasoneDexamethasone results in increased expression of ASS1 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in increased expression of ASS1 mRNA]20032058
D064730Dexrazoxane[Doxorubicin co-treated with Dexrazoxane] results in decreased expression of ASS1 mRNA26873546
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ASS1 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ASS1 mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ASS1 mRNA21266533
D002945CisplatinASS1 protein affects the susceptibility to Cisplatin16217747
D002945CisplatinCisplatin affects the expression of ASS1 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of ASS1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ASS1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of ASS1 protein22023808
D004008DiclofenacDiclofenac results in decreased expression of ASS1 mRNA26934552
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of ASS1 mRNA15784690
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of ASS1 mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ASS1 protein20935162
D004052Diethylnitrosamine[Phenobarbital co-treated with Diethylnitrosamine] results in decreased expression of ASS1 protein20935162
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of ASS1 mRNA15289156
D002117CalcitriolCalcitriol results in decreased expression of ASS1 mRNA12875902
D004237DiuronDiuron metabolite results in increased expression of ASS1 mRNA24172598
D004317Doxorubicin[Doxorubicin co-treated with Dexrazoxane] results in decreased expression of ASS1 mRNA26873546
D004317DoxorubicinDoxorubicin results in increased expression of ASS1 mRNA26873546
C118739entinostatentinostat results in increased expression of ASS1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASS1 mRNA"27188386
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of ASS1 mRNA20064776
D000431EthanolEthanol results in decreased expression of ASS1 protein23200777
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ASS1 mRNA12655037
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ASS1 mRNA17351261|1755790
C540355fenamidonefenamidone results in increased expression of ASS1 mRNA27029645
D005472Fluorouracil[Fluorouracil co-treated with irinotecan] results in decreased expression of ASS1 mRNA16391804
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ASS1 mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of ASS1 mRNA27664576
C039281furanfuran binds to ASS1 protein22240984
C039281furanfuran results in decreased expression of ASS1 mRNA15120968
D019833GenisteinGenistein results in increased expression of ASS1 mRNA15757668
D019833GenisteinGenistein results in increased expression of ASS1 mRNA15289156
D005897GlafenineGlafenine results in decreased expression of ASS1 mRNA24136188
D005944GlucosamineGlucosamine inhibits the reaction [IL1B results in increased expression of ASS1 mRNA]17109745
C412815GW 4064GW 4064 results in increased expression of ASS1 mRNA26655953
D017313FenretinideFenretinide results in increased expression of ASS1 mRNA28973697
C492448ICG 001ICG 001 results in increased expression of ASS1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ASS1 mRNA25613284
C051890irinotecan[Fluorouracil co-treated with irinotecan] results in decreased expression of ASS1 mRNA16391804
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of ASS1 mRNA27392435
C008261lead acetatelead acetate results in decreased expression of ASS1 mRNA11578147
C008261lead acetatelead acetate results in decreased expression of ASS1 protein21247988
C045463leflunomideleflunomide results in increased expression of ASS1 mRNA19751817
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ASS1 mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of ASS1 mRNA15120968
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ASS1 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASS1 mRNA"27188386
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ASS1 mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of ASS1 mRNA24810058
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of ASS1 protein24810058
D008942MitoxantroneASS1 protein affects the susceptibility to Mitoxantrone16217747
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ASS1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ASS1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ASS1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ASS1 mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of ASS1 mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of ASS1 mRNA22714537
D009569Nitric Oxide[troglitazone results in increased expression of ASS1 protein] which results in increased abundance of Nitric Oxide18375203
D009569Nitric OxideASS1 protein results in increased susceptibility to Nitric Oxide25033204
C002741N-nitrosomorpholineN-nitrosomorpholine results in decreased expression of ASS1 protein19716841
C572573N-nitroso-tris-chloroethylureaN-nitroso-tris-chloroethylurea results in increased expression of ASS1 mRNA27935865
