Gene: MSN

4478
HEL70|IMD50
moesin
protein-coding
Xq12
Ensembl:ENSG00000147065 MIM:309845 Vega:OTTHUMG00000021723 UniprotKB:P26038
NG_012516.1
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
9   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STOM0.908
ANO60.896
LTBR0.895
LRP100.894
TLN10.893
SLC39A10.893
PTTG1IP0.891
MAPKAPK20.891
MYL12A0.888
LIMS10.887

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCC12-0.606
SLC7A4-0.584
CALHM1-0.583
PPEF1-0.575
KCNB2-0.574
MARCH4-0.548
NEUROD6-0.545
ADRA1D-0.537
GPR61-0.535
SMIM18-0.535

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of MSN mRNA"25380136
D000082AcetaminophenAcetaminophen results in decreased expression of MSN mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MSN mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MSN mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of MSN mRNA"22863853
C023650anilineaniline results in increased nitrosation of MSN protein21708182
C006632arsenic trioxidearsenic trioxide results in decreased expression of MSN protein25419056
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MSN mRNA19770486
C006780bisphenol Abisphenol A affects the expression of MSN mRNA25181051
C006780bisphenol A[Fructose co-treated with bisphenol A] results in increased expression of MSN protein26930160
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased phosphorylation of MSN protein22174045
D001761BleomycinBleomycin results in decreased expression of MSN protein25933445
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of MSN mRNA15336504
C584509C646 compoundC646 compound results in decreased expression of MSN mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MSN mRNA25993096
D000074262Canola OilCanola Oil metabolite results in decreased expression of MSN mRNA27363782
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of MSN mRNA27339419
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of MSN mRNA19395590
C043211carvedilolcarvedilol results in decreased expression of MSN protein20403466
C100187chloropicrinchloropicrin affects the expression of MSN mRNA26352163
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MSN mRNA20938992
D003300CopperCopper results in increased expression of MSN mRNA16629173
C030973cupric oxidecupric oxide results in increased expression of MSN protein25470785
D003471CuprizoneCuprizone results in increased expression of MSN mRNA26577399|2752363
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MSN mRNA]18200517
C057862cyanoginosin LRcyanoginosin LR results in increased expression of MSN mRNA23342045
D016572CyclosporineCyclosporine results in increased expression of MSN mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of MSN mRNA19770486
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MSN mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of MSN mRNA21266533
D002945CisplatinCisplatin results in decreased expression of MSN protein20540955
C000944dicrotophosdicrotophos results in decreased expression of MSN mRNA28302478
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of MSN mRNA26924002
D004041Dietary FatsDietary Fats results in increased expression of MSN mRNA18042831
C014476diethyl maleatediethyl maleate results in increased reduction of MSN protein19843705
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of MSN mRNA25380136
C024629dimethyl phthalatedimethyl phthalate affects the expression of MSN mRNA26924002
D004237DiuronDiuron results in increased expression of MSN mRNA21551480
C540355fenamidonefenamidone results in increased expression of MSN mRNA27029645
D005419FlavonoidsFlavonoids results in decreased expression of MSN mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MSN mRNA20938992
D005632Fructose[Fructose co-treated with bisphenol A] results in increased expression of MSN protein26930160
D005839GentamicinsGentamicins results in increased expression of MSN protein22061828
D005897GlafenineGlafenine results in increased expression of MSN mRNA24136188
D006493HeparinHeparin results in increased expression of MSN protein17488504
C492448ICG 001ICG 001 results in decreased expression of MSN mRNA26191083
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of MSN mRNA27339419
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MSN mRNA20938992
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of MSN protein26558463
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of MSN mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of MSN protein26558463
