Gene info: ID 4502

Gene: MT2A

GENE ID: 4502

Synonyms: MT-2|MT-II|MT2

Description: metallothionein 2A

Gene type: protein-coding

Location: 16q13

dbXrefs: Ensembl:ENSG00000125148 MIM:156360 Vega:OTTHUMG00000133281 UniprotKB:P02795

RefSeq: NC_000016.10

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 7

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : NA (AD) NA (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg06663317	chr16:56641101	MT2A		4.700e-10	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MT1M	0.924
MT1X	0.896
RHOC	0.881
GNG5	0.876
MT1E	0.876
MAPKAPK2	0.856
S100A16	0.853
RAB13	0.853
PXDC1	0.841
IFITM3	0.837

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NXPH2	-0.539
CALHM1	-0.531
ABCC12	-0.523
CNTN6	-0.519
ZNF860	-0.517
XKR4	-0.516
PPEF1	-0.515
TYRP1	-0.515
TRPC5	-0.514
GRIN3A	-0.511

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01593	Zinc	Small Molecule	7440-66-6	Approved\|Investigational	Target
DB00515	Cisplatin	Small Molecule	15663-27-1	Approved	Enzyme
DB00526	Oxaliplatin	Small Molecule	61825-94-3	Approved\|Investigational	Enzyme
DB00958	Carboplatin	Small Molecule	41575-94-4	Approved	Enzyme
DB09130	Copper	Small Molecule	7440-50-8	Approved\|Investigational	Carrier