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ASS1 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of ASS1 mRNA26516004
D010126OzoneOzone results in increased expression of ASS1 mRNA25838073
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASS1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of ASS1 mRNA26272509
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of ASS1 mRNA26705709
C046012pentanalpentanal results in increased expression of ASS1 mRNA26079696
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of ASS1 mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of ASS1 mRNA18692542|2172336
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ASS1 mRNA20452409|2172336
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ASS1 protein20452409
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of ASS1 mRNA17097637
D010634PhenobarbitalPhenobarbital results in decreased expression of ASS1 protein19952500
D010634PhenobarbitalPhenobarbital results in decreased expression of ASS1 mRNA23091169
D010634Phenobarbital[Phenobarbital co-treated with Diethylnitrosamine] results in decreased expression of ASS1 protein20935162
D010795Phthalic AcidsPhthalic Acids results in decreased expression of ASS1 mRNA15728792
C006253pirinixic acidpirinixic acid results in decreased expression of ASS1 mRNA17426115|2081375
C006253pirinixic acidpirinixic acid results in decreased expression of ASS1 protein15226431
C006253pirinixic acidpirinixic acid results in decreased expression of ASS1 mRNA17164430|1916217
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of ASS1 mRNA19162173
D011372ProgestinsProgestins results in increased expression of ASS1 mRNA19609016
C005556propionaldehydepropionaldehyde results in increased expression of ASS1 mRNA26079696
D011441PropylthiouracilPropylthiouracil affects the expression of ASS1 mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of ASS1 mRNA27029645
D011794QuercetinQuercetin results in decreased expression of ASS1 mRNA21632981
C059514resveratrolresveratrol results in increased expression of ASS1 mRNA18089832
C059514resveratrolresveratrol results in increased expression of ASS1 protein18089832
C059514resveratrolresveratrol results in increased expression of ASS1 protein25505154
D012402RotenoneRotenone results in increased expression of ASS1 mRNA24810058
D012643SeleniumSelenium results in increased expression of ASS1 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ASS1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of ASS1 mRNA22431001
D012834SilverSilver analog results in increased expression of ASS1 mRNA24974767
D019821SimvastatinSimvastatin results in decreased expression of ASS1 mRNA16414398
D012906SmokeSmoke results in decreased expression of ASS1 mRNA21095227
C017947sodium arsenitesodium arsenite affects the expression of ASS1 mRNA19590694
C017947sodium arsenitesodium arsenite results in decreased expression of ASS1 mRNA19590694
C016104sodium bichromatesodium bichromate results in decreased expression of ASS1 mRNA25993096
D017673Sodium Chloride, Dietary"ASS1 protein affects the susceptibility to Sodium Chloride, Dietary"15257170
D017673Sodium Chloride, Dietary"Sodium Chloride, Dietary deficiency results in decreased expression of ASS1 mRNA"15257170
D012969Sodium FluorideSodium Fluoride results in decreased expression of ASS1 mRNA27862939
D012999SomanSoman results in decreased expression of ASS1 mRNA19281266
C016766sulforafansulforafan results in decreased expression of ASS1 mRNA26833863
C021751tanshinonetanshinone results in decreased expression of ASS1 mRNA15849732
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in increased expression of ASS1 mRNA]20032058
C004648testosterone enanthatetestosterone enanthate affects the expression of ASS1 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ASS1 mRNA16443690
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ASS1 mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ASS1 mRNA15034205|1977048
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ASS1 mRNA16054898|1649779
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ASS1 protein16497791
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of ASS1 mRNA28973375
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ASS1 mRNA16979875
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ASS1 mRNA25613284
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of ASS1 mRNA28943392
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ASS1 mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ASS1 mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ASS1 protein22595367
C052342topiramatetopiramate results in decreased expression of ASS1 mRNA16979414
D019772TopotecanASS1 protein affects the susceptibility to Topotecan16217747
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ASS1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of ASS1 mRNA25729387
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in decreased expression of ASS1 mRNA15894607
