Gene: MT1B

4490
MT-1B|MT-IB|MT1|MT1Q|MTP
metallothionein 1B
protein-coding
16q13
Ensembl:ENSG00000169688 MIM:156349 Vega:OTTHUMG00000133277 UniprotKB:P07438
NC_000016.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.003e-1 (AD)  9.009e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PAGE2B0.43
CXCL10.409
CSF30.403
LCE3B0.385
C2CD4B0.373
PLIN50.362
CYP11A10.353
SMOX0.353
SERPINH10.352
C10orf1050.352

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
VLDLR-0.282
ROBO2-0.279
EPHA3-0.278
CALN1-0.275
GPR158-0.274
GAD1-0.27
ZBTB24-0.27
SLC39A10-0.269
ERC2-0.268
HDAC9-0.268

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalCarrier
ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of MT1B mRNA11793227
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MT1B mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of MT1B gene27153756
D000447AldehydesAldehydes results in increased expression of MT1B mRNA25014914
C006632arsenic trioxidearsenic trioxide results in decreased expression of MT1B mRNA22521957
C006632arsenic trioxidearsenic trioxide results in increased expression of MT1B mRNA19128835
D018053ArsenitesArsenites affects the expression of MT1B mRNA19411561
C406592azaspiracidazaspiracid results in increased expression of MT1B mRNA28939011
C028559bathocuproine sulfonate[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of MT1B mRNA15477007
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MT1B mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MT1B mRNA21871943
D004958EstradiolEstradiol affects the expression of MT1B mRNA22574217
C551172bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV)"bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) results in increased expression of MT1B mRNA"20162321
C025703bleomycetinbleomycetin results in increased expression of MT1B mRNA21040473
C018475butyraldehydebutyraldehyde results in increased expression of MT1B mRNA26079696
D002104CadmiumCadmium results in increased expression of MT1B protein7487904
D002104CadmiumCadmium results in increased expression of MT1B mRNA21297354|2256248
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MT1B mRNA26314618
C037123cadmium sulfatecadmium sulfate results in increased expression of MT1B mRNA12064557|1467641
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of MT1B mRNA24690739
D003300Copper[Organoselenium Compounds binds to Copper] which results in increased expression of MT1B mRNA25167922
D019327Copper SulfateCopper Sulfate results in decreased expression of MT1B mRNA20599845
D019327Copper SulfateCopper Sulfate results in increased expression of MT1B mRNA16283523|1954981
C029892cupric chloridecupric chloride promotes the reaction [Disulfiram results in increased expression of MT1B mRNA]19789329
C029892cupric chloridecupric chloride results in increased expression of MT1B mRNA17211630
C030973cupric oxidecupric oxide results in increased expression of MT1B mRNA22077320
D003671DEET[fipronil co-treated with DEET] results in decreased expression of MT1B mRNA27091632
D003907DexamethasoneDexamethasone results in increased expression of MT1B mRNA25047013
D011397Promegestonemethoxyacetic acid promotes the reaction [Promegestone results in increased expression of MT1B mRNA]15103026
D011397PromegestonePromegestone results in increased expression of MT1B mRNA15103026
D004221Disulfiramcupric chloride promotes the reaction [Disulfiram results in increased expression of MT1B mRNA]19789329
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of MT1B mRNA24690739
D004221DisulfiramDisulfiram results in increased expression of MT1B mRNA19789329
C082360fipronil[fipronil co-treated with DEET] results in decreased expression of MT1B mRNA27091632
C082360fipronilfipronil results in decreased expression of MT1B mRNA27091632
D006046GoldGold results in increased expression of MT1B mRNA25523186
C511402Grape Seed ProanthocyanidinsGrape Seed Proanthocyanidins results in decreased expression of MT1B mRNA20471814
C410337K 7174K 7174 results in decreased expression of MT1B mRNA24086573
C013598methoxyacetic acidmethoxyacetic acid promotes the reaction [Promegestone results in increased expression of MT1B mRNA]15103026
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc co-treated with ochratoxin A] results in increased expression of MT1B mRNA"19720134