D008777MethyltestosteroneMethyltestosterone results in decreased expression of MSN mRNA29191790
C517284monomethyl phthalatemonomethyl phthalate affects the expression of MSN mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of MSN protein"22001959
C031721naphthalene[naphthalene co-treated with CFTR gene mutant form] results in decreased expression of MSN protein19438287
C031721naphthalenenaphthalene results in increased reduction of MSN protein19843705
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of MSN mRNA25380136
D009569Nitric OxideNitric Oxide deficiency results in increased phosphorylation of MSN protein14732730
D010100OxygenOxygen deficiency affects the localization of MSN protein20164382
D000073878Palm OilPalm Oil results in increased expression of MSN mRNA18042831
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of MSN protein19954255
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of MSN protein19954255
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of MSN mRNA28973697
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in decreased expression of MSN mRNA22790973
D010634PhenobarbitalPhenobarbital affects the expression of MSN mRNA23091169
D010656PhenylephrinePhenylephrine results in increased expression of MSN mRNA18158353
D010705PhosgenePhosgene affects the expression of MSN mRNA16300373
D010862PilocarpinePilocarpine results in increased expression of MSN mRNA14656328
D011441PropylthiouracilPropylthiouracil results in increased expression of MSN mRNA24780913
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of MSN protein19264907
C513428pyrachlostrobinpyrachlostrobin results in increased expression of MSN mRNA27029645
C012526quercitrinquercitrin affects the expression of MSN mRNA25193878
D011929RazoxaneRazoxane results in decreased expression of MSN mRNA19915844
C089730rosiglitazonerosiglitazone affects the expression of MSN protein19556978
D012643SeleniumSelenium results in increased expression of MSN mRNA19244175
D012715Sesame OilSesame Oil results in increased expression of MSN mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog affects the secretion of MSN protein25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of MSN mRNA22431001
C009277sodium arsenatesodium arsenate results in increased expression of MSN mRNA21795629
D012969Sodium FluorideSodium Fluoride results in increased expression of MSN protein27548804|2891852
D012999SomanSoman results in increased expression of MSN mRNA19281266
C471405sorafenibsorafenib results in increased phosphorylation of MSN protein19338580
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of MSN mRNA16214533
C004648testosterone enanthatetestosterone enanthate affects the expression of MSN mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MSN mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MSN mRNA19770486
D013849ThimerosalThimerosal results in decreased expression of MSN mRNA27188386
C009495titanium dioxidetitanium dioxide results in decreased expression of MSN mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MSN mRNA28111298
D014050TolueneMSN gene polymorphism affects the susceptibility to Toluene28013218
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MSN mRNA]18200517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of MSN mRNA18200517
C057693troglitazonetroglitazone results in increased expression of MSN protein21315101
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in decreased expression of MSN mRNA15885361
D014635Valproic AcidValproic Acid results in decreased expression of MSN mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of MSN gene29154799
D014640VancomycinVancomycin results in decreased expression of MSN mRNA18930951
C025643vinclozolinvinclozolin affects the expression of MSN mRNA19015723
C025643vinclozolinvinclozolin results in decreased expression of MSN mRNA18042343
C025643vinclozolinvinclozolin results in increased expression of MSN mRNA23034163
C029297vinylidene chloridevinylidene chloride results in increased expression of MSN mRNA26682919
D014810Vitamin EVitamin E results in increased expression of MSN mRNA19244175
C108830Y 27632Y 27632 deficiency results in increased phosphorylation of MSN protein14732730

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003725double-stranded RNA binding-IDA21266579  
GO:0003779actin binding-IEA-  
GO:0005102signaling receptor binding-IPI15819698  
GO:0005200structural constituent of cytoskeleton-TAS1924289  
GO:0005515protein binding-IPI7844168  9430655  10806479  15020681  16938849  17046996  
