Gene: MT1G

4495
MT1|MT1K
metallothionein 1G
protein-coding
16q13
Ensembl:ENSG00000125144 MIM:156353 Vega:OTTHUMG00000133275 UniprotKB:P13640
NC_000016.10
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.221e-1 (AD)  7.829e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MT1F0.894
MT1E0.863
MT2A0.787
MT1M0.778
MT1H0.747
SORBS30.742
EFEMP20.742
FAM107A0.739
PHYHD10.737
IL17RC0.731

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TYRP1-0.475
COL19A1-0.451
XKR4-0.45
IL12RB2-0.444
PTPN3-0.442
KCNH1-0.439
EPHA5-0.438
SOWAHB-0.438
GABRG3-0.437
ADTRP-0.434

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalCarrier
ID Drug Name Action PubMed
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl affects the expression of MT1G mRNA"20638727
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of MT1G mRNA"20206263
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT1G mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT1G mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT1G mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT1G mRNA"27188386
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to MT1G protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to MT1G protein]26598702
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT1G mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT1G mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT1G mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT1G mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of MT1G mRNA11793227|2142099
D000111AcetylcysteineAcetylcysteine inhibits the reaction [elesclomol results in increased expression of MT1G mRNA]18723479
D016604Aflatoxin B1Aflatoxin B1 affects the expression of MT1G protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of MT1G mRNA21632981
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of MT1G gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of MT1G mRNA21641981
D000638AmiodaroneAmiodarone results in increased expression of MT1G mRNA19774075
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of MT1G mRNA24449571
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to MT1G protein]26598702
C006632arsenic trioxidearsenic trioxide results in increased expression of MT1G mRNA15725085|1912883
D018053ArsenitesArsenites affects the expression of MT1G mRNA19411561
C406592azaspiracidazaspiracid results in increased expression of MT1G mRNA28939011
C028559bathocuproine sulfonate[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of MT1G mRNA15477007
D001554BenzeneBenzene results in decreased expression of MT1G mRNA21843810
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MT1G mRNA20064835|2010694
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MT1G mRNA21871943
D004958EstradiolEstradiol results in decreased expression of MT1G mRNA17982697
D004958EstradiolEstradiol results in increased expression of MT1G mRNA19153601|2010694
D004958Estradiol[Parathion co-treated with Estradiol] results in decreased expression of MT1G mRNA17982697
C483161beta-hydroxy simvastatin acidbeta-hydroxy simvastatin acid results in increased expression of MT1G mRNA18192240
C551172bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV)"bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) results in increased expression of MT1G mRNA"20162321
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of MT1G mRNA12414654
C584509C646 compoundC646 compound results in increased expression of MT1G mRNA26191083
D002104CadmiumCadmium results in increased expression of MT1G mRNA15952643|1643970
D002104Cadmium"[Water Pollutants, Chemical co-treated with Cadmium] results in increased expression of MT1G mRNA"26472158
D019256Cadmium Chloride[Cadmium Chloride co-treated with sodium arsenite] results in increased expression of MT1G mRNA26472158
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of MT1G mRNA19426795
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MT1G mRNA26314618|2647215
D002110CaffeineCaffeine results in increased expression of MT1G mRNA11793227
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT1G mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of MT1G mRNA26272509
C100187chloropicrinchloropicrin results in increased expression of MT1G mRNA26352163
D003300CopperCopper results in increased expression of MT1G mRNA2830259
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of MT1G mRNA24690739
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of MT1G mRNA20971185
D003300Copper[Organoselenium Compounds binds to Copper] which results in increased expression of MT1G mRNA25167922
D019327Copper SulfateCopper Sulfate results in decreased expression of MT1G mRNA20599845
D019327Copper SulfateCopper Sulfate results in increased expression of MT1G mRNA16283523|1954981
C029892cupric chloridecupric chloride promotes the reaction [Disulfiram results in increased expression of MT1G mRNA]19789329
C030973cupric oxidecupric oxide results in increased expression of MT1G mRNA22077320
