Gene: MT1F

4494
MT1
metallothionein 1F
protein-coding
16q13
Ensembl:ENSG00000198417 MIM:156352 Vega:OTTHUMG00000176838 UniprotKB:P04733
NC_000016.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.200e-1 (AD)  8.011e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MT1G0.894
MT1E0.853
PHYHD10.758
EFEMP20.731
CSRP10.699
METRN0.698
SELENBP10.69
CTDSP10.69
FXYD10.69
GSTM20.689

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HRH2-0.46
IL12RB2-0.453
KCNH1-0.44
GCNT4-0.436
GABRG3-0.431
TYRP1-0.431
ANKRD34C-0.426
MCHR2-0.425
ARHGAP20-0.421
CLVS1-0.42

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalCarrier
ID Drug Name Action PubMed
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of MT1F mRNA"20638727
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of MT1F mRNA"20206263
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of MT1F mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of MT1F mRNA]28655636
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT1F mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT1F mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT1F mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT1F mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of MT1F mRNA"19561079
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of MT1F mRNA19038236
C0757734-phenylbutyric acid4-phenylbutyric acid results in increased expression of MT1F mRNA14583596
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT1F mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT1F mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT1F mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT1F mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of MT1F mRNA29067470
D000111AcetylcysteineAcetylcysteine inhibits the reaction [elesclomol results in increased expression of MT1F mRNA]18723479
D000638AmiodaroneAmiodarone results in increased expression of MT1F mRNA19774075
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of MT1F mRNA24449571
D001151Arsenic"[Water Pollutants, Chemical co-treated with Arsenic] results in increased expression of MT1F mRNA"26472158
C006632arsenic trioxidearsenic trioxide results in decreased expression of MT1F mRNA22521957
C006632arsenic trioxidearsenic trioxide results in increased expression of MT1F mRNA19128835|1941714
D001280AtrazineAtrazine results in increased expression of MT1F mRNA25929836
C406592azaspiracidazaspiracid results in increased expression of MT1F mRNA28939011
C028559bathocuproine sulfonate[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of MT1F mRNA15477007
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MT1F mRNA20064835|2010694
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of MT1F mRNA19619570
D004958EstradiolEstradiol results in decreased expression of MT1F mRNA23019147
D004958EstradiolEstradiol results in increased expression of MT1F mRNA19153601|1961957
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid results in increased expression of MT1F mRNA18192240
C551172bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV)"bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) results in increased expression of MT1F mRNA"20162321
C006780bisphenol Abisphenol A results in decreased expression of MT1F mRNA27685785
C018475butyraldehydebutyraldehyde results in increased expression of MT1F mRNA26079696
D002104CadmiumCadmium results in increased expression of MT1F mRNA15952643|1643970
D002104Cadmium"[Water Pollutants, Chemical co-treated with Cadmium] results in increased expression of MT1F mRNA"26472158
D019256Cadmium Chloride[Cadmium Chloride co-treated with sodium arsenite] results in increased expression of MT1F mRNA26472158
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of MT1F mRNA19426795|2647268
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MT1F mRNA26314618|2647215
C037123cadmium sulfatecadmium sulfate results in increased expression of MT1F mRNA21783983
D002330CarmustineMT1F mRNA affects the susceptibility to Carmustine16365179
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT1F mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of MT1F mRNA26272509
D002994ClofibrateClofibrate results in decreased expression of MT1F mRNA16081524
D003300CopperCopper results in increased expression of MT1F mRNA2830259
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of MT1F mRNA24690739
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of MT1F mRNA20971185
D003300Copper[Organoselenium Compounds binds to Copper] which results in increased expression of MT1F mRNA25167922
D019327Copper SulfateCopper Sulfate results in increased expression of MT1F mRNA16283523|1954981
C029892cupric chloridecupric chloride deficiency results in decreased expression of MT1F mRNA17211630