ID	Drug Name	Action	PubMed
C015699	1,2-benzisothiazoline-3-one	"1,2-benzisothiazoline-3-one results in increased expression of MT2A mRNA"	20491607
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of MT2A mRNA"	19162173
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MT2A mRNA"	19114083
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Zinc results in increased expression of MT2A mRNA]	17363595
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MT2A protein inhibits the reaction [Tunicamycin results in decreased phosphorylation of AKT1 protein]]	24680926
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of MT2A mRNA"	15215175
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MT2A mRNA"	15215175
C030370	2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone	"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of MT2A mRNA"	20206263
C019499	2-nitrofluorene	2-nitrofluorene results in decreased expression of MT2A mRNA	15890375
C055802	2-nonynoic acid methyl ester	2-nonynoic acid methyl ester results in increased expression of MT2A mRNA	20491607
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of MT2A mRNA"	26410179\|2696702
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of MT2A protein"	23527585
C012928	3-dimethylaminopropylamine	3-dimethylaminopropylamine results in increased expression of MT2A mRNA	20491607
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of MT2A mRNA"	25380136
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT2A mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT2A mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT2A mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT2A mRNA"	27188386
C517041	(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of MT2A mRNA"	19561079
C032642	4-aminophenylarsenoxide	4-aminophenylarsenoxide binds to MT2A protein	26598702
C032642	4-aminophenylarsenoxide	arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to MT2A protein]	26598702
C065250	4-hydroxy-equilenin	4-hydroxy-equilenin results in decreased expression of MT2A mRNA	15135645
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of MT2A mRNA	15890375
C029728	4-phenylenediamine	4-phenylenediamine results in increased expression of MT2A mRNA	16314067
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT2A mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT2A mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT2A mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT2A mRNA"	27188386
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of MT2A mRNA]	9545559
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [gallium nitrate results in increased expression of MT2A mRNA]	18586083
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Nickel results in increased expression of MT2A mRNA]	19097988
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]	25724285
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A protein]]	25724285
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Paraquat results in increased expression of MT2A mRNA]	25724285
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Paraquat results in increased expression of MT2A protein]	25724285
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A mRNA]]	25724285
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A protein]]	25724285
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]	25724285
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Zinc Sulfate results in increased expression of MT2A protein]	25724285
D000111	Acetylcysteine	Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]]	25724285
D000111	Acetylcysteine	Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A protein]]]	25724285
D000111	Acetylcysteine	Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat results in increased expression of MT2A mRNA]]	25724285
D000111	Acetylcysteine	Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat results in increased expression of MT2A protein]]	25724285
D000111	Acetylcysteine	Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A mRNA]]]	25724285
D000111	Acetylcysteine	Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A protein]]]	25724285
D000111	Acetylcysteine	Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]	25724285
D000111	Acetylcysteine	Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate results in increased expression of MT2A protein]]	25724285
D000111	Acetylcysteine	EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]]	25724285
D000111	Acetylcysteine	EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A protein]]]	25724285
D000111	Acetylcysteine	EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat results in increased expression of MT2A mRNA]]	25724285
D000111	Acetylcysteine	EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat results in increased expression of MT2A protein]]	25724285
D000111	Acetylcysteine	EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A mRNA]]]	25724285
D000111	Acetylcysteine	EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A protein]]]	25724285
D000111	Acetylcysteine	EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]	25724285
D000111	Acetylcysteine	EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate results in increased expression of MT2A protein]]	25724285
D020106	Acrylamide	[Acrylamide co-treated with aluminum chloride] results in increased expression of MT2A mRNA	25858877
D020106	Acrylamide	Acrylamide results in decreased expression of MT2A mRNA	28959563
D020106	Acrylamide	Acrylamide results in increased expression of MT2A mRNA	25858877
C109238	acyline	acyline results in decreased expression of MT2A mRNA	17510436
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of MT2A mRNA	21641981\|2701795
D016604	Aflatoxin B1	gluconic acid inhibits the reaction [Zinc Sulfate promotes the reaction [Aflatoxin B1 results in increased expression of MT2A mRNA]]	27017951
D016604	Aflatoxin B1	Zinc Sulfate promotes the reaction [Aflatoxin B1 results in increased expression of MT2A mRNA]	27017951
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of MT2A mRNA	15890375
D013196	Dihydrotestosterone	Dihydrotestosterone results in decreased expression of MT2A mRNA	20945400
C010845	aluminum chloride	[Acrylamide co-treated with aluminum chloride] results in increased expression of MT2A mRNA	25858877
C010845	aluminum chloride	aluminum chloride results in increased expression of MT2A mRNA	25858877
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of MT2A mRNA	16483693
D000966	Antimony Potassium Tartrate	Antimony Potassium Tartrate results in increased expression of MT2A mRNA	28713220
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of MT2A mRNA	24449571
D016718	Arachidonic Acid	Arachidonic Acid promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]	12566070
D001151	Arsenic	Arsenic results in decreased expression of MT2A mRNA	17637929
D001151	Arsenic	Arsenic results in increased expression of MT2A mRNA	11032763\|1740969
C006632	arsenic trioxide	arsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to MT2A protein]	26598702
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of MT2A mRNA	22521957
C006632	arsenic trioxide	arsenic trioxide results in increased expression of MT2A mRNA	11678611\|1468238
C006632	arsenic trioxide	arsenic trioxide results in increased expression of MT2A protein	14682389
C006632	arsenic trioxide	Atrazine promotes the reaction [arsenic trioxide results in increased expression of MT2A mRNA]	11678611
C006632	arsenic trioxide	MT2A protein inhibits the reaction [arsenic trioxide results in increased expression of BAX protein]	23664956
C006632	arsenic trioxide	MT2A protein inhibits the reaction [arsenic trioxide results in increased expression of CASP12 protein modified form]	23664956
C006632	arsenic trioxide	MT2A protein inhibits the reaction [arsenic trioxide results in increased expression of CASP3 protein modified form]	23664956
C006632	arsenic trioxide	MT2A protein inhibits the reaction [arsenic trioxide results in increased expression of MAPK1 protein modified form]	23664956
C006632	arsenic trioxide	MT2A protein inhibits the reaction [arsenic trioxide results in increased expression of MAPK3 protein modified form]	23664956
C006632	arsenic trioxide	MT2A protein promotes the reaction [arsenic trioxide results in increased expression of DDIT3 protein]	23664956
C006632	arsenic trioxide	MT2A protein results in decreased susceptibility to arsenic trioxide	23664956
C015001	arsenite	arsenite results in increased expression of MT2A mRNA	1493605
D018053	Arsenites	Arsenites affects the expression of MT2A mRNA	19411561
D017636	Asbestos, Amphibole	"Asbestos, Amphibole results in increased expression of MT2A protein"	20855422
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite affects the expression of MT2A mRNA"	25757056
D000069059	Atorvastatin Calcium	Atorvastatin Calcium inhibits the reaction [Fructose results in increased expression of MT2A mRNA]	21122807
D001280	Atrazine	Atrazine promotes the reaction [arsenic trioxide results in increased expression of MT2A mRNA]	11678611
D001280	Atrazine	Atrazine results in increased expression of MT2A mRNA	22378314
C406592	azaspiracid	azaspiracid results in increased expression of MT2A mRNA	28939011
C024986	barium chloride	barium chloride results in increased expression of MT2A mRNA	26732703
C024986	barium chloride	Plant Extracts inhibits the reaction [barium chloride results in increased expression of MT2A mRNA]	26732703
D001542	Benomyl	Benomyl results in increased expression of MT2A mRNA	15885261
D019817	Benzoic Acid	Benzoic Acid results in increased expression of MT2A mRNA	20491607
D001564	Benzo(a)pyrene	"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] results in increased expression of MT2A mRNA"	17690111
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MT2A mRNA	20064835\|2010694
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MT2A mRNA	21632981\|2187194
C526327	benzyl cinnamate	benzyl cinnamate results in increased expression of MT2A mRNA	20491607
D004958	Estradiol	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of MT2A mRNA	19619570
D004958	Estradiol	Estradiol results in decreased expression of MT2A mRNA	17982697\|2301914
D004958	Estradiol	[Estradiol results in increased activity of ESR2 protein] which results in increased expression of MT2A mRNA	12399409
D004958	Estradiol	Estradiol results in increased expression of MT2A mRNA	16202921\|1915360
D004958	Estradiol	[Parathion co-treated with Estradiol] results in decreased expression of MT2A mRNA	17982697
D004958	Estradiol	[Estradiol co-treated with Plant Preparations] results in decreased expression of MT2A mRNA	26945725
D004958	Estradiol	Estradiol results in decreased expression of MT2A mRNA	26945725
C483161	beta-hydroxy simvastatin acid	beta-hydroxy simvastatin acid results in increased expression of MT2A mRNA	18192240
C044887	beta-methylcholine	beta-methylcholine affects the expression of MT2A mRNA	21179406
C004541	biochanin A	biochanin A results in increased expression of MT2A mRNA	10656621
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of MT2A mRNA	28628672
C583563	bis(cysteinato)zincate(lI)	bis(cysteinato)zincate(lI) results in increased expression of MT2A mRNA	23085594
C067982	bis(N,N-diethyldithiocarbamate)Cu (II) complex	"bis(N,N-diethyldithiocarbamate)Cu (II) complex results in increased expression of MT2A mRNA"	26961606
C067982	bis(N,N-diethyldithiocarbamate)Cu (II) complex	"MTF1 protein affects the reaction [bis(N,N-diethyldithiocarbamate)Cu (II) complex results in increased expression of MT2A mRNA]"	26961606
C551172	bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV)	"bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) results in increased expression of MT2A mRNA"	20162321
C006780	bisphenol A	bisphenol A results in increased expression of MT2A mRNA	25181051
C025703	bleomycetin	bleomycetin results in increased expression of MT2A mRNA	21040473
C025703	bleomycetin	bleomycetin results in increased expression of MT2A protein	21040473
C032036	bromobenzene	bromobenzene results in increased expression of MT2A mRNA	15056800
D019819	Budesonide	Budesonide results in increased expression of MT2A mRNA	9973176
D019819	Budesonide	Terbutaline affects the reaction [Budesonide results in increased expression of MT2A mRNA]	9973176
D020122	tert-Butylhydroperoxide	MT2A protein inhibits the reaction [tert-Butylhydroperoxide results in increased abundance of Reactive Oxygen Species]	16402917
D020122	tert-Butylhydroperoxide	MT2A protein promotes the reaction [tert-Butylhydroperoxide results in increased expression of HMOX1 mRNA]	16636651
D020122	tert-Butylhydroperoxide	MT2A protein promotes the reaction [tert-Butylhydroperoxide results in increased expression of SOD2 mRNA]	16636651
D020122	tert-Butylhydroperoxide	MT2A protein promotes the reaction [tert-Butylhydroperoxide results in increased expression of TXNRD1 mRNA]	16636651
D020122	tert-Butylhydroperoxide	MT2A protein results in decreased susceptibility to tert-Butylhydroperoxide	16636651
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of MT2A mRNA	12414654\|1640291
C584509	C646 compound	C646 compound affects the expression of MT2A mRNA	26191083
D002104	Cadmium	Cadmium results in increased expression of MT2A mRNA	11985888
