Gene info: ID 4488

Gene: MSX2

GENE ID: 4488

Synonyms: CRS2|FPP|HOX8|MSH|PFM|PFM1

Description: msh homeobox 2

Gene type: protein-coding

Location: 5q35.2

dbXrefs: Ensembl:ENSG00000120149 MIM:123101 Vega:OTTHUMG00000130556 UniprotKB:P35548

RefSeq: NG_008124.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.102e-1 (AD) 7.007e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HS3ST3A1	0.737
GLP1R	0.716
SFRP2	0.638
LPAR4	0.576
MSX1	0.571
ELN	0.568
NDNF	0.546
RASSF10	0.533
ST6GALNAC2	0.532
PFKFB2	0.516

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SMYD1	-0.429
THEMIS	-0.424
HS3ST2	-0.399
SEMA3E	-0.383
FOXP2	-0.378
NPFFR2	-0.377
DACH1	-0.358
PDZRN4	-0.358
SH2D1B	-0.358
HS3ST4	-0.351

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of MSX2 mRNA"	21346803
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"	27188386
D020106	Acrylamide	Acrylamide results in decreased expression of MSX2 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of MSX2 gene	27153756
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of MSX2 mRNA	16483693
D000935	Antifungal Agents	Antifungal Agents results in decreased expression of MSX2 mRNA	21254369
C006632	arsenic trioxide	MSX2 protein results in decreased susceptibility to arsenic trioxide	20707922
C015001	arsenite	arsenite results in increased methylation of MSX2 promoter	23974009
D001205	Ascorbic Acid	[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of MSX2 mRNA	28189605
D001205	Ascorbic Acid	cadmium sulfate inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of MSX2 mRNA]	28189605
C487081	belinostat	belinostat results in increased expression of MSX2 mRNA	26272509
C487081	belinostat	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"	27188386
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MSX2 mRNA	22228805
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MSX2 mRNA	23735875
D004958	Estradiol	Estradiol results in decreased expression of MSX2 mRNA	19167446
D004958	Estradiol	Estradiol results in increased expression of MSX2 mRNA	17450229
C031463	beta-glycerophosphoric acid	[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of MSX2 mRNA	28189605
C031463	beta-glycerophosphoric acid	cadmium sulfate inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of MSX2 mRNA]	28189605
C006780	bisphenol A	bisphenol A results in decreased expression of MSX2 mRNA	22576693
C006780	bisphenol A	bisphenol A results in increased methylation of MSX2 gene	22576693
C006780	bisphenol A	bisphenol A affects the methylation of MSX2 promoter	27334623
C006780	bisphenol A	bisphenol A results in decreased expression of MSX2 mRNA	26063408
C006780	bisphenol A	bisphenol A results in decreased expression of MSX2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of MSX2 gene	28505145
C584509	C646 compound	C646 compound results in decreased expression of MSX2 mRNA	26191083
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of MSX2 promoter	22457795
C037123	cadmium sulfate	cadmium sulfate inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of MSX2 mRNA]	28189605
C055494	caffeic acid phenethyl ester	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of MSX2 mRNA	20360939
D002220	Carbamazepine	Carbamazepine affects the expression of MSX2 mRNA	25979313
C084597	chlorcyclizine	chlorcyclizine results in increased expression of MSX2 mRNA	21058326
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased expression of MSX2 mRNA	26272509
C007076	citral	citral results in decreased expression of MSX2 mRNA	15581867
C018021	cobaltous chloride	cobaltous chloride results in increased expression of MSX2 mRNA	19376846
D003375	Coumestrol	Coumestrol results in decreased expression of MSX2 mRNA	19167446
D003471	Cuprizone	Cuprizone results in increased expression of MSX2 mRNA	26577399
D003907	Dexamethasone	[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of MSX2 mRNA	28189605
D003907	Dexamethasone	cadmium sulfate inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of MSX2 mRNA]	28189605
D004041	Dietary Fats	Dietary Fats results in increased expression of MSX2 mRNA	25016146
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of MSX2 mRNA	20360939