18586956  20642453  21044950  21148287  22363216  22952686  
23241358  23855374  24351927  24695735  24794857  24904275  
25009464  26824392  27357661  
GO:0019899enzyme binding-IPI15922359  
GO:0019901protein kinase binding-IPI19255442  
GO:0050839cell adhesion molecule binding-IPI12082081  
GO ID GO Term Qualifier Evidence PubMed
GO:0001771immunological synapse formation-IDA27405666  
GO:0007010cytoskeleton organization-IEA-  
GO:0007159leukocyte cell-cell adhesion-IEP12082081  
GO:0008360regulation of cell shape-IMP24862762  
GO:0008361regulation of cell size-IMP24862762  
GO:0008361regulation of cell sizeNOTIMP22467863  
GO:0010628positive regulation of gene expression-IGI23264465  
GO:0022612gland morphogenesis-IMP24862762  
GO:0022614membrane to membrane docking-IEP12082081  
GO:0035722interleukin-12-mediated signaling pathway-TAS-  
GO:0042098T cell proliferation-IDA27405666  
GO:0045198establishment of epithelial cell apical/basal polarity-IMP24862762  
GO:0050900leukocyte migration-IEP12082081  
GO:0061028establishment of endothelial barrier-IGI23264465  
GO:0070489T cell aggregation-IDA27405666  
GO:0071394cellular response to testosterone stimulus-IDA24065547  
GO:0071803positive regulation of podosome assembly-IEA-  
GO:0072678T cell migration-IDA27405666  
GO:1902115regulation of organelle assembly-IGI21148287  
GO:1902966positive regulation of protein localization to early endosome-IGI21148287  
GO:1903364positive regulation of cellular protein catabolic process-IGI21148287  
GO:2000401regulation of lymphocyte migration-IMP19255442  
GO:2000643positive regulation of early endosome to late endosome transport-IGI21148287  
GO ID GO Term Qualifier Evidence PubMed
GO:0001931uropod-IEA-  
GO:0005615extracellular space-HDA16502470  
GO:0005634nucleus-HDA16791210  
GO:0005737cytoplasm-HDA16791210  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005856cytoskeleton-TAS16130169  
GO:0005886plasma membrane-IDA-  
GO:0005902microvillus-IDA12082081  
GO:0005925focal adhesion-HDA21423176  
GO:0005925focal adhesioncolocalizes_withIDA21282464  
GO:0009986cell surface-IDA15922359  
GO:0016323basolateral plasma membrane-IEA-  
GO:0016324apical plasma membrane-IDA24862762  
GO:0030175filopodium-IDA12082081  24065547  
GO:0031143pseudopodium-IDA24065547  
GO:0031528microvillus membrane-IEA-  
GO:0031982vesicle-HDA19190083  
GO:0043209myelin sheath-IEA-  
GO:0045177apical part of cell-IDA12082081  
GO:0048471perinuclear region of cytoplasm-IDA24862762  
GO:0070062extracellular exosome-HDA12519789  19056867  19199708  20458337  21362503  23533145  
GO:0071437invadopodium-IDA25486435  
GO:0071944cell periphery-IDA22291017  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-373760L1CAM interactionsTAS
R-HSA-373760L1CAM interactionsIEA
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-437239Recycling pathway of L1TAS
R-HSA-437239Recycling pathway of L1IEA
R-HSA-447115Interleukin-12 family signalingTAS
R-HSA-449147Signaling by InterleukinsTAS
R-HSA-8950505Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulationTAS
R-HSA-9020591Interleukin-12 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23012412Cannabinoid receptor 1-expressing neurons in the nucleus accumbens. (2012 Oct 2)Winters BDProc Natl Acad Sci U S A
17515006Use of Medicare summary notice inserts to generate interest in the Medicare stop smoking program. (2007 May-Jun)Maglione MAm J Health Promot
29268097Drp1 Mitochondrial Fission in D1 Neurons Mediates Behavioral and Cellular Plasticity during Early Cocaine Abstinence. (2017 Dec 20)Chandra RNeuron
26059306[Depression and addiction comorbidity: towards a common molecular target?]. (2015 May)Arango-Lievano MMed Sci (Paris)
27470168Distinct Synaptic Strengthening of the Striatal Direct and Indirect Pathways Drives Alcohol Consumption. (2017 Jun 1)Cheng YBiol Psychiatry
24001687Acute binge pattern cocaine administration induces region-specific effects in D1-r- and D2-r-expressing cells in eGFP transgenic mice. (2013 Dec 3)Lawhorn CNeuroscience
21028815Metabonomic investigation of liver profiles of nonpolar metabolites obtained from alcohol-dosed rats and mice using high mass accuracy MSn analysis. (2011 Feb 4)Loftus NJ Proteome Res
22754497Calcium-permeable AMPA receptors in the VTA and nucleus accumbens after cocaine exposure: when, how, and why? (2012)Wolf MEFront Mol Neurosci
17904896First-hit heart attack risk calculators on the world wide web: implications for laypersons and healthcare practitioners. (2008 Jun)Roberts EBInt J Med Inform