D002104	Cadmium	Cadmium binds to MT2A protein	15698955
D002104	Cadmium	Cadmium results in increased expression of MT2A mRNA	11032763\|1271689
D002104	Cadmium	Cadmium results in increased expression of MT2A protein	15664440
D002104	Cadmium	[Chromium co-treated with Cadmium co-treated with Lead] results in increased expression of MT2A mRNA	11032763
D002104	Cadmium	chromium hexavalent ion inhibits the reaction [Cadmium results in increased expression of MT2A mRNA]	12716893
D002104	Cadmium	MT2A promoter polymorphism affects the transport of Cadmium	25157674
D002104	Cadmium	MT2A promoter polymorphism results in increased abundance of Cadmium	20303360
D002104	Cadmium	MT2A protein results in decreased susceptibility to Cadmium	19433272
D002104	Cadmium	Cadmium results in increased expression of MT2A mRNA	12944175
D002104	Cadmium	Cadmium binds to MT2A protein	11087412
D002104	Cadmium	Cadmium results in decreased expression of MT2A mRNA	14694715
D002104	Cadmium	Cadmium affects the expression of MT2A mRNA	12140172
D002104	Cadmium	Cadmium affects the expression of MT2A protein	12140172
D002104	Cadmium	Cadmium results in decreased expression of MT2A	17948763
D002104	Cadmium	Cadmium results in increased expression of MT2A	12974610\|1574851
D002104	Cadmium	Cadmium results in increased expression of MT2A mRNA	11430474\|1175008
D002104	Cadmium	Cadmium results in increased expression of MT2A protein	17443291
D002104	Cadmium	MT2A protein results in decreased susceptibility to Cadmium	17443291
D002104	Cadmium	MT2A promoter polymorphism affects the abundance of Cadmium	25900616
D019256	Cadmium Chloride	Cadmium Chloride promotes the reaction [NFE2L2 protein binds to MT2A promoter]	26827822
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of MT2A mRNA	26827822
D019256	Cadmium Chloride	NFE2L2 protein promotes the reaction [Cadmium Chloride results in increased expression of MT2A mRNA]	26827822
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of MT2A mRNA	11985888
D019256	Cadmium Chloride	Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of MT2A mRNA]	9545559
D019256	Cadmium Chloride	Cadmium Chloride inhibits the reaction [Lipopolysaccharides results in increased expression of MT2A mRNA]	9138684
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of MT2A mRNA	19426795
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of MT2A mRNA	10403520\|1167860
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of MT2A protein	15788722
D019256	Cadmium Chloride	[Ethinyl Estradiol co-treated with Cadmium Chloride] results in increased expression of MT2A mRNA	23135549
D019256	Cadmium Chloride	MT2A protein results in decreased susceptibility to Cadmium Chloride	16636651\|7729958
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of MT2A mRNA	15499971
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of MT2A mRNA	22110744\|2245702
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of MT2A	20096345
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of MT2A mRNA	17327699\|1909676
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of MT2A protein	17443291
D019256	Cadmium Chloride	[lead acetate co-treated with Cadmium Chloride] results in increased expression of MT2A mRNA	24184865
D019256	Cadmium Chloride	lead acetate promotes the reaction [Cadmium Chloride results in increased expression of MT2A mRNA]	19096765
D019256	Cadmium Chloride	MT2A protein results in decreased susceptibility to Cadmium Chloride	17443291
D019256	Cadmium Chloride	Zinc inhibits the reaction [Cadmium Chloride results in increased expression of MT2A]	20096345
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of MT2A mRNA	21883094
D019256	Cadmium Chloride	PTEN mutant form inhibits the reaction [Cadmium Chloride results in increased expression of MT2A mRNA]	21883094
C037123	cadmium sulfate	cadmium sulfate results in increased expression of MT2A mRNA	10362023\|2178398
D002259	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of MT2A mRNA	16039398
D002330	Carmustine	MT2A mRNA affects the susceptibility to Carmustine	16365179
C004656	chloroacetaldehyde	chloroacetaldehyde affects the expression of MT2A mRNA	25596134
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT2A mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased expression of MT2A mRNA	26272509
C100187	chloropicrin	chloropicrin results in decreased expression of MT2A mRNA	26352163
D002857	Chromium	[Chromium co-treated with Cadmium co-treated with Lead] results in increased expression of MT2A mRNA	11032763
C074702	chromium hexavalent ion	chromium hexavalent ion inhibits the reaction [Cadmium results in increased expression of MT2A mRNA]	12716893
C074702	chromium hexavalent ion	chromium hexavalent ion inhibits the reaction [Zinc results in increased expression of MT2A mRNA]	12716893
C041167	chromium nitrate	chromium nitrate results in increased expression of MT2A mRNA	20491607
C059262	cidofovir	cidofovir results in increased expression of MT2A mRNA	25596134
D003035	Cobalt	Cobalt results in increased expression of MT2A mRNA	14971665
C018021	cobaltous chloride	cobaltous chloride results in increased expression of MT2A mRNA	19376846\|2294125
C018021	cobaltous chloride	cobaltous chloride deficiency results in increased expression of MT2A mRNA	17706837
C018021	cobaltous chloride	cobaltous chloride results in increased expression of MT2A mRNA	19278353\|2438626
C018021	cobaltous chloride	[Oxygen deficiency co-treated with cobaltous chloride] results in increased expression of MT2A mRNA	19278353
C026305	cobalt sulfate	cobalt sulfate results in increased expression of MT2A mRNA	10362023
D003300	Copper	Copper results in increased expression of MT2A mRNA	17409696\|2830259
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of MT2A mRNA	20971185
D003300	Copper	[Organoselenium Compounds binds to Copper] which results in increased expression of MT2A mRNA	25167922
D003300	Copper	Copper affects the expression of MT2A mRNA	12140172
D003300	Copper	Copper affects the expression of MT2A protein	12140172
D003300	Copper	[Copper co-treated with Dietary Sucrose] results in decreased expression of MT2A mRNA	26033743
D003300	Copper	MT2A promoter polymorphism affects the abundance of Copper	25900616
C098468	copper histidine	copper histidine results in increased expression of MT2A mRNA	24170205
D019327	Copper Sulfate	Copper Sulfate results in increased expression of MT2A mRNA	10362023\|1628352
C030123	coumarin	coumarin results in increased expression of MT2A mRNA	18480146
C029892	cupric chloride	cupric chloride results in increased expression of MT2A mRNA	24113165
C029892	cupric chloride	cupric chloride affects the expression of MT2A mRNA	20945374
C029892	cupric chloride	cupric chloride promotes the reaction [Disulfiram results in increased expression of MT2A mRNA]	19789329
C029892	cupric chloride	cupric chloride results in increased expression of MT2A mRNA	17211630\|1740970
C029892	cupric chloride	cupric chloride results in increased expression of MT2A mRNA	23174565
C030973	cupric oxide	cupric oxide results in increased expression of MT2A mRNA	22077320
D003471	Cuprizone	Cuprizone results in increased expression of MT2A mRNA	27523638
D003474	Curcumin	Curcumin affects the reaction [Mercuric Chloride results in increased expression of MT2A mRNA]	20229497
D003474	Curcumin	Curcumin results in increased expression of MT2A mRNA	20229497
D016572	Cyclosporine	Cyclosporine results in increased expression of MT2A mRNA	20106945\|2556210
D003561	Cytarabine	Cytarabine results in decreased expression of MT2A mRNA	21198554
D003609	Dactinomycin	Dactinomycin inhibits the reaction [zinc chloride results in increased expression of MT2A mRNA]	17234632
C004742	daidzein	daidzein results in increased expression of MT2A mRNA	10656621
D003634	DDT	DDT results in decreased expression of MT2A mRNA	25014179
D003634	DDT	MT2A protein inhibits the reaction [DDT results in decreased expression of HSD17B1 mRNA]	12858341
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of MT2A mRNA	23640034
C017180	decamethrin	decamethrin results in increased expression of MT2A mRNA	19017407
C014347	decitabine	decitabine affects the expression of MT2A mRNA	23300844
C014347	decitabine	decitabine results in increased expression of MT2A mRNA	19151715
D003676	Deferoxamine	[Deferoxamine results in decreased abundance of Iron] which results in increased expression of MT2A mRNA	12393473
D013759	Dronabinol	Dronabinol results in decreased expression of MT2A mRNA	18454173
D003703	Demecolcine	Demecolcine results in increased expression of MT2A mRNA	23649840
D003907	Dexamethasone	Dexamethasone promotes the reaction [Methylcholanthrene results in increased expression of MT2A mRNA]	23994556
D003907	Dexamethasone	Dexamethasone promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of MT2A mRNA]	23994556
D003907	Dexamethasone	Dexamethasone results in increased expression of MT2A mRNA	23994556\|2504701
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of MT2A mRNA	28628672
D003907	Dexamethasone	Methylcholanthrene promotes the reaction [Dexamethasone results in increased expression of MT2A mRNA]	23994556
D003907	Dexamethasone	NR3C1 protein affects the reaction [Dexamethasone promotes the reaction [Methylcholanthrene results in increased expression of MT2A mRNA]]	23994556
D003907	Dexamethasone	NR3C1 protein affects the reaction [Dexamethasone results in increased expression of MT2A mRNA]	23994556
D003907	Dexamethasone	NR3C1 protein affects the reaction [Methylcholanthrene promotes the reaction [Dexamethasone results in increased expression of MT2A mRNA]]	23994556
D003907	Dexamethasone	Tetrachlorodibenzodioxin promotes the reaction [Dexamethasone results in increased expression of MT2A mRNA]	23994556
D003907	Dexamethasone	Dexamethasone results in increased expression of MT2A mRNA	15851833
D003907	Dexamethasone	Dexamethasone results in increased expression of MT2A mRNA	2771874
C041517	dibenzo(a,l)pyrene	"[Benzo(a)pyrene co-treated with dibenzo(a,l)pyrene] results in increased expression of MT2A mRNA"	17690111
C020735	dibutyldichlorotin	dibutyldichlorotin results in increased expression of MT2A mRNA	10722888
D002945	Cisplatin	Cisplatin affects the expression of MT2A mRNA	23300844
D002945	Cisplatin	Cisplatin results in increased expression of MT2A mRNA	12680227\|2559613
D002945	Cisplatin	MT2A protein affects the susceptibility to Cisplatin	2116401
D002945	Cisplatin	MT2A protein results in decreased susceptibility to Cisplatin	16394183
D002945	Cisplatin	Cisplatin results in increased expression of MT2A mRNA	22023808
D003633	Dichlorodiphenyl Dichloroethylene	Dichlorodiphenyl Dichloroethylene results in increased expression of MT2A mRNA	15885261
D019422	Dietary Sucrose	[Copper co-treated with Dietary Sucrose] results in decreased expression of MT2A mRNA	26033743
C014476	diethyl maleate	diethyl maleate results in increased expression of MT2A mRNA	20491607
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of MT2A mRNA	21527772
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of MT2A mRNA	15890375
D019813	1,2-Dimethylhydrazine	"1,2-Dimethylhydrazine results in decreased expression of MT2A mRNA"	27840820
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of MT2A mRNA	15890375\|2538013
D011397	Promegestone	methoxyacetic acid promotes the reaction [Promegestone results in increased expression of MT2A mRNA]	15103026
D011397	Promegestone	Promegestone results in increased expression of MT2A mRNA	15103026
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of MT2A mRNA	20491607
C029402	diphenylcyclopropenone	diphenylcyclopropenone results in increased expression of MT2A mRNA	20491607
D004221	Disulfiram	cupric chloride promotes the reaction [Disulfiram results in increased expression of MT2A mRNA]	19789329
D004221	Disulfiram	Disulfiram results in increased expression of MT2A mRNA	19789329
D004050	Ditiocarb	Ditiocarb analog results in increased expression of MT2A mRNA	26961605
D004317	Doxorubicin	[Doxorubicin co-treated with pluronic block copolymer p85] results in increased expression of MT2A mRNA	16579640
D004317	Doxorubicin	Doxorubicin results in increased expression of MT2A mRNA	16579640
D004317	Doxorubicin	MT2A protein results in decreased susceptibility to Doxorubicin	11309296
D004317	Doxorubicin	[Doxorubicin co-treated with MT2A protein] results in decreased expression of ACADL protein	16144979
D004317	Doxorubicin	[Doxorubicin co-treated with MT2A protein] results in decreased expression of ALDOART1 protein	16144979
D004317	Doxorubicin	[Doxorubicin co-treated with MT2A protein] results in decreased expression of ENO3 protein	16144979
D004317	Doxorubicin	[Doxorubicin co-treated with MT2A protein] results in decreased expression of MB protein	16144979
D004317	Doxorubicin	[Doxorubicin co-treated with MT2A protein] results in decreased expression of PDHB protein	16144979
D004317	Doxorubicin	[Doxorubicin co-treated with MT2A protein] results in decreased expression of TPM1 protein	16144979
D004317	Doxorubicin	[Doxorubicin co-treated with MT2A protein] results in decreased expression of VIM protein	16144979
D004317	Doxorubicin	[Doxorubicin co-treated with MT2A protein] results in increased expression of COX5A protein	16144979