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of MSX2 mRNA	16513791
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of MSX2 mRNA	17394237
D004054	Diethylstilbestrol	MSX2 affects the susceptibility to Diethylstilbestrol	15591538
D004054	Diethylstilbestrol	MSX2 protein results in decreased susceptibility to Diethylstilbestrol	16513791
D002117	Calcitriol	Calcitriol results in increased expression of MSX2 mRNA	16002434
C118739	entinostat	entinostat results in increased expression of MSX2 mRNA	26272509
D004967	Estrogens	[Estrogens co-treated with Progesterone] results in increased expression of MSX2 mRNA	17546050
D004967	Estrogens	Estrogens results in increased expression of MSX2 mRNA	17546050
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of MSX2 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MSX2 mRNA	17942748
D005459	Fluorides	Fluorides inhibits the reaction [potassium phosphate results in increased expression of MSX2 mRNA]	24561004
D005472	Fluorouracil	Fluorouracil results in decreased expression of MSX2 protein	15352031
D005472	Fluorouracil	MSX2 protein affects the susceptibility to Fluorouracil	15352031
C039281	furan	furan results in decreased expression of MSX2 mRNA	25539665
C577920	GSK126	GSK126 results in increased expression of MSX2 mRNA	26424790
C409722	hexaconazole	hexaconazole results in decreased expression of MSX2 mRNA	22045034
C492448	ICG 001	ICG 001 results in decreased expression of MSX2 mRNA	26191083
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of MSX2 mRNA	24796395
C008261	lead acetate	lead acetate results in decreased expression of MSX2 mRNA	22609695
C533894	LG 100815	LG 100815 results in decreased expression of MSX2 mRNA	16951191
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of MSX2 mRNA	12057914
D015122	Mercaptopurine	Mercaptopurine results in decreased expression of MSX2 mRNA	23358152
C042720	mercuric bromide	mercuric bromide results in increased expression of MSX2 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"	27188386
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of MSX2 mRNA	23179753\|2627250
C004925	methylmercuric chloride	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"	27188386
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of MSX2 mRNA	29191790
C500085	muraglitazar	muraglitazar results in increased expression of MSX2 mRNA	21515302
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog affects the expression of MSX2 mRNA"	21624382
C062198	octa-2,4,6-trienoic acid	"octa-2,4,6-trienoic acid results in decreased expression of MSX2 mRNA"	16951191
D010100	Oxygen	Oxygen deficiency results in decreased expression of MSX2 mRNA	24236059
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of MSX2 mRNA	26272509
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in increased expression of MSX2 mRNA	23602845
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of MSX2 mRNA	26272509
C013216	potassium phosphate	Fluorides inhibits the reaction [potassium phosphate results in increased expression of MSX2 mRNA]	24561004
C013216	potassium phosphate	potassium phosphate results in increased expression of MSX2 mRNA	24561004
D011374	Progesterone	[Estrogens co-treated with Progesterone] results in increased expression of MSX2 mRNA	17546050
D011374	Progesterone	Progesterone results in decreased expression of MSX2 mRNA	22238285
D011374	Progesterone	Progesterone results in increased expression of MSX2 mRNA	17546050
C009166	retinol acetate	retinol acetate results in increased expression of MSX2 mRNA	16772331
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of MSX2 mRNA	21427059
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of MSX2 mRNA	23806026
C501413	tesaglitazar	tesaglitazar results in increased expression of MSX2 mRNA	21515302
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MSX2 mRNA	24058054
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MSX2 mRNA	17942748
D014212	Tretinoin	Tretinoin results in decreased expression of MSX2 mRNA	23724009
D014212	Tretinoin	Tretinoin results in increased expression of MSX2 mRNA	17138961\|2193413
D014212	Tretinoin	Tretinoin results in increased expression of MSX2 mRNA	16604517