D016572CyclosporineCyclosporine results in decreased expression of MT1G mRNA20106945|2163298
D016572CyclosporineCyclosporine results in increased expression of MT1G mRNA27989131
D003907DexamethasoneDexamethasone results in increased expression of MT1G mRNA16144937
D002945CisplatinMT1G protein results in decreased susceptibility to Cisplatin22639083
D002945Cisplatinpropargylglycine inhibits the reaction [MT1G protein results in decreased susceptibility to Cisplatin]22639083
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of MT1G mRNA28412506
C051904dinophysistoxin 1dinophysistoxin 1 results in increased expression of MT1G mRNA28939011
D004221Disulfiramcupric chloride promotes the reaction [Disulfiram results in increased expression of MT1G mRNA]19789329
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of MT1G mRNA24690739
D004221DisulfiramDisulfiram results in increased expression of MT1G mRNA19789329
D004317Doxorubicin[Doxorubicin co-treated with pluronic block copolymer p85] results in increased expression of MT1G mRNA16579640
D004317DoxorubicinDoxorubicin results in increased expression of MT1G mRNA16579640
D004391DustDust results in increased expression of MT1G mRNA17805423
C512195elesclomolAcetylcysteine inhibits the reaction [elesclomol results in increased expression of MT1G mRNA]18723479
C512195elesclomolelesclomol results in increased expression of MT1G mRNA18723479
C118739entinostatentinostat results in increased expression of MT1G mRNA27188386
D017965gamma-Linolenic Acidgamma-Linolenic Acid results in increased expression of MT1G mRNA20664735
C511402Grape Seed ProanthocyanidinsGrape Seed Proanthocyanidins results in decreased expression of MT1G mRNA20471814
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of MT1G mRNA12414654
C475919hydroxytamoxifenGPER1 protein affects the reaction [hydroxytamoxifen results in increased expression of MT1G mRNA]19153601
C475919hydroxytamoxifenhydroxytamoxifen results in increased expression of MT1G mRNA19153601
C492448ICG 001ICG 001 results in increased expression of MT1G mRNA26191083
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with Sirolimus] affects the expression of MT1G mRNA25307878
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of MT1G mRNA26752646
C008261lead acetatelead acetate results in increased expression of MT1G mRNA22839698
C045463leflunomideleflunomide affects the expression of MT1G mRNA28988120
D018021Lithium ChlorideLithium Chloride results in increased expression of MT1G mRNA23527032
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of MT1G mRNA18497975
C042720mercuric bromidemercuric bromide results in increased expression of MT1G mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT1G mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of MT1G mRNA28001369
C437683motexafin gadoliniummotexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of MT1G mRNA]16357179
C437683motexafin gadoliniummotexafin gadolinium results in increased expression of MT1G mRNA15867382|1635717
D009532NickelNickel results in increased expression of MT1G mRNA24768652|2558310
C029938nickel sulfatenickel sulfate results in increased expression of MT1G mRNA16780908
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of MT1G mRNA"19013360
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of MT1G mRNA20971185
D019319Okadaic AcidOkadaic Acid results in increased expression of MT1G mRNA28939011
D016566Organoselenium Compounds[Organoselenium Compounds binds to Copper] which results in increased expression of MT1G mRNA25167922
D010100OxygenOxygen deficiency results in increased expression of MT1G mRNA24236059
D010278Parathion[Parathion co-treated with Estradiol] results in decreased expression of MT1G mRNA17982697
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of MT1G mRNA18593933
C568608PCI 5002PCI 5002 results in increased expression of MT1G mRNA18593933
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT1G mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of MT1G mRNA26272509
D010938Plant OilsPlant Oils results in decreased expression of MT1G mRNA23370395
C422648pluronic block copolymer p85[Doxorubicin co-treated with pluronic block copolymer p85] results in increased expression of MT1G mRNA16579640
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of MT1G mRNA21334430
D011192Potassium DichromatePotassium Dichromate results in decreased expression of MT1G protein23718831
D011374ProgesteroneProgesterone results in increased expression of MT1G mRNA18037150|2179573
D011374ProgesteroneProgesterone results in decreased expression of MT1G17510236
C009055propargylglycinepropargylglycine inhibits the reaction [MT1G protein results in decreased susceptibility to Cisplatin]22639083
C020972pyrrolidine dithiocarbamic acid[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of MT1G mRNA15477007
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid results in increased expression of MT1G mRNA15477007