D004317	Doxorubicin	[Doxorubicin co-treated with MT2A protein] results in increased expression of FABP3 protein	16144979
D004317	Doxorubicin	[Doxorubicin co-treated with MT2A protein] results in increased expression of PRDX6 protein	16144979
D004317	Doxorubicin	[Doxorubicin co-treated with MT2A protein] results in increased expression of TNNT2 protein	16144979
D004317	Doxorubicin	[MT2A protein affects the expression of COX5A protein] which results in decreased susceptibility to Doxorubicin	16144979
D004317	Doxorubicin	MT2A protein inhibits the reaction [Doxorubicin results in decreased expression of COX5A protein]	16144979
D004317	Doxorubicin	MT2A protein results in decreased susceptibility to Doxorubicin	16144979\|9294117
D004391	Dust	Dust results in decreased expression of MT2A mRNA	17805423
D004391	Dust	Dust results in increased expression of MT2A mRNA	9325024
C118739	entinostat	entinostat results in increased expression of MT2A mRNA	27188386
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [IL6 protein results in increased expression of MT2A mRNA]	20471814
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [zinc chloride results in increased expression of MT2A mRNA]	20471814
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of MT2A mRNA	20471814
D000431	Ethanol	Ethanol results in increased expression of MT2A mRNA	15475485\|1763792
D000431	Ethanol	Ethanol results in increased expression of MT2A protein	17637929
D000431	Ethanol	LEPR gene mutant form inhibits the reaction [Ethanol results in increased expression of MT2A mRNA]	15475485
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with Cadmium Chloride] results in increased expression of MT2A mRNA	23135549
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of MT2A mRNA	23135549
C433928	EUK-134	Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]]	25724285
C433928	EUK-134	Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A protein]]]	25724285
C433928	EUK-134	Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat results in increased expression of MT2A mRNA]]	25724285
C433928	EUK-134	Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat results in increased expression of MT2A protein]]	25724285
C433928	EUK-134	Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A mRNA]]]	25724285
C433928	EUK-134	Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A protein]]]	25724285
C433928	EUK-134	Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]	25724285
C433928	EUK-134	Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate results in increased expression of MT2A protein]]	25724285
C433928	EUK-134	EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]	25724285
C433928	EUK-134	EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A protein]]	25724285
C433928	EUK-134	EUK-134 inhibits the reaction [Paraquat results in increased expression of MT2A mRNA]	25724285
C433928	EUK-134	EUK-134 inhibits the reaction [Paraquat results in increased expression of MT2A protein]	25724285
C433928	EUK-134	EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A mRNA]]	25724285
C433928	EUK-134	EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A protein]]	25724285
C433928	EUK-134	EUK-134 inhibits the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]	25724285
C433928	EUK-134	EUK-134 inhibits the reaction [Zinc Sulfate results in increased expression of MT2A protein]	25724285
C433928	EUK-134	EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]]	25724285
C433928	EUK-134	EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A protein]]]	25724285
C433928	EUK-134	EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat results in increased expression of MT2A mRNA]]	25724285
C433928	EUK-134	EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat results in increased expression of MT2A protein]]	25724285
C433928	EUK-134	EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A mRNA]]]	25724285
C433928	EUK-134	EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A protein]]]	25724285
C433928	EUK-134	EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]	25724285
C433928	EUK-134	EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate results in increased expression of MT2A protein]]	25724285
C084519	farnesal	farnesal results in increased expression of MT2A mRNA	20491607
C013531	ferric ammonium citrate	[ferric ammonium citrate results in decreased abundance of Iron] which results in increased expression of MT2A mRNA	12393473
C024555	ferric chloride	ferric chloride results in decreased expression of MT2A mRNA	26378417
D005290	Ferric Compounds	Ferric Compounds results in increased expression of MT2A mRNA	24035972
C020748	ferrous sulfate	ferrous sulfate results in increased expression of and affects the localization of MT2A protein	17241390
C020748	ferrous sulfate	[Zinc Sulfate co-treated with ferrous sulfate] results in increased expression of and affects the localization of MT2A protein	17241390
D016650	Fluorescein-5-isothiocyanate	Fluorescein-5-isothiocyanate results in increased expression of MT2A mRNA	20491607
D005485	Flutamide	Flutamide results in increased expression of MT2A mRNA	15885261
D005632	Fructose	Atorvastatin Calcium inhibits the reaction [Fructose results in increased expression of MT2A mRNA]	21122807
D005632	Fructose	Fructose results in increased expression of MT2A mRNA	21122807
C039281	furan	furan results in increased expression of MT2A mRNA	26194646
C027235	gallium nitrate	Acetylcysteine inhibits the reaction [gallium nitrate results in increased expression of MT2A mRNA]	18586083
C027235	gallium nitrate	gallium nitrate results in increased expression of MT2A mRNA	18586083
C027235	gallium nitrate	gallium nitrate results in increased expression of MT2A protein	18586083
D019833	Genistein	Genistein results in increased expression of MT2A mRNA	10656621
C040641	genistin	genistin analog results in increased expression of MT2A mRNA	16719502
D005839	Gentamicins	Gentamicins results in decreased expression of MT2A mRNA	22061828
D005897	Glafenine	Glafenine results in increased expression of MT2A mRNA	24136188
D005938	Glucocorticoids	Glucocorticoids results in increased expression of MT2A mRNA	11878821\|9926163
C030691	gluconic acid	gluconic acid inhibits the reaction [Zinc Sulfate promotes the reaction [Aflatoxin B1 results in increased expression of MT2A mRNA]]	27017951
D005947	Glucose	Glucose results in increased expression of MT2A mRNA	23056475
D005947	Glucose	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Glucose results in increased expression of MT2A mRNA]"	23056475
D005947	Glucose	zinc chloride promotes the reaction [Glucose results in increased expression of MT2A mRNA]	23056475
D005990	Glycerol	Glycerol results in increased expression of MT2A mRNA	20491607
D006046	Gold	Gold results in increased expression of MT2A mRNA	25523186
C511402	Grape Seed Proanthocyanidins	Grape Seed Proanthocyanidins inhibits the reaction [IL6 protein results in increased expression of MT2A mRNA]	20471814
C511402	Grape Seed Proanthocyanidins	Grape Seed Proanthocyanidins inhibits the reaction [zinc chloride results in increased expression of MT2A mRNA]	20471814
C511402	Grape Seed Proanthocyanidins	Grape Seed Proanthocyanidins results in decreased expression of MT2A mRNA	20471814
D006427	Hemin	[Hemin results in decreased abundance of Iron] which results in increased expression of MT2A mRNA	12393473
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of MT2A mRNA	21179406
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of MT2A mRNA	12414654
D006861	Hydrogen Peroxide	MT2A protein inhibits the reaction [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species]	19433272
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of MT2A mRNA	16972253
C020755	hydroxycitronellal	hydroxycitronellal results in increased expression of MT2A mRNA	20491607
C475919	hydroxytamoxifen	GPER1 protein affects the reaction [hydroxytamoxifen results in increased expression of MT2A mRNA]	19153601
C475919	hydroxytamoxifen	hydroxytamoxifen results in increased expression of MT2A mRNA	19153601
D007069	Ifosfamide	Ifosfamide results in increased expression of MT2A mRNA	25596134
C474021	indirubin-3'-monoxime	[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of MT2A mRNA	18958680
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of MT2A mRNA	28628672
D007501	Iron	[Deferoxamine results in decreased abundance of Iron] which results in increased expression of MT2A mRNA	12393473
D007501	Iron	[ferric ammonium citrate results in decreased abundance of Iron] which results in increased expression of MT2A mRNA	12393473
D007501	Iron	[Hemin results in decreased abundance of Iron] which results in increased expression of MT2A mRNA	12393473
D007501	Iron	Iron deficiency results in increased expression of MT2A mRNA	16629162
D007501	Iron	Iron results in increased expression of and affects the localization of MT2A protein	17241390
D007501	Iron	[Zinc co-treated with Iron] results in increased expression of and affects the localization of MT2A protein	17241390
D019266	Iron, Dietary	"Iron, Dietary affects the expression of MT2A mRNA"	15637178
C051140	iron(II)-ascorbic acid complex	iron(II)-ascorbic acid complex results in increased expression of MT2A mRNA	19540330
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of MT2A mRNA	28628672
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of MT2A mRNA	26752646
C410337	K 7174	K 7174 results in decreased expression of MT2A mRNA	24086573
C006552	kaempferol	kaempferol results in increased expression of MT2A mRNA	10656621
D007608	Kainic Acid	Kainic Acid results in increased expression of MT2A mRNA	12692462
D007854	Lead	[Chromium co-treated with Cadmium co-treated with Lead] results in increased expression of MT2A mRNA	11032763
D007854	Lead	Lead results in increased expression of MT2A mRNA	11032763
D007854	Lead	MT2A gene SNP affects the abundance of Lead	22005883
C008261	lead acetate	lead acetate results in increased expression of MT2A mRNA	22821446
C008261	lead acetate	lead acetate results in increased expression of MT2A mRNA	22839698
C008261	lead acetate	[lead acetate co-treated with Cadmium Chloride] results in increased expression of MT2A mRNA	24184865
C008261	lead acetate	lead acetate promotes the reaction [Cadmium Chloride results in increased expression of MT2A mRNA]	19096765
C008261	lead acetate	lead acetate results in increased expression of MT2A mRNA	22641619\|2560105
C008261	lead acetate	Melatonin promotes the reaction [lead acetate results in increased expression of MT2A mRNA]	25601058
D008070	Lipopolysaccharides	Cadmium Chloride inhibits the reaction [Lipopolysaccharides results in increased expression of MT2A mRNA]	9138684
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of MT2A mRNA	9138684
D008070	Lipopolysaccharides	Mercuric Chloride inhibits the reaction [Lipopolysaccharides results in increased expression of MT2A mRNA]	9138684
D008070	Lipopolysaccharides	zinc chloride inhibits the reaction [Lipopolysaccharides results in increased expression of MT2A mRNA]	9138684
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of MT2A mRNA	25613284
D008095	Lithocholic Acid	Lithocholic Acid results in increased expression of MT2A mRNA	21311750
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of MT2A mRNA	26378955
D008550	Melatonin	Melatonin promotes the reaction [lead acetate results in increased expression of MT2A mRNA]	25601058
D015122	Mercaptopurine	Mercaptopurine results in increased expression of MT2A mRNA	23358152
C042720	mercuric bromide	mercuric bromide results in increased expression of MT2A mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT2A mRNA"	27188386
D008627	Mercuric Chloride	Mercuric Chloride inhibits the reaction [Lipopolysaccharides results in increased expression of MT2A mRNA]	9138684
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of MT2A mRNA	10362023\|9138684
D008627	Mercuric Chloride	Curcumin affects the reaction [Mercuric Chloride results in increased expression of MT2A mRNA]	20229497
D008627	Mercuric Chloride	Mercuric Chloride affects the expression of MT2A mRNA	10991963
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of MT2A mRNA	20229497
D008628	Mercury	[MT1M gene polymorphism co-treated with MT2A gene polymorphism] affects the susceptibility to Mercury	23827881
D008628	Mercury	MT2A gene polymorphism affects the susceptibility to Mercury	23827881
D008628	Mercury	MT2A gene SNP affects the abundance of Mercury	22233731
D008628	Mercury	Mercury results in increased expression of MT2A	15138662
D008628	Mercury	Mercury results in increased expression of MT2A protein	12491035
D008628	Mercury	Mercury results in increased expression of MT2A mRNA	2771874\|9462895\|
D008694	Methamphetamine	Methamphetamine results in increased expression of MT2A mRNA	20801194
D008701	Methapyrilene	Methapyrilene results in increased expression of MT2A mRNA	15890375
C013598	methoxyacetic acid	methoxyacetic acid promotes the reaction [Promegestone results in increased expression of MT2A mRNA]	15103026
D008731	Methoxychlor	MT2A protein inhibits the reaction [Methoxychlor results in decreased expression of HSD17B1 mRNA]	12858341
D008748	Methylcholanthrene	AHR protein affects the reaction [Methylcholanthrene results in increased expression of MT2A mRNA]	23994556
