Gene: MSX2

4488
CRS2|FPP|HOX8|MSH|PFM|PFM1
msh homeobox 2
protein-coding
5q35.2
Ensembl:ENSG00000120149 MIM:123101 Vega:OTTHUMG00000130556 UniprotKB:P35548
NG_008124.1
PubMed
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.102e-1 (AD)  7.007e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HS3ST3A10.737
GLP1R0.716
SFRP20.638
LPAR40.576
MSX10.571
ELN0.568
NDNF0.546
RASSF100.533
ST6GALNAC20.532
PFKFB20.516

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMYD1-0.429
THEMIS-0.424
HS3ST2-0.399
SEMA3E-0.383
FOXP2-0.378
NPFFR2-0.377
DACH1-0.358
PDZRN4-0.358
SH2D1B-0.358
HS3ST4-0.351

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of MSX2 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of MSX2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MSX2 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MSX2 mRNA16483693
D000935Antifungal AgentsAntifungal Agents results in decreased expression of MSX2 mRNA21254369
C006632arsenic trioxideMSX2 protein results in decreased susceptibility to arsenic trioxide20707922
C015001arsenitearsenite results in increased methylation of MSX2 promoter23974009
D001205Ascorbic Acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of MSX2 mRNA28189605
D001205Ascorbic Acidcadmium sulfate inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of MSX2 mRNA]28189605
C487081belinostatbelinostat results in increased expression of MSX2 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MSX2 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MSX2 mRNA23735875
D004958EstradiolEstradiol results in decreased expression of MSX2 mRNA19167446
D004958EstradiolEstradiol results in increased expression of MSX2 mRNA17450229
C031463beta-glycerophosphoric acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of MSX2 mRNA28189605
C031463beta-glycerophosphoric acidcadmium sulfate inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of MSX2 mRNA]28189605
C006780bisphenol Abisphenol A results in decreased expression of MSX2 mRNA22576693
C006780bisphenol Abisphenol A results in increased methylation of MSX2 gene22576693
C006780bisphenol Abisphenol A affects the methylation of MSX2 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of MSX2 mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of MSX2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MSX2 gene28505145
C584509C646 compoundC646 compound results in decreased expression of MSX2 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of MSX2 promoter22457795
C037123cadmium sulfatecadmium sulfate inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of MSX2 mRNA]28189605
C055494caffeic acid phenethyl ester[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of MSX2 mRNA20360939
D002220CarbamazepineCarbamazepine affects the expression of MSX2 mRNA25979313
C084597chlorcyclizinechlorcyclizine results in increased expression of MSX2 mRNA21058326
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of MSX2 mRNA26272509
C007076citralcitral results in decreased expression of MSX2 mRNA15581867
C018021cobaltous chloridecobaltous chloride results in increased expression of MSX2 mRNA19376846
D003375CoumestrolCoumestrol results in decreased expression of MSX2 mRNA19167446
D003471CuprizoneCuprizone results in increased expression of MSX2 mRNA26577399
D003907Dexamethasone[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of MSX2 mRNA28189605
D003907Dexamethasonecadmium sulfate inhibits the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in increased expression of MSX2 mRNA]28189605
D004041Dietary FatsDietary Fats results in increased expression of MSX2 mRNA25016146
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of MSX2 mRNA20360939
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of MSX2 mRNA16513791
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of MSX2 mRNA17394237
D004054DiethylstilbestrolMSX2 affects the susceptibility to Diethylstilbestrol15591538
D004054DiethylstilbestrolMSX2 protein results in decreased susceptibility to Diethylstilbestrol16513791
D002117CalcitriolCalcitriol results in increased expression of MSX2 mRNA16002434
C118739entinostatentinostat results in increased expression of MSX2 mRNA26272509
D004967Estrogens[Estrogens co-treated with Progesterone] results in increased expression of MSX2 mRNA17546050
D004967EstrogensEstrogens results in increased expression of MSX2 mRNA17546050
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MSX2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MSX2 mRNA17942748
D005459FluoridesFluorides inhibits the reaction [potassium phosphate results in increased expression of MSX2 mRNA]24561004
D005472FluorouracilFluorouracil results in decreased expression of MSX2 protein15352031
D005472FluorouracilMSX2 protein affects the susceptibility to Fluorouracil15352031
C039281furanfuran results in decreased expression of MSX2 mRNA25539665
C577920GSK126GSK126 results in increased expression of MSX2 mRNA26424790
C409722hexaconazolehexaconazole results in decreased expression of MSX2 mRNA22045034
C492448ICG 001ICG 001 results in decreased expression of MSX2 mRNA26191083
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of MSX2 mRNA24796395
C008261lead acetatelead acetate results in decreased expression of MSX2 mRNA22609695
C533894LG 100815LG 100815 results in decreased expression of MSX2 mRNA16951191
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of MSX2 mRNA12057914
D015122MercaptopurineMercaptopurine results in decreased expression of MSX2 mRNA23358152
C042720mercuric bromidemercuric bromide results in increased expression of MSX2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MSX2 mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"27188386