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc] results in increased expression of MT1B mRNA"19720134
C025589ochratoxin A"[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc co-treated with ochratoxin A] results in increased expression of MT1B mRNA"19720134
C118580octylmethoxycinnamateoctylmethoxycinnamate results in decreased expression of MT1B mRNA20071424
D016566Organoselenium Compounds[Organoselenium Compounds binds to Copper] which results in increased expression of MT1B mRNA25167922
C046012pentanalpentanal results in increased expression of MT1B mRNA26079696
D010938Plant OilsPlant Oils results in decreased expression of MT1B mRNA23370395
D011374ProgesteroneProgesterone results in increased expression of MT1B mRNA18037150
C005556propionaldehydepropionaldehyde results in increased expression of MT1B mRNA26079696
C020972pyrrolidine dithiocarbamic acid[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of MT1B mRNA15477007
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid results in increased expression of MT1B mRNA15477007
D012402RotenoneMT1B protein inhibits the reaction [Rotenone results in increased activity of CASP3 protein]16402917
D012402RotenoneMT1B protein inhibits the reaction [Rotenone results in increased activity of CASP7 protein]16402917
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of MT1B mRNA23806026
D012834SilverSilver analog results in increased expression of MT1B mRNA27180073
D012834SilverSilver results in increased expression of MT1B mRNA26014281|2895954
D012835Silver NitrateSilver Nitrate analog results in increased expression of MT1B mRNA22831968
D012835Silver NitrateSilver Nitrate results in increased expression of MT1B mRNA19508889|2283196
C017947sodium arsenitesodium arsenite results in increased expression of MT1B mRNA20371982|2451658
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MT1B mRNA26238291
D013853ThioacetamideThioacetamide results in increased expression of MT1B mRNA11793227
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MT1B mRNA28065790
C495433tris(1,10-phenanthroline)chromium(III) chloride"tris(1,10-phenanthroline)chromium(III) chloride inhibits the reaction [Zinc results in increased expression of MT1B mRNA]"20043934
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of MT1B mRNA"26179874
D014635Valproic AcidValproic Acid results in increased expression of MT1B mRNA23527032
D024483Vitamin K 3Vitamin K 3 affects the expression of MT1B mRNA20044591
D015032Zinc"[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc co-treated with ochratoxin A] results in increased expression of MT1B mRNA"19720134
D015032Zinc"[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc] results in increased expression of MT1B mRNA"19720134
D015032Zinc"tris(1,10-phenanthroline)chromium(III) chloride inhibits the reaction [Zinc results in increased expression of MT1B mRNA]"20043934
D015032ZincZinc results in increased expression of MT1B mRNA11168427|2004393
D019287Zinc SulfateZinc Sulfate results in increased expression of MT1B mRNA22722935

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008270zinc ion binding-ISS-  
GO:0046872metal ion binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006882cellular zinc ion homeostasis-IBA21873635  
GO:0010273detoxification of copper ion-IBA21873635  
GO:0045926negative regulation of growth-ISS-  
GO:0050794regulation of cellular process-IBA21873635  
GO:0071276cellular response to cadmium ion-IBA21873635  
GO:0071280cellular response to copper ion-IBA21873635  
GO:0071294cellular response to zinc ion-IBA21873635  
GO:0071294cellular response to zinc ion-IEP11168427  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-ISS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-ISS-  
GO:0048471perinuclear region of cytoplasm-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-5660526Response to metal ionsIEA
R-HSA-5661231Metallothioneins bind metalsIEA
R-HSA-8953897Cellular responses to external stimuliIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26529669Genetic variation in metallothionein and metal-regulatory transcription factor 1 in relation to urinary cadmium, copper, and zinc. (2015 Dec 15)Adams SVToxicol Appl Pharmacol