D008748	Methylcholanthrene	Dexamethasone promotes the reaction [Methylcholanthrene results in increased expression of MT2A mRNA]	23994556
D008748	Methylcholanthrene	Methylcholanthrene promotes the reaction [Dexamethasone results in increased expression of MT2A mRNA]	23994556
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of MT2A mRNA	23994556
D008748	Methylcholanthrene	NR3C1 protein affects the reaction [Dexamethasone promotes the reaction [Methylcholanthrene results in increased expression of MT2A mRNA]]	23994556
D008748	Methylcholanthrene	NR3C1 protein affects the reaction [Methylcholanthrene promotes the reaction [Dexamethasone results in increased expression of MT2A mRNA]]	23994556
D008748	Methylcholanthrene	NR3C1 protein affects the reaction [Methylcholanthrene results in increased expression of MT2A mRNA]	23994556
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of MT2A mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate affects the expression of MT2A mRNA	12974610
C437683	motexafin gadolinium	motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of MT2A mRNA]	16357179
C437683	motexafin gadolinium	motexafin gadolinium results in increased expression of MT2A mRNA	15867382\|1635717
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of MT2A mRNA	25380136
D009532	Nickel	Acetylcysteine inhibits the reaction [Nickel results in increased expression of MT2A mRNA]	19097988
D009532	Nickel	Nickel results in increased expression of MT2A mRNA	14971665\|1909798
D009532	Nickel	Nickel results in increased expression of MT2A protein	19097988
D009532	Nickel	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Nickel results in increased expression of MT2A mRNA]"	19097988
C022838	nickel chloride	nickel chloride results in increased expression of MT2A mRNA	26378417\|2847226
C022838	nickel chloride	nickel chloride affects the expression of MT2A mRNA	22110744
C029938	nickel sulfate	nickel sulfate results in increased expression of MT2A mRNA	16314067\|2049160
D009599	Nitroprusside	[Nitroprusside results in increased abundance of nitrosonium ion] which results in increased expression of MT2A mRNA	12393473
D009599	Nitroprusside	Nitroprusside results in increased expression of MT2A mRNA	17018880
D009599	Nitroprusside	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Nitroprusside results in increased expression of MT2A mRNA]"	17018880
D009599	Nitroprusside	Zinc Sulfate promotes the reaction [Nitroprusside results in increased expression of MT2A mRNA]	17018880
C504137	nitrosonium ion	[Nitroprusside results in increased abundance of nitrosonium ion] which results in increased expression of MT2A mRNA	12393473
C014112	N-methyl-4-aminophenol	N-methyl-4-aminophenol results in increased expression of MT2A mRNA	20491607
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc co-treated with ochratoxin A] results in increased expression of MT2A mRNA"	19720134
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc] results in increased expression of MT2A mRNA"	19720134
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Nickel results in increased expression of MT2A mRNA]"	19097988
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Nitroprusside results in increased expression of MT2A mRNA]"	17018880
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased expression of MT2A mRNA]"	19097988
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Glucose results in increased expression of MT2A mRNA]"	23056475
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of MT2A mRNA	20971185
C025589	ochratoxin A	"[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc co-treated with ochratoxin A] results in increased expression of MT2A mRNA"	19720134
C025589	ochratoxin A	ochratoxin A results in increased expression of MT2A mRNA	19720134\|2339161
C025589	ochratoxin A	Zinc deficiency inhibits the reaction [ochratoxin A results in increased expression of MT2A mRNA]	19720134
C025589	ochratoxin A	Zinc promotes the reaction [ochratoxin A results in increased expression of MT2A mRNA]	23391613
C025589	ochratoxin A	[MT1A protein co-treated with MT2A protein] results in decreased susceptibility to ochratoxin A	24792326
C025589	ochratoxin A	[MT1A protein co-treated with MT2A protein] inhibits the reaction [ochratoxin A results in decreased expression of MBP protein]	24792326
C025589	ochratoxin A	ochratoxin A results in decreased expression of MT2A protein	24792326
D019301	Oleic Acid	[Oleic Acid co-treated with Palmitic Acid] results in increased expression of MT2A mRNA	26854922
D016627	Oxidopamine	MT2A protein results in decreased susceptibility to Oxidopamine	14604781
D009828	Oleanolic Acid	Oleanolic Acid results in increased expression of MT2A mRNA	17637929
D009828	Oleanolic Acid	Oleanolic Acid results in increased expression of MT2A protein	17637929
D016566	Organoselenium Compounds	[Organoselenium Compounds binds to Copper] which results in increased expression of MT2A mRNA	25167922
C030110	oxaliplatin	MT2A protein affects the susceptibility to oxaliplatin	16773204
C030110	oxaliplatin	oxaliplatin results in decreased expression of MT2A mRNA	16773204
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of MT2A mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of MT2A mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in increased expression of MT2A mRNA	17914565\|2423605
D010100	Oxygen	[Oxygen deficiency co-treated with cobaltous chloride] results in increased expression of MT2A mRNA	19278353
D010100	Oxygen	Oxygen deficiency results in increased expression of MT2A mRNA	17706837\|1927835
D010100	Oxygen	Oxygen results in increased expression of MT2A mRNA	15680347
D010126	Ozone	[Ozone co-treated with Particulate Matter] results in increased expression of MT2A mRNA	23805001
D010126	Ozone	Ozone results in increased expression of MT2A mRNA	23805001\|2862317
D017239	Paclitaxel	MT2A mRNA results in increased susceptibility to Paclitaxel	16322897
D019308	Palmitic Acid	Palmitic Acid results in decreased expression of MT2A mRNA	17658692
D019308	Palmitic Acid	[Oleic Acid co-treated with Palmitic Acid] results in increased expression of MT2A mRNA	26854922
D010269	Paraquat	Paraquat results in increased expression of MT2A mRNA	14503839
D010269	Paraquat	Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]	25724285
D010269	Paraquat	Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A protein]]	25724285
D010269	Paraquat	Acetylcysteine inhibits the reaction [Paraquat results in increased expression of MT2A mRNA]	25724285
D010269	Paraquat	Acetylcysteine inhibits the reaction [Paraquat results in increased expression of MT2A protein]	25724285
D010269	Paraquat	Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A mRNA]]	25724285
D010269	Paraquat	Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A protein]]	25724285
D010269	Paraquat	Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]]	25724285
D010269	Paraquat	Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A protein]]]	25724285
D010269	Paraquat	Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat results in increased expression of MT2A mRNA]]	25724285
D010269	Paraquat	Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat results in increased expression of MT2A protein]]	25724285
D010269	Paraquat	Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A mRNA]]]	25724285
D010269	Paraquat	Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A protein]]]	25724285
D010269	Paraquat	EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]	25724285
D010269	Paraquat	EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A protein]]	25724285
D010269	Paraquat	EUK-134 inhibits the reaction [Paraquat results in increased expression of MT2A mRNA]	25724285
D010269	Paraquat	EUK-134 inhibits the reaction [Paraquat results in increased expression of MT2A protein]	25724285
D010269	Paraquat	EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A mRNA]]	25724285
D010269	Paraquat	EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A protein]]	25724285
D010269	Paraquat	EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]]	25724285
D010269	Paraquat	EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A protein]]]	25724285
D010269	Paraquat	EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat results in increased expression of MT2A mRNA]]	25724285
D010269	Paraquat	EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat results in increased expression of MT2A protein]]	25724285
D010269	Paraquat	EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A mRNA]]]	25724285
D010269	Paraquat	EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A protein]]]	25724285
D010269	Paraquat	Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]	20553223\|2572428
D010269	Paraquat	Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A protein]	25724285
D010269	Paraquat	Paraquat results in increased expression of MT2A mRNA	20553223\|2572428
D010269	Paraquat	Paraquat results in increased expression of MT2A protein	25724285
D010269	Paraquat	Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A mRNA]	20553223\|2572428
D010269	Paraquat	Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A protein]	25724285
D010278	Parathion	[Parathion co-treated with Estradiol] results in decreased expression of MT2A mRNA	17982697
D052638	Particulate Matter	Particulate Matter results in increased expression of MT2A mRNA	22178795
D052638	Particulate Matter	Particulate Matter results in increased expression of MT2A mRNA	9325024
D052638	Particulate Matter	[Ozone co-treated with Particulate Matter] results in increased expression of MT2A mRNA	23805001
D052638	Particulate Matter	Particulate Matter results in increased expression of MT2A mRNA	23805001
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of MT2A mRNA	18593933
C568608	PCI 5002	PCI 5002 results in increased expression of MT2A mRNA	18593933
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of MT2A mRNA	26705709
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in decreased expression of MT2A mRNA	23602845
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of MT2A mRNA	17560707
D010634	Phenobarbital	Phenobarbital results in decreased expression of MT2A mRNA	19162173
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT2A mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of MT2A mRNA	26272509
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of MT2A mRNA	15890375
C006253	pirinixic acid	pirinixic acid results in decreased expression of MT2A mRNA	15890375\|1916217
D010894	Piroxicam	Piroxicam results in decreased expression of MT2A mRNA	21858171
D010936	Plant Extracts	Plant Extracts inhibits the reaction [barium chloride results in increased expression of MT2A mRNA]	26732703
D028321	Plant Preparations	[Estradiol co-treated with Plant Preparations] results in decreased expression of MT2A mRNA	26945725
D010984	Platinum	Platinum results in increased expression of MT2A mRNA	28465190
C422648	pluronic block copolymer p85	[Doxorubicin co-treated with pluronic block copolymer p85] results in increased expression of MT2A mRNA	16579640
C060540	polyhexamethyleneguanidine	polyhexamethyleneguanidine results in increased expression of MT2A mRNA	27989595
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of MT2A protein	23718831
D011374	Progesterone	Progesterone results in increased expression of MT2A mRNA	18037150\|2179573
C010423	pyrithione zinc	pyrithione zinc results in increased expression of MT2A mRNA	20151177\|2142477
C010423	pyrithione zinc	pyrithione zinc results in increased expression of MT2A protein	20151177
C010423	pyrithione zinc	[zinc chloride co-treated with pyrithione zinc] results in increased expression of MT2A mRNA	20801194
D011794	Quercetin	Quercetin results in increased expression of MT2A mRNA	10656621\|2163298
D011794	Quercetin	Quercetin affects the expression of MT2A mRNA	18178720
C068040	quinone methide	quinone methide results in increased expression of MT2A mRNA	9851254
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in increased expression of MT2A mRNA	20945400
D017382	Reactive Oxygen Species	MT2A protein inhibits the reaction [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species]	19433272
D017382	Reactive Oxygen Species	MT2A protein inhibits the reaction [Rotenone results in increased abundance of Reactive Oxygen Species]	16402917
D017382	Reactive Oxygen Species	MT2A protein inhibits the reaction [tert-Butylhydroperoxide results in increased abundance of Reactive Oxygen Species]	16402917
D012402	Rotenone	MT2A protein inhibits the reaction [Rotenone results in increased abundance of Reactive Oxygen Species]	16402917
D012402	Rotenone	MT2A protein inhibits the reaction [Rotenone results in increased activity of CASP3 protein]	16402917
D012402	Rotenone	MT2A protein inhibits the reaction [Rotenone results in increased activity of CASP7 protein]	16402917
D012402	Rotenone	Rotenone results in increased expression of MT2A mRNA	16402917
C010327	salinomycin	salinomycin results in decreased expression of MT2A mRNA	19682730
C078903	seocalcitol	seocalcitol results in decreased expression of MT2A mRNA	12040012
D012834	Silver	Silver analog results in increased expression of MT2A mRNA	24974767\|2718007
D012834	Silver	Silver results in increased expression of MT2A mRNA	22036727\|2254637