D008777MethyltestosteroneMethyltestosterone results in decreased expression of MSX2 mRNA29191790
C500085muraglitazarmuraglitazar results in increased expression of MSX2 mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of MSX2 mRNA"21624382
C062198octa-2,4,6-trienoic acid"octa-2,4,6-trienoic acid results in decreased expression of MSX2 mRNA"16951191
D010100OxygenOxygen deficiency results in decreased expression of MSX2 mRNA24236059
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of MSX2 mRNA26272509
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of MSX2 mRNA23602845
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of MSX2 mRNA26272509
C013216potassium phosphateFluorides inhibits the reaction [potassium phosphate results in increased expression of MSX2 mRNA]24561004
C013216potassium phosphatepotassium phosphate results in increased expression of MSX2 mRNA24561004
D011374Progesterone[Estrogens co-treated with Progesterone] results in increased expression of MSX2 mRNA17546050
D011374ProgesteroneProgesterone results in decreased expression of MSX2 mRNA22238285
D011374ProgesteroneProgesterone results in increased expression of MSX2 mRNA17546050
C009166retinol acetateretinol acetate results in increased expression of MSX2 mRNA16772331
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of MSX2 mRNA21427059
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of MSX2 mRNA23806026
C501413tesaglitazartesaglitazar results in increased expression of MSX2 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MSX2 mRNA24058054
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MSX2 mRNA17942748
D014212TretinoinTretinoin results in decreased expression of MSX2 mRNA23724009
D014212TretinoinTretinoin results in increased expression of MSX2 mRNA17138961|2193413
D014212TretinoinTretinoin results in increased expression of MSX2 mRNA16604517
C032910triadimefontriadimefon results in decreased expression of MSX2 mRNA21254369
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of MSX2 mRNA24935251|2627250
C057693troglitazonetroglitazone results in decreased expression of MSX2 mRNA21515302
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MSX2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of MSX2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of MSX2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of MSX2 mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in decreased expression of MSX2 mRNA22045034
D014635Valproic AcidValproic Acid results in increased expression of MSX2 mRNA19136453
D001335Vehicle EmissionsVehicle Emissions affects the methylation of MSX2 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0000989transcription factor activity, transcription factor binding-IEA-  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IEA-  
GO:0003712transcription coregulator activity-ISS-  
GO:0005515protein binding-IPI12145306  
GO:0008134transcription factor binding-IEA-  
GO:0043565sequence-specific DNA binding-IDA9073066  
GO:0044212transcription regulatory region DNA binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IMP14671321  
GO:0000122negative regulation of transcription by RNA polymerase II-ISS-  
GO:0001649osteoblast differentiation-ISS-  
GO:0002063chondrocyte development-IEA-  
GO:0002076osteoblast development-IEA-  
GO:0003148outflow tract septum morphogenesis-IEA-  
GO:0003198epithelial to mesenchymal transition involved in endocardial cushion formation-IEA-  
GO:0003416endochondral bone growth-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0009952anterior/posterior pattern specification-IEA-  
GO:0023019signal transduction involved in regulation of gene expression-IEA-  
GO:0030513positive regulation of BMP signaling pathway-IEA-  
GO:0032792negative regulation of CREB transcription factor activity-IEA-  
GO:0035115embryonic forelimb morphogenesis-IEA-  
GO:0035116embryonic hindlimb morphogenesis-IEA-  
GO:0035313wound healing, spreading of epidermal cells-IEA-  
GO:0035880embryonic nail plate morphogenesis-IEA-  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0045599negative regulation of fat cell differentiation-IEA-  
GO:0045617negative regulation of keratinocyte differentiation-IEA-  
GO:0045669positive regulation of osteoblast differentiation-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-ISS-  
GO:0048863stem cell differentiation-IEA-  
GO:0051795positive regulation of timing of catagen-IEA-  
GO:0060346bone trabecula formation-IEA-  
GO:0060363cranial suture morphogenesis-TAS8968743  
GO:0060364frontal suture morphogenesis-IEA-  
GO:0060444branching involved in mammary gland duct morphogenesis-IEA-  
GO:0061312BMP signaling pathway involved in heart development-IEA-  
GO:0070166enamel mineralization-IEA-  
GO:0071392cellular response to estradiol stimulus-IEA-  
GO:0090427activation of meiosis-IEA-  
GO:2000678negative regulation of transcription regulatory region DNA binding-ISS-  
GO:2001055positive regulation of mesenchymal cell apoptotic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA-  
GO:0016607nuclear speck-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-8878166Transcriptional regulation by RUNX2IEA
R-HSA-8939902Regulation of RUNX2 expression and activityIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
8664424Prenatal craniofacial development: new insights on normal and abnormal mechanisms. (1995)Johnston MCCrit Rev Oral Biol Med
19345526[Origin of the mediacalcosis in kidney failure]. (2009 May)Torres PAJ Mal Vasc
7632866Prenatal craniofacial development: new insights on normal and abnormal mechanisms. (1995)Johnston MCCrit Rev Oral Biol Med