Gene: MT1M

4499
MT-1M|MT-IM|MT1|MT1K
metallothionein 1M
protein-coding
16q13
Ensembl:ENSG00000205364 MIM:156357 Vega:OTTHUMG00000176938 UniprotKB:Q8N339
NG_030326.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.819e-2 (AD)  8.864e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MT2A0.924
MT1X0.909
MT1E0.861
RHOC0.831
ROM10.82
RAB130.814
TMBIM10.812
GNG50.812
MT1A0.805
IFITM30.803

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TYRP1-0.55
NXPH2-0.546
ZNF860-0.544
CALHM1-0.54
ABCC12-0.537
ZNF385D-0.537
CNTN6-0.536
XKR4-0.534
PPEF1-0.534
PCDHAC1-0.528

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalCarrier
ID Drug Name Action PubMed
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of MT1M mRNA"23146750
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT1M mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MT1M mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of MT1M mRNA"19561079
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT1M mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MT1M mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of MT1M mRNA21420995
D000111AcetylcysteineAcetylcysteine inhibits the reaction [elesclomol results in increased expression of MT1M mRNA]18723479
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of MT1M mRNA24449571
D001151ArsenicArsenic affects the methylation of MT1M gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of MT1M mRNA19128835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MT1M mRNA20064835
D004958EstradiolEstradiol results in increased expression of MT1M mRNA20106945|2163298
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of MT1M mRNA17404688
C025703bleomycetinbleomycetin results in increased expression of MT1M mRNA21040473
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of MT1M mRNA15336504
D002104CadmiumCadmium results in increased expression of MT1M mRNA16439709|2117241
D019256Cadmium ChlorideCadmium Chloride results in increased expression of MT1M mRNA26314618|2880257
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT1M mRNA"27188386
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of MT1M mRNA20971185
D003300Copper[Organoselenium Compounds binds to Copper] which results in increased expression of MT1M mRNA25167922
D019327Copper SulfateCopper Sulfate results in decreased expression of MT1M mRNA20599845
D019327Copper SulfateCopper Sulfate results in increased expression of MT1M mRNA19549813|2059984
D016572CyclosporineCyclosporine results in increased expression of MT1M mRNA20106945|2798913
C014347decitabinedecitabine results in increased expression of MT1M mRNA21856257
D003907DexamethasoneDexamethasone results in increased expression of MT1M mRNA25047013
D002945Cisplatin[STK17A protein results in decreased expression of MT1M mRNA] which results in increased susceptibility to Cisplatin21489989
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of MT1M mRNA28412506
C512195elesclomolAcetylcysteine inhibits the reaction [elesclomol results in increased expression of MT1M mRNA]18723479
C512195elesclomolelesclomol results in increased expression of MT1M mRNA18723479
D005472FluorouracilFluorouracil results in increased expression of MT1M protein15352031
D005472FluorouracilMT1M protein affects the susceptibility to Fluorouracil15352031
D005485FlutamideFlutamide results in increased expression of MT1M mRNA24793618
C511402Grape Seed ProanthocyanidinsGrape Seed Proanthocyanidins results in decreased expression of MT1M mRNA20471814
C492448ICG 001ICG 001 results in increased expression of MT1M mRNA26191083
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with Sirolimus] affects the expression of MT1M mRNA25307878
C008261lead acetatelead acetate results in increased expression of MT1M mRNA22839698
C045463leflunomideleflunomide results in increased expression of MT1M mRNA28988120
D008628MercuryMT1M gene polymorphism affects the susceptibility to Mercury23827881
D008628Mercury[MT1M gene polymorphism co-treated with MT2A gene polymorphism] affects the susceptibility to Mercury23827881
D008628MercuryMT1M gene SNP affects the abundance of Mercury22233731
D009532NickelNickel results in increased expression of MT1M mRNA25583101
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of MT1M mRNA20971185
C558013NSC 689534NSC 689534 results in increased expression of MT1M mRNA20971185
D016566Organoselenium Compounds[Organoselenium Compounds binds to Copper] which results in increased expression of MT1M mRNA25167922
D010100OxygenOxygen deficiency results in increased expression of MT1M mRNA24236059
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of MT1M mRNA18593933
C568608PCI 5002PCI 5002 results in increased expression of MT1M mRNA18593933
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MT1M mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of MT1M mRNA26272509
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of MT1M mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of MT1M mRNA17404688|1807036
D011794QuercetinQuercetin results in increased expression of MT1M mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of MT1M mRNA23806026
D012834SilverSilver results in increased expression of MT1M mRNA26014281|2655175
D020123Sirolimus[(+)-JQ1 compound co-treated with Sirolimus] affects the expression of MT1M mRNA25307878
C017947sodium arsenitesodium arsenite results in increased expression of MT1M mRNA12679051|2451658
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of MT1M mRNA28065790
D014635Valproic AcidValproic Acid results in decreased expression of MT1M mRNA24383497|2800136
D014635Valproic AcidValproic Acid results in increased expression of MT1M mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of MT1M gene29154799
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of MT1M mRNA18593933
D015032ZincZinc results in increased expression of MT1M mRNA16870260|1907100
C016837zinc chloridezinc chloride results in increased expression of MT1M mRNA16870260

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008270zinc ion binding-ISS-  
GO:0046872metal ion binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006882cellular zinc ion homeostasis-IBA21873635  
GO:0010273detoxification of copper ion-IBA21873635  
GO:0045926negative regulation of growth-ISS-  
GO:0050794regulation of cellular process-IBA21873635  
GO:0071276cellular response to cadmium ion-IBA21873635  
GO:0071280cellular response to copper ion-IBA21873635  
GO:0071294cellular response to zinc ion-IBA21873635  
GO:0071294cellular response to zinc ion-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-ISS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-ISS-  
GO:0048471perinuclear region of cytoplasm-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-5660526Response to metal ionsIEA
R-HSA-5661231Metallothioneins bind metalsIEA
R-HSA-8953897Cellular responses to external stimuliIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19472401The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history: a target for risk diagnosis and prevention of esophageal cancers. (2009 Aug 1)Oka DCancer