D012835	Silver Nitrate	Silver Nitrate results in increased expression of MT2A mRNA	10362023\|2049160
C017947	sodium arsenite	sodium arsenite results in increased expression of MT2A mRNA	12377979\|1267905
C017947	sodium arsenite	sodium arsenite results in increased expression of MT2A protein	11693492\|1976613
C016104	sodium bichromate	sodium bichromate affects the expression of MT2A mRNA	22110744
C016104	sodium bichromate	sodium bichromate results in increased expression of MT2A mRNA	25993096
D012989	Soil Pollutants	Soil Pollutants affects the expression of MT2A mRNA	23631162
D013311	Streptozocin	Streptozocin results in decreased expression of MT2A mRNA	24927960
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of MT2A mRNA	26378955
C047246	temozolomide	MT2A mRNA affects the susceptibility to temozolomide	16365179
D013726	Terbutaline	Terbutaline affects the reaction [Budesonide results in increased expression of MT2A mRNA]	9973176
D013749	Tetrachlorodibenzodioxin	Dexamethasone promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of MT2A mRNA]	23994556
D013749	Tetrachlorodibenzodioxin	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of MT2A mRNA	19619570
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [Dexamethasone results in increased expression of MT2A mRNA]	23994556
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of MT2A mRNA	16039398\|1961957
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MT2A mRNA	11489354\|2010694
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of MT2A mRNA	11521753\|1846511
D013755	Tetradecanoylphorbol Acetate	BAG1 protein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MT2A mRNA]	20858459
D013755	Tetradecanoylphorbol Acetate	[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of MT2A mRNA	18958680
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate results in increased expression of MT2A mRNA	20858459
D013853	Thioacetamide	Thioacetamide results in decreased expression of MT2A mRNA	23411599
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of MT2A mRNA	27404394\|2786577
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of MT2A mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of MT2A mRNA	18087596
C056583	tolmetin glucuronide	tolmetin glucuronide results in increased expression of MT2A mRNA	26528891
D014050	Toluene	Toluene results in decreased expression of MT2A mRNA	22967744
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of MT2A mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of MT2A mRNA	25729387
C011559	tributyltin	tributyltin results in decreased expression of MT2A mRNA	27614199
D014303	Trinitrotoluene	Trinitrotoluene results in increased expression of MT2A mRNA	11409192
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of MT2A mRNA"	26179874
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of MT2A mRNA	29024780
C057693	troglitazone	troglitazone results in increased expression of MT2A mRNA	19631733
D017973	Tungsten Compounds	Tungsten Compounds results in increased expression of MT2A mRNA	14971665
D014415	Tunicamycin	MT2A protein inhibits the reaction [Tunicamycin results in decreased phosphorylation of AKT1 protein]	24680926
D014415	Tunicamycin	MT2A protein inhibits the reaction [Tunicamycin results in increased cleavage of CASP3 protein]	24680926
D014415	Tunicamycin	MT2A protein inhibits the reaction [Tunicamycin results in increased expression of DDIT3 protein]	24680926
D014415	Tunicamycin	MT2A protein inhibits the reaction [Tunicamycin results in increased expression of HSPA5 protein]	24680926
D014415	Tunicamycin	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MT2A protein inhibits the reaction [Tunicamycin results in decreased phosphorylation of AKT1 protein]]	24680926
D014501	Uranium	Uranium results in increased expression of MT2A mRNA	14971665
D014520	Urethane	Urethane results in increased expression of MT2A mRNA	28818685
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in increased expression of MT2A mRNA	10491327
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of MT2A mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of MT2A mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of MT2A mRNA	19101580\|2317975
D014635	Valproic Acid	Valproic Acid results in decreased expression of MT2A mRNA	23665938
C100058	vanillin	vanillin results in increased expression of MT2A mRNA	20491607
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of MT2A mRNA	23897985
D014750	Vincristine	Vincristine results in increased expression of MT2A mRNA	23649840
D024483	Vitamin K 3	Vitamin K 3 results in increased expression of MT2A mRNA	12414654
D015215	Zidovudine	[Zidovudine co-treated with IFNA1 protein] results in increased expression of MT2A mRNA	20370541
D015032	Zinc	Zinc promotes the reaction [MTF1 protein binds to MT2A promoter]	21883094
D015032	Zinc	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Zinc results in increased expression of MT2A mRNA]	17363595
D015032	Zinc	CEBPA protein inhibits the reaction [Zinc results in increased expression of MT2A mRNA]	15389791
D015032	Zinc	CEBPA protein promotes the reaction [MTF1 protein promotes the reaction [Zinc results in increased expression of MT2A mRNA]]	17363595
D015032	Zinc	chromium hexavalent ion inhibits the reaction [Zinc results in increased expression of MT2A mRNA]	12716893
D015032	Zinc	MTF1 protein promotes the reaction [Zinc results in increased expression of MT2A mRNA]	17363595
D015032	Zinc	"[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc co-treated with ochratoxin A] results in increased expression of MT2A mRNA"	19720134
D015032	Zinc	"[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc] results in increased expression of MT2A mRNA"	19720134
D015032	Zinc	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased expression of MT2A mRNA]"	19097988
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of MT2A mRNA	18593933
D015032	Zinc	Zinc binds to MT2A protein	15698955\|1722427
D015032	Zinc	Zinc deficiency inhibits the reaction [ochratoxin A results in increased expression of MT2A mRNA]	19720134
D015032	Zinc	Zinc promotes the reaction [IL1A protein results in increased expression of MT2A mRNA]	1502195
D015032	Zinc	Zinc promotes the reaction [IL1B protein results in increased expression of MT2A mRNA]	1502195
D015032	Zinc	Zinc promotes the reaction [MTF1 protein binds to MT2A enhancer]	16460681
D015032	Zinc	Zinc promotes the reaction [MTF1 protein binds to MT2A promoter]	1459136
D015032	Zinc	Zinc promotes the reaction [ochratoxin A results in increased expression of MT2A mRNA]	23391613
D015032	Zinc	Zinc results in increased expression of MT2A mRNA	11127411\|1116842
D015032	Zinc	Zinc binds to MT2A protein	11087412
D015032	Zinc	Zinc results in increased expression of MT2A mRNA	15612480
D015032	Zinc	Zinc affects the expression of MT2A mRNA	14690761
D015032	Zinc	[Zinc co-treated with Iron] results in increased expression of and affects the localization of MT2A protein	17241390
D015032	Zinc	Zinc deficiency results in increased expression of MT2A	20128680
D015032	Zinc	Zinc deficiency results in increased expression of MT2A mRNA	12672911
D015032	Zinc	Zinc inhibits the reaction [Cadmium Chloride results in increased expression of MT2A]	20096345
D015032	Zinc	Zinc results in increased expression of and affects the localization of MT2A protein	17241390
D015032	Zinc	Zinc results in increased expression of MT2A mRNA	17241390\|2696702
D019345	Zinc Acetate	motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of MT2A mRNA]	16357179
D019345	Zinc Acetate	Zinc Acetate results in increased expression of MT2A mRNA	16357179
C016837	zinc chloride	Dactinomycin inhibits the reaction [zinc chloride results in increased expression of MT2A mRNA]	17234632
C016837	zinc chloride	epigallocatechin gallate inhibits the reaction [zinc chloride results in increased expression of MT2A mRNA]	20471814
C016837	zinc chloride	Grape Seed Proanthocyanidins inhibits the reaction [zinc chloride results in increased expression of MT2A mRNA]	20471814
C016837	zinc chloride	[zinc chloride co-treated with pyrithione zinc] results in increased expression of MT2A mRNA	20801194
C016837	zinc chloride	zinc chloride inhibits the reaction [Lipopolysaccharides results in increased expression of MT2A mRNA]	9138684
C016837	zinc chloride	zinc chloride results in increased expression of MT2A mRNA	16870260\|1723463
C016837	zinc chloride	zinc chloride promotes the reaction [Glucose results in increased expression of MT2A mRNA]	23056475
C016837	zinc chloride	zinc chloride results in increased expression of MT2A mRNA	17637929
C016837	zinc chloride	zinc chloride results in increased expression of MT2A protein	17637929
D017967	Zinc Compounds	Zinc Compounds results in increased expression of MT2A mRNA	24035972
D019287	Zinc Sulfate	Arachidonic Acid promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]	12566070
D019287	Zinc Sulfate	gluconic acid inhibits the reaction [Zinc Sulfate promotes the reaction [Aflatoxin B1 results in increased expression of MT2A mRNA]]	27017951
D019287	Zinc Sulfate	PTEN promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]	21883094
D019287	Zinc Sulfate	Zinc Sulfate promotes the reaction [Aflatoxin B1 results in increased expression of MT2A mRNA]	27017951
D019287	Zinc Sulfate	Zinc Sulfate promotes the reaction [MTF1 protein binds to MT2A enhancer]	16460681
D019287	Zinc Sulfate	Zinc Sulfate promotes the reaction [Nitroprusside results in increased expression of MT2A mRNA]	17018880
D019287	Zinc Sulfate	Zinc Sulfate results in increased expression of MT2A mRNA	10362023\|1256607
D019287	Zinc Sulfate	Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]	25724285
D019287	Zinc Sulfate	Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A protein]]	25724285
D019287	Zinc Sulfate	Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A mRNA]]	25724285
D019287	Zinc Sulfate	Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A protein]]	25724285
D019287	Zinc Sulfate	Acetylcysteine inhibits the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]	25724285
D019287	Zinc Sulfate	Acetylcysteine inhibits the reaction [Zinc Sulfate results in increased expression of MT2A protein]	25724285
D019287	Zinc Sulfate	Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]]	25724285
D019287	Zinc Sulfate	Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A protein]]]	25724285
D019287	Zinc Sulfate	Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A mRNA]]]	25724285
D019287	Zinc Sulfate	Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A protein]]]	25724285
D019287	Zinc Sulfate	Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]	25724285
D019287	Zinc Sulfate	Acetylcysteine promotes the reaction [EUK-134 inhibits the reaction [Zinc Sulfate results in increased expression of MT2A protein]]	25724285
D019287	Zinc Sulfate	EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]	25724285
D019287	Zinc Sulfate	EUK-134 inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A protein]]	25724285
D019287	Zinc Sulfate	EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A mRNA]]	25724285
D019287	Zinc Sulfate	EUK-134 inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A protein]]	25724285
D019287	Zinc Sulfate	EUK-134 inhibits the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]	25724285
D019287	Zinc Sulfate	EUK-134 inhibits the reaction [Zinc Sulfate results in increased expression of MT2A protein]	25724285
D019287	Zinc Sulfate	EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]]	25724285
D019287	Zinc Sulfate	EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A protein]]]	25724285
D019287	Zinc Sulfate	EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A mRNA]]]	25724285
D019287	Zinc Sulfate	EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A protein]]]	25724285
D019287	Zinc Sulfate	EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]]	25724285
D019287	Zinc Sulfate	EUK-134 promotes the reaction [Acetylcysteine inhibits the reaction [Zinc Sulfate results in increased expression of MT2A protein]]	25724285
D019287	Zinc Sulfate	Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]	20553223\|2572428
D019287	Zinc Sulfate	Paraquat promotes the reaction [Zinc Sulfate results in increased expression of MT2A protein]	25724285
D019287	Zinc Sulfate	[Zinc Sulfate co-treated with ferrous sulfate] results in increased expression of and affects the localization of MT2A protein	17241390
D019287	Zinc Sulfate	Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A mRNA]	20553223\|2572428
D019287	Zinc Sulfate	Zinc Sulfate promotes the reaction [Paraquat results in increased expression of MT2A protein]	25724285
D019287	Zinc Sulfate	Zinc Sulfate results in increased expression of and affects the localization of MT2A protein	17241390
D019287	Zinc Sulfate	Zinc Sulfate results in increased expression of MT2A mRNA	17241390\|2055322
D019287	Zinc Sulfate	Zinc Sulfate results in increased expression of MT2A protein	25724285
D019287	Zinc Sulfate	PTEN mutant form inhibits the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]	21883094
C088658	zoledronic acid	zoledronic acid results in increased expression of MT2A mRNA	24714768\|2559613
C027368	zomepirac glucuronide	zomepirac glucuronide results in increased expression of MT2A mRNA	26528891