C029892cupric chloridecupric chloride promotes the reaction [Disulfiram results in increased expression of MT1F mRNA]19789329
C029892cupric chloridecupric chloride results in increased expression of MT1F mRNA17211630
C030973cupric oxidecupric oxide results in increased expression of MT1F mRNA22077320
D003471CuprizoneCuprizone results in increased expression of MT1F mRNA27523638
D016572CyclosporineCyclosporine results in increased expression of MT1F mRNA20106945|2556210
C014347decitabinedecitabine affects the expression of MT1F mRNA23300844
D003703DemecolcineDemecolcine results in increased expression of MT1F mRNA23649840
D002945CisplatinCisplatin affects the expression of MT1F mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of MT1F mRNA27392435
D002945CisplatinMT1F protein affects the susceptibility to Cisplatin16217747
D004221Disulfiramcupric chloride promotes the reaction [Disulfiram results in increased expression of MT1F mRNA]19789329
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of MT1F mRNA24690739
D004221DisulfiramDisulfiram results in increased expression of MT1F mRNA19789329
C512195elesclomolAcetylcysteine inhibits the reaction [elesclomol results in increased expression of MT1F mRNA]18723479
C512195elesclomolelesclomol results in increased expression of MT1F mRNA18723479
C118739entinostatentinostat results in increased expression of MT1F mRNA27188386
D004397FonofosFonofos results in increased methylation of MT1F promoter22847954
D006046GoldGold results in increased expression of MT1F mRNA25523186
C511402Grape Seed ProanthocyanidinsGrape Seed Proanthocyanidins results in decreased expression of MT1F mRNA20471814
C475919hydroxytamoxifenGPER1 protein affects the reaction [hydroxytamoxifen results in increased expression of MT1F mRNA]19153601
C475919hydroxytamoxifenhydroxytamoxifen results in increased expression of MT1F mRNA19153601
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of MT1F mRNA27392435
C544151jinfukangjinfukang results in increased expression of MT1F mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MT1F mRNA23086925
C410337K 7174K 7174 results in decreased expression of MT1F mRNA24086573
C008261lead acetatelead acetate results in increased expression of MT1F mRNA22839698
C045463leflunomideleflunomide results in increased expression of MT1F mRNA28988120
D008070LipopolysaccharidesLipopolysaccharides affects the expression of MT1F mRNA28070326
D008070LipopolysaccharidesPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of MT1F mRNA]28070326
C042720mercuric bromidemercuric bromide results in increased expression of MT1F mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT1F mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MT1F mRNA28001369
C437683motexafin gadoliniummotexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of MT1F mRNA]16357179
C437683motexafin gadoliniummotexafin gadolinium results in increased expression of MT1F mRNA15867382|1635717
C437683motexafin gadoliniumZinc Acetate affects the reaction [motexafin gadolinium results in increased expression of MT1F mRNA]16357179
D009532NickelNickel results in increased expression of MT1F mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in increased expression of MT1F mRNA16780908|2271453
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of MT1F mRNA20971185
C558013NSC 689534NSC 689534 results in increased expression of MT1F mRNA20971185
D016566Organoselenium Compounds[Organoselenium Compounds binds to Copper] which results in increased expression of MT1F mRNA25167922
D019308Palmitic AcidPalmitic Acid results in decreased expression of MT1F mRNA17658692
D010278ParathionParathion results in increased methylation of MT1F promoter22847954
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of MT1F mRNA]28655636
D052638Particulate MatterParticulate Matter results in decreased expression of MT1F mRNA28655636
D052638Particulate MatterParticulate Matter results in increased expression of MT1F mRNA22178795|2785190
C410127PCB 180PCB 180 affects the expression of MT1F mRNA21703328
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of MT1F mRNA18593933
C568608PCI 5002PCI 5002 results in increased expression of MT1F mRNA18593933
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of MT1F mRNA26705709
C046012pentanalpentanal results in increased expression of MT1F mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT1F mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of MT1F mRNA26272509
D010894PiroxicamPiroxicam results in increased expression of MT1F mRNA21858171
D010936Plant ExtractsPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of MT1F mRNA]28070326
D011374ProgesteroneProgesterone results in increased expression of MT1F mRNA21795739