C032910	triadimefon	triadimefon results in decreased expression of MSX2 mRNA	21254369
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of MSX2 mRNA	24935251\|2627250
C057693	troglitazone	troglitazone results in decreased expression of MSX2 mRNA	21515302
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of MSX2 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased methylation of MSX2 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of MSX2 mRNA	19101580\|2317975
D014635	Valproic Acid	Valproic Acid results in decreased expression of MSX2 mRNA	22045034
D014635	Valproic Acid	Valproic Acid results in increased expression of MSX2 mRNA	19136453
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of MSX2 gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	-	IEA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISA	-
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0000989	transcription factor activity, transcription factor binding	-	IEA	-
GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	-	IEA	-
GO:0003712	transcription coregulator activity	-	ISS	-
GO:0005515	protein binding	-	IPI	12145306
GO:0008134	transcription factor binding	-	IEA	-
GO:0043565	sequence-specific DNA binding	-	IDA	9073066
GO:0044212	transcription regulatory region DNA binding	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IMP	14671321
GO:0000122	negative regulation of transcription by RNA polymerase II	-	ISS	-
GO:0001649	osteoblast differentiation	-	ISS	-
GO:0002063	chondrocyte development	-	IEA	-
GO:0002076	osteoblast development	-	IEA	-
GO:0003148	outflow tract septum morphogenesis	-	IEA	-
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	-	IEA	-
GO:0003416	endochondral bone growth	-	IEA	-
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0008285	negative regulation of cell proliferation	-	IEA	-
GO:0009952	anterior/posterior pattern specification	-	IEA	-
GO:0023019	signal transduction involved in regulation of gene expression	-	IEA	-
GO:0030513	positive regulation of BMP signaling pathway	-	IEA	-
GO:0032792	negative regulation of CREB transcription factor activity	-	IEA	-
GO:0035115	embryonic forelimb morphogenesis	-	IEA	-
GO:0035116	embryonic hindlimb morphogenesis	-	IEA	-
GO:0035313	wound healing, spreading of epidermal cells	-	IEA	-
GO:0035880	embryonic nail plate morphogenesis	-	IEA	-
GO:0043066	negative regulation of apoptotic process	-	IEA	-
GO:0045599	negative regulation of fat cell differentiation	-	IEA	-
GO:0045617	negative regulation of keratinocyte differentiation	-	IEA	-
GO:0045669	positive regulation of osteoblast differentiation	-	IEA	-
GO:0045892	negative regulation of transcription, DNA-templated	-	ISS	-
GO:0048863	stem cell differentiation	-	IEA	-
GO:0051795	positive regulation of timing of catagen	-	IEA	-
GO:0060346	bone trabecula formation	-	IEA	-
GO:0060363	cranial suture morphogenesis	-	TAS	8968743
GO:0060364	frontal suture morphogenesis	-	IEA	-
GO:0060444	branching involved in mammary gland duct morphogenesis	-	IEA	-
GO:0061312	BMP signaling pathway involved in heart development	-	IEA	-
GO:0070166	enamel mineralization	-	IEA	-
GO:0071392	cellular response to estradiol stimulus	-	IEA	-
GO:0090427	activation of meiosis	-	IEA	-
GO:2000678	negative regulation of transcription regulatory region DNA binding	-	ISS	-
GO:2001055	positive regulation of mesenchymal cell apoptotic process	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005829	cytosol	-	IDA	-
GO:0016607	nuclear speck	-	IDA	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-212436	Generic Transcription Pathway	IEA
R-HSA-73857	RNA Polymerase II Transcription	IEA
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-8878166	Transcriptional regulation by RUNX2	IEA
R-HSA-8939902	Regulation of RUNX2 expression and activity	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
8664424	Prenatal craniofacial development: new insights on normal and abnormal mechanisms. (1995)	Johnston MC	Crit Rev Oral Biol Med
19345526	[Origin of the mediacalcosis in kidney failure]. (2009 May)	Torres PA	J Mal Vasc
7632866	Prenatal craniofacial development: new insights on normal and abnormal mechanisms. (1995)	Johnston MC	Crit Rev Oral Biol Med