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	12646258 12970870 14550308 15541360 16778767
GO:0008144	drug binding	-	IDA	19536566
GO:0008270	zinc ion binding	-	IDA	19536566
GO:0008270	zinc ion binding	-	ISS	-
GO:0046872	metal ion binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006878	cellular copper ion homeostasis	-	TAS	6719135
GO:0006882	cellular zinc ion homeostasis	-	IBA	21873635
GO:0010038	response to metal ion	-	TAS	-
GO:0010273	detoxification of copper ion	-	IBA	21873635
GO:0035690	cellular response to drug	-	IDA	19536566
GO:0036016	cellular response to interleukin-3	-	IEP	11168427
GO:0036018	cellular response to erythropoietin	-	IEP	11168427
GO:0045926	negative regulation of growth	-	ISS	-
GO:0050794	regulation of cellular process	-	IBA	21873635
GO:0060333	interferon-gamma-mediated signaling pathway	-	TAS	-
GO:0071276	cellular response to cadmium ion	-	IBA	21873635
GO:0071280	cellular response to copper ion	-	IBA	21873635
GO:0071294	cellular response to zinc ion	-	IBA	21873635
GO:0071294	cellular response to zinc ion	-	IEP	11168427

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	ISS	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005737	cytoplasm	-	ISS	-
GO:0005829	cytosol	-	TAS	-
GO:0048471	perinuclear region of cytoplasm	-	ISS	-