D011374ProgesteroneProgesterone results in decreased expression of MT1F17510236
C020972pyrrolidine dithiocarbamic acid[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of MT1F mRNA15477007
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid results in increased expression of MT1F mRNA15477007
D015125OxyquinolineOxyquinoline results in decreased expression of MT1F mRNA21632981
C010327salinomycinsalinomycin results in increased expression of MT1F mRNA22215106
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of MT1F mRNA25895662
D012834SilverSilver analog results in increased expression of MT1F mRNA24974767|2718007
D012834SilverSilver results in increased expression of MT1F mRNA26014281|2655175
D012835Silver NitrateSilver Nitrate analog results in increased expression of MT1F mRNA22831968
D012835Silver NitrateSilver Nitrate results in increased expression of MT1F mRNA22831968
C017947sodium arsenite[Cadmium Chloride co-treated with sodium arsenite] results in increased expression of MT1F mRNA26472158
C017947sodium arsenitesodium arsenite results in increased expression of MT1F mRNA24516582
D018038Sodium SeleniteSodium Selenite results in increased expression of MT1F mRNA18175754
C025462sulindac sulfidesulindac sulfide results in increased expression of MT1F mRNA16184548
C047246temozolomideMT1F mRNA affects the susceptibility to temozolomide16365179
C012568terbufosterbufos results in increased methylation of MT1F promoter22847954
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of MT1F mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MT1F mRNA19619570|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of MT1F mRNA11489354|2163298
C056583tolmetin glucuronidetolmetin glucuronide results in increased expression of MT1F mRNA26528891
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of MT1F mRNA"26179874
D014520UrethaneUrethane results in decreased expression of MT1F mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT1F mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of MT1F mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of MT1F mRNA19101580|2317975
D014638VanadatesVanadates results in decreased expression of MT1F mRNA22714537
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of MT1F mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of MT1F mRNA28655636
D014750VincristineVincristine results in increased expression of MT1F mRNA23649840
C111237vorinostatvorinostat results in increased expression of MT1F mRNA27188386
D014874Water Pollutants, Chemical"[Water Pollutants, Chemical co-treated with Arsenic] results in increased expression of MT1F mRNA"26472158
D014874Water Pollutants, Chemical"[Water Pollutants, Chemical co-treated with Cadmium] results in increased expression of MT1F mRNA"26472158
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of MT1F mRNA18593933
D015032ZincZinc results in increased expression of MT1F mRNA15226459|1687026
D019345Zinc Acetatemotexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of MT1F mRNA]16357179
D019345Zinc AcetateZinc Acetate affects the reaction [motexafin gadolinium results in increased expression of MT1F mRNA]16357179
D019345Zinc AcetateZinc Acetate results in increased expression of MT1F mRNA16357179
C016837zinc chloridezinc chloride results in increased expression of MT1F mRNA16870260
D019287Zinc SulfateZinc Sulfate results in increased expression of MT1F mRNA15226459|1633035
C027368zomepirac glucuronidezomepirac glucuronide results in increased expression of MT1F mRNA26528891

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO:0008270zinc ion binding-ISS-  
GO:0046872metal ion binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006882cellular zinc ion homeostasis-IBA21873635  
GO:0010273detoxification of copper ion-IBA21873635  
GO:0045926negative regulation of growth-ISS-  
GO:0050794regulation of cellular process-IBA21873635  
GO:0071276cellular response to cadmium ion-IBA21873635  
GO:0071276cellular response to cadmium ion-IEP16827180  
GO:0071280cellular response to copper ion-IBA21873635  
GO:0071294cellular response to zinc ion-IBA21873635  
GO:0071294cellular response to zinc ion-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA8619255  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA8619255  
GO:0048471perinuclear region of cytoplasm-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-5660526Response to metal ionsIEA
R-HSA-5661231Metallothioneins bind metalsIEA
R-HSA-8953897Cellular responses to external stimuliIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19038236Gene expression profiles in HPV-immortalized human cervical cells treated with the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. (2009 Feb 12)Prokopczyk BChem Biol Interact