D014212TretinoinTretinoin results in decreased expression of ASS1 mRNA12875902|1589460
D014241TrichloroethyleneTrichloroethylene results in increased expression of ASS1 mRNA19254012
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASS1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of ASS1 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in decreased expression of ASS1 mRNA15901671
D014266TrientineTrientine results in decreased expression of ASS1 protein19634143
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ASS1 mRNA"26179874
C057693troglitazonetroglitazone promotes the reaction [PPARG protein binds to ASS1 promoter]18375203
C057693troglitazonetroglitazone promotes the reaction [[PPARG protein binds to ASS1 promoter] which results in increased expression of ASS1 mRNA]18375203|1837520
C057693troglitazonetroglitazone results in increased expression of ASS1 mRNA18375203
C057693troglitazonetroglitazone results in increased expression of ASS1 protein18375203
C057693troglitazone[troglitazone results in increased expression of ASS1 protein] which results in increased abundance of Nitric Oxide18375203
C057693troglitazonetroglitazone results in increased expression of ASS1 mRNA19140230
C406224valdecoxibvaldecoxib results in decreased expression of ASS1 mRNA24136188
D014635Valproic AcidValproic Acid results in decreased expression of ASS1 mRNA24935251|2800136
D014635Valproic AcidValproic Acid results in decreased expression of ASS1 mRNA15901671
D014638VanadatesVanadates results in decreased expression of ASS1 mRNA22714537
D014640VancomycinVancomycin results in increased expression of ASS1 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ASS1 gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ASS1 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of ASS1 mRNA26272509
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of ASS1 mRNA15784690
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ASS1 mRNA16979875

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0004055argininosuccinate synthase activity-IBA21873635  
GO:0004055argininosuccinate synthase activity-IMP7977368  8792870  18473344  27287393  28985504  
GO:0005515protein binding-IPI12620389  17496144  28985504  
GO:0005524ATP binding-IEA-  
GO:0015643toxic substance binding-IEA-  
GO:0016597amino acid binding-IMP7977368  
GO:0042802identical protein binding-IPI16189514  21988832  25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0000050urea cycle-IBA21873635  
GO:0000050urea cycle-IEA-  
GO:0000050urea cycle-IMP7977368  8792870  18473344  27287393  
GO:0000052citrulline metabolic process-IMP7977368  
GO:0000053argininosuccinate metabolic process-IBA21873635  
GO:0000053argininosuccinate metabolic process-IMP7977368  
GO:0001822kidney development-IEA-  
GO:0001889liver development-IEA-  
GO:0006526arginine biosynthetic process-IBA21873635  
GO:0006526arginine biosynthetic process-IEA-  
GO:0006526arginine biosynthetic process-IMP8792870  18473344  27287393  
GO:0006531aspartate metabolic process-IMP7977368  
GO:0006953acute-phase response-IEA-  
GO:0007494midgut development-IEA-  
GO:0007568aging-IEA-  
GO:0007584response to nutrient-IEA-  
GO:0007623circadian rhythm-IDA28985504  
GO:0010043response to zinc ion-IEA-  
GO:0010046response to mycotoxin-IEA-  
GO:0032355response to estradiol-IEA-  
GO:0045429positive regulation of nitric oxide biosynthetic process-IMP21106532  
GO:0060416response to growth hormone-IEA-  
GO:0060539diaphragm development-IEA-  
GO:0071222cellular response to lipopolysaccharide-IEA-  
GO:0071230cellular response to amino acid stimulus-IEA-  
GO:0071242cellular response to ammonium ion-IEA-  
GO:0071320cellular response to cAMP-IEA-  
GO:0071346cellular response to interferon-gamma-IEA-  
GO:0071356cellular response to tumor necrosis factor-IEA-  
GO:0071377cellular response to glucagon stimulus-IEA-  
GO:0071400cellular response to oleic acid-IEA-  
GO:0071418cellular response to amine stimulus-IEA-  
GO:0071499cellular response to laminar fluid shear stress-IMP21106532  
GO:0071549cellular response to dexamethasone stimulus-IEA-  
GO:1903038negative regulation of leukocyte cell-cell adhesion-IMP21106532  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-TAS6194510  
GO:0005741mitochondrial outer membrane-IEA-  
GO:0005764lysosome-IEA-  
GO:0005783endoplasmic reticulum-IEA-  
GO:0005829cytosol-IDA28985504  
GO:0005829cytosol-TAS-  
GO:0043204perikaryon-IEA-  
GO:0043209myelin sheath-IEA-  
GO:0070062extracellular exosome-HDA19056867  23533145  
GO:0070852cell body fiber-IEA-  
KEGG ID KEGG Term
hsa00250Alanine, aspartate and glutamate metabolism
hsa00330Arginine and proline metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-351202Metabolism of polyaminesTAS
R-HSA-70635Urea cycleTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25683020Impact of visceral fat and pro-inflammatory factors on the pathogenesis of age-related macular degeneration. (2015 Sep)Haas PActa Ophthalmol