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-1280215	Cytokine Signaling in Immune system	TAS
R-HSA-168256	Immune System	TAS
R-HSA-5660526	Response to metal ions	TAS
R-HSA-5660526	Response to metal ions	IEA
R-HSA-5661231	Metallothioneins bind metals	TAS
R-HSA-5661231	Metallothioneins bind metals	IEA
R-HSA-877300	Interferon gamma signaling	TAS
R-HSA-8953897	Cellular responses to external stimuli	TAS
R-HSA-8953897	Cellular responses to external stimuli	IEA
R-HSA-913531	Interferon Signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26529669	Genetic variation in metallothionein and metal-regulatory transcription factor 1 in relation to urinary cadmium, copper, and zinc. (2015 Dec 15)	Adams SV	Toxicol Appl Pharmacol
26688266	DNA methylation is differentially associated with environmental cadmium exposure based on sex and smoking status. (2016 Feb)	Virani S	Chemosphere
26594907	Polymorphism of Metallothionein 2A Modifies Lead Body Burden in Workers Chronically Exposed to the Metal. (2016)	Fernandes KC	Public Health Genomics
23053628	Metallothionein 2A genetic polymorphisms and risk of ductal breast cancer. (2014 Feb)	Krzeslak A	Clin Exp Med
29173474	Metallothionein 2A gene polymorphism and trace elements in mother-newborn pairs in the Croatian population. (2018 Jan)	Sekovanic A	J Trace Elem Med Biol
19603079	Influence of smoking on colonic gene expression profile in Crohn's disease. (2009 Jul 15)	Nielsen OH	PLoS One
22995156	A polymorphism in metallothionein 1A (MT1A) is associated with cadmium-related excretion of urinary beta 2-microglobulin. (2012 Dec 15)	Lei L	Toxicol Appl Pharmacol