D011794QuercetinQuercetin results in decreased expression of MT1G mRNA21632981
D015125OxyquinolineOxyquinoline results in decreased expression of MT1G mRNA21632981
C010327salinomycinsalinomycin results in increased expression of MT1G mRNA22215106
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of MT1G mRNA23806026
D012834SilverSilver analog results in increased expression of MT1G mRNA24974767
D012834SilverSilver results in increased expression of MT1G mRNA26014281|2895954
D020123Sirolimus[(+)-JQ1 compound co-treated with Sirolimus] affects the expression of MT1G mRNA25307878
C017947sodium arsenite[Cadmium Chloride co-treated with sodium arsenite] results in increased expression of MT1G mRNA26472158
C017947sodium arsenitesodium arsenite results in increased expression of MT1G mRNA11693492|1267905
C016766sulforafansulforafan results in decreased expression of MT1G mRNA26833863
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of MT1G mRNA20106945|2163298
D013853ThioacetamideThioacetamide results in increased expression of MT1G mRNA11793227
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of MT1G mRNA27865774
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of MT1G mRNA27404394
C056583tolmetin glucuronidetolmetin glucuronide results in increased expression of MT1G mRNA26528891
C012589trichostatin Atrichostatin A affects the expression of MT1G mRNA28542535
D014520UrethaneUrethane results in increased expression of MT1G mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT1G mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of MT1G mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of MT1G mRNA23179753|2352703
D014750VincristineVincristine results in increased expression of MT1G mRNA23649840
D024483Vitamin K 3Vitamin K 3 affects the expression of MT1G mRNA20044591
D024483Vitamin K 3Vitamin K 3 results in increased expression of MT1G mRNA12414654
D014874Water Pollutants, Chemical"[Water Pollutants, Chemical co-treated with Cadmium] results in increased expression of MT1G mRNA"26472158
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in increased expression of MT1G mRNA20370541
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of MT1G mRNA18593933
D015032ZincZinc results in increased expression of MT1G mRNA11168427|1522645
D019345Zinc Acetatemotexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of MT1G mRNA]16357179
D019345Zinc AcetateZinc Acetate results in increased expression of MT1G mRNA16357179
C016837zinc chloridezinc chloride results in increased expression of MT1G mRNA16870260
D019287Zinc SulfateIL1A protein promotes the reaction [Zinc Sulfate results in increased expression of MT1G mRNA]22722935
D019287Zinc SulfateTNF protein promotes the reaction [Zinc Sulfate results in increased expression of MT1G mRNA]22722935
D019287Zinc SulfateZinc Sulfate results in increased expression of MT1G mRNA12756304|1522645
C088658zoledronic acidzoledronic acid results in increased expression of MT1G mRNA24714768
C027368zomepirac glucuronidezomepirac glucuronide results in increased expression of MT1G mRNA26528891

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12646258  12970870  
GO:0008270zinc ion binding-IDA8119276  
GO:0046872metal ion binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006882cellular zinc ion homeostasis-IBA21873635  
GO:0010273detoxification of copper ion-IBA21873635  
GO:0030224monocyte differentiation-NAS8119276  
GO:0035924cellular response to vascular endothelial growth factor stimulus-IEP15735762  
GO:0042117monocyte activation-NAS8119276  
GO:0045926negative regulation of growth-IDA18332874  
GO:0050794regulation of cellular process-IBA21873635  
GO:0071276cellular response to cadmium ion-IBA21873635  
GO:0071276cellular response to cadmium ion-IEP3403543  16827180  19330122  
GO:0071280cellular response to copper ion-IBA21873635  
GO:0071280cellular response to copper ion-IEP3403543  
GO:0071294cellular response to zinc ion-IBA21873635  
GO:0071294cellular response to zinc ion-IDA7559655  
GO:0071294cellular response to zinc ion-IEP3403543  8119276  11168427  15735762  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA7559655  15735762  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA3403543  
GO:0048471perinuclear region of cytoplasm-IDA15735762  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-5660526Response to metal ionsIEA
R-HSA-5661231Metallothioneins bind metalsIEA
R-HSA-8953897Cellular responses to external stimuliIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24479813ANKS1B is a smoking-related molecular alteration in clear cell renal cell carcinoma. (2014 Jan 31)Eckel-Passow JEBMC Urol
17068819Discovery of deregulation of zinc homeostasis and its associated genes in esophageal squamous cell carcinoma using cDNA microarray. (2007 Jan 15)Kumar AInt J Cancer
19506903RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4A, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell lung cancer in China. (2009 Dec)Lin QJ Cancer Res Clin Oncol